Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0000231 ATF6-alpha activates chaperone genes Reactome Homo sapiens 10 27
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
HSP90B1 ENSG00000166598 7184 Cytoplasm 0.06666667 4.0 0.0 0.5
ATF4 ENSG00000128272 468 Cytoplasm/Nucleus 0.0625 4.0 0.2727273 0.0
ATF6 ENSG00000118217 22926 Cytoplasm/Nucleus 0.09090909 12.0 5.19697 0.1818182
CALR ENSG00000179218 811 Cytoplasm/Nucleus 0.06666667 3.0 0.0 1.0
HSPA5 ENSG00000044574 3309 Cytoplasm/Nucleus 0.1 10.0 8.616667 0.2666667
NFYC ENSG00000066136 4802 Cytoplasm/Nucleus 0.08333333 8.0 0.2909091 0.4642857
XBP1 ENSG00000100219 7494 Cytoplasm/Nucleus 0.08333333 7.0 0.2909091 0.6190476
DDIT3 ENSG00000175197 1649 Nucleus 0.08333333 9.0 3.95 0.25
NFYA ENSG00000001167 4800 Nucleus 0.08333333 8.0 0.2909091 0.4642857
NFYB ENSG00000120837 4801 Nucleus 0.07692308 7.0 0.09090909 0.4285714
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
HSP90B1 ENSG00000166598 7184 Cytoplasm 126.0 23613.09 1.56E-6 0.07022222
ATF4 ENSG00000128272 468 Cytoplasm/Nucleus 251.0 46997.58 1.56E-6 0.01711554
ATF6 ENSG00000118217 22926 Cytoplasm/Nucleus 75.0 15154.18 1.55E-6 0.02342342
CALR ENSG00000179218 811 Cytoplasm/Nucleus 175.0 25926.92 1.56E-6 0.02824302
HSPA5 ENSG00000044574 3309 Cytoplasm/Nucleus 665.0 313409.5 1.56E-6 0.01434913
NFYC ENSG00000066136 4802 Cytoplasm/Nucleus 104.0 7199.099 1.55E-6 0.03995519
XBP1 ENSG00000100219 7494 Cytoplasm/Nucleus 100.0 164117.0 1.55E-6 0.02585859
DDIT3 ENSG00000175197 1649 Nucleus 166.0 9876.787 1.55E-6 0.02409639
NFYA ENSG00000001167 4800 Nucleus 139.0 16514.97 1.55E-6 0.05140236
NFYB ENSG00000120837 4801 Nucleus 111.0 10493.08 1.55E-6 0.04193284
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
HSP90B1 ENSG00000166598 7184 Cytoplasm 11.0 2561.43 3.98E-7 0.16363636
ATF4 ENSG00000128272 468 Cytoplasm/Nucleus 14.0 37408.9 3.98E-7 0.02197802
ATF6 ENSG00000118217 22926 Cytoplasm/Nucleus 18.0 708.5104 3.98E-7 0.07843137
CALR ENSG00000179218 811 Cytoplasm/Nucleus 68.0 15238.48 3.98E-7 0.04126427
HSPA5 ENSG00000044574 3309 Cytoplasm/Nucleus 136.0 157125.6 3.99E-7 0.10664488
NFYC ENSG00000066136 4802 Cytoplasm/Nucleus 55.0 7669.406 3.98E-7 0.06599327
XBP1 ENSG00000100219 7494 Cytoplasm/Nucleus 54.0 290287.0 3.99E-7 0.02655486
DDIT3 ENSG00000175197 1649 Nucleus 21.0 9450.597 3.98E-7 0.05238095
NFYA ENSG00000001167 4800 Nucleus 65.0 39962.96 3.99E-7 0.0625
NFYB ENSG00000120837 4801 Nucleus 54.0 19940.86 3.99E-7 0.07337526
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
ATF4 DDIT3 7
ATF6 DDIT3 2
ATF6 HSPA5 1
ATF6 XBP1 4
HSP90B1 HSPA5 4
NFYA NFYB 7
NFYA NFYC 7
NFYB NFYC 8
ATF4 HSPA5 1
ATF6 CALR 1
ATF6 HSP90B1 1
ATF6 NFYA 1
ATF6 NFYC 4
CALR HSP90B1 1
CALR HSPA5 1
HSPA5 XBP1 1
NFYA DDIT3 1
NFYA HSPA5 1
NFYA XBP1 1
NFYB DDIT3 1
NFYB HSPA5 1
NFYB XBP1 1
NFYC DDIT3 1
NFYC HSPA5 1
NFYC XBP1 1
XBP1 DDIT3 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0000231 pathway0002579 7 0.7 Protein processing in endoplasmic reticulum KEGG 166 1160
pathway0000231 pathway0000230 6 0.6 ATF4 activates genes Reactome 25 112