KnockTF-Search

T(co)F Overview

T(co)F:	PBX1
Species:	Homo sapiens
Knock-Method:	siRNA
T(co)F Class:	Homeo domain factors
T(co)F Superclass:	Helix-turn-helix domains
Biosample Name:	MCF7
Tissue Type:	Mammary_gland
Biosample Type:	Cell line
# of Control:	4
# of Treat:	4
Data Source:	GEO
Profile ID:	GSE39418
Platform:	GPL10558
Pubmed ID:	23576735

PBX1- Target Gene Network

T(co)F

up-regulated gene

down-regulated gene

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:

Target Gene Information of PBX1

Showing 1 to 15 of 18,780 entries

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Target Gene	T(co)F	Mean Expr. of Control	Mean Expr. of Treat	Fold Change	Log2FC	Rank	P-value	Corrected _P	Promoter _T(co)F	SE_T(co)F	TE_T(co)F

Target Gene	T(co)F	Mean Expr. of Control	Mean Expr. of Treat	Fold Change	Log2FC	Rank	P-value	Corrected _P	Promoter _T(co)F	SE_T(co)F	TE_T(co)F
H19	PBX1	9.59919	7.65032	0.259019	-1.94887	1	5.93428465523701e-10	1.22158928431407e-05	71 AHR	446 PBX1	432 PBX1
CALCR	PBX1	7.08345	8.67217	3.00783	1.58872	2	8.32043510975275e-10	1.22158928431407e-05	45 PBX1	289 PBX1	428 PBX1
ENPP5	PBX1	6.82609	8.24032	2.66517	1.41423	3	2.67138599437462e-08	0.000112468483232205	46 PBX1	270 PBX1	383 PBX1
PABPC4L	PBX1	7.45506	8.63084	2.25915	1.17578	4	1.18941816671195e-08	6.85937456742781e-05	50 AML1	369 PBX1	633 PBX1
TIMP3	PBX1	7.31562	6.18744	0.457491	-1.12818	5	3.32944980675682e-06	0.0013099771922144	58 AHRARNT	595 PBX1	587 PBX1
PBX1	PBX1	7.78336	6.65953	0.458874	-1.12383	6	1.05912023956482e-09	1.22158928431407e-05	89 PBX1	589 PBX1	659 PBX1
REEP5	PBX1	10.8351	9.72736	0.464015	-1.10776	7	9.28767282717227e-08	0.000200857534478634	46 AHRARNT	517 PBX1	395 PBX1
KIAA1324	PBX1	8.8307	9.87194	2.05799	1.04124	8	3.54525054902184e-07	0.000471818305758668	52 AREB6	554 PBX1	545 PBX1
PROS1	PBX1	6.23899	7.27579	2.05168	1.03681	9	1.58157866276282e-06	0.00097908421396982	34 ARID3A	187 AIRE	418 PBX1
GDF15	PBX1	11.6451	10.6177	0.490599	-1.02738	10	3.0815237437473e-06	0.00127923387655177	40 CEBPB	506 PBX1	450 PBX1
PSCA	PBX1	8.03205	7.01791	0.495126	-1.01413	11	0.000325929606195586	0.0186410185679003	49 ASCL1	434 PBX1	445 PBX1
HINT1	PBX1	10.7683	11.7706	2.00331	1.00238	12	7.70418072983243e-07	0.000680990907819433	38 AHRARNT	477 PBX1	579 PBX1
TXNIP	PBX1	11.1622	12.1582	1.99449	0.996019	13	5.63301481735628e-07	0.00058175797137747	59 AHRARNT	455 PBX1	412 PBX1
RASD1	PBX1	9.53861	8.56196	0.508157	-0.976653	14	0.00372340422004899	0.0777935016707298	83 AP1	525 PBX1	503 PBX1
FXYD4	PBX1	6.91946	5.94457	0.508781	-0.974884	15	7.46855280072422e-08	0.000172284576007106	46 BCL6B	425 PBX1	415 PBX1

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#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.

Function Analysis of Downstream Target Genes of PBX1

Upregulated.Pathways Downregulated.Pathways Global.Plots

Upstream Pathway Annotation of PBX1

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T(co)F	Pathway Name	Source	Gene Number
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Target Gene Expression Analysis

Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression

Expression Atlas of PBX1

T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)

T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines