T(co)F Overview
T(co)F: FOXO1
Species: Homo sapiens
Knock-Method: shRNA
T(co)F Class: Fork head / winged helix factors
T(co)F Superclass: Helix-turn-helix domains
Biosample Name: RS4;11
Tissue Type: Haematopoietic_and_lymphoid_tissue
Biosample Type: Cell line
# of Control: 2
# of Treat: 2
Data Source: GEO
Profile ID: GSE86066
Platform: GPL6244
Pubmed ID: -

FOXO1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of FOXO1
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of FOXO1
Upstream Pathway Annotation of FOXO1
T(co)F Pathway Name Source Gene Number
FOXO1 Negative regulation of gene expression ( Insulin receptor signaling (D. melanogaster) ) INOH 7
FOXO1 Negative regulation of gene expression ( Insulin receptor signaling (Mammal) ) INOH 7
FOXO1 Hs_NAD_metabolism,_sirtuins_and_aging_WP3630_88178 WikiPathways 8
FOXO1 AKT phosphorylates targets in the nucleus Reactome 9
FOXO1 Hs_Angiopoietin_Like_Protein_8_Regulatory_Pathway_WP3915_90629 WikiPathways 9
FOXO1 Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581 WikiPathways 9
FOXO1 Hs_Energy_Metabolism_WP1541_91584 WikiPathways 13
FOXO1 Regulation of gene expression in beta cells Reactome 17
FOXO1 Hs_Follicle_Stimulating_Hormone_(FSH)_signaling_pathway_WP2035_86080 WikiPathways 20
FOXO1 Insulin/IGF pathway-protein kinase B signaling cascade PANTHER 22
FOXO1 Constitutive Signaling by AKT1 E17K in Cancer Reactome 25
FOXO1 Hs_AGE-RAGE_pathway_WP2324_89798 WikiPathways 27
FOXO1 IL-7 NetPath 28
FOXO1 Hs_Rac1-Pak1-p38-MMP-2_pathway_WP3303_87628 WikiPathways 32
FOXO1 Class I PI3K signaling events mediated by Akt PID 35
FOXO1 Hs_ErbB_Signaling_Pathway_WP673_91869 WikiPathways 37
FOXO1 PI3 kinase pathway PANTHER 38
FOXO1 Signaling events mediated by HDAC Class III PID 41
FOXO1 FSH NetPath 44
FOXO1 IL6-mediated signaling events PID 48
FOXO1 Angiopoietin receptor Tie2-mediated signaling PID 50
FOXO1 FoxO family signaling PID 50
FOXO1 Regulation of Androgen receptor activity PID 54
FOXO1 Regulation of nuclear SMAD2/3 signaling PID 82
FOXO1 IL3 NetPath 84
FOXO1 Prostate cancer KEGG 85
FOXO1 IL6 NetPath 85
FOXO1 CXCR4-mediated signaling events PID 87
FOXO1 MAPK6/MAPK4 signaling Reactome 90
FOXO1 Leptin NetPath 98
FOXO1 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 WikiPathways 122
FOXO1 Insulin signaling pathway KEGG 134
FOXO1 Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 WikiPathways 153
FOXO1 BCR NetPath 161
FOXO1 AndrogenReceptor NetPath 167
FOXO1 TGF_beta_Receptor NetPath 220
FOXO1 TNFalpha NetPath 274
FOXO1 Pathways in cancer KEGG 321
FOXO1 EGFR1 NetPath 475
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of FOXO1
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines