KnockTF-Search

T(co)F Overview

T(co)F:	SOX2
Species:	Homo sapiens
Knock-Method:	siRNA
T(co)F Class:	High-mobility group (HMG) domain factors
T(co)F Superclass:	Other all-alpha-helical DNA-binding domains
Biosample Name:	LN229
Tissue Type:	Central_nervous_system
Biosample Type:	Cell line
# of Control:	2
# of Treat:	2
Data Source:	GEO
Profile ID:	GSE23838
Platform:	GPL1426
Pubmed ID:	21211035

T(co)F

up-regulated gene

down-regulated gene

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:

Target Gene Information of SOX2

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Target Gene	T(co)F	Mean Expr. of Control	Mean Expr. of Treat	Fold Change	Log2FC	Rank	P-value	Corrected _P	Promoter _T(co)F	SE_T(co)F	TE_T(co)F

Target Gene	T(co)F	Mean Expr. of Control	Mean Expr. of Treat	Fold Change	Log2FC	Rank	P-value	Corrected _P	Promoter _T(co)F	SE_T(co)F	TE_T(co)F
HMOX1	SOX2	1.30392	3.39318	2.60231	1.37979	1	0.00767	0.5371	35 CEBPB	483 SOX2	467 SOX2
VGF	SOX2	1.35064	3.47201	2.57065	1.36213	2	0.01191	0.5371	143 AHR	465 SOX2	462 SOX2
SCG2	SOX2	1.28387	2.78585	2.16989	1.11762	3	0.00373	0.51112	47 AP1FJ	537 SOX2	565 SOX2
S100A1	SOX2	3.198	1.50728	0.47132	-1.08522	4	0.04192	0.60766	33 AHR	429 SOX2	456 SOX2
DDIT3	SOX2	1.40881	2.84861	2.02199	1.01578	5	0.00684	0.5371	107 SOX2	399 SOX2	422 SOX2
NGFR	SOX2	1.49543	2.9696	1.98579	0.98971	6	0.04204	0.60766	64 AP2	483 SOX2	514 SOX2
SLC30A1	SOX2	1.51663	3.00807	1.98339	0.98797	7	0.03071	0.59002	77 AHR	451 SOX2	446 SOX2
SIGLEC9	SOX2	1.19489	2.35904	1.97426	0.98131	8	0.35001	0.92521	46 ARNT	249 SOX2	408 SOX2
CSPG4	SOX2	2.8816	1.52557	0.52942	-0.91752	9	0.02198	0.5371	57 AP1	442 SOX2	445 SOX2
DKK1	SOX2	1.21547	2.28322	1.87847	0.90956	10	0.01745	0.5371	54 AML1	547 SOX2	377 SOX2
LMO4	SOX2	2.67526	1.46441	0.54739	-0.86936	11	0.00057	0.45459	101 AHR	572 SOX2	420 SOX2
ATF3	SOX2	1.48191	2.70549	1.82568	0.86844	12	7e-04	0.45459	50 AP1	597 SOX2	529 SOX2
TM4SF1	SOX2	2.77689	1.53294	0.55203	-0.85717	13	0.01081	0.5371	36 AML1	396 SOX2	367 SOX2
GADD45A	SOX2	1.49954	2.70521	1.80403	0.85123	14	0.0139	0.5371	87 AHR	557 SOX2	507 SOX2
CYP1A1	SOX2	1.14163	2.05824	1.80289	0.85031	15	0.01179	0.5371	65 AHR	490 SOX2	446 SOX2

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#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.

Function Analysis of Downstream Target Genes of SOX2

Upregulated.Pathways Downregulated.Pathways Global.Plots

Upstream Pathway Annotation of SOX2

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T(co)F	Pathway Name	Source	Gene Number
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Target Gene Expression Analysis

Expression Atlas of SOX2