KnockTF-Search

T(co)F Overview

T(co)F:	SP100
Species:	Homo sapiens
Knock-Method:	siRNA
T(co)F Class:	SAND domain factors
T(co)F Superclass:	alpha-Helices exposed by beta-structures
Biosample Name:	MCF7
Tissue Type:	Mammary_gland
Biosample Type:	Cell line
# of Control:	3
# of Treat:	1
Data Source:	GEO
Profile ID:	GSE31912
Platform:	GPL570
Pubmed ID:	22536322

SP100- Target Gene Network

T(co)F

up-regulated gene

down-regulated gene

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:

Target Gene Information of SP100

Showing 1 to 15 of 16,242 entries

Search:

Target Gene	T(co)F	Mean Expr. of Control	Mean Expr. of Treat	Fold Change	Log2FC	Rank	P-value	Corrected _P	Promoter _T(co)F	SE_T(co)F	TE_T(co)F

Target Gene	T(co)F	Mean Expr. of Control	Mean Expr. of Treat	Fold Change	Log2FC	Rank	P-value	Corrected _P	Promoter _T(co)F	SE_T(co)F	TE_T(co)F
AGR3	SP100	6.87473	4.7221	0.224902	-2.15263	1	0.207070188878138	0.999952086018951	23 AREB6	509 AIRE	535 AHR
CMPK2	SP100	6.86674	5.27042	0.33072	-1.59632	2	0.186969513460028	0.999952086018951	45 AP1	609 AHR	469 AHR
IFI44L	SP100	6.86473	5.29963	0.337954	-1.5651	3	0.279640132057712	0.999952086018951	22 BACH1	201 ALX1	284 ALX1
MAT2A	SP100	10.0853	11.4693	2.61005	1.38408	4	0.00948632980502662	0.999952086018951	67 AHRARNT	487 AHRARNT	435 AHRARNT
IFI44	SP100	6.47546	5.10812	0.387604	-1.36734	5	0.275512082088967	0.999952086018951	22 ATF6	346 ALX1	440 ALX1
FGF13	SP100	6.01003	4.67963	0.397658	-1.3304	6	0.303151087672726	0.999952086018951	110 AHR	329 AHR	616 AHR
UPK3A	SP100	6.04652	7.31242	2.40477	1.2659	7	0.00701372793909858	0.999952086018951	57 AP4	467 AHR	448 AHR
USP18	SP100	8.24492	7.02442	0.429133	-1.2205	8	0.0798367297245591	0.999952086018951	39 AR	432 AHR	454 AIRE
SAMD9	SP100	5.45456	4.24764	0.433192	-1.20692	9	0.348821583198726	0.999952086018951	37 ASCL1	424 ALX1	433 AML1
SERTAD3	SP100	8.23969	9.42715	2.27753	1.18747	10	0.0228722990970537	0.999952086018951	90 AP2	364 AHR	449 AHR
ENO2	SP100	7.5753	6.45983	0.461542	-1.11547	11	0.00325318288598269	0.999952086018951	74 AHR	458 AHR	450 AHR
IFIT3	SP100	7.75004	6.6372	0.462384	-1.11284	12	0.270332811539757	0.999952086018951	42 BARX1	453 AIRE	372 AIRE
NUPR1	SP100	6.2226	7.32228	2.14307	1.09968	13	0.0739983508974488	0.999952086018951	49 AHR	437 AHR	425 AHR
TRIM16	SP100	8.89183	9.94836	2.07991	1.05652	14	0.241105837264526	0.999952086018951	14 ESRRA	325 AIRE	407 AIRE
CEACAM6	SP100	6.7004	5.70695	0.502276	-0.993446	15	0.182652367948853	0.999952086018951	21 AREB6	435 AHR	366 AHR

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#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.

Function Analysis of Downstream Target Genes of SP100

Upregulated.Pathways Downregulated.Pathways Global.Plots

Upstream Pathway Annotation of SP100

From 1 to 2 results, Total 2 items

Search:

T(co)F	Pathway Name	Source	Gene Number
SP100	SUMOylation of DNA damage response and repair proteins	Reactome	76
SP100	Interferon gamma signaling	Reactome	88

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Target Gene Expression Analysis

Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression

Expression Atlas of SP100

T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)

T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines