T(co)F Overview
T(co)F: STAT5A
Species: Homo sapiens
Knock-Method: CRISPRi
T(co)F Class: STAT domain factors
T(co)F Superclass: Immunoglobulin fold
Biosample Name: K562
Tissue Type: Haematopoietic_and_lymphoid_tissue
Biosample Type: Cell line
# of Control: 2
# of Treat: 2
Data Source: ENCODE
Profile ID: ENCSR376CFR
Platform: -
Pubmed ID: 22955616

STAT5A- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of STAT5A
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of STAT5A
Upstream Pathway Annotation of STAT5A
T(co)F Pathway Name Source Gene Number
STAT5A IL-2 signaling pathway(JAK1 JAK3 STAT5) ( IL-2 signaling(JAK1 JAK3 STAT5) ) INOH 7
STAT5A IL-3 signaling pathway(JAK1 JAK2 STAT5) ( IL-3 signaling(JAK1 JAK2 STAT5) ) INOH 7
STAT5A Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH 8
STAT5A Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH 8
STAT5A Growth hormone signaling pathway(JAK2 STAT5) ( Growth hormone signaling(JAK2 STAT5) ) INOH 9
STAT5A Interleukin-7 signaling Reactome 11
STAT5A Signaling by Leptin Reactome 11
STAT5A IL-5 signaling pathway(JAK1 JAK2 STAT1 STAT5) ( IL-5 signaling(JAK1 JAK2 STAT1 STAT5) ) INOH 11
STAT5A EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) INOH 12
STAT5A IL-7 signaling pathway(JAK1 JAK3 STAT5) ( IL-7 signaling(JAK1 JAK3 STAT5) ) INOH 13
STAT5A Interleukin-2 signaling Reactome 14
STAT5A IL5-mediated signaling events PID 14
STAT5A Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH 14
STAT5A Prolactin receptor signaling Reactome 15
STAT5A JAK/STAT signaling pathway PANTHER 15
STAT5A Hs_IL-7_Signaling_Pathway_WP205_89854 WikiPathways 16
STAT5A Hs_Bladder_Cancer_WP2828_89143 WikiPathways 17
STAT5A Signaling by cytosolic FGFR1 fusion mutants Reactome 18
STAT5A Growth hormone receptor signaling Reactome 24
STAT5A Interleukin-3, 5 and GM-CSF signaling Reactome 24
STAT5A IL9 NetPath 24
STAT5A TSLP NetPath 24
STAT5A Nuclear signaling by ERBB4 Reactome 25
STAT5A IL27-mediated signaling events PID 26
STAT5A Hs_AGE-RAGE_pathway_WP2324_89798 WikiPathways 27
STAT5A IL3-mediated signaling events PID 27
STAT5A IL-7 NetPath 28
STAT5A Downstream signal transduction Reactome 29
STAT5A PDGF signaling pathway (Mammal) ( PDGF signaling pathway ) INOH 29
STAT5A IL2 signaling events mediated by STAT5 PID 30
STAT5A Hs_Association_Between_Physico-Chemical_Features_and_Toxicity_Associated_Pathways_WP3680_90113 WikiPathways 31
STAT5A Hs_IL-2_Signaling_Pathway_WP49_91243 WikiPathways 33
STAT5A EPO signaling pathway PID 33
STAT5A Hs_Interferon_type_I_signaling_pathways_WP585_85198 WikiPathways 35
STAT5A Hs_IL-5_Signaling_Pathway_WP127_78498 WikiPathways 35
STAT5A Hs_IL-3_Signaling_Pathway_WP286_78583 WikiPathways 35
STAT5A ErbB4 signaling events PID 35
STAT5A Hs_Regulation_of_Actin_Cytoskeleton_WP51_79977 WikiPathways 36
STAT5A CD40/CD40L signaling PID 36
STAT5A Trk receptor signaling mediated by PI3K and PLC-gamma PID 36
STAT5A Signaling by SCF-KIT Reactome 37
STAT5A Hs_ErbB_Signaling_Pathway_WP673_91869 WikiPathways 37
STAT5A IL23-mediated signaling events PID 37
STAT5A GMCSF-mediated signaling events PID 38
STAT5A Signaling events mediated by TCPTP PID 40
STAT5A Hs_IL-4_Signaling_Pathway_WP395_89828 WikiPathways 41
STAT5A Hs_Tryptophan_metabolism_WP465_85055 WikiPathways 45
STAT5A Hs_Kit_receptor_signaling_pathway_WP304_78799 WikiPathways 46
STAT5A Angiopoietin receptor Tie2-mediated signaling PID 50
STAT5A Hs_Prolactin_Signaling_Pathway_WP2037_90015 WikiPathways 52
STAT5A Acute myeloid leukemia KEGG 53
STAT5A Signaling events mediated by PTP1B PID 53
STAT5A Signaling events mediated by Stem cell factor receptor (c-Kit) PID 53
STAT5A Hs_TYROBP_Causal_Network_WP3945_90843 WikiPathways 54
STAT5A IL2-mediated signaling events PID 54
STAT5A RAC1 signaling pathway PID 54
STAT5A IL5 NetPath 59
STAT5A IL12-mediated signaling events PID 62
STAT5A Validated nuclear estrogen receptor alpha network PID 65
STAT5A IL4-mediated signaling events PID 66
STAT5A Chronic myeloid leukemia KEGG 69
STAT5A IL4 NetPath 75
STAT5A IL2 NetPath 81
STAT5A ErbB signaling pathway KEGG 83
STAT5A IL3 NetPath 84
STAT5A IL6 NetPath 85
STAT5A Glucocorticoid receptor regulatory network PID 85
STAT5A Interleukin signaling pathway PANTHER 86
STAT5A CXCR4-mediated signaling events PID 87
STAT5A JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) INOH 97
STAT5A Leptin NetPath 98
STAT5A KitReceptor NetPath 104
STAT5A Prolactin NetPath 105
STAT5A Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 WikiPathways 107
STAT5A EGF receptor signaling pathway PANTHER 109
STAT5A PDGF signaling pathway PANTHER 113
STAT5A PDGFR-beta signaling pathway PID 125
STAT5A Jak-STAT signaling pathway KEGG 149
STAT5A Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) INOH 178
STAT5A TCR NetPath 261
STAT5A TNFalpha NetPath 274
STAT5A Pathways in cancer KEGG 321
STAT5A EGFR1 NetPath 475
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of STAT5A
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines