Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0001572 p38 MAPK pathway PANTHER Homo sapiens 31 137
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
EEF2K ENSG00000103319 29904 Cytoplasm 0.01818182 14.0 0.1560295 0.10989011
MAP3K10 ENSG00000130758 4294 Cytoplasm 0.01724138 6.0 0.0 0.2
MAP3K5 ENSG00000197442 4217 Cytoplasm 0.01818182 17.0 0.0 0.07352941
MAPK13 ENSG00000156711 5603 Cytoplasm 0.02325581 48.0 20.25703 0.03723404
TRAF6 ENSG00000175104 7189 Cytoplasm 0.0212766 43.0 17.16259 0.05204873
DUSP10 ENSG00000143507 11221 Cytoplasm/Nucleus 0.01785714 17.0 0.4196815 0.02941176
EIF4E ENSG00000151247 1977 Cytoplasm/Nucleus 0.01724138 13.0 0.3773585 0.06410256
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 0.02 34.0 2.427033 0.0516934
HSPB1 ENSG00000106211 3315 Cytoplasm/Nucleus 0.01785714 16.0 0.3060749 0.05833333
MAP2K6 ENSG00000108984 5608 Cytoplasm/Nucleus 0.02325581 69.0 32.70448 0.02642796
MAPK11 ENSG00000185386 5600 Cytoplasm/Nucleus 0.02702703 89.0 77.31055 0.01532176
MAPK12 ENSG00000188130 6300 Cytoplasm/Nucleus 0.02380952 50.0 15.02965 0.03428571
MAPKAPK2 ENSG00000162889 9261 Cytoplasm/Nucleus 0.01923077 44.0 4.891322 0.02219873
MAPKAPK3 ENSG00000114738 7867 Cytoplasm/Nucleus 0.01886792 28.0 1.963432 0.03968254
MEF2D ENSG00000116604 4209 Cytoplasm/Nucleus 0.01724138 9.0 0.03737664 0.11111111
MKNK2 ENSG00000099875 2872 Cytoplasm/Nucleus 0.01785714 13.0 1.036936 0.05128205
RPS6KA5 ENSG00000100784 9252 Cytoplasm/Nucleus 0.01818182 16.0 0.1697512 0.075
IL1R1 ENSG00000115594 3554 Membrane 0.01351351 7.0 0.0 0.14285714
MAP2K4 ENSG00000065559 6416 Unknown 0.0212766 39.0 12.48153 0.05668016
MAP3K7 ENSG00000135341 6885 Unknown 0.02040816 51.0 1.604386 0.03137255
MAPK14 ENSG00000112062 1432 Unknown 0.02941176 109.0 147.8194 0.01138294
MEF2B ENSG00000064489 100271849 Unknown 0.01724138 8.0 0.03230146 0.14285714
MKNK1 ENSG00000079277 8569 Unknown 0.01785714 19.0 1.380204 0.02339181
SPPL2B ENSG00000005206 56928 Unknown 0.01612903 4.0 0.0 0.16666667
TAB1 ENSG00000100324 10454 Unknown 0.02 44.0 10.34761 0.0359408
TAB2 ENSG00000055208 23118 Unknown 0.02 29.0 2.05299 0.08374384
GADD45A ENSG00000116717 1647 Nucleus 0.01724138 8.0 0.2373994 0.07142857
MAP3K4 ENSG00000085511 4216 Nucleus 0.01639344 12.0 0.7606112 0.06060606
MEF2C ENSG00000081189 4208 Nucleus 0.01818182 18.0 1.124056 0.05882353
RPS6KA4 ENSG00000162302 8986 Nucleus 0.01754386 9.0 0.07642293 0.05555556
SRF ENSG00000112658 6722 Nucleus 0.01960784 31.0 0.8337596 0.04731183
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
EEF2K ENSG00000103319 29904 Cytoplasm 56.0 93.0 1.54E-6 0.015584416
MAP3K10 ENSG00000130758 4294 Cytoplasm 156.0 79.3 1.55E-6 0.0191067
MAP3K5 ENSG00000197442 4217 Cytoplasm 1572.0 10700.0 1.56E-6 0.001272265
MAPK13 ENSG00000156711 5603 Cytoplasm 1530.0 5010.0 1.55E-6 9.9172E-4
TRAF6 ENSG00000175104 7189 Cytoplasm 4812.0 283000.0 1.56E-6 6.24089E-4
DUSP10 ENSG00000143507 11221 Cytoplasm/Nucleus 131.0 1.53 1.55E-6 0.003992954
EIF4E ENSG00000151247 1977 Cytoplasm/Nucleus 833.0 61900.0 1.55E-6 0.008648652
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 3468.0 49000.0 1.56E-6 3.90234E-4
HSPB1 ENSG00000106211 3315 Cytoplasm/Nucleus 611.0 25100.0 1.56E-6 0.007222774
MAP2K6 ENSG00000108984 5608 Cytoplasm/Nucleus 2682.0 7380.0 1.56E-6 3.98028E-4
MAPK11 ENSG00000185386 5600 Cytoplasm/Nucleus 3606.0 96400.0 1.56E-6 9.00487E-4
MAPK12 ENSG00000188130 6300 Cytoplasm/Nucleus 1802.0 7750.0 1.56E-6 8.45504E-4
MAPKAPK2 ENSG00000162889 9261 Cytoplasm/Nucleus 1421.0 8100.0 1.55E-6 4.68823E-4
MAPKAPK3 ENSG00000114738 7867 Cytoplasm/Nucleus 596.0 900.0 1.55E-6 0.017037956
MEF2D ENSG00000116604 4209 Cytoplasm/Nucleus 74.0 477.0 1.55E-6 0.050721955
MKNK2 ENSG00000099875 2872 Cytoplasm/Nucleus 78.0 209.0 1.54E-6 0.006660007
RPS6KA5 ENSG00000100784 9252 Cytoplasm/Nucleus 627.0 4510.0 1.55E-6 0.00267005
IL1R1 ENSG00000115594 3554 Membrane 947.0 2170.0 1.55E-6 0.00874465
MAP2K4 ENSG00000065559 6416 Unknown 4071.0 5050.0 1.55E-6 1.59213E-4
MAP3K7 ENSG00000135341 6885 Unknown 5836.0 93700.0 1.56E-6 2.59125E-4
MAPK14 ENSG00000112062 1432 Unknown 9287.0 427000.0 1.56E-6 2.56589E-4
MEF2B ENSG00000064489 100271849 Unknown 24.0 41.8 1.54E-6 0.148550725
MKNK1 ENSG00000079277 8569 Unknown 491.0 2300.0 1.55E-6 0.002377489
SPPL2B ENSG00000005206 56928 Unknown 4.0 0.0 1.54E-6 0.166666667
TAB1 ENSG00000100324 10454 Unknown 2002.0 9670.0 1.56E-6 7.09935E-4
TAB2 ENSG00000055208 23118 Unknown 1549.0 5690.0 1.56E-6 0.001697353
GADD45A ENSG00000116717 1647 Nucleus 339.0 1750.0 1.55E-6 0.010176118
MAP3K4 ENSG00000085511 4216 Nucleus 245.0 185.0 1.55E-6 0.004550017
MEF2C ENSG00000081189 4208 Nucleus 316.0 28200.0 1.55E-6 0.009222423
RPS6KA4 ENSG00000162302 8986 Nucleus 165.0 104.0 1.55E-6 0.008499631
SRF ENSG00000112658 6722 Nucleus 617.0 15200.0 1.56E-6 0.005467385
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
EEF2K ENSG00000103319 29904 Cytoplasm 26.0 0.0815 3.66E-6 0.04
MAP3K10 ENSG00000130758 4294 Cytoplasm 34.0 57.6 3.67E-6 0.212121212
MAP3K5 ENSG00000197442 4217 Cytoplasm 283.0 2370.0 3.67E-6 0.012505325
MAPK13 ENSG00000156711 5603 Cytoplasm 344.0 1950.0 3.68E-6 0.011034646
TRAF6 ENSG00000175104 7189 Cytoplasm 168.0 6480.0 3.67E-6 0.025520388
DUSP10 ENSG00000143507 11221 Cytoplasm/Nucleus 41.0 0.27 3.66E-6 0.007317073
EIF4E ENSG00000151247 1977 Cytoplasm/Nucleus 13.0 0.0465 3.66E-6 0.064102564
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 528.0 9170.0 3.68E-6 0.003126617
HSPB1 ENSG00000106211 3315 Cytoplasm/Nucleus 67.0 9.45 3.67E-6 0.020805066
MAP2K6 ENSG00000108984 5608 Cytoplasm/Nucleus 347.0 406.0 3.67E-6 0.008112475
MAPK11 ENSG00000185386 5600 Cytoplasm/Nucleus 483.0 4470.0 3.68E-6 0.007508398
MAPK12 ENSG00000188130 6300 Cytoplasm/Nucleus 370.0 2070.0 3.68E-6 0.010151615
MAPKAPK2 ENSG00000162889 9261 Cytoplasm/Nucleus 289.0 198.0 3.67E-6 0.006271626
MAPKAPK3 ENSG00000114738 7867 Cytoplasm/Nucleus 117.0 35.7 3.67E-6 0.018567639
MEF2D ENSG00000116604 4209 Cytoplasm/Nucleus 9.0 0.00178 3.66E-6 0.111111111
MKNK2 ENSG00000099875 2872 Cytoplasm/Nucleus 60.0 60.2 3.67E-6 0.011299435
RPS6KA5 ENSG00000100784 9252 Cytoplasm/Nucleus 58.0 1.61 3.67E-6 0.044162129
IL1R1 ENSG00000115594 3554 Membrane 7.0 0.0 3.65E-6 0.142857143
MAP2K4 ENSG00000065559 6416 Unknown 615.0 1660.0 3.68E-6 0.003246736
MAP3K7 ENSG00000135341 6885 Unknown 321.0 21700.0 3.68E-6 0.023831776
MAPK14 ENSG00000112062 1432 Unknown 921.0 32300.0 3.68E-6 0.004010291
MEF2B ENSG00000064489 100271849 Unknown 8.0 0.00153 3.66E-6 0.142857143
MKNK1 ENSG00000079277 8569 Unknown 131.0 184.0 3.67E-6 0.021374046
SPPL2B ENSG00000005206 56928 Unknown 4.0 0.0 3.66E-6 0.166666667
TAB1 ENSG00000100324 10454 Unknown 167.0 1860.0 3.67E-6 0.018757665
TAB2 ENSG00000055208 23118 Unknown 29.0 19.0 3.66E-6 0.083743842
GADD45A ENSG00000116717 1647 Nucleus 31.0 95.3 3.67E-6 0.12688172
MAP3K4 ENSG00000085511 4216 Nucleus 88.0 62.1 3.67E-6 0.015673981
MEF2C ENSG00000081189 4208 Nucleus 37.0 2.72 3.67E-6 0.028528529
RPS6KA4 ENSG00000162302 8986 Nucleus 43.0 1.94 3.67E-6 0.053156146
SRF ENSG00000112658 6722 Nucleus 166.0 100.0 3.67E-6 0.008178167
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
DUSP10 MAPK11 4
DUSP10 MAPK12 2
DUSP10 MAPK13 2
DUSP10 MAPK14 7
ELK1 SRF 6
GADD45A MAP2K6 3
GADD45A MAP3K4 6
IL1R1 TAB1 2
IL1R1 TRAF6 8
MAP2K4 MAPK11 3
MAP2K4 MAPK12 3
MAP2K4 MAPK13 2
MAP2K4 MAPK14 7
MAP2K6 MAPK11 5
MAP2K6 MAPK12 8
