Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0001112 IL-7 NetPath Homo sapiens 28 203
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
BAD ENSG00000002330 572 Cytoplasm 0.01923077 36.0 0.0 0.015873016
CLTC ENSG00000141367 1213 Cytoplasm 0.02 4.0 0.1727511 0.5
FYN ENSG00000010810 2534 Cytoplasm 0.02777778 47.0 5.801702 0.098057354
GSK3A ENSG00000105723 2931 Cytoplasm 0.02083333 25.0 0.0 0.05
IRS1 ENSG00000169047 3667 Cytoplasm 0.02439024 49.0 1.80004 0.055272109
JAK1 ENSG00000162434 3716 Cytoplasm 0.03125 94.0 17.02061 0.033173187
JAK3 ENSG00000105639 3718 Cytoplasm 0.03030303 83.0 14.28572 0.042021746
MAP2K1 ENSG00000169032 5604 Cytoplasm 0.02564103 115.0 0.4794934 0.013119756
CBLB ENSG00000114423 868 Cytoplasm/Nucleus 0.02272727 19.0 0.09747653 0.239766082
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 0.02040816 21.0 0.05017498 0.028571429
FOXO3 ENSG00000118689 2309 Cytoplasm/Nucleus 0.01886792 23.0 0.0974359 0.015810277
IRS2 ENSG00000185950 8660 Cytoplasm/Nucleus 0.02325581 30.0 0.3693292 0.110344828
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 0.025 116.0 0.4076449 0.011844078
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 0.02777778 148.0 8.462555 0.00965251
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 0.02702703 134.0 5.252331 0.010436539
PTK2B ENSG00000120899 2185 Cytoplasm/Nucleus 0.025 34.0 0.5054932 0.137254902
STAM ENSG00000136738 8027 Cytoplasm/Nucleus 0.01960784 11.0 0.8365385 0.109090909
STAT1 ENSG00000115415 6772 Cytoplasm/Nucleus 0.02702703 69.0 4.152208 0.045183291
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 0.02941176 70.0 12.72063 0.05300207
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 0.02941176 68.0 8.656114 0.059262511
AKT1 ENSG00000142208 207 Membrane 0.03333333 194.0 77.2001 0.007852145
IL2RG ENSG00000147168 3561 Membrane 0.03030303 58.0 3.939551 0.086509377
PIK3R1 ENSG00000145675 5295 Membrane 0.02702703 99.0 6.544771 0.021026592
SHC1 ENSG00000160691 6464 Membrane 0.02941176 58.0 9.692473 0.079249849
GSK3B ENSG00000082701 2932 Unknown 0.02380952 54.0 0.6971045 0.032844165
STAT3 ENSG00000168610 6774 Unknown 0.02857143 80.0 6.56619 0.038291139
IL7 ENSG00000104432 3574 Secreted 0.02173913 23.0 0.4010795 0.154150198
IL7R ENSG00000168685 3575 Secreted 0.02272727 34.0 0.7904754 0.099821747
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BAD ENSG00000002330 572 Cytoplasm 4485.0 12124.42 1.55E-6 8.39E-5
CLTC ENSG00000141367 1213 Cytoplasm 699.0 166129.7 1.56E-6 0.0114
FYN ENSG00000010810 2534 Cytoplasm 9828.0 511487.2 1.56E-6 4.85E-4
GSK3A ENSG00000105723 2931 Cytoplasm 885.0 2465.304 1.55E-6 0.00129
IRS1 ENSG00000169047 3667 Cytoplasm 4154.0 22041.17 1.56E-6 7.58E-4
JAK1 ENSG00000162434 3716 Cytoplasm 8612.0 95406.96 1.56E-6 2.71E-4
JAK3 ENSG00000105639 3718 Cytoplasm 4002.0 22777.91 1.56E-6 9.36E-4
MAP2K1 ENSG00000169032 5604 Cytoplasm 23272.0 37657.94 1.56E-6 1.47E-5
CBLB ENSG00000114423 868 Cytoplasm/Nucleus 1299.0 34894.56 1.56E-6 0.00669
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 1320.0 45804.93 1.56E-6 0.00162
FOXO3 ENSG00000118689 2309 Cytoplasm/Nucleus 1569.0 45471.35 1.56E-6 0.0022
IRS2 ENSG00000185950 8660 Cytoplasm/Nucleus 2517.0 13027.48 1.56E-6 0.00167
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 22859.0 10457.71 1.55E-6 9.5E-6
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 33563.0 1132138.0 1.56E-6 2.83E-5
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 29207.0 849501.6 1.56E-6 3.17E-5
PTK2B ENSG00000120899 2185 Cytoplasm/Nucleus 2732.0 39891.83 1.56E-6 0.00291
STAM ENSG00000136738 8027 Cytoplasm/Nucleus 218.0 1068.001 1.55E-6 0.0194
STAT1 ENSG00000115415 6772 Cytoplasm/Nucleus 9900.0 278294.6 1.56E-6 2.9E-4
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 7688.0 195804.1 1.56E-6 4.69E-4
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 6515.0 71134.33 1.56E-6 5.43E-4
AKT1 ENSG00000142208 207 Membrane 52751.0 2150216.0 1.57E-6 1.74E-5
IL2RG ENSG00000147168 3561 Membrane 2184.0 16783.94 1.55E-6 0.00277
PIK3R1 ENSG00000145675 5295 Membrane 31452.0 733597.1 1.56E-6 4.03E-5
SHC1 ENSG00000160691 6464 Membrane 13549.0 311909.8 1.56E-6 2.6E-4
GSK3B ENSG00000082701 2932 Unknown 9387.0 367205.8 1.56E-6 1.84E-4
STAT3 ENSG00000168610 6774 Unknown 10644.0 313180.8 1.56E-6 2.82E-4
IL7 ENSG00000104432 3574 Secreted 469.0 2878.889 1.55E-6 0.0127
IL7R ENSG00000168685 3575 Secreted 603.0 732.5515 1.55E-6 0.0238
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BAD ENSG00000002330 572 Cytoplasm 665.0 462.0 2.95858E-4 0.001834405
CLTC ENSG00000141367 1213 Cytoplasm 139.0 1450.0 3.26052E-4 0.075800229
FYN ENSG00000010810 2534 Cytoplasm 2122.0 17800.0 3.52361E-4 0.002945279
GSK3A ENSG00000105723 2931 Cytoplasm 298.0 365.0 2.97531E-4 0.00526518
IRS1 ENSG00000169047 3667 Cytoplasm 977.0 1620.0 3.21543E-4 0.003848768
JAK1 ENSG00000162434 3716 Cytoplasm 1977.0 3720.0 3.3389E-4 0.001842034
JAK3 ENSG00000105639 3718 Cytoplasm 830.0 1130.0 3.13676E-4 0.005322133
MAP2K1 ENSG00000169032 5604 Cytoplasm 3187.0 2050.0 3.37041E-4 4.41412E-4
CBLB ENSG00000114423 868 Cytoplasm/Nucleus 447.0 778.0 3.14367E-4 0.024488117
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 420.0 2630.0 3.17058E-4 0.006557563
FOXO3 ENSG00000118689 2309 Cytoplasm/Nucleus 444.0 510.0 3.20924E-4 0.009405568
IRS2 ENSG00000185950 8660 Cytoplasm/Nucleus 750.0 562.0 3.1348E-4 0.005557632
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 2527.0 815.0 3.1736E-4 4.12959E-4
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 5156.0 48800.0 3.73692E-4 4.73077E-4
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 4741.0 37700.0 3.67107E-4 4.62168E-4
PTK2B ENSG00000120899 2185 Cytoplasm/Nucleus 654.0 1260.0 3.1348E-4 0.010124994
STAM ENSG00000136738 8027 Cytoplasm/Nucleus 100.0 161.0 3.00571E-4 0.063838384
STAT1 ENSG00000115415 6772 Cytoplasm/Nucleus 2507.0 16000.0 3.53232E-4 0.001538549
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 2173.0 16500.0 3.50263E-4 0.002097566
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 1793.0 5730.0 3.46741E-4 0.002642967
AKT1 ENSG00000142208 207 Membrane 8322.0 100000.0 3.86847E-4 2.77642E-4
IL2RG ENSG00000147168 3561 Membrane 358.0 128.0 3.0349E-4 0.017636105
PIK3R1 ENSG00000145675 5295 Membrane 4346.0 40100.0 3.6914E-4 7.18516E-4
SHC1 ENSG00000160691 6464 Membrane 2671.0 17900.0 3.62319E-4 0.002124357
GSK3B ENSG00000082701 2932 Unknown 1641.0 17600.0 3.47584E-4 0.001609667
STAT3 ENSG00000168610 6774 Unknown 2751.0 23400.0 3.62582E-4 0.001531741
IL7 ENSG00000104432 3574 Secreted 23.0 0.0266 2.57467E-4 0.154150198
IL7R ENSG00000168685 3575 Secreted 104.0 70.2 2.98686E-4 0.05545183
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
AKT1 BAD 10
AKT1 FOXO1 13
AKT1 FOXO3 11
AKT1 GSK3A 9
AKT1 GSK3B 13
AKT1 IRS1 3
AKT1 STAT1 3
AKT1 STAT3 2
CBLB AKT1 1
CBLB FYN 4
CBLB PIK3R1 6
CBLB SHC1 4
FOXO1 STAT3 2
FYN AKT1 2
FYN IRS1 4
FYN PIK3R1 6
FYN SHC1 7
FYN STAT1 3
FYN STAT3 5
FYN STAT5A 2
FYN STAT5B 2
GSK3A STAT3 1
GSK3B STAT1 1
GSK3B STAT3 1
GSK3B STAT5A 1
GSK3B STAT5B 1
IL2RG AKT1 2
IL2RG IL7 8
IL2RG IL7R 7
IL2RG JAK1 8
IL2RG JAK3 9
IL2RG PIK3R1 4
IL2RG SHC1 4
IL2RG STAT1 3
IL2RG STAT3 2
IL2RG STAT5A 4
IL2RG STAT5B 3
IL7 IL7R 9
IL7 IRS1 1
IL7 IRS2 1
IL7 JAK3 3
IL7R JAK1 6
IL7R JAK3 5
IL7R PIK3R1 4
IL7R PTK2B 5
IL7R STAT3 3
IL7R STAT5A 4
IL7R STAT5B 5
IL7 STAT5A 1
IL7 STAT5B 1
IRS1 IRS2 4
IRS1 JAK1 5
IRS1 JAK3 4
IRS1 PIK3R1 11
IRS1 SHC1 7
IRS2 JAK1 5
IRS2 JAK3 3
IRS2 PIK3R1 8
IRS2 SHC1 4
JAK1 AKT1 4
JAK1 JAK3 5
JAK1 MAPK1 2
JAK1 MAPK3 2
JAK1 PIK3R1 6
JAK1 PTK2B 4
JAK1 SHC1 4
JAK1 STAM 2
JAK1 STAT1 9
JAK1 STAT3 11
JAK1 STAT5A 8
JAK1 STAT5B 7
JAK3 AKT1 3
JAK3 PIK3R1 7
JAK3 PTK2B 5
JAK3 SHC1 3
JAK3 STAM 4
JAK3 STAT1 5
JAK3 STAT3 8
JAK3 STAT5A 9
JAK3 STAT5B 6
MAP2K1 AKT1 1
MAP2K1 GSK3B 1
MAP2K1 MAP2K2 7
MAP2K1 MAPK1 13
MAP2K1 MAPK3 12
MAP2K1 STAT1 1
MAP2K1 STAT3 2
MAP2K1 STAT5A 1
MAP2K1 STAT5B 1
MAP2K2 AKT1 1
MAP2K2 MAPK1 10
MAP2K2 MAPK3 11
MAP2K2 STAT1 1
MAP2K2 STAT3 2
MAP2K2 STAT5A 1
MAP2K2 STAT5B 1
MAPK1 AKT1 2
MAPK1 BAD 3
MAPK1 FOXO3 1
MAPK1 IRS1 4
MAPK1 IRS2 2
MAPK1 MAPK3 4
MAPK1 SHC1 5
MAPK1 STAT1 2
MAPK1 STAT3 6
MAPK1 STAT5A 6
MAPK1 STAT5B 3
MAPK3 AKT1 1
MAPK3 BAD 2
MAPK3 FOXO3 1
MAPK3 GSK3B 1
MAPK3 IRS1 3
MAPK3 IRS2 2
MAPK3 SHC1 2
MAPK3 STAT1 3
MAPK3 STAT3 5
MAPK3 STAT5A 5
MAPK3 STAT5B 2
PIK3R1 AKT1 6
PIK3R1 SHC1 8
PIK3R1 STAT3 4
PTK2B AKT1 1
PTK2B GSK3B 1
PTK2B PIK3R1 1
PTK2B STAT1 1
PTK2B STAT3 4
PTK2B STAT5A 1
PTK2B STAT5B 2
SHC1 AKT1 3
SHC1 MAP2K1 1
SHC1 STAT5A 4
SHC1 STAT5B 3
STAT1 STAT3 8
STAT1 STAT5A 5
STAT1 STAT5B 3
STAT3 STAT5A 4
STAT3 STAT5B 6
STAT5A AKT1 1
STAT5A STAT5B 4
STAT5B AKT1 2
STAT5B IRS1 1
AKT1 CLTC 1
CBLB IL2RG 1
CBLB IL7R 1
CBLB IRS1 1
CBLB JAK1 1
CBLB JAK3 1
CBLB PTK2B 1
CLTC FYN 1
CLTC SHC1 1
CLTC STAM 1
FOXO1 GSK3B 3
FOXO3 FOXO1 1
FYN IL2RG 1
FYN IL7R 4
FYN JAK1 1
FYN JAK3 1
FYN MAPK1 1
FYN PTK2B 4
GSK3A GSK3B 1
GSK3B FYN 1
GSK3B MAPK1 2
IL2RG IRS1 1
IL2RG IRS2 1
IL2RG MAP2K1 1
IL2RG MAP2K2 1
IL2RG MAPK1 1
IL2RG MAPK3 1
IL2RG PTK2B 1
IL2RG STAM 1
IL7 JAK1 2
IL7 PIK3R1 1
IL7R STAT1 1
IL7 SHC1 1
IRS2 AKT1 1
IRS2 FYN 1
JAK1 FOXO1 1
JAK1 MAP2K1 2
JAK1 MAP2K2 2
JAK3 MAP2K1 1
JAK3 MAP2K2 1
JAK3 MAPK1 1
JAK3 MAPK3 1
MAP2K1 BAD 1
MAP2K2 BAD 1
PIK3R1 MAP2K1 1
PIK3R1 MAP2K2 1
PTK2B SHC1 1
SHC1 MAP2K2 1
SHC1 STAT3 1
STAT1 GSK3A 1
STAT1 SHC1 1
STAT5A GSK3A 1
STAT5A PIK3R1 1
STAT5A STAM 1
STAT5B GSK3A 1
STAT5B PIK3R1 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0001112 pathway0002466 4 0.8 ERK cascade ( Integrin signaling pathway ) INOH 5 11
pathway0001112 pathway0000704 4 0.8 ERK cascade ( GPCR Adenosine A2A receptor signaling pathway ) INOH 5 11
pathway0001112 pathway0000707 4 0.8 ERK cascade ( GPCR signaling (G alpha s, Epac and ERK) ) INOH 5 11
pathway0001112 pathway0000658 22 0.7857143 EGFR1 NetPath 475 10010
pathway0001112 pathway0001120 21 0.75 IL2 NetPath 81 1364
pathway0001112 pathway0001189 8 0.7272727 Interleukin-7 signaling Reactome 11 45
pathway0001112 pathway0002879 8 0.7272727 Hs_IL-9_Signaling_Pathway_WP22_79264 WikiPathways 11 49
pathway0001112 pathway0001246 20 0.7142857 KitReceptor NetPath 104 1591
pathway0001112 pathway0001264 20 0.7142857 Leptin NetPath 98 1355
pathway0001112 pathway0001105 5 0.7142857 IL-2 signaling pathway(JAK1 JAK3 STAT5) ( IL-2 signaling(JAK1 JAK3 STAT5) ) INOH 7 22
pathway0001112 pathway0001113 9 0.6923077 IL-7 signaling pathway(JAK1 JAK3 STAT5) ( IL-7 signaling(JAK1 JAK3 STAT5) ) INOH 13 65
pathway0001112 pathway0002872 11 0.6875 Hs_IL-7_Signaling_Pathway_WP205_89854 WikiPathways 16 85
pathway0001112 pathway0001135 16 0.6666667 IL9 NetPath 24 200
pathway0001112 pathway0001446 4 0.6666667 Negative feedback regulation of MAPK pathway Reactome 6 16
pathway0001112 pathway0000700 4 0.6666667 ERK cascade ( EGF signaling pathway Diagram ) INOH 6 15
pathway0001112 pathway0000708 4 0.6666667 ERK cascade ( HGF signaling pathway ) INOH 6 15
pathway0001112 pathway0000714 4 0.6666667 ERK cascade ( VEGF signaling pathway ) INOH 6 15
pathway0001112 pathway0001119 18 0.6428571 IL2-mediated signaling events PID 54 871
pathway0001112 pathway0001132 18 0.6428571 IL6 NetPath 85 1335
pathway0001112 pathway0001128 17 0.6071429 IL4 NetPath 75 1239
pathway0001112 pathway0001727 17 0.6071429 Prolactin NetPath 105 1733
pathway0001112 pathway0001126 16 0.5714286 IL3 NetPath 84 1284
pathway0001112 pathway0002199 16 0.5714286 TCR NetPath 261 4161
pathway0001112 pathway0002467 4 0.5714286 ERK cascade ( PDGF signaling pathway ) INOH 7 18
pathway0001112 pathway0002844 16 0.5714286 Hs_IL-2_Signaling_Pathway_WP49_91243 WikiPathways 33 332
pathway0001112 pathway0000270 16 0.5714286 BCR NetPath 161 2850
pathway0001112 pathway0000697 4 0.5714286 ERK cascade ( B cell receptor signaling ) INOH 7 22
pathway0001112 pathway0000699 4 0.5714286 ERK cascade ( CD4 T cell receptor signaling ) INOH 7 22
pathway0001112 pathway0000705 4 0.5714286 ERK cascade ( GPCR GroupI metabotropic glutamate receptor signaling pathway ) INOH 7 22
pathway0001112 pathway0000706 4 0.5714286 ERK cascade ( GPCR signaling (G alpha q) ) INOH 7 22
pathway0001112 pathway0000712 4 0.5714286 ERK cascade ( JAK-STAT pathway and regulation pathway Diagram ) INOH 7 22
pathway0001112 pathway0001130 15 0.5357143 IL5 NetPath 59 739
pathway0001112 pathway0001697 15 0.5357143 Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) INOH 178 3507
pathway0001112 pathway0002568 15 0.5357143 Chemokine signaling pathway KEGG 187 4644
pathway0001112 pathway0002656 15 0.5357143 Pathways in cancer KEGG 321 8293
pathway0001112 pathway0001186 7 0.5 Interleukin-2 signaling Reactome 14 71
pathway0001112 pathway0001191 14 0.5 Interleukin signaling pathway PANTHER 86 1548
pathway0001112 pathway0001604 14 0.5 PDGF signaling pathway PANTHER 113 1684
pathway0001112 pathway0002003 5 0.5 Signal attenuation Reactome 10 45
pathway0001112 pathway0002880 3 0.5 Hs_Insulin_signalling_in_adipocytes_(diabetic_condition)_WP3635_86059 WikiPathways 6 9
pathway0001112 pathway0002881 3 0.5 Hs_Insulin_signalling_in_adipocytes_(normal_condition)_WP3634_86060 WikiPathways 6 9
pathway0001112 pathway0000701 4 0.5 ERK cascade ( FGF signaling pathway ) INOH 8 26
pathway0001112 pathway0000709 4 0.5 ERK cascade ( IGF1 signaling pathway ) INOH 8 26
pathway0001112 pathway0000710 4 0.5 ERK cascade ( Insulin receptor signaling (D. melanogaster) ) INOH 8 26
pathway0001112 pathway0000711 4 0.5 ERK cascade ( Insulin receptor signaling (Mammal) ) INOH 8 26
pathway0001112 pathway0000713 4 0.5 ERK cascade ( NGF signaling pathway ) INOH 8 26
pathway0001112 pathway0000900 4 0.5 Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH 8 29
pathway0001112 pathway0000901 4 0.5 Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH 8 29