Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0000178 Angiopoietin receptor Tie2-mediated signaling PID Homo sapiens 50 441
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
BMX ENSG00000102010 660 Cytoplasm 0.010752688 12.0 0.2788996 0.22727273
FYN ENSG00000010810 2534 Cytoplasm 0.014925373 83.0 34.47516 0.06641199
GRB14 ENSG00000115290 2888 Cytoplasm 0.010526316 11.0 0.07603514 0.14545455
PTPN11 ENSG00000179295 5781 Cytoplasm 0.012987013 69.0 10.2528 0.0571185
RAC1 ENSG00000136238 5879 Cytoplasm 0.014084507 94.0 23.14696 0.04529856
RASA1 ENSG00000145715 5921 Cytoplasm 0.012345679 25.0 2.853011 0.32666667
CDKN1A ENSG00000124762 1026 Cytoplasm/Nucleus 0.012048193 34.0 3.477275 0.11586453
CRK ENSG00000167193 1398 Cytoplasm/Nucleus 0.012987013 46.0 5.774467 0.14009662
ELF1 ENSG00000120690 1997 Cytoplasm/Nucleus 0.011111111 11.0 0.2710649 0.36363636
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 0.011235955 57.0 1.76472 0.03070175
ETS1 ENSG00000134954 2113 Cytoplasm/Nucleus 0.012048193 27.0 1.390876 0.21937322
FES ENSG00000182511 2242 Cytoplasm/Nucleus 0.011111111 19.0 0.7490804 0.14035088
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 0.010752688 23.0 0.9206935 0.02371542
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 0.014285714 96.0 54.25803 0.04078947
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 0.013888889 83.0 40.40351 0.04613576
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 0.01369863 66.0 35.54674 0.07272727
NCK1 ENSG00000158092 4690 Cytoplasm/Nucleus 0.012048193 46.0 5.254707 0.09178744
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 0.012820513 42.0 7.433905 0.12891986
NOS3 ENSG00000164867 4846 Cytoplasm/Nucleus 0.010204082 14.0 3.639056 0.13186813
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 0.012658228 42.0 11.12704 0.1068525
RPS6KB1 ENSG00000108443 6198 Cytoplasm/Nucleus 0.011904762 44.0 2.104404 0.08350951
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 0.014084507 63.0 14.78492 0.09933436
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 0.012987013 49.0 7.961739 0.10884354
TNIP2 ENSG00000168884 79155 Cytoplasm/Nucleus 0.010989011 12.0 0.2551571 0.21212121
AGTR1 ENSG00000144891 185 Membrane 0.009803922 7.0 0.6777786 0.42857143
AKT1 ENSG00000142208 207 Membrane 0.013888889 191.0 80.1875 0.01014053
DOK2 ENSG00000147443 9046 Membrane 0.011111111 21.0 0.6357586 0.16666667
GRB7 ENSG00000141738 2886 Membrane 0.011111111 18.0 0.752769 0.16339869
ITGA5 ENSG00000161638 3678 Membrane 0.011363636 23.0 1.799894 0.1541502
ITGB1 ENSG00000150093 3688 Membrane 0.011363636 35.0 4.830665 0.07226891
PIK3CA ENSG00000121879 5290 Membrane 0.01369863 118.0 20.22589 0.02390265
PIK3R1 ENSG00000145675 5295 Membrane 0.014285714 137.0 40.69721 0.02028768
PLD2 ENSG00000129219 5338 Membrane 0.011363636 15.0 0.3331139 0.28571429
PXN ENSG00000089159 5829 Membrane 0.012820513 59.0 10.23409 0.07013442
SHC1 ENSG00000160691 6464 Membrane 0.014925373 98.0 20.31853 0.05259836
TEK ENSG00000120156 7010 Membrane 0.015873016 75.0 140.6918 0.06774775
FN1 ENSG00000115414 2335 Unknown 0.012658228 42.0 15.55922 0.1068525
GRB2 ENSG00000177885 2885 Unknown 0.013513514 103.0 15.49387 0.03102989
MAPK14 ENSG00000112062 1432 Unknown 0.013888889 61.0 22.74873 0.09617486
PAK1 ENSG00000149269 5058 Unknown 0.0125 66.0 13.12865 0.04662005
PTK2 ENSG00000169398 5747 Unknown 0.01369863 111.0 45.87934 0.02882883
ELF2 ENSG00000109381 1998 Nucleus 0.011111111 13.0 0.3820321 0.28205128
ANGPT1 ENSG00000154188 284 Secreted 0.014925373 53.0 65.72026 0.10449927
ANGPT2 ENSG00000091879 285 Secreted 0.012048193 26.0 21.64833 0.12615385
ANGPT4 ENSG00000101280 51378 Secreted 0.009433962 3.0 0.0 0.33333333
F2 ENSG00000180210 2147 Secreted 0.010869565 10.0 3.253483 0.11111111
FGF2 ENSG00000138685 2247 Secreted 0.012345679 32.0 7.551105 0.15725806
MMP2 ENSG00000087245 4313 Secreted 0.010638298 8.0 0.4279449 0.14285714
PLG ENSG00000122194 5340 Secreted 0.010416667 7.0 0.08068182 0.38095238
TNF ENSG00000232810 7124 Secreted 0.012658228 50.0 23.54111 0.07510204
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BMX ENSG00000102010 660 Cytoplasm 55.0 10.1 1.55E-6 0.0869
FYN ENSG00000010810 2534 Cytoplasm 9828.0 511000.0 1.56E-6 4.85E-4
GRB14 ENSG00000115290 2888 Cytoplasm 85.0 6.77 1.55E-6 0.0322
PTPN11 ENSG00000179295 5781 Cytoplasm 9733.0 167000.0 1.56E-6 2.5E-4
RAC1 ENSG00000136238 5879 Cytoplasm 14443.0 874000.0 1.56E-6 1.69E-4
RASA1 ENSG00000145715 5921 Cytoplasm 1607.0 6400.0 1.55E-6 0.00321
CDKN1A ENSG00000124762 1026 Cytoplasm/Nucleus 3911.0 109000.0 1.56E-6 8.1E-4
CRK ENSG00000167193 1398 Cytoplasm/Nucleus 4161.0 46800.0 1.56E-6 8.51E-4
ELF1 ENSG00000120690 1997 Cytoplasm/Nucleus 54.0 113.0 1.55E-6 0.11
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 3468.0 49000.0 1.56E-6 3.9E-4
ETS1 ENSG00000134954 2113 Cytoplasm/Nucleus 716.0 15200.0 1.56E-6 0.00784
FES ENSG00000182511 2242 Cytoplasm/Nucleus 341.0 1140.0 1.55E-6 0.00659
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 1320.0 45800.0 1.56E-6 0.00162
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 33563.0 1130000.0 1.56E-6 2.83E-5
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 29207.0 850000.0 1.56E-6 3.17E-5
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 11158.0 360000.0 1.56E-6 1.42E-4
NCK1 ENSG00000158092 4690 Cytoplasm/Nucleus 2321.0 9060.0 1.56E-6 0.00215
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 11386.0 280000.0 1.56E-6 2.06E-4
NOS3 ENSG00000164867 4846 Cytoplasm/Nucleus 741.0 289000.0 1.56E-6 0.00398
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 11059.0 663000.0 1.57E-6 3.08E-4
RPS6KB1 ENSG00000108443 6198 Cytoplasm/Nucleus 3539.0 54900.0 1.56E-6 3.46E-4
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 7688.0 196000.0 1.56E-6 4.69E-4
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 6515.0 71100.0 1.56E-6 5.43E-4
TNIP2 ENSG00000168884 79155 Cytoplasm/Nucleus 93.0 267.0 1.55E-6 0.0776
AGTR1 ENSG00000144891 185 Membrane 1411.0 16200.0 1.55E-6 0.0032
AKT1 ENSG00000142208 207 Membrane 52751.0 2150000.0 1.57E-6 1.74E-5
DOK2 ENSG00000147443 9046 Membrane 277.0 32.3 1.55E-6 0.0101
GRB7 ENSG00000141738 2886 Membrane 180.0 138.0 1.55E-6 0.0193
ITGA5 ENSG00000161638 3678 Membrane 1247.0 6440.0 1.55E-6 0.00928
ITGB1 ENSG00000150093 3688 Membrane 3891.0 368000.0 1.56E-6 0.00113
PIK3CA ENSG00000121879 5290 Membrane 27859.0 414000.0 1.56E-6 5.51E-5
PIK3R1 ENSG00000145675 5295 Membrane 31452.0 734000.0 1.56E-6 4.03E-5
PLD2 ENSG00000129219 5338 Membrane 723.0 98500.0 1.55E-6 0.00761
PXN ENSG00000089159 5829 Membrane 3210.0 123000.0 1.56E-6 0.00188
SHC1 ENSG00000160691 6464 Membrane 13549.0 312000.0 1.56E-6 2.6E-4
TEK ENSG00000120156 7010 Membrane 275.0 19300.0 1.55E-6 0.0109
FN1 ENSG00000115414 2335 Unknown 2115.0 124000.0 1.56E-6 0.00399
GRB2 ENSG00000177885 2885 Unknown 29079.0 822000.0 1.57E-6 5.64E-5
MAPK14 ENSG00000112062 1432 Unknown 9287.0 427000.0 1.56E-6 2.57E-4
PAK1 ENSG00000149269 5058 Unknown 5363.0 83300.0 1.56E-6 2.49E-4
PTK2 ENSG00000169398 5747 Unknown 9391.0 242000.0 1.56E-6 3.21E-4
ELF2 ENSG00000109381 1998 Nucleus 36.0 3.36 1.55E-6 0.0921
ANGPT1 ENSG00000154188 284 Secreted 191.0 234.0 1.55E-6 0.0195
ANGPT2 ENSG00000091879 285 Secreted 63.0 1420.0 1.55E-6 0.0261
ANGPT4 ENSG00000101280 51378 Secreted 6.0 0.0 1.53E-6 0.0667
F2 ENSG00000180210 2147 Secreted 1381.0 111000.0 1.55E-6 7.85E-4
FGF2 ENSG00000138685 2247 Secreted 3268.0 46500.0 1.56E-6 0.0014
MMP2 ENSG00000087245 4313 Secreted 292.0 22800.0 1.56E-6 0.014
PLG ENSG00000122194 5340 Secreted 704.0 36600.0 1.55E-6 0.00106
TNF ENSG00000232810 7124 Secreted 4479.0 293000.0 1.56E-6 0.00102
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BMX ENSG00000102010 660 Cytoplasm 29.0 2.47 1.38122E-4 0.118226601
FYN ENSG00000010810 2534 Cytoplasm 1971.0 35700.0 1.7325E-4 0.003097194
GRB14 ENSG00000115290 2888 Cytoplasm 28.0 1.72 1.39899E-4 0.126984127
PTPN11 ENSG00000179295 5781 Cytoplasm 2393.0 7510.0 1.70271E-4 0.001673988
RAC1 ENSG00000136238 5879 Cytoplasm 4026.0 140000.0 1.83722E-4 6.724E-4
RASA1 ENSG00000145715 5921 Cytoplasm 526.0 6510.0 1.57233E-4 0.012543907
CDKN1A ENSG00000124762 1026 Cytoplasm/Nucleus 806.0 23300.0 1.73702E-4 0.007043447
CRK ENSG00000167193 1398 Cytoplasm/Nucleus 1158.0 8600.0 1.66973E-4 0.004111043
ELF1 ENSG00000120690 1997 Cytoplasm/Nucleus 32.0 353.0 1.50376E-4 0.179435484
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 573.0 2890.0 1.6714E-4 0.003801609
ETS1 ENSG00000134954 2113 Cytoplasm/Nucleus 202.0 5250.0 1.69348E-4 0.046450914
FES ENSG00000182511 2242 Cytoplasm/Nucleus 67.0 23.7 1.42491E-4 0.054274084
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 290.0 3310.0 1.61186E-4 0.013435151
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 5647.0 122000.0 1.91571E-4 4.01908E-4
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 5295.0 94900.0 1.89179E-4 3.9334E-4
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 2657.0 58300.0 1.84366E-4 0.001118607
NCK1 ENSG00000158092 4690 Cytoplasm/Nucleus 623.0 1690.0 1.54703E-4 0.010281131
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 1581.0 24600.0 1.76803E-4 0.002146534
NOS3 ENSG00000164867 4846 Cytoplasm/Nucleus 222.0 554.0 1.59236E-4 0.017161958
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 1610.0 39200.0 1.83117E-4 0.002921455
RPS6KB1 ENSG00000108443 6198 Cytoplasm/Nucleus 558.0 7730.0 1.69722E-4 0.005701306
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 1634.0 35300.0 1.79308E-4 0.003234992
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 1105.0 9710.0 1.73762E-4 0.005193783
TNIP2 ENSG00000168884 79155 Cytoplasm/Nucleus 12.0 0.198 1.36388E-4 0.212121212
AGTR1 ENSG00000144891 185 Membrane 32.0 1220.0 1.42592E-4 0.110887097
AKT1 ENSG00000142208 207 Membrane 9285.0 328000.0 1.9976E-4 2.07281E-4
DOK2 ENSG00000147443 9046 Membrane 69.0 11.9 1.42531E-4 0.083120205
GRB7 ENSG00000141738 2886 Membrane 57.0 5.19 1.39063E-4 0.05764411
ITGA5 ENSG00000161638 3678 Membrane 291.0 1480.0 1.46585E-4 0.04140301
ITGB1 ENSG00000150093 3688 Membrane 912.0 56000.0 1.70126E-4 0.005705125
PIK3CA ENSG00000121879 5290 Membrane 7107.0 70400.0 1.83419E-4 2.95273E-4
PIK3R1 ENSG00000145675 5295 Membrane 7548.0 88700.0 1.85288E-4 2.41448E-4
PLD2 ENSG00000129219 5338 Membrane 199.0 5990.0 1.52068E-4 0.024364246
PXN ENSG00000089159 5829 Membrane 935.0 9210.0 1.6469E-4 0.005201021
SHC1 ENSG00000160691 6464 Membrane 3723.0 28900.0 1.80538E-4 9.94587E-4
TEK ENSG00000120156 7010 Membrane 101.0 2370.0 1.5006E-4 0.05009901
FN1 ENSG00000115414 2335 Unknown 549.0 8270.0 1.57779E-4 0.013714385
GRB2 ENSG00000177885 2885 Unknown 5986.0 66400.0 1.83857E-4 4.14669E-4
MAPK14 ENSG00000112062 1432 Unknown 1830.0 65300.0 1.85494E-4 0.002225827
PAK1 ENSG00000149269 5058 Unknown 946.0 4450.0 1.6581E-4 0.003172366
PTK2 ENSG00000169398 5747 Unknown 2042.0 23300.0 1.67617E-4 0.001831216
ELF2 ENSG00000109381 1998 Nucleus 13.0 0.138 1.34916E-4 0.282051282
ANGPT1 ENSG00000154188 284 Secreted 71.0 111.0 1.47059E-4 0.080482897
ANGPT2 ENSG00000091879 285 Secreted 26.0 422.0 1.41663E-4 0.126153846
ANGPT4 ENSG00000101280 51378 Secreted 3.0 0.0 1.08389E-4 0.333333333
F2 ENSG00000180210 2147 Secreted 66.0 1150.0 1.39315E-4 0.02983683
FGF2 ENSG00000138685 2247 Secreted 99.0 525.0 1.53728E-4 0.070707071
MMP2 ENSG00000087245 4313 Secreted 101.0 1040.0 1.6284E-4 0.037821782
PLG ENSG00000122194 5340 Secreted 77.0 1040.0 1.38447E-4 0.028708134
TNF ENSG00000232810 7124 Secreted 807.0 26000.0 1.74398E-4 0.007391897
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
AKT1 CDKN1A 9
AKT1 FOXO1 13
AKT1 NFKB1 3
AKT1 NOS3 9
AKT1 RAC1 5
AKT1 RELA 4
AKT1 RPS6KB1 6
ANGPT1 ANGPT2 2
ANGPT1 BMX 1
ANGPT1 DOK2 3
ANGPT1 FES 1
ANGPT1 GRB14 3
ANGPT1 GRB7 3
ANGPT1 ITGA5 2
ANGPT1 MAPK14 1
ANGPT1 MAPK8 1
ANGPT1 MMP2 1
ANGPT1 NCK1 1
ANGPT1 PIK3CA 3
ANGPT1 PIK3R1 3
ANGPT1 PLG 1
ANGPT1 TEK 9
ANGPT2 CDKN1A 3
ANGPT2 FES 1
ANGPT2 FYN 1
ANGPT2 MAPK14 1
ANGPT2 PIK3CA 1
ANGPT2 PIK3R1 1
ANGPT2 STAT5A 1
ANGPT2 TEK 8
ANGPT4 TEK 5
BMX PTK2 3
CRK DOK2 3
CRK FYN 2
CRK GRB2 5
CRK MAPK8 6
CRK PIK3CA 2
CRK PIK3R1 6
CRK PTK2 5
CRK PTPN11 3
CRK PXN 7
DOK2 GRB2 2
DOK2 NCK1 6
DOK2 RASA1 6
DOK2 TEK 3
ETS1 STAT5B 3
ETS1 TNF 2
F2 MAPK8 1
F2 NOS3 1
FES PAK1 1
FES PIK3CA 1
FES PIK3R1 4
FGF2 AKT1 2
FGF2 MAPK1 2
FGF2 MAPK14 1
FGF2 MAPK3 2
FN1 FYN 5
FN1 GRB2 3
FN1 ITGA5 9
FN1 ITGB1 9
FN1 MAPK1 1
FN1 MAPK3 1
FN1 PTK2 4
FN1 PXN 6
FN1 RAC1 3
FOXO1 PAK1 2
FYN AKT1 2
FYN FES 1
FYN GRB2 3
FYN MAPK14 3
FYN NCK1 3
FYN PAK1 2
FYN PIK3CA 2
FYN PIK3R1 6
FYN PLD2 3
FYN PTK2 5
FYN PTPN11 5
FYN PXN 5
FYN RAC1 2
FYN RASA1 3
FYN SHC1 7
FYN STAT5A 2
FYN STAT5B 2
GRB14 AKT1 1
GRB14 TEK 3
GRB2 AKT1 3
GRB2 MAPK1 2
GRB2 NCK1 2
GRB2 PAK1 4
GRB2 PIK3CA 4
GRB2 PIK3R1 9
GRB2 PTK2 8
GRB2 PTPN11 9
GRB2 PXN 2
GRB2 RAC1 2
GRB2 SHC1 13
GRB2 TEK 3
GRB7 PTK2 6
GRB7 TEK 3
ITGA5 ITGB1 10
ITGA5 PTK2 3
ITGA5 PXN 3
ITGB1 PTK2 6
ITGB1 PXN 7
MAPK14 CDKN1A 1
MAPK14 ELK1 5
MAPK14 MAPK3 5
MAPK14 NFKB1 1
MAPK14 PXN 1
MAPK14 RELA 2
MAPK14 SHC1 2
MAPK14 STAT5B 1
MAPK1 AKT1 2
MAPK1 CDKN1A 1
MAPK1 ELF1 1
MAPK1 ELF2 1
MAPK1 ELK1 9
MAPK1 ETS1 7
MAPK1 MAPK3 4
MAPK1 PXN 5
MAPK1 RAC1 1
MAPK1 RELA 1
MAPK1 RPS6KB1 5
MAPK1 SHC1 5
MAPK1 STAT5A 6
MAPK1 STAT5B 3
MAPK3 AKT1 1
MAPK3 ELF1 1
MAPK3 ELK1 8
MAPK3 ETS1 5
MAPK3 PTPN11 4
MAPK3 PXN 3
MAPK3 RAC1 2
MAPK3 RELA 1
MAPK3 RPS6KB1 2
MAPK3 SHC1 2
MAPK3 STAT5A 5
MAPK3 STAT5B 2
MAPK8 ELF1 1
MAPK8 ELF2 1
MAPK8 ELK1 3
MAPK8 ETS1 1
MAPK8 PXN 3
MAPK8 RPS6KB1 4
MAPK8 STAT5A 2
MAPK8 STAT5B 2
NCK1 MAPK14 1
NCK1 MAPK8 1
NCK1 PAK1 10
NCK1 PTK2 3
NCK1 PXN 3
NCK1 RAC1 4
NCK1 RASA1 4
NFKB1 RELA 12
NFKB1 TNF 4
NFKB1 TNIP2 7
PAK1 CRK 1
PAK1 MAPK14 3
PAK1 MAPK8 3
PAK1 PXN 4
PAK1 RAC1 9
PAK1 SHC1 2
PAK1 STAT5A 1
PAK1 STAT5B 1
PIK3CA AKT1 5
PIK3CA PIK3R1 14
PIK3CA PTK2 4
PIK3CA PTPN11 3
PIK3CA PXN 1
PIK3CA RAC1 4
PIK3CA RELA 1
PIK3CA RPS6KB1 4
PIK3CA SHC1 3
PIK3R1 AKT1 6
PIK3R1 PTK2 6
PIK3R1 PTPN11 7
PIK3R1 PXN 3
PIK3R1 RAC1 6
PIK3R1 RELA 3
PIK3R1 RPS6KB1 2
PIK3R1 SHC1 8
PLD2 MAPK1 1
PLD2 MAPK3 1
PTK2 AKT1 2
PTK2 MAPK1 2
PTK2 PTPN11 3
PTK2 PXN 12
PTK2 RAC1 5
PTK2 SHC1 4
PTK2 STAT5A 1
PTK2 STAT5B 1
PTPN11 AKT1 2
PTPN11 MAPK1 3
PTPN11 PXN 4
PTPN11 SHC1 4
PTPN11 STAT5A 4
PTPN11 STAT5B 3
PTPN11 TEK 3
RAC1 MAPK14 2
RAC1 MAPK8 5
RAC1 STAT5A 1
RASA1 AKT1 1
RASA1 MAPK8 1
RASA1 SHC1 4
RELA TNF 3
RELA TNIP2 5
RPS6KB1 PTK2 1
RPS6KB1 STAT5A 1
RPS6KB1 STAT5B 1
SHC1 AKT1 3
SHC1 RAC1 2
SHC1 STAT5A 4
SHC1 STAT5B 3
SHC1 TEK 5
STAT5A AKT1 1
STAT5A STAT5B 4
STAT5B AKT1 2
TEK BMX 1
TEK FES 1
TEK FYN 1
TEK MAPK14 1
TEK MAPK8 1
TEK MMP2 1
TEK NCK1 1
TEK PIK3CA 2
TEK PIK3R1 2
TEK PLG 1
TEK STAT5A 1
TEK TNIP2 3
TNF AKT1 1
TNF MAPK1 1
TNF MAPK14 2
TNF MAPK3 1
TNF MAPK8 3
TNF MMP2 1
TNF RPS6KB1 1
AGTR1 ANGPT2 1
AGTR1 FGF2 1
AGTR1 MAPK1 2
AGTR1 MAPK3 1
AGTR1 NOS3 1
AGTR1 TNF 1
AKT1 ETS1 1
AKT1 MAPK14 3
AKT1 MAPK8 2
AKT1 PAK1 4
AKT1 PLD2 1
ANGPT1 CRK 1
ANGPT1 ELF2 1
ANGPT1 GRB2 2
ANGPT1 ITGB1 1
ANGPT1 NFKB1 1
ANGPT1 PLD2 1
ANGPT1 PTPN11 2
ANGPT1 RASA1 1
ANGPT1 RELA 1
ANGPT1 SHC1 2
ANGPT1 TNIP2 1
ANGPT4 ANGPT2 1
BMX PAK1 2
BMX PIK3R1 2
BMX STAT5A 1
CDKN1A FOXO1 3
CDKN1A MAPK8 2
CDKN1A NFKB1 1
CDKN1A SHC1 1
CDKN1A TNIP2 1
CRK ELK1 2
CRK FN1 1
CRK NCK1 1
CRK RAC1 3
CRK SHC1 4
CRK STAT5A 3
CRK STAT5B 2
DOK2 PAK1 1
DOK2 PXN 1
DOK2 SHC1 1
ELF1 NCK1 1
ELF1 NFKB1 2
ELF1 RAC1 1
ELF1 RELA 1
ELF1 TEK 2
ELF2 MAPK3 1
ELF2 RASA1 1
ELF2 STAT5A 1
ELF2 STAT5B 1
ELF2 TEK 1
ELK1 FN1 1
ELK1 FYN 1
ELK1 GRB2 1
ELK1 RAC1 1
ELK1 RELA 1
ELK1 SHC1 1
ETS1 ANGPT1 1
ETS1 ANGPT2 1
ETS1 FYN 1
ETS1 MAPK14 1
ETS1 NFKB1 3
ETS1 PTK2 1
ETS1 PTPN11 1
ETS1 SHC1 1
F2 ANGPT1 1
F2 ANGPT2 1
F2 FN1 2
F2 ITGA5 1
FES RAC1 1
FES RASA1 2
FGF2 ANGPT2 1
FGF2 FN1 1
FGF2 MMP2 1
FGF2 NFKB1 1
FGF2 RAC1 1
FGF2 RELA 1
FN1 ANGPT1 1
FN1 PLG 1
FN1 SHC1 1
FN1 TEK 1
FOXO1 ANGPT2 1
FOXO1 GRB7 1
FOXO1 TEK 1
FYN BMX 1
FYN FGF2 1
FYN GRB7 1
FYN ITGA5 2
FYN ITGB1 2
FYN MAPK1 1
FYN MAPK8 1
FYN TNF 1
GRB14 NFKB1 1
GRB14 PIK3R1 2
GRB2 FGF2 1
GRB2 GRB7 1
GRB2 MAPK14 1
GRB2 PLD2 1
GRB2 RASA1 2
GRB7 PTPN11 1
GRB7 SHC1 1
ITGA5 CRK 1
ITGA5 RAC1 1
ITGA5 SHC1 1
ITGA5 TEK 1
ITGB1 CRK 1
ITGB1 MMP2 1
ITGB1 RPS6KB1 1
ITGB1 SHC1 1
ITGB1 TEK 1
MAPK14 MAPK8 2
MAPK14 PLG 1
MAPK14 PTPN11 1
MAPK14 RASA1 1
MAPK1 MAPK14 4
MAPK1 MAPK8 2
MAPK1 NFKB1 1
MAPK1 PAK1 2
MAPK1 TNIP2 1
MAPK3 GRB2 1
MAPK3 MAPK8 1
MAPK3 NFKB1 1
MAPK3 TEK 2
MAPK8 PIK3R1 2
NCK1 SHC1 1
NFKB1 SHC1 2
NFKB1 STAT5A 1
NOS3 MAPK1 1
NOS3 MAPK3 1
NOS3 PTPN11 1
PAK1 RELA 2
PAK1 RPS6KB1 3
PIK3CA CDKN1A 1
PIK3CA FGF2 1
PIK3CA NCK1 1
PIK3CA NFKB1 1
PIK3CA RASA1 1
PIK3CA STAT5A 1
PIK3CA STAT5B 1
PIK3R1 CDKN1A 1
PIK3R1 FGF2 1
PIK3R1 NCK1 1
PIK3R1 NFKB1 1
PIK3R1 RASA1 1
PLD2 PIK3CA 1
PLD2 PIK3R1 1
PLD2 RPS6KB1 1
PLG RELA 1
PTK2 MAPK3 1
PTK2 NFKB1 1
PTK2 PAK1 1
PTK2 RASA1 1
PTPN11 FGF2 1
PTPN11 RAC1 2
PXN RAC1 1
PXN RASA1 2
RAC1 DOK2 1
RAC1 ITGB1 1
RAC1 NFKB1 1
RAC1 RELA 1
RAC1 RPS6KB1 1
RASA1 STAT5A 1
RASA1 STAT5B 1
RELA CDKN1A 1
RELA SHC1 2
RPS6KB1 CRK 1
RPS6KB1 PXN 1
SHC1 FGF2 1
SHC1 MAPK8 1
STAT5A ANGPT1 1
STAT5A CDKN1A 1
STAT5A ETS1 1
STAT5A FN1 1
STAT5A GRB7 1
STAT5A MAPK14 1
STAT5A PIK3R1 1
STAT5B FN1 1
STAT5B PIK3R1 1
STAT5B TEK 1
STAT5B TNIP2 1
TEK CDKN1A 1
TEK CRK 1
TEK NFKB1 1
TEK PLD2 1
TEK RASA1 1
TEK RELA 1
TNF ANGPT1 1
TNF CDKN1A 1
TNF ELK1 1
TNF NOS3 1
TNF PIK3CA 1
TNF PIK3R1 1
TNF PTK2 1
TNF PXN 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0000178 pathway0002243 12 0.6666667 Tie2 Signaling Reactome 18 101
pathway0000178 pathway0000658 31 0.62 EGFR1 NetPath 475 10010
pathway0000178 pathway0002763 18 0.5625 Hs_Rac1-Pak1-p38-MMP-2_pathway_WP3303_87628 WikiPathways 32 197
pathway0000178 pathway0000700 3 0.5 ERK cascade ( EGF signaling pathway Diagram ) INOH 6 15
pathway0000178 pathway0000708 3 0.5 ERK cascade ( HGF signaling pathway ) INOH 6 15
pathway0000178 pathway0000714 3 0.5 ERK cascade ( VEGF signaling pathway ) INOH 6 15
pathway0000178 pathway0000793 3 0.5 Fibronectin matrix formation Reactome 6 15
pathway0000178 pathway0002765 4 0.5 Hs_Chemokine_signaling_pathway_WP3929_90949 WikiPathways 8 21