Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0001543 Oncogene Induced Senescence Reactome Homo sapiens 30 146
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
CDK4 ENSG00000135446 1019 Cytoplasm 0.02272727 41.0 21.48401 0.0695122
CDKN2B ENSG00000147883 1030 Cytoplasm 0.015625 16.0 0.2857143 0.04166667
RPS27A ENSG00000143947 6233 Cytoplasm 0.01923077 10.0 0.9834373 0.44444444
UBA52 ENSG00000221983 7311 Cytoplasm 0.01851852 8.0 0.7827778 0.57142857
UBC ENSG00000150991 7316 Cytoplasm 0.02083333 12.0 5.943491 0.42424242
CDK6 ENSG00000105810 1021 Cytoplasm/Nucleus 0.02040816 34.0 9.750566 0.04991087
CDKN2A ENSG00000147889 1029 Cytoplasm/Nucleus 0.02631579 72.0 100.7808 0.02973396
CDKN2C ENSG00000123080 1031 Cytoplasm/Nucleus 0.02 16.0 0.1154401 0.28333333
CDKN2D ENSG00000129355 1032 Cytoplasm/Nucleus 0.01724138 11.0 0.1154401 0.14545455
E2F1 ENSG00000101412 1869 Cytoplasm/Nucleus 0.02222222 28.0 17.04581 0.13227513
ERF ENSG00000105722 2077 Cytoplasm/Nucleus 0.01612903 10.0 1.830023 0.08888889
ETS1 ENSG00000134954 2113 Cytoplasm/Nucleus 0.02 19.0 2.191368 0.12865497
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 0.01851852 26.0 4.796262 0.04615385
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 0.01851852 20.0 3.613391 0.07894737
MDM2 ENSG00000135679 4193 Cytoplasm/Nucleus 0.0212766 52.0 12.82991 0.02488688
TNRC6A ENSG00000090905 27327 Cytoplasm/Nucleus 0.01886792 11.0 1.962844 0.23636364
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 0.02702703 56.0 62.14776 0.0525974
AGO1 ENSG00000092847 26523 Unknown 0.02 15.0 3.29034 0.23809524
AGO3 ENSG00000126070 192669 Unknown 0.01785714 12.0 1.289886 0.31818182
AGO4 ENSG00000134698 192670 Unknown 0.01724138 10.0 0.6928105 0.26666667
MOV10 ENSG00000155363 4343 Unknown 0.02272727 18.0 14.98537 0.30065359
TNRC6B ENSG00000100354 23112 Unknown 0.01724138 10.0 0.5883041 0.26666667
TNRC6C ENSG00000078687 57690 Unknown 0.01818182 10.0 0.8962065 0.26666667
E2F2 ENSG00000007968 1870 Nucleus 0.02040816 15.0 0.4740266 0.36190476
E2F3 ENSG00000112242 1871 Nucleus 0.02222222 19.0 9.568607 0.2748538
ETS2 ENSG00000157557 2114 Nucleus 0.01960784 19.0 31.82138 0.07602339
ID1 ENSG00000125968 3397 Nucleus 0.01265823 2.0 0.0 0.0
SP1 ENSG00000185591 6667 Nucleus 0.02325581 30.0 23.13394 0.11954023
TFDP1 ENSG00000198176 7027 Nucleus 0.02083333 21.0 6.573444 0.17619048
UBB ENSG00000170315 7314 Nucleus 0.01818182 7.0 0.02666667 0.66666667
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
CDK4 ENSG00000135446 1019 Cytoplasm 2094.0 33700.0 1.56E-6 0.00259
CDKN2B ENSG00000147883 1030 Cytoplasm 315.0 143.0 1.55E-6 0.00736
RPS27A ENSG00000143947 6233 Cytoplasm 8445.0 940000.0 1.56E-6 9.49E-4
UBA52 ENSG00000221983 7311 Cytoplasm 7270.0 455000.0 1.56E-6 0.0011
UBC ENSG00000150991 7316 Cytoplasm 7688.0 614000.0 1.56E-6 8.32E-4
CDK6 ENSG00000105810 1021 Cytoplasm/Nucleus 1202.0 2340.0 1.55E-6 0.00147
CDKN2A ENSG00000147889 1029 Cytoplasm/Nucleus 1709.0 38000.0 1.56E-6 0.00396
CDKN2C ENSG00000123080 1031 Cytoplasm/Nucleus 144.0 38.1 1.55E-6 0.0275
CDKN2D ENSG00000129355 1032 Cytoplasm/Nucleus 112.0 34.4 1.55E-6 0.0306
E2F1 ENSG00000101412 1869 Cytoplasm/Nucleus 2673.0 379000.0 1.56E-6 0.00371
ERF ENSG00000105722 2077 Cytoplasm/Nucleus 28.0 0.923 1.55E-6 0.135
ETS1 ENSG00000134954 2113 Cytoplasm/Nucleus 716.0 15200.0 1.56E-6 0.00784
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 33563.0 1130000.0 1.56E-6 2.83E-5
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 29207.0 850000.0 1.56E-6 3.17E-5
MDM2 ENSG00000135679 4193 Cytoplasm/Nucleus 2666.0 363000.0 1.56E-6 0.00187
TNRC6A ENSG00000090905 27327 Cytoplasm/Nucleus 104.0 420.0 1.55E-6 0.022
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 8418.0 2450000.0 1.57E-6 7.36E-4
AGO1 ENSG00000092847 26523 Unknown 269.0 5340.0 1.55E-6 0.0768
AGO3 ENSG00000126070 192669 Unknown 114.0 1350.0 1.55E-6 0.0172
AGO4 ENSG00000134698 192670 Unknown 101.0 587.0 1.55E-6 0.0176
MOV10 ENSG00000155363 4343 Unknown 156.0 6520.0 1.56E-6 0.0757
TNRC6B ENSG00000100354 23112 Unknown 88.0 71.6 1.55E-6 0.0201
TNRC6C ENSG00000078687 57690 Unknown 94.0 180.0 1.55E-6 0.0174
E2F2 ENSG00000007968 1870 Nucleus 895.0 5110.0 1.56E-6 0.00857
E2F3 ENSG00000112242 1871 Nucleus 1112.0 29600.0 1.56E-6 0.00863
ETS2 ENSG00000157557 2114 Nucleus 212.0 11300.0 1.56E-6 0.0274
ID1 ENSG00000125968 3397 Nucleus 71.0 400.0 1.55E-6 0.0579
SP1 ENSG00000185591 6667 Nucleus 1577.0 413000.0 1.56E-6 0.00757
TFDP1 ENSG00000198176 7027 Nucleus 790.0 30900.0 1.56E-6 0.0121
UBB ENSG00000170315 7314 Nucleus 6474.0 494000.0 1.56E-6 0.00112
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
CDK4 ENSG00000135446 1019 Cytoplasm 650.0 11900.0 3.99E-7 0.015664336
CDKN2B ENSG00000147883 1030 Cytoplasm 87.0 274.0 3.99E-7 0.021651965
RPS27A ENSG00000143947 6233 Cytoplasm 8445.0 2060000.0 4.0E-7 8.7747E-4
UBA52 ENSG00000221983 7311 Cytoplasm 7270.0 873000.0 4.0E-7 0.001030852
UBC ENSG00000150991 7316 Cytoplasm 7682.0 1600000.0 4.0E-7 7.21493E-4
CDK6 ENSG00000105810 1021 Cytoplasm/Nucleus 207.0 318.0 3.99E-7 0.011725529
CDKN2A ENSG00000147889 1029 Cytoplasm/Nucleus 449.0 5740.0 3.99E-7 0.038518136
CDKN2C ENSG00000123080 1031 Cytoplasm/Nucleus 78.0 64.1 3.99E-7 0.055611056
CDKN2D ENSG00000129355 1032 Cytoplasm/Nucleus 55.0 37.3 3.99E-7 0.042424242
E2F1 ENSG00000101412 1869 Cytoplasm/Nucleus 516.0 127000.0 3.99E-7 0.025634078
ERF ENSG00000105722 2077 Cytoplasm/Nucleus 10.0 20.1 3.98E-7 0.088888889
ETS1 ENSG00000134954 2113 Cytoplasm/Nucleus 19.0 18.5 3.99E-7 0.128654971
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 2105.0 344000.0 4.0E-7 0.001645548
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 1781.0 307000.0 4.0E-7 0.002046572
MDM2 ENSG00000135679 4193 Cytoplasm/Nucleus 533.0 92000.0 3.99E-7 0.01068572
TNRC6A ENSG00000090905 27327 Cytoplasm/Nucleus 104.0 1100.0 3.99E-7 0.017923824
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 1932.0 2260000.0 4.0E-7 0.004693499
AGO1 ENSG00000092847 26523 Unknown 269.0 10300.0 3.99E-7 0.076180436
AGO3 ENSG00000126070 192669 Unknown 114.0 1980.0 3.99E-7 0.016767583
AGO4 ENSG00000134698 192670 Unknown 101.0 2350.0 3.99E-7 0.017029703
MOV10 ENSG00000155363 4343 Unknown 156.0 38000.0 3.99E-7 0.069644334
TNRC6B ENSG00000100354 23112 Unknown 88.0 431.0 3.99E-7 0.018547544
TNRC6C ENSG00000078687 57690 Unknown 90.0 594.0 3.99E-7 0.016978777
E2F2 ENSG00000007968 1870 Nucleus 127.0 138.0 3.99E-7 0.112735908
E2F3 ENSG00000112242 1871 Nucleus 171.0 1450.0 3.99E-7 0.083384933
ETS2 ENSG00000157557 2114 Nucleus 19.0 8210.0 3.99E-7 0.076023392
ID1 ENSG00000125968 3397 Nucleus 2.0 0.0 3.97E-7 0.0
SP1 ENSG00000185591 6667 Nucleus 210.0 123000.0 3.99E-7 0.125541126
TFDP1 ENSG00000198176 7027 Nucleus 306.0 67600.0 3.99E-7 0.039001393
UBB ENSG00000170315 7314 Nucleus 6348.0 955000.0 4.0E-7 0.001001917
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
AGO1 CDKN2A 1
AGO1 MOV10 2
AGO1 TNRC6A 4
AGO1 TNRC6B 4
AGO1 TNRC6C 3
AGO3 CDKN2A 1
AGO3 TNRC6A 3
AGO3 TNRC6B 3
AGO3 TNRC6C 3
AGO4 CDKN2A 1
AGO4 TNRC6A 3
AGO4 TNRC6B 3
AGO4 TNRC6C 3
CDK4 CDK6 5
CDK4 CDKN2A 9
CDK4 CDKN2B 4
CDK4 CDKN2C 5
CDK4 CDKN2D 4
CDK4 E2F1 4
CDK6 CDKN2A 8
CDK6 CDKN2B 3
CDK6 CDKN2C 5
CDK6 CDKN2D 6
CDK6 TFDP1 4
CDKN2A E2F1 6
CDKN2A E2F2 2
CDKN2A E2F3 2
CDKN2A MDM2 9
CDKN2A MOV10 2
CDKN2A SP1 3
CDKN2A TFDP1 2
CDKN2A TP53 4
E2F1 E2F2 4
E2F1 E2F3 2
E2F1 SP1 5
E2F1 TFDP1 8
E2F2 SP1 3
E2F2 TFDP1 6
E2F3 SP1 4
E2F3 TFDP1 5
ETS1 ETS2 3
ETS2 ID1 2
MAPK1 ERF 3
MAPK1 ETS1 7
MAPK1 ETS2 3
MAPK1 MAPK3 4
MAPK1 SP1 3
MAPK1 TP53 4
MAPK3 ERF 2
MAPK3 ETS1 5
MAPK3 ETS2 3
MAPK3 SP1 3
MAPK3 TP53 3
MDM2 RPS27A 3
MDM2 TP53 12
MDM2 UBB 3
MDM2 UBC 4
RPS27A UBA52 3
SP1 CDKN2B 3
SP1 TP53 8
TFDP1 TP53 3
AGO1 AGO3 1
AGO1 MDM2 2
AGO1 TP53 1
AGO1 UBC 2
AGO3 AGO4 2
AGO3 MOV10 1
AGO3 UBC 1
AGO4 MOV10 1
CDK4 E2F2 2
CDK4 E2F3 2
CDK4 ETS1 2
CDK4 MDM2 2
CDK4 SP1 2
CDK4 TFDP1 2
CDK4 TP53 1
CDK6 E2F1 2
CDK6 E2F2 2
CDK6 E2F3 2
CDK6 MDM2 2
CDKN2A CDKN2C 1
CDKN2A ETS1 1
CDKN2A ETS2 1
CDKN2A RPS27A 1
CDKN2B E2F1 1
CDKN2C E2F1 2
CDKN2C E2F2 1
CDKN2C E2F3 1
CDKN2C TP53 2
CDKN2D MDM2 1
CDKN2D SP1 1
CDKN2D TP53 1
E2F1 ERF 1
E2F1 MDM2 3
E2F1 MOV10 2
E2F1 TP53 2
E2F1 UBC 1
E2F2 E2F3 1
E2F2 MOV10 1
E2F2 TP53 1
E2F3 MOV10 1
E2F3 TP53 1
E2F3 UBA52 1
ETS1 E2F3 1
ETS1 SP1 3
ETS1 TP53 2
ETS2 E2F3 1
ETS2 ERF 1
ETS2 TP53 3
MAPK1 CDK4 1
MAPK3 CDK4 1
MDM2 SP1 2
MDM2 UBA52 1
MOV10 RPS27A 1
MOV10 TNRC6A 1
MOV10 TNRC6B 1
MOV10 TNRC6C 1
MOV10 TP53 2
MOV10 UBA52 1
MOV10 UBB 1
MOV10 UBC 1
RPS27A SP1 2
RPS27A TP53 3
RPS27A UBB 1
RPS27A UBC 1
SP1 CDKN2C 1
SP1 TFDP1 1
SP1 TNRC6A 1
TFDP1 AGO1 1
TFDP1 CDKN2C 1
TFDP1 ERF 1
TNRC6A CDKN2A 1
TNRC6A UBC 1
TNRC6B CDKN2A 1
TNRC6B UBC 1
TNRC6C CDKN2A 1
TNRC6C TP53 2
TP53 UBA52 1
TP53 UBB 3
TP53 UBC 4
UBA52 UBB 1
UBA52 UBC 1
UBB UBC 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0001543 pathway0001699 6 0.8571429 Post-transcriptional silencing by small RNAs Reactome 7 17
pathway0001543 pathway0001559 25 0.8333333 Oxidative Stress Induced Senescence Reactome 120 3580
pathway0001543 pathway0002280 4 0.8 TRAF6 Mediated Induction of proinflammatory cytokines Reactome 5 10
pathway0001543 pathway0000222 4 0.8 Assembly Of The HIV Virion Reactome 5 10
pathway0001543 pathway0002101 6 0.6666667 Stabilization of p53 Reactome 9 35
pathway0001543 pathway0000630 4 0.5 Downregulation of ERBB4 signaling Reactome 8 26