Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0001674 Plasma membrane estrogen receptor signaling PID Homo sapiens 42 384
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
IGF1 ENSG00000017427 3479 Cytoplasm 0.01449275 34.0 2.149304 0.11764706
KRAS ENSG00000133703 3845 Cytoplasm 0.01694915 82.0 8.745886 0.0469738
PLCB1 ENSG00000182621 23236 Cytoplasm 0.01515152 74.0 6.314615 0.04516846
SOS1 ENSG00000115904 6654 Cytoplasm 0.015625 154.0 4.967704 0.01027077
STRN ENSG00000115808 6801 Cytoplasm 0.01234568 5.0 0.0 0.3
BCAR1 ENSG00000050820 9564 Cytoplasm/Nucleus 0.01538462 34.0 2.495609 0.17825312
ESR1 ENSG00000091831 2099 Cytoplasm/Nucleus 0.02 81.0 70.25164 0.06882716
ESR2 ENSG00000140009 2100 Cytoplasm/Nucleus 0.01470588 20.0 7.716559 0.25263158
GNAZ ENSG00000128266 2781 Cytoplasm/Nucleus 0.01449275 17.0 0.948964 0.34558824
MAPK11 ENSG00000185386 5600 Cytoplasm/Nucleus 0.01369863 18.0 0.8951999 0.22875817
NOS3 ENSG00000164867 4846 Cytoplasm/Nucleus 0.01408451 31.0 2.297413 0.11612903
PLCB2 ENSG00000137841 5330 Cytoplasm/Nucleus 0.01515152 70.0 5.362024 0.0505176
PLCB3 ENSG00000149782 5331 Cytoplasm/Nucleus 0.01515152 69.0 5.309252 0.05200341
ROCK2 ENSG00000134318 9475 Cytoplasm/Nucleus 0.01298701 21.0 5.258082 0.02380952
SRC ENSG00000197122 6714 Cytoplasm/Nucleus 0.01886792 81.0 63.05256 0.06604938
RHOA ENSG00000067560 387 Cytoskeleton/Nucleus 0.01694915 47.0 31.63091 0.13876041
AKT1 ENSG00000142208 207 Membrane 0.01785714 140.0 35.10968 0.01973279
GNA11 ENSG00000088256 2767 Membrane 0.01538462 46.0 3.177615 0.12753623
GNA13 ENSG00000120063 10672 Membrane 0.01408451 13.0 0.2540698 0.74358974
GNA14 ENSG00000156049 9630 Membrane 0.01388889 24.0 0.7759341 0.17753623
GNA15 ENSG00000060558 2769 Membrane 0.01388889 26.0 0.8394124 0.15076923
GNAI1 ENSG00000127955 2770 Membrane 0.01785714 48.0 16.57916 0.18173759
GNAI2 ENSG00000114353 2771 Membrane 0.01754386 45.0 9.029241 0.20505051
GNAI3 ENSG00000065135 2773 Membrane 0.01754386 45.0 8.439261 0.20505051
GNAO1 ENSG00000087258 2775 Membrane 0.01666667 32.0 4.053391 0.33870968
GNAQ ENSG00000156052 2776 Membrane 0.01612903 73.0 11.56178 0.05555556
GNAS ENSG00000087460 2778 Membrane 0.01492537 20.0 2.043802 0.45263158
GNB1 ENSG00000078369 2782 Membrane 0.01923077 64.0 23.21813 0.11755952
HBEGF ENSG00000113070 1839 Membrane 0.01470588 21.0 8.832877 0.29047619
HRAS ENSG00000174775 3265 Membrane 0.01960784 96.0 24.76948 0.05767544
IGF1R ENSG00000140443 3480 Membrane 0.01666667 64.0 28.82712 0.06845238
MSN ENSG00000147065 4478 Membrane 0.01086957 4.0 0.2104167 0.16666667
NRAS ENSG00000213281 4893 Membrane 0.01694915 72.0 7.666093 0.06103286
PIK3CA ENSG00000121879 5290 Membrane 0.01923077 150.0 35.1133 0.02389262
PIK3R1 ENSG00000145675 5295 Membrane 0.01886792 153.0 32.71359 0.02201582
SHC1 ENSG00000160691 6464 Membrane 0.015625 80.0 5.274535 0.03734177
GNG2 ENSG00000186469 54331 Unknown 0.01923077 57.0 21.65311 0.14849624
GRB2 ENSG00000177885 2885 Unknown 0.01587302 114.0 4.346089 0.01956218
PELP1 ENSG00000141456 27043 Nucleus 0.01449275 21.0 0.6868299 0.31428571
GNAL ENSG00000141404 2774 Secreted 0.01315789 8.0 0.1184615 0.89285714
MMP2 ENSG00000087245 4313 Secreted 0.01298701 7.0 1.310912 0.47619048
MMP9 ENSG00000100985 4318 Secreted 0.01098901 3.0 0.0 1.0
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
IGF1 ENSG00000017427 3479 Cytoplasm 1260.0 84435.0 1.56E-6 0.00215
KRAS ENSG00000133703 3845 Cytoplasm 15339.0 61692.76 1.56E-6 8.92E-5
PLCB1 ENSG00000182621 23236 Cytoplasm 7736.0 62261.8 1.56E-6 1.39E-4
SOS1 ENSG00000115904 6654 Cytoplasm 23511.0 177320.3 1.56E-6 6.54E-5
STRN ENSG00000115808 6801 Cytoplasm 5.0 0.0 1.54E-6 0.3
BCAR1 ENSG00000050820 9564 Cytoplasm/Nucleus 2452.0 62239.13 1.56E-6 0.00243
ESR1 ENSG00000091831 2099 Cytoplasm/Nucleus 1715.0 360622.6 1.56E-6 0.00554
ESR2 ENSG00000140009 2100 Cytoplasm/Nucleus 95.0 14341.32 1.55E-6 0.0571
GNAZ ENSG00000128266 2781 Cytoplasm/Nucleus 583.0 10315.23 1.56E-6 0.0132
MAPK11 ENSG00000185386 5600 Cytoplasm/Nucleus 3606.0 96380.64 1.56E-6 9.0E-4
NOS3 ENSG00000164867 4846 Cytoplasm/Nucleus 741.0 288702.1 1.56E-6 0.00398
PLCB2 ENSG00000137841 5330 Cytoplasm/Nucleus 6016.0 29783.78 1.55E-6 2.23E-4
PLCB3 ENSG00000149782 5331 Cytoplasm/Nucleus 6130.0 60392.54 1.55E-6 2.19E-4
ROCK2 ENSG00000134318 9475 Cytoplasm/Nucleus 1010.0 7660.195 1.56E-6 0.00175
SRC ENSG00000197122 6714 Cytoplasm/Nucleus 14851.0 1349351.0 1.57E-6 2.68E-4
RHOA ENSG00000067560 387 Cytoskeleton/Nucleus 5830.0 484436.0 1.56E-6 6.32E-4
AKT1 ENSG00000142208 207 Membrane 52751.0 2150216.0 1.57E-6 1.74E-5
GNA11 ENSG00000088256 2767 Membrane 2211.0 66865.59 1.56E-6 0.00332
GNA13 ENSG00000120063 10672 Membrane 393.0 4752.46 1.55E-6 0.0164
GNA14 ENSG00000156049 9630 Membrane 1316.0 33016.0 1.55E-6 0.00762
GNA15 ENSG00000060558 2769 Membrane 1128.0 27691.83 1.55E-6 0.0103
GNAI1 ENSG00000127955 2770 Membrane 4275.0 394594.7 1.56E-6 0.00131
GNAI2 ENSG00000114353 2771 Membrane 4108.0 437262.2 1.56E-6 0.00137
GNAI3 ENSG00000065135 2773 Membrane 3202.0 201966.9 1.56E-6 0.00192
GNAO1 ENSG00000087258 2775 Membrane 1080.0 21182.88 1.56E-6 0.0108
GNAQ ENSG00000156052 2776 Membrane 4339.0 168680.5 1.56E-6 9.82E-4
GNAS ENSG00000087460 2778 Membrane 4371.0 207756.7 1.56E-6 4.75E-4
GNB1 ENSG00000078369 2782 Membrane 3528.0 3225799.0 1.56E-6 0.00277
HBEGF ENSG00000113070 1839 Membrane 1139.0 13837.38 1.55E-6 0.00473
HRAS ENSG00000174775 3265 Membrane 21752.0 305380.1 1.56E-6 6.79E-5
IGF1R ENSG00000140443 3480 Membrane 2050.0 25194.74 1.56E-6 0.00201
MSN ENSG00000147065 4478 Membrane 60.0 204.4095 1.55E-6 0.0362
NRAS ENSG00000213281 4893 Membrane 14710.0 64247.83 1.56E-6 1.13E-4
PIK3CA ENSG00000121879 5290 Membrane 27859.0 413843.6 1.56E-6 5.51E-5
PIK3R1 ENSG00000145675 5295 Membrane 31452.0 733597.1 1.56E-6 4.03E-5
SHC1 ENSG00000160691 6464 Membrane 13549.0 311909.8 1.56E-6 2.6E-4
GNG2 ENSG00000186469 54331 Unknown 2424.0 219871.3 1.56E-6 0.00576
GRB2 ENSG00000177885 2885 Unknown 29079.0 821731.5 1.57E-6 5.64E-5
PELP1 ENSG00000141456 27043 Nucleus 92.0 41729.08 1.55E-6 0.0595
GNAL ENSG00000141404 2774 Secreted 1791.0 719319.4 1.55E-6 9.95E-4
MMP2 ENSG00000087245 4313 Secreted 292.0 22758.34 1.56E-6 0.014
MMP9 ENSG00000100985 4318 Secreted 325.0 41455.88 1.55E-6 0.0139
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
IGF1 ENSG00000017427 3479 Cytoplasm 216.0 40.56292 1.55715E-4 0.020585702
KRAS ENSG00000133703 3845 Cytoplasm 2404.0 6011.354 1.70126E-4 0.001302449
PLCB1 ENSG00000182621 23236 Cytoplasm 600.0 106.562 1.49993E-4 0.002687813
SOS1 ENSG00000115904 6654 Cytoplasm 4430.0 16438.32 1.75009E-4 5.66042E-4
STRN ENSG00000115808 6801 Cytoplasm 5.0 0.0 1.35999E-4 0.3
BCAR1 ENSG00000050820 9564 Cytoplasm/Nucleus 1017.0 10548.14 1.68606E-4 0.005086754
ESR1 ENSG00000091831 2099 Cytoplasm/Nucleus 746.0 61632.87 1.8352E-4 0.010896594
ESR2 ENSG00000140009 2100 Cytoplasm/Nucleus 82.0 1859.405 1.56104E-4 0.060523939
GNAZ ENSG00000128266 2781 Cytoplasm/Nucleus 296.0 1321.372 1.57654E-4 0.017315621
MAPK11 ENSG00000185386 5600 Cytoplasm/Nucleus 707.0 11850.25 1.75377E-4 0.006070417
NOS3 ENSG00000164867 4846 Cytoplasm/Nucleus 222.0 554.2659 1.59236E-4 0.017161958
PLCB2 ENSG00000137841 5330 Cytoplasm/Nucleus 786.0 925.678 1.46349E-4 0.001831413
PLCB3 ENSG00000149782 5331 Cytoplasm/Nucleus 647.0 122.5582 1.40984E-4 0.002421273
ROCK2 ENSG00000134318 9475 Cytoplasm/Nucleus 213.0 2001.929 1.56299E-4 0.008282399
SRC ENSG00000197122 6714 Cytoplasm/Nucleus 4405.0 181138.2 1.90476E-4 9.50019E-4
RHOA ENSG00000067560 387 Cytoskeleton/Nucleus 1977.0 111431.6 1.72682E-4 0.001860976
AKT1 ENSG00000142208 207 Membrane 9285.0 328254.0 1.9976E-4 2.07281E-4
GNA11 ENSG00000088256 2767 Membrane 325.0 2294.368 1.50421E-4 0.012763533
GNA13 ENSG00000120063 10672 Membrane 177.0 666.2263 1.47406E-4 0.019517206
GNA14 ENSG00000156049 9630 Membrane 249.0 1626.432 1.48655E-4 0.011789092
GNA15 ENSG00000060558 2769 Membrane 260.0 1682.932 1.48655E-4 0.010810811
GNAI1 ENSG00000127955 2770 Membrane 634.0 5038.598 1.62787E-4 0.008352395
GNAI2 ENSG00000114353 2771 Membrane 751.0 6557.082 1.60539E-4 0.006338216
GNAI3 ENSG00000065135 2773 Membrane 607.0 4152.463 1.638E-4 0.009531266
GNAO1 ENSG00000087258 2775 Membrane 383.0 1733.21 1.60103E-4 0.017497574
GNAQ ENSG00000156052 2776 Membrane 451.0 4657.764 1.51906E-4 0.007184036
GNAS ENSG00000087460 2778 Membrane 264.0 329.8083 1.42086E-4 0.006538772
GNB1 ENSG00000078369 2782 Membrane 587.0 59542.8 1.67983E-4 0.010198208
HBEGF ENSG00000113070 1839 Membrane 100.0 83.59625 1.56274E-4 0.066666667
HRAS ENSG00000174775 3265 Membrane 4283.0 43489.59 1.85185E-4 7.45373E-4
IGF1R ENSG00000140443 3480 Membrane 337.0 264.555 1.58983E-4 0.015172389
MSN ENSG00000147065 4478 Membrane 16.0 13.07704 1.32153E-4 0.125
NRAS ENSG00000213281 4893 Membrane 2219.0 11136.01 1.7584E-4 0.001738409
PIK3CA ENSG00000121879 5290 Membrane 7107.0 70413.28 1.83419E-4 2.95273E-4
PIK3R1 ENSG00000145675 5295 Membrane 7548.0 88681.9 1.85288E-4 2.41448E-4
SHC1 ENSG00000160691 6464 Membrane 3723.0 28877.94 1.80538E-4 9.94587E-4
GNG2 ENSG00000186469 54331 Unknown 522.0 5988.74 1.61031E-4 0.01272972
GRB2 ENSG00000177885 2885 Unknown 5986.0 66382.46 1.83857E-4 4.14669E-4
PELP1 ENSG00000141456 27043 Nucleus 44.0 65.06301 1.50512E-4 0.109936575
GNAL ENSG00000141404 2774 Secreted 79.0 162.1312 1.42086E-4 0.040571243
MMP2 ENSG00000087245 4313 Secreted 101.0 1039.892 1.6284E-4 0.037821782
MMP9 ENSG00000100985 4318 Secreted 138.0 6759.607 1.58882E-4 0.030254946
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
AKT1 ESR1 3
AKT1 NOS3 9
BCAR1 ESR1 5
BCAR1 GRB2 3
BCAR1 PIK3R1 3
BCAR1 SOS1 2
BCAR1 SRC 8
ESR1 ESR2 6
ESR1 GNAI1 3
ESR1 GNAI2 2
ESR1 GNAI3 2
ESR1 GNAS 2
ESR1 GNB1 3
ESR1 GNG2 1
ESR1 GRB2 4
ESR1 HRAS 2
ESR1 IGF1 2
ESR1 IGF1R 3
ESR1 NOS3 3
ESR1 PELP1 4
ESR1 PIK3CA 2
ESR1 PIK3R1 6
ESR1 ROCK2 2
ESR1 SHC1 4
ESR1 SOS1 3
ESR1 SRC 7
ESR1 STRN 3
ESR2 MAPK11 2
ESR2 NOS3 2
GNA11 GNAQ 2
GNA11 GNB1 5
GNA11 PLCB1 5
GNA11 PLCB2 4
GNA11 PLCB3 4
GNA13 GNG2 3
GNA14 PLCB1 4
GNA14 PLCB2 4
GNA14 PLCB3 4
GNA15 PLCB1 5
GNA15 PLCB2 4
GNA15 PLCB3 4
GNAI1 AKT1 1
GNAI1 BCAR1 1
GNAI1 GNAI3 3
GNAI1 GNB1 5
GNAI1 GNG2 5
GNAI1 HRAS 2
GNAI1 NOS3 1
GNAI1 PIK3CA 1
GNAI1 PIK3R1 1
GNAI1 PLCB1 2
GNAI1 PLCB2 2
GNAI1 PLCB3 2
GNAI1 SRC 1
GNAI2 AKT1 1
GNAI2 BCAR1 1
GNAI2 GNB1 6
GNAI2 GNG2 4
GNAI2 HRAS 2
GNAI2 NOS3 1
GNAI2 PIK3CA 1
GNAI2 PIK3R1 1
GNAI2 PLCB1 2
GNAI2 PLCB2 2
GNAI2 PLCB3 2
GNAI2 SRC 1
GNAI3 AKT1 1
GNAI3 BCAR1 1
GNAI3 GNB1 5
GNAI3 GNG2 4
GNAI3 HRAS 2
GNAI3 NOS3 1
GNAI3 PIK3CA 1
GNAI3 PIK3R1 1
GNAI3 PLCB1 2
GNAI3 PLCB2 2
GNAI3 PLCB3 2
GNAI3 SRC 1
GNAO1 AKT1 1
GNAO1 BCAR1 1
GNAO1 NOS3 1
GNAO1 PLCB1 2
GNAO1 PLCB2 2
GNAO1 PLCB3 2
GNAO1 SRC 1
GNAQ GNB1 5
GNAQ PIK3CA 3
GNAQ PIK3R1 2
GNAQ PLCB1 8
GNAQ PLCB2 7
GNAQ PLCB3 5
GNAS GNB1 7
GNAS GNG2 4
GNAZ AKT1 1
GNAZ BCAR1 1
GNAZ NOS3 1
GNAZ SRC 1
GNB1 BCAR1 1
GNB1 GNG2 9
GNB1 MAPK11 1
GNB1 NOS3 1
GNB1 PIK3CA 2
GNB1 PIK3R1 2
GNB1 PLCB1 3
GNB1 PLCB2 3
GNB1 PLCB3 3
GNB1 SHC1 2
GNB1 SRC 3
GNG2 BCAR1 1
GNG2 MAPK11 1
GNG2 NOS3 1
GNG2 PIK3CA 3
GNG2 PIK3R1 2
GNG2 PLCB1 4
GNG2 PLCB2 4
GNG2 PLCB3 4
GNG2 SHC1 2
GNG2 SRC 1
GRB2 AKT1 3
GRB2 HRAS 4
GRB2 KRAS 3
GRB2 PIK3CA 4
GRB2 PIK3R1 9
GRB2 SHC1 13
GRB2 SOS1 12
GRB2 SRC 5
HBEGF PIK3CA 2
HBEGF PIK3R1 2
HBEGF RHOA 1
HBEGF SHC1 1
HBEGF SOS1 1
HRAS PIK3CA 8
HRAS PIK3R1 7
HRAS SOS1 7
IGF1 AKT1 1
IGF1 BCAR1 1
IGF1 IGF1R 12
IGF1 PIK3CA 2
IGF1 PIK3R1 2
IGF1R AKT1 1
IGF1R BCAR1 1
IGF1R HRAS 2
IGF1R KRAS 1
IGF1R PIK3CA 3
IGF1R PIK3R1 8
IGF1R SHC1 9
IGF1 SHC1 2
KRAS PIK3CA 5
KRAS PIK3R1 3
MAPK11 AKT1 1
MAPK11 ESR1 1
MMP2 HBEGF 2
NRAS PIK3CA 5
NRAS PIK3R1 3
PELP1 AKT1 1
PELP1 PIK3CA 1
PELP1 SHC1 1
PELP1 SOS1 1
PELP1 SRC 4
PIK3CA AKT1 5
PIK3CA PIK3R1 14
PIK3CA PLCB1 2
PIK3CA PLCB2 2
PIK3CA PLCB3 2
PIK3CA RHOA 2
PIK3CA SHC1 3
PIK3CA SOS1 3
PIK3R1 AKT1 6
PIK3R1 PLCB1 2
PIK3R1 PLCB2 2
PIK3R1 PLCB3 2
PIK3R1 RHOA 2
PIK3R1 SHC1 8
PIK3R1 SOS1 8
PIK3R1 SRC 8
RHOA AKT1 2
RHOA ROCK2 5
ROCK2 MSN 1
SHC1 AKT1 3
SHC1 MAPK11 1
SHC1 SOS1 10
SHC1 SRC 6
SOS1 AKT1 3
SOS1 KRAS 6
SOS1 NRAS 5
SOS1 SRC 3
SRC AKT1 4
SRC HRAS 4
SRC KRAS 3
SRC MAPK11 2
SRC NRAS 4
SRC PIK3CA 2
STRN AKT1 1
AKT1 ESR2 2
BCAR1 PELP1 1
ESR1 GNA11 1
ESR1 GNA13 1
ESR1 GNA14 1
ESR1 GNA15 1
ESR1 GNAL 1
ESR1 GNAO1 1
ESR1 GNAQ 1
ESR1 GNAZ 1
ESR1 MMP2 1
ESR2 GNA11 1
ESR2 GNA14 1
ESR2 GNA15 1
ESR2 GNAL 1
ESR2 GNAQ 1
ESR2 GNAS 1
ESR2 GNB1 1
ESR2 GNG2 1
ESR2 HBEGF 1
ESR2 PELP1 2
ESR2 SRC 2
GNA11 GNA13 1
GNA11 GNAI1 1
GNA11 GNAI2 1
GNA11 GNAI3 1
GNA11 GNAO1 1
GNA11 GNAS 2
GNA11 GNG2 3
GNA11 HRAS 1
GNA11 KRAS 1
GNA11 NRAS 1
GNA11 PIK3CA 1
GNA11 PIK3R1 1
GNA13 GNAI1 1
GNA13 GNAI2 1
GNA13 GNAI3 1
GNA13 GNAO1 1
GNA13 GNAQ 1
GNA13 GNAS 1
GNA13 GNB1 2
GNA13 RHOA 2
GNA14 GNB1 3
GNA14 GNG2 3
GNA14 HRAS 1
GNA14 KRAS 1
GNA14 NRAS 1
GNA14 PIK3CA 1
GNA14 PIK3R1 1
GNA15 GNB1 3
GNA15 GNG2 3
GNA15 HRAS 1
GNA15 KRAS 1
GNA15 NRAS 1
GNA15 PIK3CA 1
GNA15 PIK3R1 1
GNAI1 GNAI2 2
GNAI1 GNAL 1
GNAI1 GNAO1 2
GNAI1 GNAQ 1
GNAI1 GNAS 1
GNAI1 IGF1R 2
GNAI1 KRAS 1
GNAI1 NRAS 1
GNAI1 RHOA 1
GNAI1 STRN 1
GNAI2 GNAI3 2
GNAI2 GNAL 1
GNAI2 GNAO1 2
GNAI2 GNAQ 1
GNAI2 GNAS 1
GNAI2 KRAS 1
GNAI2 NRAS 1
GNAI2 RHOA 1
GNAI3 GNAL 1
GNAI3 GNAO1 2
GNAI3 GNAQ 1
GNAI3 GNAS 1
GNAI3 KRAS 1
GNAI3 NRAS 1
GNAI3 RHOA 1
GNAL GNAS 1
GNAL GNB1 3
GNAL GNG2 2
GNAO1 GNAQ 1
GNAO1 GNAS 1
GNAO1 GNB1 3
GNAO1 GNG2 3
GNAO1 HRAS 1
GNAO1 PIK3CA 1
GNAO1 PIK3R1 1
GNAO1 RHOA 1
GNAQ GNAS 2
GNAQ GNG2 3
GNAQ HRAS 1
GNAQ KRAS 1
GNAQ NRAS 1
GNAQ RHOA 1
GNAQ ROCK2 1
GNAS GRB2 1
GNAS NOS3 1
GNAZ GNB1 2
GNAZ GNG2 2
GNAZ HRAS 1
GNAZ PLCB1 1
GNAZ PLCB2 1
GNAZ PLCB3 1
GNAZ RHOA 1
GNB1 AKT1 2
GNB1 GRB2 1
GNB1 HRAS 1
GNB1 RHOA 1
GNB1 SOS1 2
GNG2 AKT1 2
GNG2 GRB2 1
GNG2 HRAS 1
GNG2 RHOA 1
GNG2 SOS1 2
GRB2 IGF1 1
GRB2 IGF1R 2
GRB2 NRAS 2
GRB2 PELP1 1
HBEGF AKT1 1
HBEGF GRB2 1
HBEGF HRAS 1
HBEGF KRAS 1
HBEGF NRAS 1
HRAS AKT1 1
HRAS MAPK11 1
HRAS MMP2 1
HRAS RHOA 1
IGF1 HRAS 1
IGF1R GNA13 1
IGF1R GNAI2 1
IGF1R GNAI3 1
IGF1R GNAO1 1
IGF1R GNAS 1
IGF1R GNAZ 1
IGF1R MSN 2
IGF1R NRAS 1
IGF1R SOS1 2
IGF1 SOS1 1
KRAS AKT1 1
KRAS HRAS 1
KRAS MAPK11 1
KRAS NRAS 1
KRAS RHOA 1
MMP2 IGF1 1
MMP2 MMP9 1
MMP9 HBEGF 1
MSN RHOA 1
NOS3 SRC 1
NRAS AKT1 1
NRAS HRAS 1
NRAS MAPK11 1
NRAS RHOA 1
PELP1 HRAS 1
PELP1 IGF1 1
PELP1 IGF1R 1
PELP1 PIK3R1 1
PIK3CA BCAR1 1
PIK3CA GNAS 1
PLCB1 HRAS 1
PLCB1 KRAS 1
PLCB1 NRAS 1
PLCB2 HRAS 1
PLCB2 KRAS 1
PLCB2 NRAS 1
PLCB2 PLCB1 1
PLCB3 HRAS 1
PLCB3 KRAS 1
PLCB3 NRAS 1
PLCB3 PLCB1 1
PLCB3 PLCB2 1
RHOA BCAR1 1
RHOA GRB2 1
SHC1 HRAS 3
SHC1 KRAS 3
SHC1 NRAS 3
SHC1 RHOA 1
SOS1 RHOA 1
SRC HBEGF 1
SRC IGF1 1
SRC IGF1R 1
SRC MMP2 1
SRC MMP9 1
SRC RHOA 2
SRC ROCK2 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0001674 pathway0001994 8 0.8888889 SHC-related events triggered by IGF1R Reactome 9 29
pathway0001674 pathway0000764 7 0.875 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Reactome 8 20
pathway0001674 pathway0001683 4 0.8 PLC beta signaling ( GPCR GroupI metabotropic glutamate receptor signaling pathway ) INOH 5 10
pathway0001674 pathway0001684 4 0.8 PLC beta signaling ( GPCR signaling (G alpha q) ) INOH 5 10
pathway0001674 pathway0001953 6 0.75 S1P5 pathway PID 8 23
pathway0001674 pathway0001995 6 0.75 SHC1 events in EGFR signaling Reactome 8 29
pathway0001674 pathway0002079 5 0.7142857 SOS-mediated signalling Reactome 7 21
pathway0001674 pathway0000972 5 0.7142857 GRB2 events in EGFR signaling Reactome 7 22
pathway0001674 pathway0002017 7 0.7 Signaling by FGFR3 fusions in cancer Reactome 10 45
pathway0001674 pathway0000055 7 0.7 Acetylcholine regulates insulin secretion Reactome 10 29
pathway0001674 pathway0000657 6 0.6666667 EGFR Transactivation by Gastrin Reactome 9 29
pathway0001674 pathway0001164 6 0.6666667 Insulin receptor signalling cascade Reactome 9 30
pathway0001674 pathway0001593 10 0.6666667 PAR4-mediated thrombin signaling events PID 15 57
pathway0001674 pathway0002019 7 0.6363636 Signaling by FGFR4 in disease Reactome 11 56
pathway0001674 pathway0002060 6 0.6 Signalling to RAS Reactome 10 39
pathway0001674 pathway0000077 3 0.6 Activation of RAS in B cells Reactome 5 9
pathway0001674 pathway0001791 5 0.5555556 Raf activation signaling (through Grb2 and Sos) ( B cell receptor signaling ) INOH 9 27
pathway0001674 pathway0001792 5 0.5555556 Raf activation signaling (through Grb2 and Sos) ( CD4 T cell receptor signaling (ERK cascade) ) INOH 9 27
pathway0001674 pathway0001793 5 0.5555556 Raf activation signaling (through Grb2 and Sos) ( CD4 T cell receptor signaling ) INOH 9 27
pathway0001674 pathway0001794 5 0.5555556 Raf activation signaling (through Grb2 and Sos) ( JAK-STAT pathway and regulation pathway Diagram ) INOH 9 27
pathway0001674 pathway0000480 8 0.5333333 Constitutive Signaling by EGFRvIII Reactome 15 107
pathway0001674 pathway0001295 22 0.5238095 LPA receptor mediated events PID 65 700
pathway0001674 pathway0001951 13 0.52 S1P3 pathway PID 25 159
pathway0001674 pathway0001507 16 0.516129 Nongenotropic Androgen signaling PID 31 254
pathway0001674 pathway0001682 8 0.5 PLC beta mediated events Reactome 16 88
pathway0001674 pathway0001803 5 0.5 Rapid glucocorticoid signaling PID 10 21
pathway0001674 pathway0001950 13 0.5 S1P2 pathway PID 26 167
pathway0001674 pathway0001952 7 0.5 S1P4 pathway PID 14 72
pathway0001674 pathway0001997 7 0.5 SHC1 events in ERBB4 signaling Reactome 14 81
pathway0001674 pathway0000001 3 0.5 5-arachidonylglycerol_biosynthesis PANTHER 6 6