Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0001649 Physiological factors Reactome Homo sapiens 12 24
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
WWTR1 ENSG00000018408 25937 Cytoplasm/Nucleus 0.05 3.0 0.0 1.0
CORIN ENSG00000145244 10699 Membrane 0.04545455 1.0 0.0 0.0
NPR1 ENSG00000169418 4881 Membrane 0.05263158 4.0 5.3 0.1666667
NPR2 ENSG00000159899 4882 Membrane 0.05 3.0 3.7 0.0
GATA4 ENSG00000136574 2626 Nucleus 0.05555556 6.0 0.4027778 0.4666667
HIPK1 ENSG00000163349 204851 Nucleus 0.05 4.0 0.0 0.5
HIPK2 ENSG00000064393 28996 Nucleus 0.05263158 5.0 0.6190476 0.4
KAT2B ENSG00000114166 8850 Nucleus 0.05882353 5.0 2.211111 0.5
NKX2-5 ENSG00000183072 1482 Nucleus 0.05555556 11.0 2.083333 0.1272727
TBX5 ENSG00000089225 6910 Nucleus 0.05555556 7.0 1.861905 0.2857143
NPPA ENSG00000175206 4878 Secreted 0.08333333 12.0 32.32183 0.1818182
NPPC ENSG00000163273 4880 Secreted 0.03703704 3.0 0.5 0.0
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
WWTR1 ENSG00000018408 25937 Cytoplasm/Nucleus 87.0 4840.0 1.55E-6 0.038492382
CORIN ENSG00000145244 10699 Membrane 1.0 0.0 1.52E-6 0.0
NPR1 ENSG00000169418 4881 Membrane 151.0 7740.0 1.55E-6 0.072317881
NPR2 ENSG00000159899 4882 Membrane 144.0 4750.0 1.54E-6 0.06954157
GATA4 ENSG00000136574 2626 Nucleus 69.0 8270.0 1.55E-6 0.038363171
HIPK1 ENSG00000163349 204851 Nucleus 15.0 40.7 1.54E-6 0.095238095
HIPK2 ENSG00000064393 28996 Nucleus 105.0 519.0 1.55E-6 0.053663004
KAT2B ENSG00000114166 8850 Nucleus 1184.0 53600.0 1.56E-6 0.011977108
NKX2-5 ENSG00000183072 1482 Nucleus 49.0 10400.0 1.55E-6 0.030612245
TBX5 ENSG00000089225 6910 Nucleus 22.0 24.1 1.54E-6 0.086580087
NPPA ENSG00000175206 4878 Secreted 218.0 12400.0 1.55E-6 0.003001733
NPPC ENSG00000163273 4880 Secreted 3.0 0.00456 1.52E-6 0.0
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
WWTR1 ENSG00000018408 25937 Cytoplasm/Nucleus 68.0 22776.94 3.99E-7 0.03248464
CORIN ENSG00000145244 10699 Membrane 1.0 0.0 3.97E-7 0.0
NPR1 ENSG00000169418 4881 Membrane 4.0 8113.468 3.98E-7 0.16666667
NPR2 ENSG00000159899 4882 Membrane 3.0 52.53224 3.97E-7 0.0
GATA4 ENSG00000136574 2626 Nucleus 26.0 17126.85 3.99E-7 0.10153846
HIPK1 ENSG00000163349 204851 Nucleus 15.0 2162.025 3.98E-7 0.08571429
HIPK2 ENSG00000064393 28996 Nucleus 20.0 3449.708 3.99E-7 0.08421053
KAT2B ENSG00000114166 8850 Nucleus 631.0 62721.84 3.99E-7 0.02870727
NKX2-5 ENSG00000183072 1482 Nucleus 22.0 3.065847 3.98E-7 0.03030303
TBX5 ENSG00000089225 6910 Nucleus 16.0 281.7768 3.98E-7 0.08333333
NPPA ENSG00000175206 4878 Secreted 20.0 16695.9 3.98E-7 0.06315789
NPPC ENSG00000163273 4880 Secreted 3.0 0.5 3.96E-7 0.0
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
GATA4 NKX2-5 4
HIPK1 NKX2-5 2
HIPK2 NKX2-5 2
NKX2-5 NPPA 2
NKX2-5 TBX5 4
NPPA NPR1 3
NPPC NPR2 3
CORIN NPPA 1
GATA4 HIPK1 1
GATA4 HIPK2 1
GATA4 NPPA 1
GATA4 TBX5 2
HIPK1 NPPA 1
HIPK2 KAT2B 1
HIPK2 NPPA 1
KAT2B NPPA 1
KAT2B NPR1 1
KAT2B TBX5 1
KAT2B WWTR1 1
NPPA NPR2 1
NPPC NPR1 1
TBX5 NPPA 1
TBX5 WWTR1 1
WWTR1 NPPA 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0001649 pathway0002460 8 0.6666667 YAP1- and WWTR1 (TAZ)-stimulated gene expression Reactome 29 144