Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0000229 ATF-2 transcription factor network PID Homo sapiens 59 451
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
ARG1 ENSG00000118520 383 Cytoplasm 0.008928571 4.0 0.0 1.0
CDK4 ENSG00000135446 1019 Cytoplasm 0.00952381 31.0 1.834367 0.08387097
HRK ENSG00000135116 8739 Cytoplasm 0.008928571 4.0 0.0 1.0
NF1 ENSG00000196712 4763 Cytoplasm 0.00990099 19.0 7.745023 0.25146199
NOS2 ENSG00000007171 4843 Cytoplasm 0.01 20.0 10.64558 0.32105263
TH ENSG00000180176 7054 Cytoplasm 0.009433962 19.0 0.2561045 0.23391813
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 0.017241379 125.0 491.4612 0.04967742
BCL2 ENSG00000171791 596 Cytoplasm/Nucleus 0.010638298 37.0 14.67111 0.17117117
BCL2L1 ENSG00000171552 598 Cytoplasm/Nucleus 0.009708738 20.0 1.743426 0.27368421
CBFB ENSG00000067955 865 Cytoplasm/Nucleus 0.009009009 6.0 0.0 0.66666667
CCNA2 ENSG00000145386 890 Cytoplasm/Nucleus 0.009615385 18.0 0.7437379 0.32679739
CCND1 ENSG00000110092 595 Cytoplasm/Nucleus 0.010204082 47.0 9.224526 0.08140611
CSRP2 ENSG00000175183 1466 Cytoplasm/Nucleus 0.008849558 3.0 0.0 1.0
CUL3 ENSG00000036257 8452 Cytoplasm/Nucleus 0.009345794 11.0 2.412474 0.30909091
DUSP10 ENSG00000143507 11221 Cytoplasm/Nucleus 0.009433962 29.0 2.354573 0.05665025
EP300 ENSG00000100393 2033 Cytoplasm/Nucleus 0.011111111 48.0 22.79511 0.14361702
ESR1 ENSG00000091831 2099 Cytoplasm/Nucleus 0.011363636 58.0 30.55124 0.09255898
FOS ENSG00000170345 2353 Cytoplasm/Nucleus 0.011363636 73.0 22.9399 0.06849315
HES1 ENSG00000114315 3280 Cytoplasm/Nucleus 0.009009009 10.0 0.05664488 0.17777778
JUN ENSG00000177606 3725 Cytoplasm/Nucleus 0.015384615 159.0 334.1537 0.02579412
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 0.011764706 103.0 54.69665 0.04054826
MAPK11 ENSG00000185386 5600 Cytoplasm/Nucleus 0.010204082 45.0 12.15444 0.06868687
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 0.011363636 94.0 44.1945 0.03912148
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 0.010869565 65.0 16.57723 0.06778846
MAPK9 ENSG00000050748 5601 Cytoplasm/Nucleus 0.010204082 61.0 11.45544 0.04153005
PRKCA ENSG00000154229 5578 Cytoplasm/Nucleus 0.009615385 24.0 8.53681 0.10144928
RUVBL2 ENSG00000183207 10856 Cytoplasm/Nucleus 0.009433962 12.0 1.343498 0.45454545
SOCS3 ENSG00000184557 9021 Cytoplasm/Nucleus 0.009259259 13.0 0.7234404 0.26923077
ACHE ENSG00000087085 43 Membrane 0.00877193 2.0 0.0 1.0
PDGFRA ENSG00000134853 5156 Membrane 0.008928571 4.0 0.1111111 0.83333333
PLAU ENSG00000122861 5328 Membrane 0.009259259 9.0 0.1545752 0.66666667
BRCA1 ENSG00000012048 672 Unknown 0.010638298 34.0 10.488 0.2228164
CXCL8 ENSG00000169429 3576 Unknown 0.00990099 21.0 3.419448 0.3
DUSP8 ENSG00000184545 1850 Unknown 0.009174312 17.0 0.2102781 0.11029412
H2AFY ENSG00000113648 9555 Unknown 0.009090909 8.0 0.8640867 0.35714286
HBG2 ENSG00000196565 3048 Unknown 0.00877193 2.0 0.0 1.0
KAT5 ENSG00000172977 10524 Unknown 0.00990099 22.0 4.394687 0.27705628
MAPK14 ENSG00000112062 1432 Unknown 0.011494253 77.0 42.38724 0.06254272
ATF3 ENSG00000162772 467 Nucleus 0.010309278 26.0 5.693467 0.26153846
CREB1 ENSG00000118260 1385 Nucleus 0.010752688 35.0 10.6421 0.22521008
DDIT3 ENSG00000175197 1649 Nucleus 0.00990099 23.0 6.1243 0.2173913
DUSP1 ENSG00000120129 1843 Nucleus 0.00952381 28.0 0.4461405 0.10582011
DUSP5 ENSG00000138166 1847 Nucleus 0.009433962 21.0 0.9972123 0.13333333
GADD45A ENSG00000116717 1647 Nucleus 0.00952381 14.0 0.2963003 0.48351648
JDP2 ENSG00000140044 122953 Nucleus 0.009433962 16.0 0.6565528 0.28333333
JUNB ENSG00000171223 3726 Nucleus 0.010638298 29.0 6.111048 0.31034483
JUND ENSG00000130522 3727 Nucleus 0.010752688 45.0 12.25426 0.12929293
POU2F1 ENSG00000143190 5451 Nucleus 0.010204082 22.0 9.236383 0.30735931
PPARGC1A ENSG00000109819 10891 Nucleus 0.00952381 20.0 0.5564393 0.20526316
RB1 ENSG00000139687 5925 Nucleus 0.010869565 60.0 30.58684 0.06666667
COL24A1 ENSG00000171502 255631 Secreted 0.00877193 2.0 0.0 1.0
IL23A ENSG00000110944 51561 Secreted 0.009259259 9.0 0.7578837 0.52777778
IL6 ENSG00000136244 3569 Secreted 0.009615385 23.0 3.329532 0.17391304
INS ENSG00000254647 3630 Secreted 0.010309278 34.0 6.109862 0.17112299
MMP2 ENSG00000087245 4313 Secreted 0.009259259 13.0 0.5009271 0.24358974
SELE ENSG00000007908 6401 Secreted 0.009009009 7.0 0.1508007 0.28571429
SERPINB5 ENSG00000206075 5268 Secreted 0.009090909 8.0 0.1350327 0.39285714
TGFB2 ENSG00000092969 7042 Secreted 0.008928571 5.0 0.1333333 0.5
IFNG ENSG00000111537 3458 Secreted/Nucleus 0.010204082 48.0 7.981403 0.08067376
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
ARG1 ENSG00000118520 383 Cytoplasm 196.0 16400.0 1.55E-6 0.00298
CDK4 ENSG00000135446 1019 Cytoplasm 2094.0 33700.0 1.56E-6 0.00259
HRK ENSG00000135116 8739 Cytoplasm 4.0 0.0 1.55E-6 1.0
NF1 ENSG00000196712 4763 Cytoplasm 272.0 7910.0 1.56E-6 0.0524
NOS2 ENSG00000007171 4843 Cytoplasm 420.0 34300.0 1.56E-6 0.00985
TH ENSG00000180176 7054 Cytoplasm 129.0 49500.0 1.55E-6 0.0193
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 2727.0 293000.0 1.56E-6 0.00401
BCL2 ENSG00000171791 596 Cytoplasm/Nucleus 1236.0 33900.0 1.56E-6 0.00248
BCL2L1 ENSG00000171552 598 Cytoplasm/Nucleus 1045.0 12300.0 1.56E-6 0.0021
CBFB ENSG00000067955 865 Cytoplasm/Nucleus 32.0 12.5 1.55E-6 0.149
CCNA2 ENSG00000145386 890 Cytoplasm/Nucleus 1114.0 8330.0 1.56E-6 0.00996
CCND1 ENSG00000110092 595 Cytoplasm/Nucleus 2739.0 100000.0 1.56E-6 0.00164
CSRP2 ENSG00000175183 1466 Cytoplasm/Nucleus 3.0 0.0 1.55E-6 1.0
CUL3 ENSG00000036257 8452 Cytoplasm/Nucleus 376.0 16900.0 1.55E-6 0.0481
DUSP10 ENSG00000143507 11221 Cytoplasm/Nucleus 131.0 1.53 1.55E-6 0.00399
EP300 ENSG00000100393 2033 Cytoplasm/Nucleus 6386.0 1380000.0 1.56E-6 0.00143
ESR1 ENSG00000091831 2099 Cytoplasm/Nucleus 1715.0 361000.0 1.56E-6 0.00554
FOS ENSG00000170345 2353 Cytoplasm/Nucleus 3623.0 68600.0 1.56E-6 7.3E-4
HES1 ENSG00000114315 3280 Cytoplasm/Nucleus 411.0 19500.0 1.55E-6 0.0118
JUN ENSG00000177606 3725 Cytoplasm/Nucleus 12667.0 3720000.0 1.57E-6 4.67E-4
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 33563.0 1130000.0 1.56E-6 2.83E-5
MAPK11 ENSG00000185386 5600 Cytoplasm/Nucleus 3606.0 96400.0 1.56E-6 9.0E-4
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 29207.0 850000.0 1.56E-6 3.17E-5
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 11158.0 360000.0 1.56E-6 1.42E-4
MAPK9 ENSG00000050748 5601 Cytoplasm/Nucleus 6317.0 61100.0 1.56E-6 1.86E-4
PRKCA ENSG00000154229 5578 Cytoplasm/Nucleus 10261.0 710000.0 1.56E-6 2.96E-4
RUVBL2 ENSG00000183207 10856 Cytoplasm/Nucleus 195.0 4220.0 1.55E-6 0.0968
SOCS3 ENSG00000184557 9021 Cytoplasm/Nucleus 2446.0 25700.0 1.56E-6 0.00128
ACHE ENSG00000087085 43 Membrane 75.0 20300.0 1.55E-6 0.0317
PDGFRA ENSG00000134853 5156 Membrane 2800.0 20200.0 1.56E-6 0.00142
PLAU ENSG00000122861 5328 Membrane 359.0 26400.0 1.55E-6 0.00643
BRCA1 ENSG00000012048 672 Unknown 3825.0 180000.0 1.56E-6 0.00194
CXCL8 ENSG00000169429 3576 Unknown 1129.0 129000.0 1.56E-6 0.0124
DUSP8 ENSG00000184545 1850 Unknown 55.0 0.0146 1.55E-6 0.0141
H2AFY ENSG00000113648 9555 Unknown 51.0 3930.0 1.55E-6 0.616
HBG2 ENSG00000196565 3048 Unknown 4.0 10200.0 1.55E-6 0.167
KAT5 ENSG00000172977 10524 Unknown 1975.0 88300.0 1.56E-6 0.00589
MAPK14 ENSG00000112062 1432 Unknown 9287.0 427000.0 1.56E-6 2.57E-4
ATF3 ENSG00000162772 467 Nucleus 169.0 9160.0 1.55E-6 0.0409
CREB1 ENSG00000118260 1385 Nucleus 1632.0 139000.0 1.56E-6 0.00288
DDIT3 ENSG00000175197 1649 Nucleus 166.0 9880.0 1.55E-6 0.0241
DUSP1 ENSG00000120129 1843 Nucleus 191.0 17.9 1.55E-6 0.0111
DUSP5 ENSG00000138166 1847 Nucleus 78.0 17.8 1.55E-6 0.0296
GADD45A ENSG00000116717 1647 Nucleus 339.0 1750.0 1.55E-6 0.0102
JDP2 ENSG00000140044 122953 Nucleus 16.0 0.0666 1.55E-6 0.283
JUNB ENSG00000171223 3726 Nucleus 350.0 6650.0 1.56E-6 0.0159
JUND ENSG00000130522 3727 Nucleus 405.0 8110.0 1.56E-6 0.00956
POU2F1 ENSG00000143190 5451 Nucleus 303.0 27900.0 1.56E-6 0.0829
PPARGC1A ENSG00000109819 10891 Nucleus 604.0 39600.0 1.56E-6 0.01
RB1 ENSG00000139687 5925 Nucleus 4373.0 218000.0 1.56E-6 0.00126
COL24A1 ENSG00000171502 255631 Secreted 24.0 2250.0 1.55E-6 0.12
IL23A ENSG00000110944 51561 Secreted 219.0 398.0 1.55E-6 0.035
IL6 ENSG00000136244 3569 Secreted 1764.0 36100.0 1.56E-6 0.00384
INS ENSG00000254647 3630 Secreted 1834.0 510000.0 1.56E-6 0.00309
MMP2 ENSG00000087245 4313 Secreted 292.0 22800.0 1.56E-6 0.014
SELE ENSG00000007908 6401 Secreted 51.0 8650.0 1.55E-6 0.0525
SERPINB5 ENSG00000206075 5268 Secreted 20.0 93.6 1.55E-6 0.137
TGFB2 ENSG00000092969 7042 Secreted 1022.0 11300.0 1.55E-6 0.00412
IFNG ENSG00000111537 3458 Secreted/Nucleus 2810.0 62900.0 1.56E-6 0.00158
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
ARG1 ENSG00000118520 383 Cytoplasm 7.0 1.13 1.39334E-4 0.666666667
CDK4 ENSG00000135446 1019 Cytoplasm 255.0 801.0 1.61421E-4 0.024857187
HRK ENSG00000135116 8739 Cytoplasm 4.0 0.0 1.3678E-4 1.0
NF1 ENSG00000196712 4763 Cytoplasm 63.0 2080.0 1.54536E-4 0.096774194
NOS2 ENSG00000007171 4843 Cytoplasm 106.0 838.0 1.59898E-4 0.059119497
TH ENSG00000180176 7054 Cytoplasm 45.0 3780.0 1.46606E-4 0.093939394
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 579.0 16500.0 1.81917E-4 0.015998231
BCL2 ENSG00000171791 596 Cytoplasm/Nucleus 336.0 9530.0 1.71409E-4 0.015458422
BCL2L1 ENSG00000171552 598 Cytoplasm/Nucleus 303.0 2710.0 1.62575E-4 0.014906126
CBFB ENSG00000067955 865 Cytoplasm/Nucleus 32.0 35.6 1.44363E-4 0.143145161
CCNA2 ENSG00000145386 890 Cytoplasm/Nucleus 266.0 1940.0 1.62787E-4 0.023918286
CCND1 ENSG00000110092 595 Cytoplasm/Nucleus 756.0 16600.0 1.76585E-4 0.005553804
CSRP2 ENSG00000175183 1466 Cytoplasm/Nucleus 3.0 0.0 1.35851E-4 1.0
CUL3 ENSG00000036257 8452 Cytoplasm/Nucleus 37.0 2710.0 1.43989E-4 0.112612613
DUSP10 ENSG00000143507 11221 Cytoplasm/Nucleus 39.0 1.2 1.36949E-4 0.031039136
EP300 ENSG00000100393 2033 Cytoplasm/Nucleus 1723.0 164000.0 1.88644E-4 0.004008081
ESR1 ENSG00000091831 2099 Cytoplasm/Nucleus 746.0 61600.0 1.8352E-4 0.010896594
FOS ENSG00000170345 2353 Cytoplasm/Nucleus 1367.0 21000.0 1.80245E-4 0.00258445
HES1 ENSG00000114315 3280 Cytoplasm/Nucleus 148.0 11200.0 1.55352E-4 0.062695348
JUN ENSG00000177606 3725 Cytoplasm/Nucleus 3540.0 384000.0 2.07297E-4 0.001375153
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 5647.0 122000.0 1.91571E-4 4.01908E-4
MAPK11 ENSG00000185386 5600 Cytoplasm/Nucleus 707.0 11900.0 1.75377E-4 0.006070417
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 5295.0 94900.0 1.89179E-4 3.9334E-4
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 2657.0 58300.0 1.84366E-4 0.001118607
MAPK9 ENSG00000050748 5601 Cytoplasm/Nucleus 1219.0 12300.0 1.75285E-4 0.002506833
PRKCA ENSG00000154229 5578 Cytoplasm/Nucleus 1524.0 27000.0 1.76274E-4 0.003369162
RUVBL2 ENSG00000183207 10856 Cytoplasm/Nucleus 102.0 792.0 1.5528E-4 0.06736556
SOCS3 ENSG00000184557 9021 Cytoplasm/Nucleus 398.0 325.0 1.54919E-4 0.009037632
ACHE ENSG00000087085 43 Membrane 2.0 0.0 1.35227E-4 1.0
PDGFRA ENSG00000134853 5156 Membrane 95.0 5700.0 1.48039E-4 0.021948488
PLAU ENSG00000122861 5328 Membrane 181.0 4800.0 1.60334E-4 0.020073665
BRCA1 ENSG00000012048 672 Unknown 576.0 46700.0 1.71999E-4 0.014456522
CXCL8 ENSG00000169429 3576 Unknown 227.0 3310.0 1.63773E-4 0.021909477
DUSP8 ENSG00000184545 1850 Unknown 23.0 0.0174 1.36054E-4 0.059288538
H2AFY ENSG00000113648 9555 Unknown 8.0 3.1 1.38428E-4 0.357142857
HBG2 ENSG00000196565 3048 Unknown 2.0 0.0 1.35227E-4 1.0
KAT5 ENSG00000172977 10524 Unknown 237.0 5170.0 1.5916E-4 0.033576486
MAPK14 ENSG00000112062 1432 Unknown 1830.0 65300.0 1.85494E-4 0.002225827
ATF3 ENSG00000162772 467 Nucleus 90.0 739.0 1.56617E-4 0.073907616
CREB1 ENSG00000118260 1385 Nucleus 476.0 19700.0 1.76491E-4 0.012976559
DDIT3 ENSG00000175197 1649 Nucleus 59.0 144.0 1.50625E-4 0.098188194
DUSP1 ENSG00000120129 1843 Nucleus 92.0 27.9 1.53304E-4 0.024128046
DUSP5 ENSG00000138166 1847 Nucleus 26.0 6.58 1.49499E-4 0.153846154
GADD45A ENSG00000116717 1647 Nucleus 105.0 1530.0 1.58529E-4 0.064102564
JDP2 ENSG00000140044 122953 Nucleus 16.0 0.411 1.44009E-4 0.283333333
JUNB ENSG00000171223 3726 Nucleus 160.0 971.0 1.60927E-4 0.037264151
JUND ENSG00000130522 3727 Nucleus 135.0 308.0 1.59974E-4 0.039911553
POU2F1 ENSG00000143190 5451 Nucleus 103.0 2550.0 1.56986E-4 0.070435941
PPARGC1A ENSG00000109819 10891 Nucleus 75.0 116.0 1.49768E-4 0.043603604
RB1 ENSG00000139687 5925 Nucleus 898.0 19100.0 1.7328E-4 0.006016094
COL24A1 ENSG00000171502 255631 Secreted 2.0 0.0 1.35227E-4 1.0
IL23A ENSG00000110944 51561 Secreted 66.0 339.0 1.49566E-4 0.145454546
IL6 ENSG00000136244 3569 Secreted 316.0 1940.0 1.62655E-4 0.017138839
INS ENSG00000254647 3630 Secreted 266.0 12100.0 1.62681E-4 0.02003121
MMP2 ENSG00000087245 4313 Secreted 101.0 1040.0 1.6284E-4 0.037821782
SELE ENSG00000007908 6401 Secreted 22.0 9.72 1.46542E-4 0.164502165
SERPINB5 ENSG00000206075 5268 Secreted 17.0 191.0 1.45243E-4 0.176470588
TGFB2 ENSG00000092969 7042 Secreted 14.0 1010.0 1.30924E-4 0.153846154
IFNG ENSG00000111537 3458 Secreted/Nucleus 796.0 20000.0 1.69492E-4 0.006257704
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
ATF2 ATF3 5
ATF2 BCL2 2
ATF2 BCL2L1 2
ATF2 BRCA1 2
ATF2 CBFB 2
ATF2 CCNA2 3
ATF2 CCND1 3
ATF2 CDK4 2
ATF2 CREB1 3
ATF2 CXCL8 2
ATF2 DDIT3 3
ATF2 DUSP1 5
ATF2 DUSP5 2
ATF2 EP300 6
ATF2 ESR1 2
ATF2 FOS 5
ATF2 GADD45A 2
ATF2 H2AFY 3
ATF2 HES1 2
ATF2 JDP2 4
ATF2 JUN 7
ATF2 JUNB 3
ATF2 JUND 4
ATF2 KAT5 2
ATF2 MMP2 2
ATF2 NF1 2
ATF2 PPARGC1A 4
ATF2 RB1 4
ATF2 RUVBL2 3
ATF2 SELE 2
ATF2 SERPINB5 2
ATF2 SOCS3 2
ATF3 FOS 2
ATF3 JUN 7
ATF3 JUND 5
BRCA1 CDK4 4
BRCA1 EP300 4
BRCA1 ESR1 5
BRCA1 KAT5 2
BRCA1 POU2F1 5
CCNA2 RB1 6
CCND1 CDK4 11
CCND1 ESR1 4
CCND1 RB1 10
CDK4 RB1 11
CREB1 EP300 4
CREB1 JUN 5
CREB1 JUND 3
CUL3 H2AFY 2
CUL3 KAT5 2
CXCL8 JUN 4
CXCL8 MAPK1 1
CXCL8 MAPK3 1
DUSP10 MAPK1 2
DUSP10 MAPK11 4
DUSP10 MAPK14 7
DUSP10 MAPK3 3
DUSP10 MAPK8 5
DUSP10 MAPK9 4
DUSP1 MAPK1 6
DUSP1 MAPK11 2
DUSP1 MAPK14 5
DUSP1 MAPK3 6
DUSP1 MAPK8 3
DUSP1 MAPK9 3
DUSP5 MAPK1 4
DUSP5 MAPK3 4
DUSP8 MAPK1 2
DUSP8 MAPK11 2
DUSP8 MAPK14 2
DUSP8 MAPK3 2
DUSP8 MAPK8 3
DUSP8 MAPK9 3
EP300 ESR1 6
EP300 FOS 3
EP300 GADD45A 2
EP300 HES1 2
EP300 JUN 5
EP300 JUNB 3
EP300 JUND 3
EP300 PPARGC1A 4
EP300 RB1 4
ESR1 FOS 3
ESR1 JUN 7
ESR1 MAPK1 3
FOS CCND1 2
FOS JUN 12
FOS JUNB 7
FOS JUND 6
FOS MMP2 2
IFNG BCL2 1
IFNG CXCL8 1
IFNG IL6 1
IL23A IL6 2
IL6 SOCS3 3
INS MAPK1 2
INS MAPK3 2
INS MAPK8 2
INS MAPK9 2
INS RB1 3
JDP2 JUN 4
JUN CCND1 2
JUN IL6 3
JUN JUNB 5
JUN JUND 4
JUN MMP2 3
JUN RB1 5
JUN SELE 2
JUN SERPINB5 2
KAT5 RUVBL2 6
MAPK11 ATF2 8
MAPK11 CREB1 1
MAPK11 DDIT3 3
MAPK11 ESR1 1
MAPK11 FOS 2
MAPK11 JUN 2
MAPK11 MAPK14 3
MAPK11 PPARGC1A 2
MAPK11 SOCS3 2
MAPK11 TH 1
MAPK14 ATF2 8
MAPK14 BCL2L1 2
MAPK14 DDIT3 4
MAPK14 ESR1 2
MAPK14 FOS 3
MAPK14 JDP2 1
MAPK14 JUN 3
MAPK14 KAT5 1
MAPK14 MAPK3 5
MAPK14 PPARGC1A 4
MAPK14 RB1 3
MAPK14 TH 1
MAPK1 ATF2 4
MAPK1 CCND1 1
MAPK1 CREB1 1
MAPK1 FOS 5
MAPK1 IFNG 3
MAPK1 JUND 3
MAPK1 MAPK3 4
MAPK1 TH 3
MAPK3 ATF2 4
MAPK3 BCL2 3
MAPK3 CCND1 1
MAPK3 CREB1 1
MAPK3 FOS 5
MAPK3 IFNG 3
MAPK3 JUN 4
MAPK3 JUND 2
MAPK3 NOS2 1
MAPK3 TH 3
MAPK8 ATF2 5
MAPK8 FOS 4
MAPK8 JUN 9
MAPK8 JUND 5
MAPK8 MAPK9 4
MAPK9 ATF2 4
MAPK9 BCL2 1
MAPK9 BCL2L1 1
MAPK9 FOS 4
MAPK9 IFNG 2
MAPK9 JDP2 1
MAPK9 JUN 8
MAPK9 JUND 2
NF1 POU2F1 2
PRKCA ATF2 2
PRKCA EP300 1
PRKCA MAPK1 1
PRKCA MAPK3 1
PRKCA MMP2 1
PRKCA NF1 1
PRKCA PLAU 1
TGFB2 NOS2 1
ARG1 ESR1 1
ATF2 ACHE 1
ATF2 ARG1 1
ATF2 COL24A1 1
ATF2 CSRP2 1
ATF2 CUL3 1
ATF2 DUSP10 1
ATF2 DUSP8 1
ATF2 HBG2 1
ATF2 HRK 1
ATF2 IL23A 1
ATF2 IL6 1
ATF2 INS 1
ATF2 NOS2 1
ATF2 PDGFRA 1
ATF2 PLAU 1
ATF2 POU2F1 1
ATF2 TGFB2 1
ATF2 TH 2
ATF3 CCNA2 1
ATF3 CCND1 1
ATF3 DDIT3 4
ATF3 DUSP1 1
ATF3 DUSP10 1
ATF3 IFNG 1
ATF3 JUNB 3
ATF3 MAPK14 2
ATF3 NF1 1
ATF3 PPARGC1A 1
ATF3 SELE 1
ATF3 TH 1
BCL2 BCL2L1 4
BCL2 BRCA1 2
BCL2 EP300 2
BCL2 HRK 3
BCL2 JUN 1
BCL2L1 HRK 4
BCL2L1 JUNB 1
BCL2L1 MAPK8 3
BCL2L1 RB1 2
BCL2 MAPK1 3
BCL2 MAPK11 2
BCL2 MAPK14 1
BCL2 MAPK8 3
BCL2 PRKCA 1
BCL2 RB1 3
BRCA1 CCNA2 2
BRCA1 CCND1 4
BRCA1 CREB1 1
BRCA1 GADD45A 1
BRCA1 H2AFY 2
BRCA1 JUN 5
BRCA1 JUNB 4
BRCA1 JUND 4
BRCA1 MAPK1 2
BRCA1 MAPK3 1
BRCA1 MAPK8 2
BRCA1 MMP2 2
BRCA1 NF1 1
BRCA1 RB1 3
BRCA1 RUVBL2 1
CBFB ESR1 1
CBFB JUN 1
CCNA2 CDK4 2
CCNA2 EP300 1
CCNA2 KAT5 1
CCND1 CUL3 1
CCND1 EP300 4
CCND1 KAT5 1
CCND1 MAPK11 1
CCND1 RUVBL2 1
CDK4 CUL3 1
CREB1 ATF3 1
CREB1 BCL2 1
CREB1 CCNA2 1
CREB1 CCND1 2
CREB1 CSRP2 1
CREB1 DUSP1 2
CREB1 ESR1 1
CREB1 FOS 2
CREB1 KAT5 2
CREB1 MAPK14 2
CREB1 NF1 1
CREB1 POU2F1 1
CREB1 PPARGC1A 2
CREB1 TH 1
CSRP2 JUN 1
CUL3 DDIT3 1
CUL3 ESR1 1
CUL3 NF1 1
CUL3 RUVBL2 1
CXCL8 BCL2 1
CXCL8 BCL2L1 1
CXCL8 CCND1 1
CXCL8 EP300 2
CXCL8 IL23A 1
CXCL8 IL6 1
DDIT3 BCL2 1
DDIT3 EP300 2
DDIT3 FOS 4
DDIT3 IL23A 1
DDIT3 JUN 2
DDIT3 JUNB 1
DDIT3 JUND 2
DDIT3 PPARGC1A 1
DUSP1 JUN 2
DUSP1 RB1 1
DUSP5 JUN 1
DUSP5 KAT5 1
DUSP5 MAPK11 1
DUSP5 MAPK14 1
DUSP5 MAPK8 1
DUSP5 MAPK9 1
DUSP5 RUVBL2 1
EP300 JDP2 1
EP300 KAT5 3
EP300 MAPK1 2
EP300 MAPK8 1
EP300 RUVBL2 2
ESR1 CCNA2 1
ESR1 GADD45A 1
ESR1 JUNB 2
ESR1 JUND 2
ESR1 KAT5 3
ESR1 MAPK3 2
ESR1 MMP2 1
ESR1 NOS2 1
ESR1 PLAU 1
ESR1 POU2F1 2
ESR1 PPARGC1A 2
ESR1 RUVBL2 2
ESR1 SERPINB5 2
ESR1 SOCS3 1
FOS CBFB 1
FOS CDK4 1
FOS CXCL8 1
FOS IFNG 1
FOS IL6 1
FOS NOS2 1
FOS PLAU 1
FOS POU2F1 2
FOS RB1 3
FOS TH 1
GADD45A JUN 1
GADD45A MAPK1 1
GADD45A MAPK14 1
GADD45A RB1 1
H2AFY CXCL8 1
H2AFY JUN 1
H2AFY JUND 1
HES1 JUN 1
HES1 PRKCA 1
HES1 RB1 1
IFNG ATF2 1
IFNG INS 1
IFNG PRKCA 1
IL23A IFNG 1
IL23A NOS2 1
IL23A SOCS3 1
IL6 MAPK1 2
IL6 MAPK3 2
INS BCL2 1
INS CREB1 1
INS CXCL8 1
INS FOS 1
INS IL6 1
INS JUN 1
INS MAPK14 1
INS MMP2 1
INS PDGFRA 1
INS PRKCA 1
JDP2 DDIT3 1
JDP2 JUNB 2
JDP2 JUND 3
JDP2 MAPK8 1
JUN ACHE 1
JUN ARG1 1
JUNB CBFB 1
JUNB CCNA2 1
JUN BCL2L1 1
JUNB IL6 1
JUNB JUND 1
JUNB KAT5 1
JUNB MAPK1 2
JUNB MAPK14 1
JUNB MAPK8 2
JUNB MAPK9 1
JUNB MMP2 1
JUNB RB1 2
JUN CCNA2 1
JUN CDK4 1
JUN COL24A1 1
JUND CCNA2 1
JUND CDK4 1
JUND CXCL8 1
JUND KAT5 1
JUND NOS2 1
JUND PLAU 1
JUN HBG2 1
JUN HRK 1
JUN IFNG 1
JUN IL23A 2
JUN MAPK1 4
JUN NOS2 1
JUN PDGFRA 1
JUN PLAU 2
JUN POU2F1 1
JUN PPARGC1A 1
JUN RUVBL2 1
JUN SOCS3 1
KAT5 MAPK8 1
KAT5 RB1 1
MAPK11 IFNG 1
MAPK11 NOS2 1
MAPK14 EP300 1
MAPK14 IFNG 1
MAPK14 MAPK8 2
MAPK14 NOS2 1
MAPK14 SOCS3 1
MAPK1 ATF3 1
MAPK1 BCL2L1 1
MAPK1 CDK4 1
MAPK1 MAPK14 4
MAPK1 MAPK8 2
MAPK1 PLAU 1
MAPK1 RB1 3
MAPK3 ATF3 1
MAPK3 BCL2L1 1
MAPK3 CDK4 1
MAPK3 JUNB 1
MAPK3 MAPK8 1
MAPK3 PLAU 1
MAPK8 GADD45A 1
MAPK8 IFNG 1
MAPK8 RB1 1
MAPK9 MAPK1 1
MAPK9 RB1 2
MAPK9 SERPINB5 1
NF1 DDIT3 1
NF1 DUSP10 1
NF1 EP300 1
NF1 ESR1 1
NF1 GADD45A 1
NF1 JDP2 1
NF1 RB1 1
NF1 SERPINB5 1
NOS2 ARG1 1
NOS2 BCL2 1
NOS2 IFNG 1
NOS2 INS 1
NOS2 RUVBL2 1
POU2F1 BCL2 1
POU2F1 BCL2L1 1
POU2F1 CCND1 2
POU2F1 DUSP10 1
POU2F1 EP300 1
POU2F1 GADD45A 1
POU2F1 IL6 1
POU2F1 JUND 1
POU2F1 NOS2 1
POU2F1 PDGFRA 1
POU2F1 PPARGC1A 1
PPARGC1A MAPK8 1
PRKCA SELE 1
RB1 SELE 1
RB1 SERPINB5 1
RB1 TGFB2 1
SOCS3 IFNG 1
TGFB2 BCL2 1
TH INS 1
TH JUN 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0000229 pathway0000080 9 0.9 Activation of the AP-1 family of transcription factors Reactome 10 35
pathway0000229 pathway0001452 6 0.5454545 Negative regulation of (nuclear import of R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) ) INOH 11 26
pathway0000229 pathway0001230 6 0.5 JNK cascade ( CD4 T cell receptor signaling (JNK cascade) ) INOH 12 48
pathway0000229 pathway0001232 3 0.5 JNK cascade ( TGF-beta signaling(through TAK1) ) INOH 6 14