T(co)F Overview
T(co)F: HDAC8
Species: Homo sapiens
Knock-Method: CRISPRi
T(co)F Class: Others
T(co)F Superclass: TcoF-DB_TcoF
Biosample Name: K562
Tissue Type: Haematopoietic_and_lymphoid_tissue
Biosample Type: Cell line
# of Control: 2
# of Treat: 2
Data Source: ENCODE
Profile ID: ENCSR369BHC
Platform: -
Pubmed ID: 22955616

HDAC8- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of HDAC8
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of HDAC8
Upstream Pathway Annotation of HDAC8
T(co)F Pathway Name Source Gene Number
HDAC8 Negative regulation of (transcription by R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) ) INOH 21
HDAC8 NOTCH1 Intracellular Domain Regulates Transcription Reactome 47
HDAC8 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Reactome 57
HDAC8 Constitutive Signaling by NOTCH1 PEST Domain Mutants Reactome 57
HDAC8 Signaling events mediated by HDAC Class I PID 89
HDAC8 HDACs deacetylate histones Reactome 94
HDAC8 Resolution of Sister Chromatid Cohesion Reactome 100
HDAC8 Separation of Sister Chromatids Reactome 163
HDAC8 Wnt signaling pathway PANTHER 250
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of HDAC8
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines