Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0001122 IL2 signaling events mediated by STAT5 PID Homo sapiens 30 232
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
GAB2 ENSG00000033327 9846 Cytoplasm 0.025 54.0 2.765746 0.092942
JAK1 ENSG00000162434 3716 Cytoplasm 0.02702703 78.0 5.454186 0.05561106
JAK3 ENSG00000105639 3718 Cytoplasm 0.02777778 73.0 7.368686 0.06544901
PRF1 ENSG00000180644 5551 Cytoplasm 0.01960784 8.0 0.0 0.75
PTPN11 ENSG00000179295 5781 Cytoplasm 0.02439024 64.0 3.172729 0.06150794
SOS1 ENSG00000115904 6654 Cytoplasm 0.02631579 86.0 6.107269 0.04240766
BCL2 ENSG00000171791 596 Cytoplasm/Nucleus 0.01785714 5.0 0.0952381 0.5
BCL2L1 ENSG00000171552 598 Cytoplasm/Nucleus 0.02173913 16.0 1.372693 0.475
CCNA2 ENSG00000145386 890 Cytoplasm/Nucleus 0.01818182 4.0 0.1262689 0.66666667
CCND2 ENSG00000118971 894 Cytoplasm/Nucleus 0.01960784 13.0 0.9177729 0.19230769
CCND3 ENSG00000112576 896 Cytoplasm/Nucleus 0.02439024 21.0 2.293323 0.57142857
CDK6 ENSG00000105810 1021 Cytoplasm/Nucleus 0.01886792 15.0 1.226644 0.0952381
ELF1 ENSG00000120690 1997 Cytoplasm/Nucleus 0.01754386 3.0 0.1002506 0.33333333
MYC ENSG00000136997 4609 Cytoplasm/Nucleus 0.02380952 24.0 6.68304 0.2826087
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 0.03225806 78.0 56.10246 0.06060606
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 0.03125 71.0 43.04511 0.07042254
FASLG ENSG00000117560 356 Membrane 0.0212766 14.0 0.01571649 0.58241758
IL2RA ENSG00000134460 3559 Membrane 0.02857143 58.0 18.30506 0.10163339
IL2RB ENSG00000100385 3560 Membrane 0.02777778 61.0 5.202541 0.09453552
IL2RG ENSG00000147168 3561 Membrane 0.02777778 60.0 5.115188 0.09774011
LCK ENSG00000182866 3932 Membrane 0.02702703 63.0 10.23584 0.08038914
PIK3CA ENSG00000121879 5290 Membrane 0.02564103 62.0 2.544147 0.07932311
PIK3R1 ENSG00000145675 5295 Membrane 0.02564103 70.0 2.35081 0.0621118
SHC1 ENSG00000160691 6464 Membrane 0.025 87.0 4.325191 0.0358193
GRB2 ENSG00000177885 2885 Unknown 0.02272727 112.0 1.49375 0.01753539
FOXP3 ENSG00000049768 50943 Nucleus 0.01886792 7.0 0.0 0.47619048
SP1 ENSG00000185591 6667 Nucleus 0.02040816 13.0 4.895635 0.21794872
IL2 ENSG00000109471 3558 Secreted 0.02857143 50.0 19.4832 0.1355102
IL4 ENSG00000113520 3565 Secreted 0.02272727 31.0 0.2015127 0.1827957
LTA ENSG00000226979 4049 Secreted 0.01960784 7.0 0.0 1.0
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
GAB2 ENSG00000033327 9846 Cytoplasm 4097.0 11500.0 1.56E-6 0.00119
JAK1 ENSG00000162434 3716 Cytoplasm 8612.0 95400.0 1.56E-6 2.71E-4
JAK3 ENSG00000105639 3718 Cytoplasm 4002.0 22800.0 1.56E-6 9.36E-4
PRF1 ENSG00000180644 5551 Cytoplasm 110.0 70.4 1.55E-6 0.0344
PTPN11 ENSG00000179295 5781 Cytoplasm 9733.0 167000.0 1.56E-6 2.5E-4
SOS1 ENSG00000115904 6654 Cytoplasm 23511.0 177000.0 1.56E-6 6.54E-5
BCL2 ENSG00000171791 596 Cytoplasm/Nucleus 1236.0 33900.0 1.56E-6 0.00248
BCL2L1 ENSG00000171552 598 Cytoplasm/Nucleus 1045.0 12300.0 1.56E-6 0.0021
CCNA2 ENSG00000145386 890 Cytoplasm/Nucleus 1114.0 8330.0 1.56E-6 0.00996
CCND2 ENSG00000118971 894 Cytoplasm/Nucleus 298.0 228.0 1.55E-6 0.0213
CCND3 ENSG00000112576 896 Cytoplasm/Nucleus 440.0 6110.0 1.56E-6 0.0107
CDK6 ENSG00000105810 1021 Cytoplasm/Nucleus 1202.0 2340.0 1.55E-6 0.00147
ELF1 ENSG00000120690 1997 Cytoplasm/Nucleus 54.0 113.0 1.55E-6 0.11
MYC ENSG00000136997 4609 Cytoplasm/Nucleus 4967.0 1640000.0 1.57E-6 0.00195
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 7688.0 196000.0 1.56E-6 4.69E-4
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 6515.0 71100.0 1.56E-6 5.43E-4
FASLG ENSG00000117560 356 Membrane 1409.0 17000.0 1.55E-6 0.00233
IL2RA ENSG00000134460 3559 Membrane 1707.0 15900.0 1.56E-6 0.00465
IL2RB ENSG00000100385 3560 Membrane 1744.0 10500.0 1.55E-6 0.00446
IL2RG ENSG00000147168 3561 Membrane 2184.0 16800.0 1.55E-6 0.00277
LCK ENSG00000182866 3932 Membrane 6696.0 202000.0 1.56E-6 8.63E-4
PIK3CA ENSG00000121879 5290 Membrane 27859.0 414000.0 1.56E-6 5.51E-5
PIK3R1 ENSG00000145675 5295 Membrane 31452.0 734000.0 1.56E-6 4.03E-5
SHC1 ENSG00000160691 6464 Membrane 13549.0 312000.0 1.56E-6 2.6E-4
GRB2 ENSG00000177885 2885 Unknown 29079.0 822000.0 1.57E-6 5.64E-5
FOXP3 ENSG00000049768 50943 Nucleus 17.0 2.49 1.54E-6 0.162
SP1 ENSG00000185591 6667 Nucleus 1577.0 413000.0 1.56E-6 0.00757
IL2 ENSG00000109471 3558 Secreted 1409.0 19100.0 1.56E-6 0.00322
IL4 ENSG00000113520 3565 Secreted 1181.0 24100.0 1.55E-6 0.00471
LTA ENSG00000226979 4049 Secreted 470.0 9460.0 1.55E-6 0.0265
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
GAB2 ENSG00000033327 9846 Cytoplasm 864.0 1200.0 1.71292E-4 0.007507725
JAK1 ENSG00000162434 3716 Cytoplasm 1074.0 6030.0 1.70999E-4 0.004963546
JAK3 ENSG00000105639 3718 Cytoplasm 606.0 1220.0 1.62022E-4 0.008629954
PRF1 ENSG00000180644 5551 Cytoplasm 60.0 31.8 1.42592E-4 0.106214689
PTPN11 ENSG00000179295 5781 Cytoplasm 2393.0 7510.0 1.70271E-4 0.001673988
SOS1 ENSG00000115904 6654 Cytoplasm 4430.0 16400.0 1.75009E-4 5.66042E-4
BCL2 ENSG00000171791 596 Cytoplasm/Nucleus 336.0 9530.0 1.71409E-4 0.015458422
BCL2L1 ENSG00000171552 598 Cytoplasm/Nucleus 303.0 2710.0 1.62575E-4 0.014906126
CCNA2 ENSG00000145386 890 Cytoplasm/Nucleus 266.0 1940.0 1.62787E-4 0.023918286
CCND2 ENSG00000118971 894 Cytoplasm/Nucleus 92.0 117.0 1.58328E-4 0.105590062
CCND3 ENSG00000112576 896 Cytoplasm/Nucleus 115.0 565.0 1.5949E-4 0.064988558
CDK6 ENSG00000105810 1021 Cytoplasm/Nucleus 179.0 170.0 1.55545E-4 0.020839872
