Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0001605 PDGFR-alpha signaling pathway PID Homo sapiens 22 96
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
JAK1 ENSG00000162434 3716 Cytoplasm 0.03225806 27.0 2.881332 0.10826211
RAPGEF1 ENSG00000107263 2889 Cytoplasm 0.02564103 18.0 0.0 0.06535948
SHB ENSG00000107338 6461 Cytoplasm 0.02777778 10.0 0.2510919 0.37777778
SOS1 ENSG00000115904 6654 Cytoplasm 0.03030303 69.0 1.429752 0.01534527
CRK ENSG00000167193 1398 Cytoplasm/Nucleus 0.03571429 36.0 23.86599 0.07936508
CRKL ENSG00000099942 1399 Cytoplasm/Nucleus 0.03125 22.0 2.112616 0.14718615
CSNK2A1 ENSG00000101266 1457 Cytoplasm/Nucleus 0.02439024 10.0 3.577243 0.06666667
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 0.02702703 22.0 10.18439 0.04329004
FOS ENSG00000170345 2353 Cytoplasm/Nucleus 0.02173913 14.0 0.6326085 0.04395604
JUN ENSG00000177606 3725 Cytoplasm/Nucleus 0.03125 17.0 13.97623 0.16176471
PLCG1 ENSG00000124181 5335 Cytoplasm/Nucleus 0.02941176 39.0 4.858178 0.04048583
CAV1 ENSG00000105974 857 Membrane 0.02857143 8.0 1.317724 0.39285714
CAV3 ENSG00000182533 859 Membrane 0.02173913 2.0 0.0 0.0
ITGAV ENSG00000138448 3685 Membrane 0.02777778 11.0 0.8836858 0.36363636
PDGFRA ENSG00000134853 5156 Membrane 0.03846154 55.0 49.55366 0.03905724
PIK3CA ENSG00000121879 5290 Membrane 0.03030303 49.0 1.569071 0.03231293
PIK3R1 ENSG00000145675 5295 Membrane 0.03333333 58.0 14.64904 0.02661827
PRRT2 ENSG00000167371 112476 Membrane 0.02380952 5.0 0.477969 0.4
SHC1 ENSG00000160691 6464 Membrane 0.03571429 60.0 7.456113 0.03107345
GRB2 ENSG00000177885 2885 Unknown 0.03571429 105.0 17.51193 0.00970696
SHF ENSG00000138606 90525 Unknown 0.02173913 1.0 0.0 0.0
SRF ENSG00000112658 6722 Nucleus 0.02439024 20.0 1.811375 0.01578947
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
JAK1 ENSG00000162434 3716 Cytoplasm 8612.0 95400.0 1.56E-6 2.71E-4
RAPGEF1 ENSG00000107263 2889 Cytoplasm 1033.0 22500.0 1.55E-6 8.99E-4
SHB ENSG00000107338 6461 Cytoplasm 180.0 2.85 1.55E-6 0.0238
SOS1 ENSG00000115904 6654 Cytoplasm 23511.0 177000.0 1.56E-6 6.54E-5
CRK ENSG00000167193 1398 Cytoplasm/Nucleus 4161.0 46800.0 1.56E-6 8.51E-4
CRKL ENSG00000099942 1399 Cytoplasm/Nucleus 2208.0 9050.0 1.55E-6 0.00119
CSNK2A1 ENSG00000101266 1457 Cytoplasm/Nucleus 542.0 19100.0 1.56E-6 0.0124
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 3468.0 49000.0 1.56E-6 3.9E-4
FOS ENSG00000170345 2353 Cytoplasm/Nucleus 3623.0 68600.0 1.56E-6 7.3E-4
JUN ENSG00000177606 3725 Cytoplasm/Nucleus 12667.0 3720000.0 1.57E-6 4.67E-4
PLCG1 ENSG00000124181 5335 Cytoplasm/Nucleus 11809.0 263000.0 1.56E-6 2.37E-4
CAV1 ENSG00000105974 857 Membrane 1007.0 42700.0 1.56E-6 0.0145
CAV3 ENSG00000182533 859 Membrane 40.0 411.0 1.55E-6 0.122
ITGAV ENSG00000138448 3685 Membrane 2732.0 55800.0 1.55E-6 0.00218
PDGFRA ENSG00000134853 5156 Membrane 2800.0 20200.0 1.56E-6 0.00142
PIK3CA ENSG00000121879 5290 Membrane 27859.0 414000.0 1.56E-6 5.51E-5
PIK3R1 ENSG00000145675 5295 Membrane 31452.0 734000.0 1.56E-6 4.03E-5
PRRT2 ENSG00000167371 112476 Membrane 127.0 272.0 1.55E-6 0.0785
SHC1 ENSG00000160691 6464 Membrane 13549.0 312000.0 1.56E-6 2.6E-4
GRB2 ENSG00000177885 2885 Unknown 29079.0 822000.0 1.57E-6 5.64E-5
SHF ENSG00000138606 90525 Unknown 1.0 0.0 1.53E-6 0.0
SRF ENSG00000112658 6722 Nucleus 617.0 15200.0 1.56E-6 0.00547
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
JAK1 ENSG00000162434 3716 Cytoplasm 1074.0 6030.0 1.70999E-4 0.004963546
RAPGEF1 ENSG00000107263 2889 Cytoplasm 341.0 149.0 1.42066E-4 0.005106089
SHB ENSG00000107338 6461 Cytoplasm 38.0 3.45 1.4298E-4 0.147937411
SOS1 ENSG00000115904 6654 Cytoplasm 4430.0 16400.0 1.75009E-4 5.66042E-4
CRK ENSG00000167193 1398 Cytoplasm/Nucleus 1158.0 8600.0 1.66973E-4 0.004111043
CRKL ENSG00000099942 1399 Cytoplasm/Nucleus 350.0 635.0 1.56887E-4 0.013655342
CSNK2A1 ENSG00000101266 1457 Cytoplasm/Nucleus 132.0 3980.0 1.64393E-4 0.036548693
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 573.0 2890.0 1.6714E-4 0.003801609
FOS ENSG00000170345 2353 Cytoplasm/Nucleus 1367.0 21000.0 1.80245E-4 0.00258445
JUN ENSG00000177606 3725 Cytoplasm/Nucleus 3540.0 384000.0 2.07297E-4 0.001375153
PLCG1 ENSG00000124181 5335 Cytoplasm/Nucleus 1953.0 14300.0 1.65098E-4 0.002245914
CAV1 ENSG00000105974 857 Membrane 229.0 7250.0 1.70561E-4 0.03409178
CAV3 ENSG00000182533 859 Membrane 2.0 0.0 1.06872E-4 0.0
ITGAV ENSG00000138448 3685 Membrane 835.0 23400.0 1.57654E-4 0.00724594
PDGFRA ENSG00000134853 5156 Membrane 95.0 5700.0 1.48039E-4 0.021948488
PIK3CA ENSG00000121879 5290 Membrane 7107.0 70400.0 1.83419E-4 2.95273E-4
PIK3R1 ENSG00000145675 5295 Membrane 7548.0 88700.0 1.85288E-4 2.41448E-4
PRRT2 ENSG00000167371 112476 Membrane 127.0 505.0 1.45054E-4 0.066991626
SHC1 ENSG00000160691 6464 Membrane 3723.0 28900.0 1.80538E-4 9.94587E-4
GRB2 ENSG00000177885 2885 Unknown 5986.0 66400.0 1.83857E-4 4.14669E-4
SHF ENSG00000138606 90525 Unknown 1.0 0.0 1.06872E-4 0.0
SRF ENSG00000112658 6722 Nucleus 231.0 6970.0 1.55715E-4 0.014041031
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
CAV1 PDGFRA 3
CAV3 PDGFRA 2
CRK CRKL 3
CRK GRB2 5
CRKL GRB2 4
CRKL PDGFRA 6
CRKL PIK3CA 1
CRKL PIK3R1 5
CRKL RAPGEF1 11
CRK PDGFRA 7
CRK PIK3CA 2
CRK PIK3R1 6
CRK RAPGEF1 11
CRK SHB 3
CRK SOS1 5
CSNK2A1 JUN 6
CSNK2A1 PIK3R1 1
CSNK2A1 SRF 4
ELK1 FOS 5
ELK1 SRF 6
FOS JUN 12
GRB2 JAK1 5
GRB2 PDGFRA 5
GRB2 PIK3CA 4
GRB2 PIK3R1 9
GRB2 PLCG1 7
GRB2 SHC1 13
GRB2 SOS1 12
ITGAV CRK 2
ITGAV PDGFRA 2
JAK1 PIK3CA 4
JAK1 PIK3R1 6
JAK1 SHC1 4
JAK1 SOS1 2
PDGFRA JAK1 2
PDGFRA PIK3CA 5
PDGFRA PIK3R1 9
PDGFRA PLCG1 9
PDGFRA RAPGEF1 4
PDGFRA SHB 2
PDGFRA SHC1 5
PDGFRA SOS1 5
PIK3CA PIK3R1 14
PIK3CA PLCG1 4
PIK3CA SHC1 3
PIK3CA SOS1 3
PIK3R1 PLCG1 7
PIK3R1 SHC1 8
PIK3R1 SOS1 8
PLCG1 SHC1 5
PLCG1 SOS1 7
PRRT2 ELK1 1
SHC1 SOS1 10
SRF FOS 3
CAV1 CSNK2A1 1
CAV1 ITGAV 2
CAV1 JUN 1
CAV1 PLCG1 3
CAV1 SHC1 1
CAV1 SOS1 1
CRK ELK1 2
CRKL JUN 1
CRKL SHC1 3
CRKL SOS1 4
CRK SHC1 4
CSNK2A1 FOS 2
ELK1 GRB2 1
ELK1 SHC1 1
GRB2 JUN 1
GRB2 PRRT2 1
GRB2 RAPGEF1 5
GRB2 SHB 2
ITGAV CRKL 1
ITGAV PIK3CA 1
ITGAV PIK3R1 1
ITGAV SHC1 1
JAK1 CRK 1
JAK1 JUN 1
JAK1 PLCG1 1
JAK1 PRRT2 1
JAK1 SHB 3
JUN CRK 1
JUN ELK1 1
JUN PDGFRA 1
JUN SHC1 1
PDGFRA SHF 1
PIK3R1 SHB 3
PLCG1 PRRT2 1
PLCG1 SHB 2
RAPGEF1 SHC1 3
SHB ITGAV 1
SRF CRK 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0001605 pathway0002594 14 0.6363636 Focal adhesion KEGG 197 5222
pathway0001605 pathway0000658 14 0.6363636 EGFR1 NetPath 475 10010
pathway0001605 pathway0001606 13 0.5909091 PDGFR-beta signaling pathway PID 125 2449
pathway0001605 pathway0002656 12 0.5454545 Pathways in cancer KEGG 321 8293
pathway0001605 pathway0002199 11 0.5 TCR NetPath 261 4161
pathway0001605 pathway0000177 11 0.5 Angiogenesis PANTHER 141 2497
pathway0001605 pathway0000270 11 0.5 BCR NetPath 161 2850
pathway0001605 pathway0001120 11 0.5 IL2 NetPath 81 1364
pathway0001605 pathway0001604 11 0.5 PDGF signaling pathway PANTHER 113 1684