Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0001212 IRF3-mediated induction of type I IFN Reactome Homo sapiens 13 46
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
DTX4 ENSG00000110042 23220 Cytoplasm 0.05263158 13.0 0.0 0.12820513
TBK1 ENSG00000183735 29110 Cytoplasm 0.08333333 40.0 11.1004 0.04230769
ZBP1 ENSG00000124256 81030 Cytoplasm 0.05263158 17.0 0.0 0.07352941
XRCC5 ENSG00000079246 7520 Cytoplasm/Nucleus 0.05882353 18.0 0.4147727 0.12418301
XRCC6 ENSG00000196419 2547 Cytoplasm/Nucleus 0.05882353 16.0 0.4147727 0.15833333
MRE11A ENSG00000020922 4361 Unknown 0.05555556 13.0 0.0 0.19230769
NLRP4 ENSG00000160505 147945 Unknown 0.05263158 13.0 0.0 0.12820513
PRKDC ENSG00000253729 5591 Unknown 0.05882353 19.0 0.8330787 0.10526316
TMEM173 ENSG00000184584 340061 Unknown 0.08333333 25.0 4.167791 0.11
DDX41 ENSG00000183258 51428 Nucleus 0.04761905 5.0 0.0 0.3
IFI16 ENSG00000163565 3428 Nucleus 0.05263158 8.0 0.0 0.35714286
IRF3 ENSG00000126456 3661 Nucleus 0.08333333 47.0 16.06918 0.03052729
TREX1 ENSG00000213689 11277 Nucleus 0.05 6.0 0.0 0.4
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
DTX4 ENSG00000110042 23220 Cytoplasm 77.0 1100.293 1.54E-6 0.029733424
TBK1 ENSG00000183735 29110 Cytoplasm 640.0 30783.72 1.55E-6 0.004088419
ZBP1 ENSG00000124256 81030 Cytoplasm 93.0 69.51932 1.54E-6 0.008648901
XRCC5 ENSG00000079246 7520 Cytoplasm/Nucleus 265.0 9919.225 1.56E-6 0.064008005
XRCC6 ENSG00000196419 2547 Cytoplasm/Nucleus 284.0 10959.0 1.56E-6 0.059697407
MRE11A ENSG00000020922 4361 Unknown 1629.0 23175.68 1.56E-6 0.005285798
NLRP4 ENSG00000160505 147945 Unknown 48.0 64.14779 1.54E-6 0.012411348
PRKDC ENSG00000253729 5591 Unknown 408.0 29778.28 1.56E-6 0.021113359
TMEM173 ENSG00000184584 340061 Unknown 110.0 20734.07 1.54E-6 0.010175146
DDX41 ENSG00000183258 51428 Nucleus 15.0 3.584141 1.53E-6 0.038095238
IFI16 ENSG00000163565 3428 Nucleus 24.0 215.4621 1.55E-6 0.126811594
IRF3 ENSG00000126456 3661 Nucleus 760.0 29345.83 1.55E-6 0.001608765
TREX1 ENSG00000213689 11277 Nucleus 11.0 0.0 1.53E-6 0.109090909
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
DTX4 ENSG00000110042 23220 Cytoplasm 64.0 6185.543 3.99E-7 0.028769841
TBK1 ENSG00000183735 29110 Cytoplasm 236.0 11945.84 3.99E-7 0.006671475
ZBP1 ENSG00000124256 81030 Cytoplasm 64.0 190.7175 3.98E-7 0.009920635
XRCC5 ENSG00000079246 7520 Cytoplasm/Nucleus 102.0 1453.05 3.99E-7 0.155503786
XRCC6 ENSG00000196419 2547 Cytoplasm/Nucleus 97.0 967.2063 3.98E-7 0.160008591
MRE11A ENSG00000020922 4361 Unknown 1372.0 19847.39 3.99E-7 0.006179652
NLRP4 ENSG00000160505 147945 Unknown 39.0 0.0 3.98E-7 0.013495277
PRKDC ENSG00000253729 5591 Unknown 100.0 1350.446 3.98E-7 0.087272727
TMEM173 ENSG00000184584 340061 Unknown 69.0 17958.06 3.99E-7 0.015345269
DDX41 ENSG00000183258 51428 Nucleus 15.0 7.662029 3.98E-7 0.038095238
IFI16 ENSG00000163565 3428 Nucleus 10.0 0.0 3.98E-7 0.222222222
IRF3 ENSG00000126456 3661 Nucleus 388.0 57781.68 3.99E-7 0.003796052
TREX1 ENSG00000213689 11277 Nucleus 6.0 0.0 3.98E-7 0.4
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
DDX41 IRF3 1
DDX41 TBK1 1
DTX4 IRF3 1
DTX4 NLRP4 2
DTX4 TBK1 2
DTX4 TMEM173 1
DTX4 ZBP1 1
IFI16 IRF3 1
IFI16 TBK1 1
IFI16 TMEM173 2
IRF3 TBK1 5
IRF3 TMEM173 2
IRF3 ZBP1 3
MRE11A IRF3 1
MRE11A PRKDC 3
MRE11A TBK1 1
MRE11A XRCC5 3
MRE11A XRCC6 4
NLRP4 IRF3 1
NLRP4 TBK1 2
NLRP4 TMEM173 1
NLRP4 ZBP1 1
PRKDC IRF3 2
PRKDC TBK1 1
PRKDC XRCC5 10
PRKDC XRCC6 8
TBK1 TMEM173 6
TREX1 IRF3 1
TREX1 TBK1 1
XRCC5 IRF3 1
XRCC5 TBK1 1
XRCC5 XRCC6 8
XRCC6 IRF3 1
XRCC6 TBK1 1
ZBP1 TBK1 2
DDX41 TMEM173 1
IFI16 XRCC5 1
IFI16 XRCC6 1
MRE11A TMEM173 1
PRKDC TMEM173 1
PRKDC TREX1 1
TMEM173 XRCC5 2
TREX1 TMEM173 1
XRCC6 TMEM173 1
ZBP1 TMEM173 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0001212 pathway0001213 6 1.0 IRF3 mediated activation of type 1 IFN Reactome 6 16
pathway0001212 pathway0002108 3 0.6 STING mediated induction of host immune responses Reactome 5 4
pathway0001212 pathway0001843 7 0.5384615 Regulation of innate immune responses to cytosolic DNA Reactome 14 43