ELF1 ENSG00000120690 1997 Cytoplasm/Nucleus 32.0 353.0 1.50376E-4 0.179435484
MYC ENSG00000136997 4609 Cytoplasm/Nucleus 1512.0 212000.0 1.92234E-4 0.005286628
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 1634.0 35300.0 1.79308E-4 0.003234992
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 1105.0 9710.0 1.73762E-4 0.005193783
FASLG ENSG00000117560 356 Membrane 237.0 1210.0 1.5977E-4 0.024279482
IL2RA ENSG00000134460 3559 Membrane 505.0 7750.0 1.6714E-4 0.015810152
IL2RB ENSG00000100385 3560 Membrane 450.0 5870.0 1.60746E-4 0.016916605
IL2RG ENSG00000147168 3561 Membrane 512.0 7080.0 1.62206E-4 0.015418603
LCK ENSG00000182866 3932 Membrane 1678.0 21400.0 1.77179E-4 0.004230979
PIK3CA ENSG00000121879 5290 Membrane 7107.0 70400.0 1.83419E-4 2.95273E-4
PIK3R1 ENSG00000145675 5295 Membrane 7548.0 88700.0 1.85288E-4 2.41448E-4
SHC1 ENSG00000160691 6464 Membrane 3723.0 28900.0 1.80538E-4 9.94587E-4
GRB2 ENSG00000177885 2885 Unknown 5986.0 66400.0 1.83857E-4 4.14669E-4
FOXP3 ENSG00000049768 50943 Nucleus 15.0 76.4 1.3177E-4 0.171428571
SP1 ENSG00000185591 6667 Nucleus 631.0 40600.0 1.79372E-4 0.014122205
IL2 ENSG00000109471 3558 Secreted 628.0 7300.0 1.66472E-4 0.009152876
IL4 ENSG00000113520 3565 Secreted 262.0 6470.0 1.58203E-4 0.021994092
LTA ENSG00000226979 4049 Secreted 18.0 1.17 1.29299E-4 0.405228758
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
CCND2 CDK6 6
CCND3 CDK6 10
FASLG PIK3CA 2
FASLG PIK3R1 4
FOXP3 IL2 2
GAB2 GRB2 7
GAB2 LCK 3
GAB2 PIK3CA 5
GAB2 PIK3R1 7
GAB2 PTPN11 7
GAB2 SHC1 7
GAB2 SOS1 3
GRB2 IL2RB 5
GRB2 JAK1 5
GRB2 PIK3CA 4
GRB2 PIK3R1 9
GRB2 PTPN11 9
GRB2 SHC1 13
GRB2 SOS1 12
IL2 IL2RA 10
IL2 IL2RB 10
IL2 IL2RG 7
IL2 JAK1 2
IL2 JAK3 3
IL2 PIK3CA 3
IL2 PIK3R1 2
IL2 PRF1 2
IL2RA IL2RB 9
IL2RA IL2RG 6
IL2RA JAK1 4
IL2RA JAK3 5
IL2RA PIK3CA 3
IL2RA PIK3R1 2
IL2RA SHC1 3
IL2RA SOS1 3
IL2RA STAT5A 4
IL2RA STAT5B 6
IL2RB IL2RG 8
IL2RB JAK1 9
IL2RB JAK3 7
IL2RB LCK 4
IL2RB PIK3CA 3
IL2RB PIK3R1 4
IL2RB SHC1 6
IL2RB SOS1 3
IL2RB STAT5A 7
IL2RB STAT5B 7
IL2RG IL4 8
IL2RG JAK1 8
IL2RG JAK3 9
IL2RG PIK3CA 3
IL2RG PIK3R1 4
IL2RG SHC1 4
IL2RG SOS1 2
IL2RG STAT5A 4
IL2RG STAT5B 3
IL2 SHC1 4
IL2 SOS1 3
IL2 STAT5A 2
IL2 STAT5B 2
IL4 JAK1 3
IL4 JAK3 3
IL4 PIK3R1 1
IL4 SHC1 2
IL4 STAT5A 2
JAK1 JAK3 5
JAK1 LCK 2
JAK1 PIK3CA 4
JAK1 PIK3R1 6
JAK1 PTPN11 7
JAK1 SHC1 4
JAK1 SOS1 2
JAK1 STAT5A 8
JAK1 STAT5B 7
JAK3 LCK 2
JAK3 PIK3CA 4
JAK3 PIK3R1 7
JAK3 PTPN11 2
JAK3 SHC1 3
JAK3 SOS1 2
JAK3 STAT5A 9
JAK3 STAT5B 6
LCK FOXP3 1
LCK PIK3CA 4
LCK PIK3R1 7
LCK PTPN11 3
LCK SHC1 4
LCK SOS1 3
LCK STAT5A 5
LCK STAT5B 3
PIK3CA PIK3R1 14
PIK3CA PTPN11 3
PIK3CA SHC1 3
PIK3CA SOS1 3
PIK3R1 PTPN11 7
PIK3R1 SHC1 8
PIK3R1 SOS1 8
PTPN11 SHC1 4
PTPN11 SOS1 5
PTPN11 STAT5A 4
PTPN11 STAT5B 3
SHC1 SOS1 10
SHC1 STAT5A 4
SHC1 STAT5B 3
SOS1 CCND3 2
STAT5A BCL2L1 3
STAT5A CCND2 3
STAT5A CCND3 2
STAT5A MYC 2
STAT5A STAT5B 4
STAT5B BCL2L1 2
STAT5B CCND2 3
STAT5B CCND3 2
STAT5B MYC 2
BCL2 BCL2L1 4
BCL2 MYC 3
CCNA2 CDK6 1
CCNA2 SP1 1
CDK6 MYC 3
ELF1 IL2 1
ELF1 IL2RA 1
ELF1 SP1 3
FASLG GRB2 3
FASLG IL2RA 1
FASLG IL2RB 1
FASLG IL2RG 1
FASLG JAK1 1
FASLG JAK3 1
FASLG LCK 2
FOXP3 IL2RA 1
GAB2 CCND3 1
GAB2 IL2 2
GAB2 IL2RA 2
GAB2 IL2RB 2
GAB2 IL2RG 2
GAB2 JAK1 2
GAB2 JAK3 2
GAB2 MYC 1
GAB2 SP1 1
GAB2 STAT5A 1
GAB2 STAT5B 1
GRB2 CCND3 1
GRB2 IL2 2
GRB2 IL2RA 3
GRB2 IL2RG 3
GRB2 IL4 1
GRB2 JAK3 2
GRB2 LCK 2
IL2 BCL2L1 1
IL2 CCND2 1
IL2 CCND3 2
IL2 MYC 1
IL2 PTPN11 1
IL2RA CCND3 1
IL2RA IL4 2
IL2RA LTA 1
IL2RA MYC 1
IL2RA PRF1 1
IL2RA PTPN11 1
IL2RB BCL2L1 1
IL2RB CCND3 1
IL2RB IL4 2
IL2RB LTA 1
IL2RB MYC 1
IL2RB PRF1 1
IL2RB PTPN11 1
IL2RG BCL2L1 1
IL2RG CCND3 1
IL2RG LTA 1
IL2RG MYC 1
IL2RG PRF1 1
IL2RG PTPN11 1
IL4 IL2 1
IL4 MYC 1
IL4 PIK3CA 2
IL4 SOS1 1
JAK1 BCL2L1 1
JAK1 CCND3 1
JAK1 LTA 1
JAK1 MYC 1
JAK3 BCL2L1 1
JAK3 CCND3 1
JAK3 LTA 1
JAK3 MYC 1
JAK3 SP1 2
LCK BCL2L1 1
LCK CCND3 1
LCK IL2 1
LCK IL2RA 1
LCK IL2RG 1
LCK MYC 1
LCK SP1 2
MYC CCND2 1
MYC SP1 4
PIK3CA BCL2L1 1
PIK3CA CCND3 1
PIK3CA STAT5A 1
PIK3CA STAT5B 1
PIK3R1 BCL2L1 1
PIK3R1 CCND3 1
PTPN11 CCND3 1
PTPN11 PRF1 1
SHC1 CCND3 1
SHC1 SP1 1
SOS1 BCL2L1 1
SOS1 CCND2 1
SOS1 MYC 1
SOS1 STAT5A 1
SOS1 STAT5B 1
SP1 CCND2 1
SP1 STAT5A 1
STAT5A BCL2 1
STAT5A CCNA2 1
STAT5A CDK6 1
STAT5A FASLG 1
STAT5A FOXP3 2
STAT5A LTA 1
STAT5A PIK3R1 1
STAT5A PRF1 1
STAT5B BCL2 1
STAT5B CCNA2 1
STAT5B CDK6 1
STAT5B FASLG 1
STAT5B FOXP3 1
STAT5B IL4 1
STAT5B LTA 2
STAT5B PIK3R1 1
STAT5B PRF1 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0001122 pathway0001105 7 1.0 IL-2 signaling pathway(JAK1 JAK3 STAT5) ( IL-2 signaling(JAK1 JAK3 STAT5) ) INOH 7 22
pathway0001122 pathway0001186 10 0.7142857 Interleukin-2 signaling Reactome 14 71
pathway0001122 pathway0002606 18 0.6 Jak-STAT signaling pathway KEGG 149 3911
pathway0001122 pathway0001119 18 0.6 IL2-mediated signaling events PID 54 871
pathway0001122 pathway0001108 4 0.5714286 IL-4 signaling pathway(JAK1 JAK3 STAT6) ( IL-4 signaling(JAK1 JAK3 STAT6) ) INOH 7 23
pathway0001122 pathway0001120 17 0.5666667 IL2 NetPath 81 1364
pathway0001122 pathway0001121 17 0.5666667 IL2 signaling events mediated by PI3K PID 38 397
pathway0001122 pathway0001189 6 0.5454545 Interleukin-7 signaling Reactome 11 45
pathway0001122 pathway0001113 7 0.5384615 IL-7 signaling pathway(JAK1 JAK3 STAT5) ( IL-7 signaling(JAK1 JAK3 STAT5) ) INOH 13 65
pathway0001122 pathway0001128 15 0.5 IL4 NetPath 75 1239
pathway0001122 pathway0002872 8 0.5 Hs_IL-7_Signaling_Pathway_WP205_89854 WikiPathways 16 85