KnockTF-Search

T(co)F Overview

T(co)F:	ERN1
Species:	Homo sapiens
Knock-Method:	CRISPR
T(co)F Class:	Others
T(co)F Superclass:	Other Cofactors
Biosample Name:	K562
Tissue Type:	Haematopoietic_and_lymphoid_tissue
Biosample Type:	Cell line
# of Control:	2
# of Treat:	2
Data Source:	ENCODE
Profile ID:	ENCSR026FEM
Platform:	-
Pubmed ID:	22955616

ERN1- Target Gene Network

T(co)F

up-regulated gene

down-regulated gene

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:

Target Gene Information of ERN1

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Target Gene	T(co)F	Mean Expr. of Control	Mean Expr. of Treat	Fold Change	Log2FC	Rank	P-value	Corrected _P	Promoter _T(co)F	SE_T(co)F	TE_T(co)F

Target Gene	T(co)F	Mean Expr. of Control	Mean Expr. of Treat	Fold Change	Log2FC	Rank	P-value	Corrected _P	Promoter _T(co)F	SE_T(co)F	TE_T(co)F
SERPINA1	ERN1	0.935	0.03	0.0320856	-4.96193	1	6.89474936994995e-06	0.0705648732380784	46 AP1	476 AHR	452 AHR
GPC3	ERN1	0.385	0.015	0.038961	-4.68182	2	0.0161815151094254	0.58778237666531	110 AHR	625 AHR	646 AHR
ALB	ERN1	4.75	0.22	0.0463158	-4.43235	3	0.000464871678611955	0.196852025361317	46 ALX3	292 AHR	313 AHRARNT
ANKRD44	ERN1	0.01	0.21	21	4.39232	4	6.04658563201165e-05	0.121032336052258	50 AP2	623 AHR	612 AHR
IGFBP1	ERN1	0.175	0.01	0.0571429	-4.12928	5	0.00172690453933458	0.365632788373658	49 AHRARNT	244 AHRARNT	375 AHRARNT
FGA	ERN1	0.325	0.02	0.0615385	-4.02237	6	0.00494848158128519	0.476887905400229	43 ALX1	317 AHRARNT	417 AHRARNT
A2M	ERN1	0.31	0.025	0.0806452	-3.63227	7	0.000417195895759675	0.182184232729553	29 AIRE	222 AHRARNT	295 AHRARNT
AGT	ERN1	0.18	0.015	0.0833333	-3.58496	8	0.00701631324696594	0.495181622793445	19 ASCL1	451 AHRARNT	340 ALX1
AMBP	ERN1	0.16	0.015	0.09375	-3.41504	9	0.0156759365502171	0.586248468655899	47 AREB6	487 AHR	494 AHR
AHSG	ERN1	0.42	0.04	0.0952381	-3.39232	10	1.35457091271007e-05	0.0705648732380784	43 CEBP	345 AHR	362 AHR
MYOZ3	ERN1	0.1	0.01	0.1	-3.32193	11	0.00468849371311033	0.476887905400229	39 ARNT	445 AHR	463 AHR
FBLN2	ERN1	0.135	0.015	0.111111	-3.16992	12	0.00240715903272112	0.394654785808855	42 ALX3	529 AHR	497 AHR
ATP8A1	ERN1	0.215	0.025	0.116279	-3.10434	13	0.109738588178167	0.728602866888613	53 AHRARNT	492 AHR	571 AHR
EVPL	ERN1	0.01	0.085	8.5	3.08746	14	0.107293072654955	0.728174578387128	51 AHR	377 AHR	409 AHR
AKNAD1	ERN1	0.015	0.125	8.33333	3.05889	15	0.0400099408964869	0.66157425514643	34 BRACH	363 AHR	387 AHR

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#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.

Function Analysis of Downstream Target Genes of ERN1

Upregulated.Pathways Downregulated.Pathways Global.Plots

Upstream Pathway Annotation of ERN1

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T(co)F	Pathway Name	Source	Gene Number
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Target Gene Expression Analysis

Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression

Expression Atlas of ERN1

T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)

T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines