Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0000901 Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH Homo sapiens 8 29
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
SOCS3 ENSG00000184557 9021 Cytoplasm/Nucleus 0.1428571 22.0 0.0 0.09090909
STAT1 ENSG00000115415 6772 Cytoplasm/Nucleus 0.1428571 15.0 0.0 0.2
STAT2 ENSG00000170581 6773 Cytoplasm/Nucleus 0.1428571 15.0 0.0 0.2
STAT4 ENSG00000138378 6775 Cytoplasm/Nucleus 0.1428571 9.0 0.0 0.58333333
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 0.1428571 16.0 0.0 0.175
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 0.1428571 13.0 0.0 0.26923077
STAT6 ENSG00000166888 6778 Cytoplasm/Nucleus 0.1428571 12.0 0.0 0.31818182
STAT3 ENSG00000168610 6774 Unknown 0.1428571 26.0 0.0 0.06461538
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
SOCS3 ENSG00000184557 9021 Cytoplasm/Nucleus 2446.0 25684.6 1.56E-6 0.001279164
STAT1 ENSG00000115415 6772 Cytoplasm/Nucleus 9900.0 278294.6 1.56E-6 2.89632E-4
STAT2 ENSG00000170581 6773 Cytoplasm/Nucleus 2228.0 42553.98 1.56E-6 0.003808732
STAT4 ENSG00000138378 6775 Cytoplasm/Nucleus 1943.0 34339.87 1.56E-6 0.004763992
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 7688.0 195804.1 1.56E-6 4.68547E-4
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 6515.0 71134.33 1.56E-6 5.43278E-4
STAT6 ENSG00000166888 6778 Cytoplasm/Nucleus 2021.0 82977.94 1.56E-6 0.005064643
STAT3 ENSG00000168610 6774 Unknown 10644.0 313180.8 1.56E-6 2.8207E-4
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
SOCS3 ENSG00000184557 9021 Cytoplasm/Nucleus 245.0 27.91526 8.78E-6 0.036868518
STAT1 ENSG00000115415 6772 Cytoplasm/Nucleus 1173.0 9488.925 8.85E-6 0.008741915
STAT2 ENSG00000170581 6773 Cytoplasm/Nucleus 764.0 4094.884 8.84E-6 0.017895741
STAT4 ENSG00000138378 6775 Cytoplasm/Nucleus 723.0 3610.016 8.84E-6 0.018471052
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 1023.0 7254.408 8.85E-6 0.011334225
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 959.0 6384.682 8.85E-6 0.012382418
STAT6 ENSG00000166888 6778 Cytoplasm/Nucleus 762.0 4037.801 8.84E-6 0.017651867
STAT3 ENSG00000168610 6774 Unknown 1157.0 13845.87 8.85E-6 0.008503976
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
SOCS3 STAT1 2
STAT1 STAT2 7
STAT1 STAT3 8
STAT1 STAT5A 5
STAT1 STAT5B 3
STAT2 STAT3 2
STAT2 STAT6 4
STAT3 SOCS3 3
STAT3 STAT4 3
STAT3 STAT5A 4
STAT3 STAT5B 6
STAT3 STAT6 2
STAT4 STAT5A 2
STAT5A STAT5B 4
STAT1 STAT4 1
STAT1 STAT6 1
STAT2 SOCS3 1
STAT2 STAT4 1
STAT2 STAT5A 1
STAT2 STAT5B 1
STAT4 SOCS3 1
STAT4 STAT5B 1
STAT4 STAT6 1
STAT5A SOCS3 1
STAT5B SOCS3 1
STAT5B STAT6 1
STAT6 SOCS3 1
STAT6 STAT5A 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0000901 pathway0002606 8 1.0 Jak-STAT signaling pathway KEGG 149 3911
pathway0000901 pathway0000899 8 1.0 Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH 14 66
pathway0000901 pathway0001191 7 0.875 Interleukin signaling pathway PANTHER 86 1548
pathway0000901 pathway0001226 7 0.875 JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) INOH 97 3460
pathway0000901 pathway0001604 7 0.875 PDGF signaling pathway PANTHER 113 1684
pathway0000901 pathway0001697 7 0.875 Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) INOH 178 3507
pathway0000901 pathway0000652 7 0.875 EGF receptor signaling pathway PANTHER 109 2585
pathway0000901 pathway0000900 7 0.875 Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH 8 29
pathway0000901 pathway0001120 6 0.75 IL2 NetPath 81 1364
pathway0000901 pathway0001128 6 0.75 IL4 NetPath 75 1239
pathway0000901 pathway0001228 6 0.75 JAK/STAT signaling pathway PANTHER 15 87
pathway0000901 pathway0002355 6 0.75 TSLP NetPath 24 159
pathway0000901 pathway0002864 6 0.75 Hs_IL-4_Signaling_Pathway_WP395_89828 WikiPathways 41 397
pathway0000901 pathway0000658 6 0.75 EGFR1 NetPath 475 10010
pathway0000901 pathway0000966 5 0.625 GMCSF-mediated signaling events PID 38 413
pathway0000901 pathway0000976 5 0.625 Growth hormone receptor signaling Reactome 24 171
pathway0000901 pathway0001116 5 0.625 IL12-mediated signaling events PID 62 684
pathway0000901 pathway0001119 5 0.625 IL2-mediated signaling events PID 54 871
pathway0000901 pathway0001123 5 0.625 IL23-mediated signaling events PID 37 345
pathway0000901 pathway0001124 5 0.625 IL27-mediated signaling events PID 26 217
pathway0000901 pathway0001132 5 0.625 IL6 NetPath 85 1335
pathway0000901 pathway0001135 5 0.625 IL9 NetPath 24 200
pathway0000901 pathway0001264 5 0.625 Leptin NetPath 98 1355
pathway0000901 pathway0001727 5 0.625 Prolactin NetPath 105 1733
pathway0000901 pathway0002040 5 0.625 Signaling events mediated by TCPTP PID 40 361
pathway0000901 pathway0002682 5 0.625 Hs_Interferon_type_I_signaling_pathways_WP585_85198 WikiPathways 35 246
pathway0000901 pathway0002844 5 0.625 Hs_IL-2_Signaling_Pathway_WP49_91243 WikiPathways 33 332
pathway0000901 pathway0000513 5 0.625 CXCR4-mediated signaling events PID 87 1183
pathway0000901 pathway0000633 5 0.625 Downstream signal transduction Reactome 29 307
pathway0000901 pathway0001112 4 0.5 IL-7 NetPath 28 203
pathway0000901 pathway0001126 4 0.5 IL3 NetPath 84 1284
pathway0000901 pathway0001127 4 0.5 IL4-mediated signaling events PID 66 512
pathway0000901 pathway0001130 4 0.5 IL5 NetPath 59 739
pathway0000901 pathway0001246 4 0.5 KitReceptor NetPath 104 1591
pathway0000901 pathway0001606 4 0.5 PDGFR-beta signaling pathway PID 125 2449
pathway0000901 pathway0002010 4 0.5 Signaling by cytosolic FGFR1 fusion mutants Reactome 18 77
pathway0000901 pathway0002022 4 0.5 Signaling by Leptin Reactome 11 48
pathway0000901 pathway0002030 4 0.5 Signaling by SCF-KIT Reactome 37 402
pathway0000901 pathway0002038 4 0.5 Signaling events mediated by PTP1B PID 53 577
pathway0000901 pathway0002199 4 0.5 TCR NetPath 261 4161
pathway0000901 pathway0002568 4 0.5 Chemokine signaling pathway KEGG 187 4644
pathway0000901 pathway0002655 4 0.5 Hepatitis C KEGG 134 1627
pathway0000901 pathway0002656 4 0.5 Pathways in cancer KEGG 321 8293
pathway0000901 pathway0002760 4 0.5 Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 WikiPathways 44 408
pathway0000901 pathway0002829 4 0.5 Hs_Kit_receptor_signaling_pathway_WP304_78799 WikiPathways 46 510
pathway0000901 pathway0002837 4 0.5 Hs_IL-5_Signaling_Pathway_WP127_78498 WikiPathways 35 321
pathway0000901 pathway0002866 4 0.5 Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 WikiPathways 107 1336
pathway0000901 pathway0000687 4 0.5 EPO signaling pathway PID 33 339
pathway0000901 pathway0000688 4 0.5 EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) INOH 12 59