Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0001702 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation Reactome Homo sapiens 10 27
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
HHEX ENSG00000152804 3087 Cytoplasm/Nucleus 0.07142857 4.0 0.09090909 0.8333333
POU5F1 ENSG00000204531 5460 Cytoplasm/Nucleus 0.11111111 14.0 5.787879 0.1978022
TSC22D1 ENSG00000102804 8848 Cytoplasm/Nucleus 0.07692308 5.0 0.4242424 0.8
CDX2 ENSG00000165556 1045 Nucleus 0.07142857 4.0 0.0 1.0
EOMES ENSG00000163508 8320 Nucleus 0.06666667 3.0 0.0 1.0
GATA6 ENSG00000141448 2627 Nucleus 0.07692308 5.0 0.75 0.7
GSC ENSG00000133937 145258 Nucleus 0.07142857 4.0 0.09090909 0.8333333
NANOG ENSG00000111704 79923 Nucleus 0.11111111 12.0 5.606061 0.2727273
SOX2 ENSG00000181449 6657 Nucleus 0.1 15.0 5.25 0.1333333
DKK1 ENSG00000107984 22943 Secreted 0.06666667 4.0 0.0 0.5
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
HHEX ENSG00000152804 3087 Cytoplasm/Nucleus 17.0 163.8799 1.54E-6 0.18382353
POU5F1 ENSG00000204531 5460 Cytoplasm/Nucleus 96.0 17767.69 1.55E-6 0.02741228
TSC22D1 ENSG00000102804 8848 Cytoplasm/Nucleus 5.0 2.322256 1.53E-6 0.8
CDX2 ENSG00000165556 1045 Nucleus 8.0 425.0182 1.53E-6 0.32142857
EOMES ENSG00000163508 8320 Nucleus 32.0 232.7686 1.54E-6 0.17943548
GATA6 ENSG00000141448 2627 Nucleus 43.0 13184.52 1.55E-6 0.06976744
GSC ENSG00000133937 145258 Nucleus 14.0 9.837749 1.54E-6 0.2967033
NANOG ENSG00000111704 79923 Nucleus 71.0 5552.811 1.54E-6 0.07686117
SOX2 ENSG00000181449 6657 Nucleus 164.0 39777.49 1.55E-6 0.02648511
DKK1 ENSG00000107984 22943 Secreted 391.0 6728.626 1.55E-6 0.00203292
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
HHEX ENSG00000152804 3087 Cytoplasm/Nucleus 4.0 0.641 3.98E-7 0.83333333
POU5F1 ENSG00000204531 5460 Cytoplasm/Nucleus 64.0 16700.0 3.98E-7 0.03422619
TSC22D1 ENSG00000102804 8848 Cytoplasm/Nucleus 5.0 5.58 3.98E-7 0.8
CDX2 ENSG00000165556 1045 Nucleus 8.0 1440.0 3.98E-7 0.28571429
EOMES ENSG00000163508 8320 Nucleus 3.0 0.0 3.98E-7 1.0
GATA6 ENSG00000141448 2627 Nucleus 19.0 22500.0 3.99E-7 0.11111111
GSC ENSG00000133937 145258 Nucleus 4.0 0.641 3.98E-7 0.83333333
NANOG ENSG00000111704 79923 Nucleus 71.0 17000.0 3.99E-7 0.07525151
SOX2 ENSG00000181449 6657 Nucleus 90.0 45700.0 3.99E-7 0.05143571
DKK1 ENSG00000107984 22943 Secreted 57.0 815.0 3.98E-7 0.03383459
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
POU5F1 SOX2 7
CDX2 NANOG 1
CDX2 POU5F1 1
CDX2 SOX2 1
CDX2 TSC22D1 1
DKK1 NANOG 1
DKK1 POU5F1 1
EOMES NANOG 1
EOMES POU5F1 1
EOMES SOX2 1
GATA6 GSC 1
GATA6 HHEX 1
GATA6 NANOG 1
GATA6 POU5F1 1
GATA6 TSC22D1 1
GSC NANOG 1
GSC POU5F1 1
GSC SOX2 1
HHEX NANOG 1
HHEX POU5F1 1
HHEX SOX2 1
NANOG TSC22D1 1
POU5F1 NANOG 1
POU5F1 TSC22D1 1
SOX2 DKK1 1
SOX2 NANOG 1
SOX2 TSC22D1 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0001702 pathway0002740 5 0.5 Hs_Endoderm_Differentiation_WP2853_88152 WikiPathways 62 260