Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0001864 Regulation of TP53 Activity through Association with Co-factors Reactome Homo sapiens 14 26
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
PPP1R13B ENSG00000088808 23368 Cytoplasm 0.04347826 6.0 0.0 0.2
AKT2 ENSG00000105221 208 Cytoplasm/Nucleus 0.04347826 7.0 0.0 0.14285714
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 0.07692308 32.0 64.09524 0.02217742
TP63 ENSG00000073282 8626 Cytoplasm/Nucleus 0.04761905 10.0 0.8333333 0.15555556
TP73 ENSG00000078900 7161 Cytoplasm/Nucleus 0.04761905 13.0 0.8333333 0.08974359
ZNF385A ENSG00000161642 25946 Cytoplasm/Nucleus 0.04 3.0 0.0 0.0
AKT1 ENSG00000142208 207 Membrane 0.04347826 8.0 0.0 0.10714286
AKT3 ENSG00000117020 10000 Membrane 0.04166667 3.0 0.0 0.33333333
PPP1R13L ENSG00000104881 10848 Unknown 0.04347826 8.0 0.0 0.10714286
TP53BP2 ENSG00000143514 7159 Unknown 0.04347826 6.0 0.0 0.2
BANP ENSG00000172530 54971 Nucleus 0.04 2.0 0.0 0.0
PHF20 ENSG00000025293 51230 Nucleus 0.04545455 8.0 1.238095 0.14285714
POU4F1 ENSG00000152192 5457 Nucleus 0.04 1.0 0.0 0.0
POU4F2 ENSG00000151615 5458 Nucleus 0.04 1.0 0.0 0.0
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
PPP1R13B ENSG00000088808 23368 Cytoplasm 61.0 1.67 1.55E-6 0.029
AKT2 ENSG00000105221 208 Cytoplasm/Nucleus 23612.0 163000.0 1.56E-6 4.86E-5
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 8418.0 2450000.0 1.57E-6 7.36E-4
TP63 ENSG00000073282 8626 Cytoplasm/Nucleus 485.0 110000.0 1.56E-6 0.00737
TP73 ENSG00000078900 7161 Cytoplasm/Nucleus 792.0 51300.0 1.56E-6 0.00533
ZNF385A ENSG00000161642 25946 Cytoplasm/Nucleus 20.0 0.00124 1.54E-6 0.0105
AKT1 ENSG00000142208 207 Membrane 52751.0 2150000.0 1.57E-6 1.74E-5
AKT3 ENSG00000117020 10000 Membrane 22158.0 86500.0 1.56E-6 5.25E-5
PPP1R13L ENSG00000104881 10848 Unknown 23.0 13.7 1.55E-6 0.0711
TP53BP2 ENSG00000143514 7159 Unknown 66.0 9.57 1.55E-6 0.0387
BANP ENSG00000172530 54971 Nucleus 2.0 0.0 1.54E-6 0.0
PHF20 ENSG00000025293 51230 Nucleus 58.0 723.0 1.55E-6 0.285
POU4F1 ENSG00000152192 5457 Nucleus 12.0 1.02 1.55E-6 0.348
POU4F2 ENSG00000151615 5458 Nucleus 6.0 0.0127 1.55E-6 0.333
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
PPP1R13B ENSG00000088808 23368 Cytoplasm 41.0 10.4 3.98E-7 0.023170732
AKT2 ENSG00000105221 208 Cytoplasm/Nucleus 1883.0 227000.0 4.0E-7 0.00208815
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 1932.0 2260000.0 4.0E-7 0.004693499
TP63 ENSG00000073282 8626 Cytoplasm/Nucleus 92.0 1900.0 3.99E-7 0.014333493
TP73 ENSG00000078900 7161 Cytoplasm/Nucleus 92.0 1610.0 3.99E-7 0.011466794
ZNF385A ENSG00000161642 25946 Cytoplasm/Nucleus 13.0 0.0636 3.98E-7 0.025641026
AKT1 ENSG00000142208 207 Membrane 2968.0 717000.0 4.0E-7 0.001152843
AKT3 ENSG00000117020 10000 Membrane 1799.0 129000.0 3.99E-7 0.002139367
PPP1R13L ENSG00000104881 10848 Unknown 8.0 0.0 3.98E-7 0.107142857
TP53BP2 ENSG00000143514 7159 Unknown 41.0 10.4 3.98E-7 0.023170732
BANP ENSG00000172530 54971 Nucleus 2.0 0.0 3.98E-7 0.0
PHF20 ENSG00000025293 51230 Nucleus 58.0 1560.0 3.99E-7 0.283726558
POU4F1 ENSG00000152192 5457 Nucleus 1.0 0.0 3.98E-7 0.0
POU4F2 ENSG00000151615 5458 Nucleus 1.0 0.0 3.98E-7 0.0
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
AKT1 AKT2 2
AKT1 PHF20 2
AKT1 TP53 4
AKT2 PHF20 1
AKT2 TP53 2
AKT3 PHF20 1
BANP TP53 4
PHF20 TP53 2
PPP1R13B TP53 2
PPP1R13B TP63 3
PPP1R13B TP73 3
PPP1R13L TP53 7
PPP1R13L TP63 2
PPP1R13L TP73 2
TP53BP2 TP63 3
TP53BP2 TP73 2
TP53 TP53BP2 6
TP53 TP63 6
TP53 TP73 3
TP53 ZNF385A 2
AKT3 TP53 1
POU4F1 TP53 1
POU4F2 TP53 1
TP63 TP73 2
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0001864 pathway0000075 5 0.625 Activation of PUMA and translocation to mitochondria Reactome 8 24
pathway0001864 pathway0000608 8 0.5714286 Direct p53 effectors PID 141 972
pathway0001864 pathway0000123 3 0.5 AKT(PKB)-GSK3beta signaling ( Insulin receptor signaling (D. melanogaster) ) INOH 6 8
pathway0001864 pathway0000124 3 0.5 AKT(PKB)-GSK3beta signaling ( Insulin receptor signaling (Mammal) ) INOH 6 8
pathway0001864 pathway0001580 3 0.5 P53 pathway feedback loops 1 PANTHER 6 16