T(co)F Overview
T(co)F: STAT6
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: STAT domain factors
T(co)F Superclass: Immunoglobulin fold
Biosample Name: A375
Tissue Type: Skin
Biosample Type: Cell line
# of Control: 3
# of Treat: 1
Data Source: GEO
Profile ID: GSE31534
Platform: GPL570
Pubmed ID: 22536322

STAT6- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of STAT6
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of STAT6
Upstream Pathway Annotation of STAT6
T(co)F Pathway Name Source Gene Number
STAT6 IL-4 signaling pathway(JAK1 JAK3 STAT6) ( IL-4 signaling(JAK1 JAK3 STAT6) ) INOH 7
STAT6 Hs_G1_to_S_cell_cycle_control_WP45_80001 WikiPathways 8
STAT6 Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH 8
STAT6 Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH 8
STAT6 IL-13 signaling pathway(JAK1 TYK2 STAT6) ( IL-13 signaling(JAK1 TYK2 STAT6) ) INOH 10
STAT6 Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH 14
STAT6 JAK/STAT signaling pathway PANTHER 15
STAT6 Hs_Cytokines_and_Inflammatory_Response_WP530_79331 WikiPathways 21
STAT6 IL9 NetPath 24
STAT6 TSLP NetPath 24
STAT6 Hs_TGF-beta_Receptor_Signaling_WP560_90187 WikiPathways 28
STAT6 Downstream signal transduction Reactome 29
STAT6 Signaling events mediated by TCPTP PID 40
STAT6 Hs_IL-4_Signaling_Pathway_WP395_89828 WikiPathways 41
STAT6 Hs_Tryptophan_metabolism_WP465_85055 WikiPathways 45
STAT6 IL12-mediated signaling events PID 62
STAT6 IL4-mediated signaling events PID 66
STAT6 IL4 NetPath 75
STAT6 Interleukin signaling pathway PANTHER 86
STAT6 JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) INOH 97
STAT6 EGF receptor signaling pathway PANTHER 109
STAT6 PDGF signaling pathway PANTHER 113
STAT6 Jak-STAT signaling pathway KEGG 149
STAT6 Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) INOH 178
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of STAT6
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines