T(co)F Overview
T(co)F: ELK1
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Tryptophan cluster factors
T(co)F Superclass: Helix-turn-helix domains
Biosample Name: MDA-MB-231
Tissue Type: Mammary_gland
Biosample Type: Cell line
# of Control: 2
# of Treat: 2
Data Source: GEO
Profile ID: GSE18849
Platform: GPL4133
Pubmed ID: 20005852

ELK1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of ELK1
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of ELK1
Upstream Pathway Annotation of ELK1
T(co)F Pathway Name Source Gene Number
ELK1 ERK cascade ( EGF signaling pathway Diagram ) INOH 6
ELK1 ERK cascade ( HGF signaling pathway ) INOH 6
ELK1 ERK cascade ( VEGF signaling pathway ) INOH 6
ELK1 ERK cascade ( PDGF signaling pathway ) INOH 7
ELK1 Hs_G_Protein_Signaling_Pathways_WP35_88601 WikiPathways 8
ELK1 ERK cascade ( FGF signaling pathway ) INOH 8
ELK1 ERK cascade ( IGF1 signaling pathway ) INOH 8
ELK1 ERK cascade ( Insulin receptor signaling (D. melanogaster) ) INOH 8
ELK1 ERK cascade ( Insulin receptor signaling (Mammal) ) INOH 8
ELK1 ERK cascade ( NGF signaling pathway ) INOH 8
ELK1 Hs_Estrogen_signaling_pathway_WP712_78491 WikiPathways 13
ELK1 Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 WikiPathways 13
ELK1 Ras signaling in the CD4+ TCR pathway PID 14
ELK1 Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 WikiPathways 15
ELK1 ERK/MAPK targets Reactome 17
ELK1 ERK cascade ( FGF8 signaling (Mouse) ) INOH 17
ELK1 ERK cascade ( FGF8 signaling (Xenopus) ) INOH 17
ELK1 FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) INOH 18
ELK1 FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) INOH 20
ELK1 Hs_Cytokines_and_Inflammatory_Response_WP530_79331 WikiPathways 21
ELK1 PDGFR-alpha signaling pathway PID 22
ELK1 Oxidative stress response PANTHER 23
ELK1 S1P2 pathway PID 26
ELK1 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade PANTHER 29
ELK1 p38 MAPK pathway PANTHER 31
ELK1 Prion diseases KEGG 34
ELK1 Hs_Structural_Pathway_of_Interleukin_1_(IL-1)_WP2637_87707 WikiPathways 34
ELK1 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin PANTHER 34
ELK1 HIF-2-alpha transcription factor network PID 34
ELK1 Trk receptor signaling mediated by the MAPK pathway PID 34
ELK1 Hs_IL-5_Signaling_Pathway_WP127_78498 WikiPathways 35
ELK1 Hs_Leptin_signaling_pathway_WP2034_89856 WikiPathways 37
ELK1 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine SMPDB 37
ELK1 ID NetPath 38
ELK1 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine SMPDB 38
ELK1 Hs_IL-4_Signaling_Pathway_WP395_89828 WikiPathways 41
ELK1 Toll receptor signaling pathway PANTHER 44
ELK1 Angiopoietin receptor Tie2-mediated signaling PID 50
ELK1 Endometrial cancer KEGG 52
ELK1 Hs_MAPK_Signaling_Pathway_WP382_79951 WikiPathways 58
ELK1 IL5 NetPath 59
ELK1 Ras Pathway PANTHER 69
ELK1 Downstream signaling in nave CD8+ T cells PID 69
ELK1 BCR signaling pathway PID 70
ELK1 Leishmaniasis KEGG 71
ELK1 Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 WikiPathways 71
ELK1 IL4 NetPath 75
ELK1 Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 WikiPathways 80
ELK1 IL2 NetPath 81
ELK1 ErbB signaling pathway KEGG 83
ELK1 Parkinson disease PANTHER 85
ELK1 Interleukin signaling pathway PANTHER 86
ELK1 GnRH signaling pathway KEGG 98
ELK1 Leptin NetPath 98
ELK1 KitReceptor NetPath 104
ELK1 Prolactin NetPath 105
ELK1 ErbB1 downstream signaling PID 105
ELK1 Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 WikiPathways 107
ELK1 PDGF signaling pathway PANTHER 113
ELK1 PDGFR-beta signaling pathway PID 125
ELK1 Insulin signaling pathway KEGG 134
ELK1 BCR NetPath 161
ELK1 Focal adhesion KEGG 197
ELK1 MAPK signaling pathway KEGG 264
ELK1 EGFR1 NetPath 475
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of ELK1
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines