Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0000703 ERK cascade ( FGF8 signaling (Xenopus) ) INOH Homo sapiens 17 71
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
BRAF ENSG00000157764 673 Cytoplasm 0.04166667 81.0 0.3965039 0.006790124
MAP2K1 ENSG00000169032 5604 Cytoplasm 0.04166667 190.0 1.556722 0.001169591
ARAF ENSG00000078061 369 Cytoplasm/Nucleus 0.03846154 62.0 0.0 0.007932311
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 0.04 44.0 0.7434523 0.013742072
ELK3 ENSG00000111145 2004 Cytoplasm/Nucleus 0.03846154 10.0 0.05456076 0.266666667
ETS1 ENSG00000134954 2113 Cytoplasm/Nucleus 0.04347826 21.0 1.100581 0.10952381
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 0.03846154 193.0 0.0 8.09586E-4
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 0.0625 159.0 28.14007 0.004219409
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 0.0625 156.0 31.07015 0.004383788
RAF1 ENSG00000132155 5894 Membrane 0.04166667 101.0 0.4807602 0.004158416
ELK4 ENSG00000158711 2005 Nucleus 0.03703704 15.0 0.0212766 0.085714286
ERG ENSG00000157554 2078 Nucleus 0.03846154 10.0 0.1037037 0.288888889
ETS2 ENSG00000157557 2114 Nucleus 0.05 23.0 2.954507 0.134387352
ETV5 ENSG00000244405 2119 Nucleus 0.03571429 4.0 0.0 1.0
ETV6 ENSG00000139083 2120 Nucleus 0.03846154 11.0 0.1037037 0.236363636
FLI1 ENSG00000151702 2313 Nucleus 0.03846154 8.0 0.08034509 0.392857143
SPI1 ENSG00000066336 6688 Nucleus 0.04347826 14.0 0.1936601 0.252747253
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BRAF ENSG00000157764 673 Cytoplasm 12094.0 42600.0 1.56E-6 4.04E-5
MAP2K1 ENSG00000169032 5604 Cytoplasm 23272.0 37700.0 1.56E-6 1.47E-5
ARAF ENSG00000078061 369 Cytoplasm/Nucleus 6326.0 11300.0 1.55E-6 1.03E-4
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 3468.0 49000.0 1.56E-6 3.9E-4
ELK3 ENSG00000111145 2004 Cytoplasm/Nucleus 63.0 13.7 1.54E-6 0.0236
ETS1 ENSG00000134954 2113 Cytoplasm/Nucleus 716.0 15200.0 1.56E-6 0.00784
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 22859.0 10500.0 1.55E-6 9.5E-6
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 33563.0 1130000.0 1.56E-6 2.83E-5
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 29207.0 850000.0 1.56E-6 3.17E-5
RAF1 ENSG00000132155 5894 Membrane 23706.0 140000.0 1.56E-6 1.64E-5
ELK4 ENSG00000158711 2005 Nucleus 277.0 134.0 1.55E-6 0.00181
ERG ENSG00000157554 2078 Nucleus 70.0 22.4 1.55E-6 0.0484
ETS2 ENSG00000157557 2114 Nucleus 212.0 11300.0 1.56E-6 0.0274
ETV5 ENSG00000244405 2119 Nucleus 39.0 3.64 1.55E-6 0.0796
ETV6 ENSG00000139083 2120 Nucleus 50.0 0.346 1.55E-6 0.0131
FLI1 ENSG00000151702 2313 Nucleus 47.0 4.74 1.55E-6 0.0796
SPI1 ENSG00000066336 6688 Nucleus 385.0 19000.0 1.56E-6 0.0169
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BRAF ENSG00000157764 673 Cytoplasm 3583.0 3690.0 8.83E-6 1.95E-4
MAP2K1 ENSG00000169032 5604 Cytoplasm 4993.0 723.0 8.8E-6 7.79E-5
ARAF ENSG00000078061 369 Cytoplasm/Nucleus 2507.0 1100.0 8.79E-6 2.82E-4
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 440.0 26.6 8.75E-6 1.66E-4
ELK3 ENSG00000111145 2004 Cytoplasm/Nucleus 32.0 0.0687 8.74E-6 0.0242
ETS1 ENSG00000134954 2113 Cytoplasm/Nucleus 64.0 11.5 8.75E-6 0.0119
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 4964.0 226.0 8.79E-6 5.85E-5
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 4109.0 11600.0 8.83E-6 2.0E-4
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 3869.0 8460.0 8.83E-6 1.94E-4
RAF1 ENSG00000132155 5894 Membrane 4968.0 8250.0 8.83E-6 1.24E-4
ELK4 ENSG00000158711 2005 Nucleus 53.0 0.0196 8.74E-6 0.00653
ERG ENSG00000157554 2078 Nucleus 32.0 0.229 8.74E-6 0.0262
ETS2 ENSG00000157557 2114 Nucleus 79.0 34.4 8.75E-6 0.0114
ETV5 ENSG00000244405 2119 Nucleus 12.0 0.0 8.74E-6 0.0909
ETV6 ENSG00000139083 2120 Nucleus 30.0 0.229 8.74E-6 0.0299
FLI1 ENSG00000151702 2313 Nucleus 24.0 0.133 8.74E-6 0.0399
SPI1 ENSG00000066336 6688 Nucleus 44.0 0.654 8.75E-6 0.0243
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
ARAF BRAF 4
ARAF MAP2K1 10
ARAF MAP2K2 8
ARAF MAPK1 2
ARAF MAPK3 2
ARAF RAF1 2
BRAF MAP2K1 12
BRAF MAP2K2 11
BRAF MAPK1 6
BRAF MAPK3 6
BRAF RAF1 9
ELK1 ELK3 3
ELK1 ELK4 3
ERG ETS2 3
ETS1 ETS2 3
ETS1 SPI1 2
ETS2 SPI1 2
MAP2K1 MAP2K2 7
MAP2K1 MAPK1 13
MAP2K1 MAPK3 12
MAP2K1 RAF1 10
MAP2K2 MAPK1 10
MAP2K2 MAPK3 11
MAP2K2 RAF1 7
MAPK1 ELK1 9
MAPK1 ELK3 2
MAPK1 ELK4 3
MAPK1 ERG 3
MAPK1 ETS1 7
MAPK1 ETS2 3
MAPK1 ETV6 2
MAPK1 FLI1 2
MAPK1 MAPK3 4
MAPK1 RAF1 5
MAPK1 SPI1 2
MAPK3 ELK1 8
MAPK3 ELK3 2
MAPK3 ELK4 4
MAPK3 ERG 2
MAPK3 ETS1 5
MAPK3 ETS2 3
MAPK3 ETV6 3
MAPK3 FLI1 2
MAPK3 RAF1 5
MAPK3 SPI1 2
ELK1 FLI1 2
ELK1 MAP2K1 1
ELK1 SPI1 1
ELK3 ELK4 1
ERG FLI1 1
ERG SPI1 1
ETS1 ELK3 1
ETS1 ERG 1
ETS1 ETV5 1
ETS1 ETV6 1
ETS1 RAF1 2
ETS2 BRAF 1
ETS2 ELK3 1
ETS2 ELK4 1
ETS2 ETV5 1
ETS2 ETV6 1
ETS2 FLI1 1
ETS2 RAF1 1
ETV6 FLI1 2
MAPK1 ETV5 1
MAPK3 ETV5 1
SPI1 BRAF 1
SPI1 ETV6 1
SPI1 MAP2K1 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0000703 pathway0000704 5 1.0 ERK cascade ( GPCR Adenosine A2A receptor signaling pathway ) INOH 5 11
pathway0000703 pathway0000705 7 1.0 ERK cascade ( GPCR GroupI metabotropic glutamate receptor signaling pathway ) INOH 7 22
pathway0000703 pathway0000706 7 1.0 ERK cascade ( GPCR signaling (G alpha q) ) INOH 7 22
pathway0000703 pathway0000707 5 1.0 ERK cascade ( GPCR signaling (G alpha s, Epac and ERK) ) INOH 5 11
pathway0000703 pathway0000708 6 1.0 ERK cascade ( HGF signaling pathway ) INOH 6 15
pathway0000703 pathway0000709 8 1.0 ERK cascade ( IGF1 signaling pathway ) INOH 8 26
pathway0000703 pathway0000710 8 1.0 ERK cascade ( Insulin receptor signaling (D. melanogaster) ) INOH 8 26
pathway0000703 pathway0000711 8 1.0 ERK cascade ( Insulin receptor signaling (Mammal) ) INOH 8 26
pathway0000703 pathway0000712 7 1.0 ERK cascade ( JAK-STAT pathway and regulation pathway Diagram ) INOH 7 22
pathway0000703 pathway0000713 8 1.0 ERK cascade ( NGF signaling pathway ) INOH 8 26
pathway0000703 pathway0000714 6 1.0 ERK cascade ( VEGF signaling pathway ) INOH 6 15
pathway0000703 pathway0001446 6 1.0 Negative feedback regulation of MAPK pathway Reactome 6 16
pathway0000703 pathway0002466 5 1.0 ERK cascade ( Integrin signaling pathway ) INOH 5 11
pathway0000703 pathway0002467 7 1.0 ERK cascade ( PDGF signaling pathway ) INOH 7 18
pathway0000703 pathway0000697 7 1.0 ERK cascade ( B cell receptor signaling ) INOH 7 22
pathway0000703 pathway0000699 7 1.0 ERK cascade ( CD4 T cell receptor signaling ) INOH 7 22
pathway0000703 pathway0000700 6 1.0 ERK cascade ( EGF signaling pathway Diagram ) INOH 6 15
pathway0000703 pathway0000701 8 1.0 ERK cascade ( FGF signaling pathway ) INOH 8 26
pathway0000703 pathway0000702 17 1.0 ERK cascade ( FGF8 signaling (Mouse) ) INOH 17 71
pathway0000703 pathway0000781 13 0.7647059 FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) INOH 20 66
pathway0000703 pathway0000782 13 0.7647059 FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) INOH 18 53
pathway0000703 pathway0001604 12 0.7058824 PDGF signaling pathway PANTHER 113 1684
pathway0000703 pathway0000698 7 0.7 ERK cascade ( CD4 T cell receptor signaling (ERK cascade) ) INOH 10 42
pathway0000703 pathway0001078 9 0.5294118 ID NetPath 38 213
pathway0000703 pathway0001191 9 0.5294118 Interleukin signaling pathway PANTHER 86 1548
pathway0000703 pathway0001805 9 0.5294118 Ras Pathway PANTHER 69 921
pathway0000703 pathway0000658 9 0.5294118 EGFR1 NetPath 475 10010