T(co)F Overview
T(co)F: RARA
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Nuclear receptors with C4 zinc fingers
T(co)F Superclass: Zinc-coordinating DNA-binding domains
Biosample Name: MCF7
Tissue Type: Mammary_gland
Biosample Type: Cell line
# of Control: 4
# of Treat: 2
Data Source: GEO
Profile ID: GSE26298
Platform: GPL570
Pubmed ID: 21299862

RARA- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of RARA
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of RARA
Upstream Pathway Annotation of RARA
T(co)F Pathway Name Source Gene Number
RARA Signaling by Retinoic Acid Reactome 20
RARA RXR and RAR heterodimerization with other nuclear receptor PID 26
RARA Retinoic acid receptors-mediated signaling PID 30
RARA FSH NetPath 44
RARA Hs_Tryptophan_metabolism_WP465_85055 WikiPathways 45
RARA Nuclear Receptor transcription pathway Reactome 51
RARA Acute myeloid leukemia KEGG 53
RARA IL3 NetPath 84
RARA Activation of anterior HOX genes in hindbrain development during early embryogenesis Reactome 120
RARA Pathways in cancer KEGG 321
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of RARA
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines