T(co)F Overview
T(co)F: TCF7L1
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: High-mobility group (HMG) domain factors
T(co)F Superclass: Other all-alpha-helical DNA-binding domains
Biosample Name: H9
Tissue Type: Embryo
Biosample Type: Stem cell
# of Control: 3
# of Treat: 3
Data Source: GEO
Profile ID: GSE69911
Platform: GPL6244
Pubmed ID: 29361574

TCF7L1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of TCF7L1
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of TCF7L1
Upstream Pathway Annotation of TCF7L1
T(co)F Pathway Name Source Gene Number
TCF7L1 Binding of TCF/LEF:CTNNB1 to target gene promoters Reactome 7
TCF7L1 Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) INOH 8
TCF7L1 Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) INOH 8
TCF7L1 Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) INOH 8
TCF7L1 Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) INOH 8
TCF7L1 Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) INOH 8
TCF7L1 Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) INOH 8
TCF7L1 Repression of WNT target genes Reactome 14
TCF7L1 Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) INOH 19
TCF7L1 Hs_White_fat_cell_differentiation_WP3946_90940 WikiPathways 30
TCF7L1 Deactivation of the beta-catenin transactivating complex Reactome 42
TCF7L1 Hs_Mesodermal_Commitment_Pathway_WP2857_87780 WikiPathways 47
TCF7L1 Validated transcriptional targets of deltaNp63 isoforms PID 47
TCF7L1 Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) INOH 47
TCF7L1 Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) INOH 47
TCF7L1 Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) INOH 47
TCF7L1 Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) INOH 47
TCF7L1 Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) INOH 47
TCF7L1 Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) INOH 47
TCF7L1 Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) INOH 49
TCF7L1 Endometrial cancer KEGG 52
TCF7L1 Acute myeloid leukemia KEGG 53
TCF7L1 Hs_Ectoderm_Differentiation_WP2858_89329 WikiPathways 56
TCF7L1 Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram ) INOH 56
TCF7L1 Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram ) INOH 56
TCF7L1 Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram ) INOH 56
TCF7L1 Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) INOH 56
TCF7L1 Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram ) INOH 56
TCF7L1 Ca2+ pathway Reactome 62
TCF7L1 Colorectal cancer KEGG 63
TCF7L1 Adherens junction KEGG 70
TCF7L1 Arrhythmogenic right ventricular cardiomyopathy (ARVC) KEGG 71
TCF7L1 Regulation of nuclear beta catenin signaling and target gene transcription PID 80
TCF7L1 Prostate cancer KEGG 85
TCF7L1 Formation of the beta-catenin:TCF transactivating complex Reactome 88
TCF7L1 Alzheimer disease-presenilin pathway PANTHER 98
TCF7L1 Melanogenesis KEGG 100
TCF7L1 Wnt signaling pathway KEGG 135
TCF7L1 Cadherin signaling pathway PANTHER 147
TCF7L1 Wnt signaling pathway PANTHER 250
TCF7L1 Pathways in cancer KEGG 321
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of TCF7L1
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines