T(co)F Overview
T(co)F: PTEN
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Others
T(co)F Superclass: TcoF-DB_TcoF
Biosample Name: A549
Tissue Type: Lung
Biosample Type: Cell line
# of Control: 3
# of Treat: 3
Data Source: GEO
Profile ID: GSE68869
Platform: GPL10558
Pubmed ID: 25995385

PTEN- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of PTEN
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of PTEN
Upstream Pathway Annotation of PTEN
T(co)F Pathway Name Source Gene Number
PTEN Negative regulation of the PI3K/AKT network Reactome 8
PTEN D-myo-inositol (1,3,4)-trisphosphate biosynthesis HumanCyc 15
PTEN AKT(PKB)-mTOR signaling ( Insulin receptor signaling (Mammal) ) INOH 15
PTEN AKT(PKB)-TOR signaling ( Insulin receptor signaling (D. melanogaster) ) INOH 15
PTEN Hypoxia response via HIF activation PANTHER 16
PTEN 3-phosphoinositide degradation HumanCyc 20
PTEN superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism HumanCyc 20
PTEN Joubert syndrome SMPDB 21
PTEN Phosphatidylinositol Phosphate Metabolism SMPDB 21
PTEN Insulin/IGF pathway-protein kinase B signaling cascade PANTHER 22
PTEN Synthesis of IP3 and IP4 in the cytosol Reactome 27
PTEN Hs_Integrated_Cancer_Pathway_WP1971_82939 WikiPathways 33
PTEN Synthesis of PIPs at the plasma membrane Reactome 34
PTEN PI3 kinase pathway PANTHER 38
PTEN p53 pathway PANTHER 39
PTEN Hs_Neural_Crest_Differentiation_WP2064_79263 WikiPathways 40
PTEN p53 pathway feedback loops 2 PANTHER 42
PTEN Inositol phosphate metabolism ( Inositol phosphate metabolism ) INOH 42
PTEN Class I PI3K signaling events PID 46
PTEN RhoA signaling pathway PID 46
PTEN Endometrial cancer KEGG 52
PTEN Signaling events mediated by Stem cell factor receptor (c-Kit) PID 53
PTEN Inositol phosphate metabolism KEGG 54
PTEN Glioma KEGG 65
PTEN p53 signaling pathway KEGG 66
PTEN superpathway of inositol phosphate compounds HumanCyc 68
PTEN Melanoma KEGG 69
PTEN TCR signaling in nave CD4+ T cells PID 69
PTEN BCR signaling pathway PID 70
PTEN AP-1 transcription factor network PID 71
PTEN Phosphatidylinositol signaling system KEGG 78
PTEN PIP3 activates AKT signaling Reactome 81
PTEN Small cell lung cancer KEGG 83
PTEN Prostate cancer KEGG 85
PTEN TP53 Regulates Metabolic Genes Reactome 85
PTEN Leptin NetPath 98
PTEN Downstream TCR signaling Reactome 101
PTEN Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 WikiPathways 122
PTEN PDGFR-beta signaling pathway PID 125
PTEN Tight junction KEGG 131
PTEN Direct p53 effectors PID 141
PTEN AndrogenReceptor NetPath 167
PTEN Inflammation mediated by chemokine and cytokine signaling pathway PANTHER 189
PTEN Focal adhesion KEGG 197
PTEN Pathways in cancer KEGG 321
PTEN EGFR1 NetPath 475
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of PTEN
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines