KnockTF-Search

T(co)F Overview

T(co)F:	SMAD5
Species:	Homo sapiens
Knock-Method:	CRISPR
T(co)F Class:	SMAD/NF-1 DNA-binding domain factors
T(co)F Superclass:	beta-Hairpin exposed by an alpha/beta-scaffold
Biosample Name:	HepG2
Tissue Type:	Liver
Biosample Type:	Cell line
# of Control:	2
# of Treat:	2
Data Source:	ENCODE
Profile ID:	ENCSR383QYT
Platform:	-
Pubmed ID:	22955616

SMAD5- Target Gene Network

T(co)F

up-regulated gene

down-regulated gene

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:

Target Gene Information of SMAD5

Showing 1 to 15 of 11,767 entries

Search:

Target Gene	T(co)F	Mean Expr. of Control	Mean Expr. of Treat	Fold Change	Log2FC	Rank	P-value	Corrected _P	Promoter _T(co)F	SE_T(co)F	TE_T(co)F

Target Gene	T(co)F	Mean Expr. of Control	Mean Expr. of Treat	Fold Change	Log2FC	Rank	P-value	Corrected _P	Promoter _T(co)F	SE_T(co)F	TE_T(co)F
CCNB3	SMAD2	0.02	0.29	14.5	3.85798	1	0.264587597899806	0.646009017324315	19 EVI1	0 NA	86 AP1FJ
IL5	SMAD2	0.325	0.025	0.0769231	-3.70044	2	0.00110578852179396	0.348373279896866	31 BARX1	447 SMAD2	443 SMAD2
PLCB2	SMAD2	0.125	0.01	0.08	-3.64386	3	0.00182870900584175	0.367798690114644	72 AP1	449 AHR	478 AHR
SELL	SMAD2	0.01	0.105	10.5	3.39232	4	0.0046148511143395	0.367798690114644	27 AML1	374 AHRARNT	409 SMAD2
CDC42EP3	SMAD2	0.1	0.01	0.1	-3.32193	5	0.00377642490991329	0.367798690114644	97 AHRARNT	593 SMAD2	545 SMAD2
LILRA4	SMAD2	0.095	0.01	0.105263	-3.24793	6	1.66786119796719e-05	0.120429012692992	23 MAZ	252 AHRARNT	300 AHRARNT
ZP1	SMAD2	0.13	0.015	0.115385	-3.11548	7	0.00213528836714518	0.367798690114644	39 ASCL2	398 SMAD2	437 SMAD2
TULP2	SMAD2	0.015	0.11	7.33333	2.87447	8	0.00607576743879331	0.367798690114644	49 AREB6	410 SMAD2	442 SMAD2
DOK7	SMAD2	0.015	0.11	7.33333	2.87447	9	0.184049931947647	0.581132301090642	62 AHR	542 SMAD2	451 SMAD2
TCAM1P	SMAD2	0.1	0.015	0.15	-2.73697	10	0.00823560068052429	0.371240395140703	26 EVI1	433 AHR	367 SMAD2
SYN1	SMAD2	0.065	0.01	0.153846	-2.70044	11	0.00659073240032744	0.367798690114644	69 AHRARNT	325 SMAD2	518 SMAD2
MMP25	SMAD2	0.065	0.01	0.153846	-2.70044	12	0.264898745836211	0.646009017324315	52 AP1	433 AHR	422 AHR
TMPRSS4	SMAD2	0.01	0.065	6.5	2.70044	13	0.00107030472150961	0.348373279896866	50 AP1FJ	596 SMAD2	440 SMAD2
MMRN1	SMAD2	0.065	0.01	0.153846	-2.70044	14	0.0834760102926728	0.467283541642673	30 ALX1	336 AIRE	458 AIRE
GRM2	SMAD2	0.015	0.095	6.33333	2.66297	15	0.00454673183139104	0.367798690114644	67 AHR	329 SMAD2	401 SMAD2

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#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.

Function Analysis of Downstream Target Genes of SMAD5

Upregulated.Pathways Downregulated.Pathways Global.Plots

Upstream Pathway Annotation of SMAD5

From 1 to 10 results, Total 13 items

Search:

T(co)F	Pathway Name	Source	Gene Number
SMAD5	Gene expression of smad7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) )	INOH	7
SMAD5	Hs_Steroid_Biosynthesis_WP496_69016	WikiPathways	8
SMAD5	Gene expression of smad6/7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) )	INOH	8
SMAD5	ALK2 signaling events	PID	11
SMAD5	Negative regulation of (transcription by R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) )	INOH	21
SMAD5	Signaling by BMP	Reactome	23
SMAD5	ALK1 signaling events	PID	26
SMAD5	BMP signaling pathway ( TGF-beta_BMP Diagram(MolecularVariation) )	INOH	34
SMAD5	BMP receptor signaling	PID	42
SMAD5	TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_BMP Diagram(MolecularVariation) )	INOH	51

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Target Gene Expression Analysis

Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression

Expression Atlas of SMAD5

T(co)F Expression in Human Normal Tissues (GTEx) T(co)F Expression in Cancer Cell Lines (CCLE)

T(co)F Expression in Human Cancers (TCGA) T(co)F Expression in Encode Cell Lines