T(co)F Overview
T(co)F: BRCA1
Species: Homo sapiens
Knock-Method: siRNA
T(co)F Class: Others
T(co)F Superclass: TcoF-DB_TF
Biosample Name: MCF7
Tissue Type: Mammary_gland
Biosample Type: Cell line
# of Control: 4
# of Treat: 4
Data Source: GEO
Profile ID: GSE40730
Platform: GPL570
Pubmed ID: 23805307

BRCA1- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of BRCA1
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of BRCA1
Upstream Pathway Annotation of BRCA1
T(co)F Pathway Name Source Gene Number
BRCA1 Hs_Signaling_Pathways_in_Glioblastoma_WP2261_89520 WikiPathways 16
BRCA1 Homologous DNA Pairing and Strand Exchange Reactome 25
BRCA1 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Reactome 26
BRCA1 Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 WikiPathways 27
BRCA1 Hs_DNA_Damage_Response_WP707_82937 WikiPathways 28
BRCA1 Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694 WikiPathways 28
BRCA1 BARD1 signaling events PID 29
BRCA1 Hs_ATM_Signaling_Pathway_WP2516_90247 WikiPathways 32
BRCA1 Resolution of D-loop Structures through Holliday Junction Intermediates Reactome 33
BRCA1 Hs_Integrated_Cancer_Pathway_WP1971_82939 WikiPathways 33
BRCA1 Aurora A signaling PID 33
BRCA1 ATM pathway PID 34
BRCA1 Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640 WikiPathways 36
BRCA1 HDR through Single Strand Annealing (SSA) Reactome 37
BRCA1 Presynaptic phase of homologous DNA pairing and strand exchange Reactome 39
BRCA1 FOXA1 transcription factor network PID 45
BRCA1 HDR through Homologous Recombination (HRR) Reactome 46
BRCA1 Fanconi anemia pathway PID 48
BRCA1 Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 WikiPathways 50
BRCA1 ATF-2 transcription factor network PID 59
BRCA1 TP53 Regulates Transcription of DNA Repair Genes Reactome 61
BRCA1 Coregulation of Androgen receptor activity PID 61
BRCA1 Validated targets of C-MYC transcriptional repression PID 63
BRCA1 Validated nuclear estrogen receptor alpha network PID 65
BRCA1 Nonhomologous End-Joining (NHEJ) Reactome 69
BRCA1 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Reactome 75
BRCA1 Meiotic synapsis Reactome 76
BRCA1 SUMOylation of DNA damage response and repair proteins Reactome 76
BRCA1 E2F transcription factor network PID 77
BRCA1 G2/M DNA damage checkpoint Reactome 84
BRCA1 Meiotic recombination Reactome 85
BRCA1 Regulation of TP53 Activity through Phosphorylation Reactome 89
BRCA1 Processing of DNA double-strand break ends Reactome 98
BRCA1 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 WikiPathways 122
BRCA1 AndrogenReceptor NetPath 167
BRCA1 TGF_beta_Receptor NetPath 220
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of BRCA1
T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)
T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines