T(co)F Overview
T(co)F: ATF2
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Basic leucine zipper factors (bZIP)
T(co)F Superclass: Basic domains
Biosample Name: K562
Tissue Type: Haematopoietic_and_lymphoid_tissue
Biosample Type: Cell line
# of Control: 2
# of Treat: 2
Data Source: GEO
Profile ID: GSE50165
Platform: GPL6884
Pubmed ID: -

ATF2- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of ATF2
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of ATF2
Upstream Pathway Annotation of ATF2
T(co)F Pathway Name Source Gene Number
ATF2 p38 cascade ( BMP2 signaling(through TAK1) ) INOH 8
ATF2 p38 cascade ( TGF-beta signaling(through TAK1) ) INOH 8
ATF2 Activation of the AP-1 family of transcription factors Reactome 10
ATF2 Hs_Energy_Metabolism_WP1541_91584 WikiPathways 13
ATF2 p38 cascade ( Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, p38 cascade) ) INOH 13
ATF2 p38 cascade ( Toll-like receptor signaling pathway (p38 cascade) ) INOH 13
ATF2 p38 cascade ( IL-1 signaling pathway (through p38 cascade) ) INOH 16
ATF2 Hs_AGE-RAGE_pathway_WP2324_89798 WikiPathways 27
ATF2 Hs_ATM_Signaling_Pathway_WP2516_90247 WikiPathways 32
ATF2 Hs_Structural_Pathway_of_Interleukin_1_(IL-1)_WP2637_87707 WikiPathways 34
ATF2 Hs_IL-1_signaling_pathway_WP195_89932 WikiPathways 34
ATF2 Signaling mediated by p38-alpha and p38-beta PID 35
ATF2 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine SMPDB 37
ATF2 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine SMPDB 38
ATF2 Hs_IL-4_Signaling_Pathway_WP395_89828 WikiPathways 41
ATF2 Transcriptional activation of mitochondrial biogenesis Reactome 43
ATF2 RhoA signaling pathway PID 46
ATF2 Circadian Clock Reactome 49
ATF2 Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 WikiPathways 50
ATF2 RAC1 signaling pathway PID 54
ATF2 IL5 NetPath 59
ATF2 ATF-2 transcription factor network PID 59
ATF2 TP53 Regulates Transcription of DNA Repair Genes Reactome 61
ATF2 IL12-mediated signaling events PID 62
ATF2 Hs_TGF-beta_Signaling_Pathway_WP366_90028 WikiPathways 67
ATF2 Regulation of retinoblastoma protein PID 67
ATF2 IL1 NetPath 69
ATF2 Ras Pathway PANTHER 69
ATF2 AP-1 transcription factor network PID 71
ATF2 CDC42 signaling events PID 71
ATF2 IL4 NetPath 75
ATF2 IL2 NetPath 81
ATF2 TSH NetPath 82
ATF2 Regulation of nuclear SMAD2/3 signaling PID 82
ATF2 IL3 NetPath 84
ATF2 RANKL NetPath 84
ATF2 TGF-beta signaling pathway PANTHER 88
ATF2 Leptin NetPath 98
ATF2 KitReceptor NetPath 104
ATF2 Apoptosis signaling pathway PANTHER 104
ATF2 ErbB1 downstream signaling PID 105
ATF2 HATs acetylate histones Reactome 142
ATF2 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 WikiPathways 153
ATF2 BCR NetPath 161
ATF2 AndrogenReceptor NetPath 167
ATF2 TGF_beta_Receptor NetPath 220
ATF2 TCR NetPath 261
ATF2 MAPK signaling pathway KEGG 264
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of ATF2
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines