KnockTF-Search

T(co)F Overview

T(co)F:	FOXA1
Species:	Homo sapiens
Knock-Method:	siRNA
T(co)F Class:	Fork head / winged helix factors
T(co)F Superclass:	Helix-turn-helix domains
Biosample Name:	MCF7
Tissue Type:	Mammary_gland
Biosample Type:	Cell line
# of Control:	6
# of Treat:	6
Data Source:	GEO
Profile ID:	GSE25315
Platform:	GPL10558
Pubmed ID:	21151129

FOXA1- Target Gene Network

T(co)F

up-regulated gene

down-regulated gene

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:

Target Gene Information of FOXA1

Showing 1 to 15 of 18,780 entries

Search:

Target Gene	T(co)F	Mean Expr. of Control	Mean Expr. of Treat	Fold Change	Log2FC	Rank	P-value	Corrected _P	Promoter _T(co)F	SE_T(co)F	TE_T(co)F

Target Gene	T(co)F	Mean Expr. of Control	Mean Expr. of Treat	Fold Change	Log2FC	Rank	P-value	Corrected _P	Promoter _T(co)F	SE_T(co)F	TE_T(co)F
S100A9	FOXA1	9.23558	12.6614	10.7469	3.42585	1	3.9122708940238e-21	1.35372397475011e-16	41 AML1	316 AHRARNT	356 AHRARNT
S100A8	FOXA1	8.6626	11.7585	8.55016	3.09595	2	8.24963306918899e-21	1.42726901730039e-16	49 AML1	316 AHRARNT	353 AHRARNT
FXYD4	FOXA1	8.24313	10.8601	6.13478	2.61701	3	5.87207163360326e-19	4.0637084533188e-15	46 BCL6B	425 AHR	415 AHR
KRT13	FOXA1	9.75323	12.3689	6.129	2.61565	4	9.23112102409503e-19	5.32358749459561e-15	52 AHR	349 AHR	429 AHR
ANXA1	FOXA1	8.15534	10.751	6.04446	2.59561	5	2.93008732903893e-20	3.3795627253135e-16	32 CDP	509 FOXA1	585 FOXA1
ASCL1	FOXA1	11.118	8.73735	0.192022	-2.38066	6	4.57635996723365e-15	1.95495318007677e-12	84 AHR	519 FOXA1	462 AHR
LCN2	FOXA1	7.97507	10.3019	5.01708	2.32685	7	3.52868028208016e-18	1.52624243900672e-14	39 AHRARNT	526 AHR	489 AHR
SPDEF	FOXA1	11.2815	8.95487	0.199349	-2.32663	8	5.35839239911425e-16	4.40224343320752e-13	33 ELF3	525 FOXA1	439 AHR
ABCA1	FOXA1	8.59908	10.8863	4.88132	2.28727	9	7.65568811336757e-16	5.40616571630091e-13	51 AHR	557 AHR	561 AHR
AKR1C3	FOXA1	10.432	12.6823	4.7576	2.25023	10	4.33034126453865e-19	3.74596171088916e-15	25 DLX1	365 FOXA1	362 FOXA1
ATP6V1B1	FOXA1	8.56222	10.766	4.60674	2.20374	11	1.2506781949952e-17	3.53649441258197e-14	39 ASCL1	416 AHR	441 AHR
HMOX1	FOXA1	8.51912	10.5805	4.17371	2.06133	12	4.81117120912121e-16	4.06039380921981e-13	35 CEBPB	483 AHRARNT	467 AHRARNT
DDIT4	FOXA1	10.9589	12.9579	3.99732	1.99903	13	7.18708286705751e-15	2.73137951142838e-12	85 AHRARNT	448 AHR	446 AHR
HIST1H4H	FOXA1	9.3593	11.3405	3.94818	1.98119	14	1.15747818878096e-18	5.72158004117127e-15	48 ASCL2	376 FOXA1	366 FOXA1
LOXL4	FOXA1	7.95682	9.93673	3.94468	1.97991	15	5.36583157438245e-14	1.27170208312864e-11	63 AP2	533 AHR	477 AHR

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#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.

Function Analysis of Downstream Target Genes of FOXA1

Upregulated.Pathways Downregulated.Pathways Global.Plots

Upstream Pathway Annotation of FOXA1

From 1 to 5 results, Total 5 items

Search:

T(co)F	Pathway Name	Source	Gene Number
FOXA1	FOXA1 transcription factor network	PID	45
FOXA1	FOXA2 and FOXA3 transcription factor networks	PID	45
FOXA1	Hs_Endoderm_Differentiation_WP2853_88152	WikiPathways	62
FOXA1	Direct p53 effectors	PID	141
FOXA1	AndrogenReceptor	NetPath	167

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Target Gene Expression Analysis

Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression

Expression Atlas of FOXA1

T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)

T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines