T(co)F Overview
T(co)F: Smad4
Species: Mus musculus
Knock-Method: siRNA
T(co)F Class: SMAD/NF-1 DNA-binding domain factors
T(co)F Superclass: beta-Hairpin exposed by an alpha/beta-scaffold
Biosample Name: bEnd3
Tissue Type: Brain
Biosample Type: Cell line
# of Control: 1
# of Treat: 1
Data Source: GEO
Profile ID: GSE15736
Platform: GPL1261
Pubmed ID: 21397841

Smad4- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of Smad4
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of Smad4
Upstream Pathway Annotation of Smad4
T(co)F Pathway Name Source Gene Number
Smad4 G1_PATHWAY BIOCARTA 26
Smad4 CTCF_PATHWAY BIOCARTA 24
Smad4 NTHI_PATHWAY BIOCARTA 22
Smad4 TOB1_PATHWAY BIOCARTA 19
Smad4 TGFB_PATHWAY BIOCARTA 17
Smad4 WNT_PATHWAY BIOCARTA 23
Smad4 SIGNALING_BY_NODAL REACTOME 6
Smad4 DEVELOPMENTAL_BIOLOGY REACTOME 484
Smad4 SIGNALING_BY_ACTIVIN REACTOME 13
Smad4 SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX REACTOME 74
Smad4 SIGNALING_BY_BMP REACTOME 28
Smad4 GENERIC_TRANSCRIPTION_PATHWAY REACTOME 842
Smad4 TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS REACTOME 37
Smad4 TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETE REACTOME 40
Smad4 DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_AC REACTOME 24
Smad4 SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIP REACTOME 26
Smad4 METABOLISM_OF_PROTEINS REACTOME 1657
Smad4 DEUBIQUITINATION REACTOME 254
Smad4 UB_SPECIFIC_PROCESSING_PROTEASES REACTOME 184
Smad4 POST_TRANSLATIONAL_PROTEIN_MODIFICATION REACTOME 1310
Smad4 GENE_EXPRESSION_TRANSCRIPTION REACTOME 1061
Smad4 TRANSCRIPTIONAL_REGULATION_BY_RUNX3 REACTOME 78
Smad4 TRANSCRIPTIONAL_REGULATION_BY_RUNX2 REACTOME 63
Smad4 RUNX2_REGULATES_BONE_DEVELOPMENT REACTOME 6
Smad4 RUNX3_REGULATES_CDKN1A_TRANSCRIPTION REACTOME 6
Smad4 SIGNALING_BY_TGFB_FAMILY_MEMBERS REACTOME 101
Smad4 FOXO_MEDIATED_TRANSCRIPTION REACTOME 21
Smad4 FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES REACTOME 8
Smad4 ID_SIGNALING_PATHWAY WP 50
Smad4 ESC_PLURIPOTENCY_PATHWAYS WP 116
Smad4 TGFBETA_SIGNALING_PATHWAY WP 52
Smad4 HEART_DEVELOPMENT WP 46
Smad4 BMP_SIGNALING_PATHWAY_IN_EYELID_DEVELOPMENT WP 20
Smad4 MIR127_IN_MESENDODERM_DIFFERENTIATION WP 10
Smad4 DELTANOTCH_SIGNALING_PATHWAY WP 82
Smad4 WNT_SIGNALING_PATHWAY_WP539 WP 108
Smad4 MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY WP 290
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of Smad4
T(co)F Expression in Mouse Cell (Fantom5) T(co)F Expression in Mouse Tissue (Fantom5)