T(co)F Overview
T(co)F: ATM
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Others
T(co)F Superclass: ENCODE_TF
Biosample Name: MCF10A
Tissue Type: Mammary_gland
Biosample Type: Cell line
# of Control: 3
# of Treat: 6
Data Source: GEO
Profile ID: GSE54268
Platform: GPL10558
Pubmed ID: 24553445

ATM- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of ATM
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of ATM
Upstream Pathway Annotation of ATM
T(co)F Pathway Name Source Gene Number
ATM Sensing of DNA Double Strand Breaks Reactome 6
ATM PLK3 signaling events PID 6
ATM Stabilization of p53 Reactome 9
ATM Hs_TP53_Network_WP1742_71700 WikiPathways 10
ATM Hs_ATM_Signaling_Network_in_Development_and_Disease_WP3878_89745 WikiPathways 11
ATM TP53 Regulates Transcription of Caspase Activators and Caspases Reactome 12
ATM Hs_Signaling_Pathways_in_Glioblastoma_WP2261_89520 WikiPathways 16
ATM Regulation of TP53 Activity through Methylation Reactome 19
ATM TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Reactome 19
ATM Canonical NF-kappaB pathway PID 24
ATM Homologous DNA Pairing and Strand Exchange Reactome 25
ATM Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Reactome 26
ATM Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 WikiPathways 27
ATM Hs_DNA_Damage_Response_WP707_82937 WikiPathways 28
ATM Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694 WikiPathways 28
ATM BARD1 signaling events PID 29
ATM p38 MAPK signaling pathway PID 29
ATM Hs_ATM_Signaling_Pathway_WP2516_90247 WikiPathways 32
ATM Resolution of D-loop Structures through Holliday Junction Intermediates Reactome 33
ATM Hs_Integrated_Cancer_Pathway_WP1971_82939 WikiPathways 33
ATM ATM pathway PID 34
ATM Regulation of TP53 Degradation Reactome 35
ATM Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974 WikiPathways 36
ATM HDR through Single Strand Annealing (SSA) Reactome 37
ATM Presynaptic phase of homologous DNA pairing and strand exchange Reactome 39
ATM p53 pathway PANTHER 39
ATM p53 pathway feedback loops 2 PANTHER 42
ATM HDR through Homologous Recombination (HRR) Reactome 46
ATM Validated transcriptional targets of deltaNp63 isoforms PID 47
ATM Fanconi anemia pathway PID 48
ATM Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 WikiPathways 50
ATM Autodegradation of the E3 ubiquitin ligase COP1 Reactome 51
ATM Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Reactome 52
ATM p53 pathway PID 59
ATM TP53 Regulates Transcription of DNA Repair Genes Reactome 61
ATM DNA Damage/Telomere Stress Induced Senescence Reactome 64
ATM p53 signaling pathway KEGG 66
ATM Nonhomologous End-Joining (NHEJ) Reactome 69
ATM Regulation of Telomerase PID 70
ATM Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Reactome 75
ATM E2F transcription factor network PID 77
ATM Regulation of HSF1-mediated heat shock response Reactome 82
ATM G2/M DNA damage checkpoint Reactome 84
ATM Meiotic recombination Reactome 85
ATM Apoptosis KEGG 88
ATM Regulation of TP53 Activity through Phosphorylation Reactome 89
ATM Processing of DNA double-strand break ends Reactome 98
ATM Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 WikiPathways 122
ATM Cell cycle KEGG 124
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of ATM
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines