T(co)F Overview
T(co)F: Stat3
Species: Mus musculus
Knock-Method: siRNA
T(co)F Class: STAT domain factors
T(co)F Superclass: Immunoglobulin fold
Biosample Name: RAW264.7
Tissue Type: Macrophage_cells
Biosample Type: Cell line
# of Control: 6
# of Treat: 6
Data Source: GEO
Profile ID: GSE152986
Platform: GPL17791
Pubmed ID: 32730332

Stat3- Target Gene Network

T(co)F   
up-regulated gene   
down-regulated gene   

#T(co)F-target relationships supported by the ChIP-seq data are represented by the thick lines

Gene Type: # of Top Genes:
Target Gene Information of Stat3
Target Gene T(co)F Mean
Expr. of
Control 		Mean
Expr. of
Treat
Fold Change Log2FC Rank P-value Corrected
_P 		Promoter
_T(co)F 		SE_T(co)F TE_T(co)F
#When clicking the '' button in the last three column of the table, the users can view T(co)Fs supported by the ChIP-seq/motif data in red.
Function Analysis of Downstream Target Genes of Stat3
Upstream Pathway Annotation of Stat3
T(co)F Pathway Name Source Gene Number
Stat3 BIOPEPTIDES_PATHWAY BIOCARTA 28
Stat3 EGF_PATHWAY BIOCARTA 28
Stat3 ERK_PATHWAY BIOCARTA 27
Stat3 IL6_PATHWAY BIOCARTA 22
Stat3 IL10_PATHWAY BIOCARTA 12
Stat3 IL22BP_PATHWAY BIOCARTA 9
Stat3 PDGF_PATHWAY BIOCARTA 29
Stat3 HER2_PATHWAY BIOCARTA 23
Stat3 MET_PATHWAY BIOCARTA 33
Stat3 TPO_PATHWAY BIOCARTA 25
Stat3 STAT3_PATHWAY BIOCARTA 8
Stat3 INTERLEUKIN_6_SIGNALING REACTOME 9
Stat3 INTERLEUKIN_7_SIGNALING REACTOME 24
Stat3 CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM REACTOME 404
Stat3 SIGNALING_BY_SCF_KIT REACTOME 36
Stat3 IMMUNE_SYSTEM REACTOME 1775
Stat3 DOWNSTREAM_SIGNAL_TRANSDUCTION REACTOME 27
Stat3 SIGNALING_BY_PDGF REACTOME 53
Stat3 SIGNALING_BY_ALK REACTOME 15
Stat3 INTERLEUKIN_1_FAMILY_SIGNALING REACTOME 119
Stat3 INTERLEUKIN_12_FAMILY_SIGNALING REACTOME 13
Stat3 SIGNALING_BY_INTERLEUKINS REACTOME 270
Stat3 INTERLEUKIN_2_FAMILY_SIGNALING REACTOME 32
Stat3 INTERLEUKIN_6_FAMILY_SIGNALING REACTOME 22
Stat3 INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING REACTOME 11
Stat3 SIGNALING_BY_MET REACTOME 70
Stat3 SIGNALING_BY_PTK6 REACTOME 49
Stat3 INTERLEUKIN_20_FAMILY_SIGNALING REACTOME 14
Stat3 INTERLEUKIN_15_SIGNALING REACTOME 11
Stat3 INTERLEUKIN_35_SIGNALLING REACTOME 7
Stat3 INTERLEUKIN_9_SIGNALING REACTOME 6
Stat3 SIGNALING_BY_RECEPTOR_TYROSINE_KINASES REACTOME 401
Stat3 INTERLEUKIN_23_SIGNALING REACTOME 6
Stat3 INTERLEUKIN_27_SIGNALING REACTOME 9
Stat3 INTERLEUKIN_21_SIGNALING REACTOME 6
Stat3 IL6_SIGNALING_PATHWAY WP 99
Stat3 EGFR1_SIGNALING_PATHWAY WP 175
Stat3 DOPAMINERGIC_NEUROGENESIS WP 30
Stat3 IL9_SIGNALING_PATHWAY WP 24
Stat3 ESC_PLURIPOTENCY_PATHWAYS WP 116
Stat3 IL7_SIGNALING_PATHWAY WP 43
Stat3 LEPTININSULIN_SIGNALING_OVERLAP WP 18
Stat3 IL3_SIGNALING_PATHWAY WP 99
Stat3 TGFBETA_SIGNALING_PATHWAY WP 52
Stat3 EPO_RECEPTOR_SIGNALING WP 26
Stat3 MICRORNAS_IN_CARDIOMYOCYTE_HYPERTROPHY WP 100
Stat3 IL2_SIGNALING_PATHWAY WP 76
Stat3 DELTANOTCH_SIGNALING_PATHWAY WP 82
Stat3 IL5_SIGNALING_PATHWAY WP 68
Stat3 CHEMOKINE_SIGNALING_PATHWAY WP 174
Stat3 KIT_RECEPTOR_SIGNALING_PATHWAY WP 67
Stat3 ADIPOGENESIS_GENES WP 132
Stat3 MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY WP 290
Stat3 COMPREHENSIVE_IL17A_SIGNALING WP 101
Target Gene Expression Analysis
Heatmap of Unsupervised Hierarchical Clustering Scatter Diagram of Differential Expression
Expression Atlas of Stat3
T(co)F Expression in Mouse Cell (Fantom5) T(co)F Expression in Mouse Tissue (Fantom5)