MAP2K6 MAPK13 5
MAP2K6 MAPK14 11
MAP2K6 MAPKAPK2 2
MAP3K10 MAP2K6 1
MAP3K5 MAP2K4 5
MAP3K5 MAP2K6 5
MAP3K5 MAPK14 2
MAP3K5 TRAF6 3
MAP3K7 MAP2K4 4
MAP3K7 MAP2K6 7
MAP3K7 MAPK11 2
MAP3K7 MAPK12 2
MAP3K7 MAPK13 2
MAP3K7 MAPK14 4
MAP3K7 TAB1 14
MAP3K7 TAB2 10
MAP3K7 TRAF6 10
MAPK11 EEF2K 2
MAPK11 EIF4E 1
MAPK11 ELK1 3
MAPK11 HSPB1 1
MAPK11 MAPK14 3
MAPK11 MAPKAPK2 8
MAPK11 MAPKAPK3 7
MAPK11 MEF2B 2
MAPK11 MEF2C 4
MAPK11 MEF2D 2
MAPK11 MKNK1 5
MAPK11 MKNK2 1
MAPK11 RPS6KA4 3
MAPK11 RPS6KA5 6
MAPK11 SPPL2B 1
MAPK11 SRF 1
MAPK11 TAB1 4
MAPK12 ELK1 2
MAPK12 MAPKAPK2 2
MAPK12 MAPKAPK3 2
MAPK12 MEF2C 3
MAPK12 MKNK1 1
MAPK12 MKNK2 1
MAPK13 EEF2K 3
MAPK13 ELK1 2
MAPK13 MAPKAPK2 2
MAPK13 MAPKAPK3 5
MAPK13 MEF2C 2
MAPK13 MKNK1 1
MAPK13 MKNK2 1
MAPK14 EIF4E 1
MAPK14 ELK1 5
MAPK14 HSPB1 2
MAPK14 MAPKAPK2 11
MAPK14 MAPKAPK3 8
MAPK14 MEF2B 2
MAPK14 MEF2C 9
MAPK14 MEF2D 4
MAPK14 MKNK1 8
MAPK14 MKNK2 4
MAPK14 RPS6KA4 7
MAPK14 RPS6KA5 9
MAPK14 SPPL2B 1
MAPK14 TAB1 7
MAPKAPK2 HSPB1 5
MAPKAPK2 SRF 5
MAPKAPK3 SRF 1
MKNK1 EIF4E 5
MKNK2 EIF4E 3
RPS6KA5 ELK1 1
RPS6KA5 SRF 1
TAB1 MAP2K4 1
TAB1 MAP2K6 2
TAB1 MAPK12 2
TAB1 MAPK13 2
TAB1 TAB2 11
TAB1 TRAF6 8
TAB2 MAP2K4 1
TAB2 MAP2K6 2
TAB2 TRAF6 11
TRAF6 MAP2K4 2
TRAF6 MAP2K6 2
TRAF6 MAPK11 2
TRAF6 MAPK14 2
EEF2K MAPK12 1
EEF2K MAPK14 1
EEF2K MAPKAPK2 1
EEF2K MAPKAPK3 1
ELK1 MAP2K6 1
ELK1 MAPKAPK2 1
ELK1 MEF2B 1
ELK1 TRAF6 1
GADD45A MAPK14 1
HSPB1 MAP2K4 2
HSPB1 MAPKAPK3 3
IL1R1 TAB2 1
MAP2K4 MAP2K6 1
MAP2K4 MAP3K10 2
MAP2K4 MAP3K4 3
MAP2K6 MAP3K4 4
MAP2K6 MAPKAPK3 1
MAP3K10 MAPK14 1
MAP3K4 MAPK13 3
MAP3K5 MAP3K7 2
MAP3K7 MEF2C 1
MAPK12 MAPK13 1
MAPK12 MEF2B 1
MAPK12 MEF2D 1
MAPK12 RPS6KA4 1
MAPK12 RPS6KA5 1
MAPK13 RPS6KA4 1
MAPK13 RPS6KA5 1
MEF2C MEF2D 1
SRF DUSP10 1
SRF MAP2K6 1
SRF MAPK14 1
SRF TRAF6 1
TAB2 MAPK11 1
TAB2 MAPK12 1
TAB2 MAPK13 1
TAB2 MAPK14 1
TRAF6 MAPK12 1
TRAF6 MAPK13 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0001572 pathway0001569 6 0.75 p38 cascade ( BMP2 signaling(through TAK1) ) INOH 8 24
pathway0001572 pathway0001570 6 0.75 p38 cascade ( TGF-beta signaling(through TAK1) ) INOH 8 24
pathway0001572 pathway0002562 23 0.7419355 MAPK signaling pathway KEGG 264 4851
pathway0001572 pathway0002474 7 0.5384615 p38 cascade ( Toll-like receptor signaling pathway (p38 cascade) ) INOH 13 53
pathway0001572 pathway0000060 9 0.5294118 activated TAK1 mediates p38 MAPK activation Reactome 17 99
pathway0001572 pathway0001560 12 0.5217391 Oxidative stress response PANTHER 23 125