KnockTF-Search

T(co)F Overview

T(co)F:	MYC
Species:	Homo sapiens
Knock-Method:	siRNA
T(co)F Class:	Basic helix-loop-helix factors (bHLH)
T(co)F Superclass:	Basic domains
Biosample Name:	DAOY M2.1
Tissue Type:	Central_nervous_system
Biosample Type:	Cell line
# of Control:	3
# of Treat:	3
Data Source:	GEO
Profile ID:	GSE22139
Platform:	GPL570
Pubmed ID:	21317922

MYC- Target Gene Network

T(co)F

up-regulated gene

down-regulated gene

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:

Target Gene Information of MYC

Showing 1 to 15 of 16,242 entries

Search:

Target Gene	T(co)F	Mean Expr. of Control	Mean Expr. of Treat	Fold Change	Log2FC	Rank	P-value	Corrected _P	Promoter _T(co)F	SE_T(co)F	TE_T(co)F

Target Gene	T(co)F	Mean Expr. of Control	Mean Expr. of Treat	Fold Change	Log2FC	Rank	P-value	Corrected _P	Promoter _T(co)F	SE_T(co)F	TE_T(co)F
IGFBP7	MYC	189.653	3519.68	18.5585	4.21401	1	1.36380213862574e-10	9.29559368491622e-08	60 MYC	553 MYC	551 MYC
MAMDC2	MYC	9.08	155.8	17.1586	4.10086	2	1.45507228886394e-10	9.29559368491622e-08	48 AP1	529 MYC	556 MYC
TGFB1I1	MYC	120.9	1927.67	15.9443	3.99497	3	4.92700163869608e-13	1.06694220485964e-08	58 AP4	446 MYC	439 MYC
IGFBP3	MYC	106.462	1681.33	15.7928	3.9812	4	4.89512131905528e-11	7.54774616267242e-08	48 AHRARNT	673 MYC	694 MYC
FILIP1L	MYC	106.499	1436.53	13.4887	3.75367	5	9.97098441608807e-12	5.53690863361898e-08	42 ASCL2	577 AHRARNT	592 MYC
CTHRC1	MYC	110.667	1481.33	13.3855	3.7426	6	4.25137739850961e-12	4.60317887823628e-08	64 MYC	475 MYC	390 MYC
HAS2	MYC	29.32	389.383	13.2805	3.73123	7	2.25695529283936e-10	1.01821597638409e-07	78 MYC	617 MYC	646 MYC
INHBA	MYC	203.219	2653.02	13.055	3.70653	8	1.80935811794121e-09	1.83951408657356e-07	64 AREB6	573 MYC	579 MYC
COL15A1	MYC	13.74	175	12.7365	3.6709	9	7.35295072953406e-11	7.54774616267242e-08	26 AREB6	558 MYC	518 MYC
MMP9	MYC	184.9	2314.67	12.5185	3.64599	10	5.11868517288793e-10	1.27408192435503e-07	59 MYC	501 MYC	501 MYC
SLC27A2	MYC	364.933	31.8733	0.0873401	-3.51721	11	6.15952442198738e-09	3.24536499654834e-07	55 AHR	562 MYC	429 MYC
MMP7	MYC	39.25	447.067	11.3902	3.50973	12	8.04159473509184e-10	1.38364040534198e-07	17 AP1	493 MYC	472 MYC
CH25H	MYC	32.63	340.1	10.4229	3.38169	13	1.68319192453733e-09	1.75542767564063e-07	51 MYC	438 MYC	491 MYC
WIPI1	MYC	45.89	475.4	10.3596	3.37289	14	6.68394929594624e-10	1.34019372225663e-07	64 AML1	502 MYC	426 MYC
LRRC17	MYC	371.1	3828.64	10.317	3.36695	15	1.02274922809863e-11	5.53690863361898e-08	39 AML1	428 AHR	384 AHR

Show entries

#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.

Function Analysis of Downstream Target Genes of MYC

Upregulated.Pathways Downregulated.Pathways Global.Plots

Upstream Pathway Annotation of MYC

From 1 to 10 results, Total 66 items

Search:

T(co)F	Pathway Name	Source	Gene Number
MYC	Binding of TCF/LEF:CTNNB1 to target gene promoters	Reactome	7
MYC	Hs_TP53_Network_WP1742_71700	WikiPathways	10
MYC	Hs_Imatinib_and_Chronic_Myeloid_Leukemia_WP3640_89384	WikiPathways	11
MYC	Cyclin E associated events during G1/S transition	Reactome	14
MYC	Cyclin A:Cdk2-associated events at S phase entry	Reactome	15
MYC	Hs_IL-7_Signaling_Pathway_WP205_89854	WikiPathways	16
MYC	Oxidative stress response	PANTHER	23
MYC	Thyroid cancer	KEGG	25
MYC	C-MYC pathway	PID	25
MYC	Hs_Gastric_Cancer_Network_2_WP2363_87523	WikiPathways	28

Show entries

<
1
2
3
4
5
6
7
>

Target Gene Expression Analysis

Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression

Expression Atlas of MYC

T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)

T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines