T(co)F Overview
T(co)F: SP1
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: C2H2 zinc finger factors
T(co)F Superclass: Zinc-coordinating DNA-binding domains
Biosample Name: HeLa
Tissue Type: Cervix
Biosample Type: Cell line
# of Control: 3
# of Treat: 3
Data Source: GEO
Profile ID: GSE37935
Platform: GPL570
Pubmed ID: 23018034

SP1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of SP1
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of SP1
Upstream Pathway Annotation of SP1
T(co)F Pathway Name Source Gene Number
SP1 Hs_Estrogen_signaling_pathway_WP712_78491 WikiPathways 13
SP1 Hs_Interleukin-11_Signaling_Pathway_WP2332_79525 WikiPathways 17
SP1 Hs_AGE-RAGE_pathway_WP2324_89798 WikiPathways 27
SP1 Hs_Androgen_receptor_signaling_pathway_WP138_79958 WikiPathways 27
SP1 Oncogene Induced Senescence Reactome 30
SP1 IL2 signaling events mediated by STAT5 PID 30
SP1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Reactome 32
SP1 Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 WikiPathways 33
SP1 HIF-2-alpha transcription factor network PID 34
SP1 Hs_Leptin_signaling_pathway_WP2034_89856 WikiPathways 37
SP1 Validated transcriptional targets of AP1 family members Fra1 and Fra2 PID 37
SP1 Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 WikiPathways 41
SP1 Activation of gene expression by SREBF (SREBP) Reactome 42
SP1 FOXM1 transcription factor network PID 43
SP1 FOXA1 transcription factor network PID 45
SP1 FOXA2 and FOXA3 transcription factor networks PID 45
SP1 Validated transcriptional targets of TAp63 isoforms PID 54
SP1 Validated targets of C-MYC transcriptional repression PID 63
SP1 IL4-mediated signaling events PID 66
SP1 Hs_TGF-beta_Signaling_Pathway_WP366_90028 WikiPathways 67
SP1 HIF-1-alpha transcription factor network PID 67
SP1 RNA polymerase II transcribes snRNA genes Reactome 70
SP1 Regulation of Telomerase PID 70
SP1 AP-1 transcription factor network PID 71
SP1 E2F transcription factor network PID 77
SP1 p73 transcription factor network PID 80
SP1 TGF-beta signaling pathway KEGG 82
SP1 Regulation of nuclear SMAD2/3 signaling PID 82
SP1 C-MYB transcription factor network PID 87
SP1 Leptin NetPath 98
SP1 Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 WikiPathways 107
SP1 PPARA activates gene expression Reactome 113
SP1 Huntington disease PANTHER 113
SP1 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 WikiPathways 122
SP1 Direct p53 effectors PID 141
SP1 AndrogenReceptor NetPath 167
SP1 Huntington's disease KEGG 182
SP1 TGF_beta_Receptor NetPath 220
SP1 EGFR1 NetPath 475
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of SP1
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines