Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0001104 IL-13 signaling pathway(JAK1 TYK2 STAT6) ( IL-13 signaling(JAK1 TYK2 STAT6) ) INOH Homo sapiens 10 45
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
IRS1 ENSG00000169047 3667 Cytoplasm 0.1 24.0 0.0 0.10144928
JAK1 ENSG00000162434 3716 Cytoplasm 0.11111111 38.0 0.6262353 0.04836415
IRS2 ENSG00000185950 8660 Cytoplasm/Nucleus 0.1 23.0 0.0 0.11067194
STAT6 ENSG00000166888 6778 Cytoplasm/Nucleus 0.09090909 27.0 0.0 0.05982906
TYK2 ENSG00000105397 7297 Cytoplasm/Nucleus 0.11111111 28.0 0.2328415 0.08994709
IL13RA1 ENSG00000131724 3597 Membrane 0.11111111 27.0 0.2095573 0.0968661
IL13RA2 ENSG00000123496 3598 Membrane 0.11111111 20.0 0.09313659 0.17894737
IL4R ENSG00000077238 3566 Unknown 0.11111111 34.0 0.465683 0.06060606
IL13 ENSG00000169194 3596 Secreted 0.11111111 19.0 0.09313659 0.19883041
IL4 ENSG00000113520 3565 Secreted 0.11111111 30.0 0.2794098 0.07816092
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
IRS1 ENSG00000169047 3667 Cytoplasm 4154.0 22041.17 1.56E-6 7.58308E-4
JAK1 ENSG00000162434 3716 Cytoplasm 8612.0 95406.96 1.56E-6 2.70908E-4
IRS2 ENSG00000185950 8660 Cytoplasm/Nucleus 2517.0 13027.48 1.56E-6 0.001673201
STAT6 ENSG00000166888 6778 Cytoplasm/Nucleus 2021.0 82977.94 1.56E-6 0.005064643
TYK2 ENSG00000105397 7297 Cytoplasm/Nucleus 2515.0 18380.07 1.56E-6 0.001931767
IL13RA1 ENSG00000131724 3597 Membrane 620.0 18272.59 1.55E-6 0.022445151
IL13RA2 ENSG00000123496 3598 Membrane 452.0 76.75757 1.55E-6 0.04266821
IL4R ENSG00000077238 3566 Unknown 799.0 721.4567 1.55E-6 0.014573355
IL13 ENSG00000169194 3596 Secreted 557.0 782.107 1.55E-6 0.012677112
IL4 ENSG00000113520 3565 Secreted 1181.0 24114.84 1.55E-6 0.004710171
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
IRS1 ENSG00000169047 3667 Cytoplasm 252.0 422.5913 8.79E-6 0.010813887
JAK1 ENSG00000162434 3716 Cytoplasm 1664.0 6632.653 8.83E-6 0.003422192
IRS2 ENSG00000185950 8660 Cytoplasm/Nucleus 163.0 70.59114 8.78E-6 0.02294933
STAT6 ENSG00000166888 6778 Cytoplasm/Nucleus 762.0 4037.801 8.84E-6 0.017651867
TYK2 ENSG00000105397 7297 Cytoplasm/Nucleus 772.0 1619.746 8.82E-6 0.012230936
IL13RA1 ENSG00000131724 3597 Membrane 234.0 32.3311 8.8E-6 0.126921243
IL13RA2 ENSG00000123496 3598 Membrane 216.0 23.69032 8.8E-6 0.149009475
IL4R ENSG00000077238 3566 Unknown 285.0 46.95569 8.8E-6 0.085495429
IL13 ENSG00000169194 3596 Secreted 303.0 131.456 8.78E-6 0.03175748
IL4 ENSG00000113520 3565 Secreted 441.0 314.4298 8.79E-6 0.022335601
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
IL13 IL13RA1 7
IL13 IL13RA2 5
IL13 IL4R 7
IL13 IRS1 1
IL13 IRS2 1
IL13 JAK1 2
IL13RA1 IL4 4
IL13RA1 IL4R 5
IL13RA1 IRS1 2
IL13RA1 IRS2 2
IL13RA1 JAK1 3
IL13RA1 STAT6 2
IL13RA1 TYK2 4
IL13RA2 IL4 3
IL13RA2 IRS1 1
IL13RA2 IRS2 1
IL13RA2 JAK1 2
IL13RA2 TYK2 2
IL13 STAT6 1
IL4 IL4R 12
IL4 IRS1 2
IL4 IRS2 2
IL4 JAK1 3
IL4R IRS1 5
IL4R IRS2 5
IL4R JAK1 7
IL4R STAT6 7
IL4R TYK2 2
IL4 TYK2 2
IRS1 IRS2 4
IRS1 JAK1 5
IRS1 TYK2 2
IRS2 JAK1 5
IRS2 TYK2 3
JAK1 STAT6 7
JAK1 TYK2 4
STAT6 IL4 2
TYK2 STAT6 3
IL13RA1 IL13RA2 1
IL13RA2 IL4R 1
IL13 TYK2 1
IL4 IL13 1
STAT6 IL13RA2 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0001104 pathway0001128 9 0.9 IL4 NetPath 75 1239
pathway0001104 pathway0001127 8 0.8 IL4-mediated signaling events PID 66 512
pathway0001104 pathway0001191 8 0.8 Interleukin signaling pathway PANTHER 86 1548
pathway0001104 pathway0001226 8 0.8 JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) INOH 97 3460
pathway0001104 pathway0002606 8 0.8 Jak-STAT signaling pathway KEGG 149 3911
pathway0001104 pathway0001108 4 0.5714286 IL-4 signaling pathway(JAK1 JAK3 STAT6) ( IL-4 signaling(JAK1 JAK3 STAT6) ) INOH 7 23
pathway0001104 pathway0001135 5 0.5 IL9 NetPath 24 200