Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0001883 Retinoic acid receptors-mediated signaling PID Homo sapiens 30 235
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
RBP1 ENSG00000114115 5947 Cytoplasm 0.01754386 3.0 0.02739726 0.0
CDK1 ENSG00000170312 983 Cytoplasm/Nucleus 0.0212766 25.0 4.192009 0.12333333
CDK7 ENSG00000134058 1022 Cytoplasm/Nucleus 0.02040816 21.0 1.360075 0.13333333
EP300 ENSG00000100393 2033 Cytoplasm/Nucleus 0.02941176 47.0 16.27482 0.14338575
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 0.02631579 45.0 6.22968 0.13131313
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 0.02631579 40.0 9.19584 0.14615385
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 0.02040816 16.0 0.3002313 0.24166667
MNAT1 ENSG00000020426 4331 Cytoplasm/Nucleus 0.01960784 15.0 0.122449 0.19047619
NCOA3 ENSG00000124151 8202 Cytoplasm/Nucleus 0.02631579 38.0 8.613836 0.17780939
NCOR2 ENSG00000196498 9612 Cytoplasm/Nucleus 0.02325581 27.0 1.337198 0.24216524
NRIP1 ENSG00000180530 8204 Cytoplasm/Nucleus 0.02325581 29.0 1.722456 0.19950739
PRKCA ENSG00000154229 5578 Cytoplasm/Nucleus 0.02083333 19.0 0.5144714 0.21052632
RARB ENSG00000077092 5915 Cytoplasm/Nucleus 0.02564103 32.0 4.277972 0.22580645
VDR ENSG00000111424 7421 Cytoplasm/Nucleus 0.02439024 32.0 4.397749 0.21169355
AKT1 ENSG00000142208 207 Membrane 0.03030303 58.0 48.32437 0.08529946
PRKCG ENSG00000126583 5582 Membrane/Nucleus 0.01923077 8.0 0.1675908 0.35714286
HDAC3 ENSG00000171720 8841 Unknown 0.02380952 30.0 1.777359 0.2137931
MAPK14 ENSG00000112062 1432 Unknown 0.02222222 22.0 0.8228463 0.26839827
PRKACA ENSG00000072062 5566 Unknown 0.02272727 20.0 1.986591 0.33157895
CCNH ENSG00000134480 902 Nucleus 0.02040816 22.0 1.174709 0.12121212
CREBBP ENSG00000005339 1387 Nucleus 0.02631579 43.0 6.198463 0.14839424
HDAC1 ENSG00000116478 3065 Nucleus 0.025 35.0 9.669001 0.15462185
KAT2B ENSG00000114166 8850 Nucleus 0.02272727 29.0 1.311127 0.18226601
NCOA1 ENSG00000084676 8648 Nucleus 0.02325581 31.0 1.850774 0.1827957
NCOA2 ENSG00000140396 10499 Nucleus 0.02272727 25.0 0.9479498 0.24666667
RARA ENSG00000131759 5914 Nucleus 0.03225806 61.0 41.21617 0.10054645
RARG ENSG00000172819 5916 Nucleus 0.02857143 39.0 13.74816 0.20512821
RXRA ENSG00000186350 6256 Nucleus 0.02777778 43.0 11.48668 0.15282392
RXRB ENSG00000204231 6257 Nucleus 0.02325581 23.0 2.652031 0.27272727
RXRG ENSG00000143171 6258 Nucleus 0.02272727 20.0 2.099993 0.32105263
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
RBP1 ENSG00000114115 5947 Cytoplasm 50.0 72151.43 1.55E-6 0.0449
CDK1 ENSG00000170312 983 Cytoplasm/Nucleus 3973.0 426977.3 1.56E-6 0.00311
CDK7 ENSG00000134058 1022 Cytoplasm/Nucleus 2623.0 63034.54 1.56E-6 0.00242
EP300 ENSG00000100393 2033 Cytoplasm/Nucleus 6386.0 1381818.0 1.56E-6 0.00143
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 33563.0 1132138.0 1.56E-6 2.83E-5
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 29207.0 849501.6 1.56E-6 3.17E-5
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 11158.0 359985.1 1.56E-6 1.42E-4
MNAT1 ENSG00000020426 4331 Cytoplasm/Nucleus 2071.0 11068.16 1.55E-6 0.00263
NCOA3 ENSG00000124151 8202 Cytoplasm/Nucleus 654.0 57684.15 1.56E-6 0.042
NCOR2 ENSG00000196498 9612 Cytoplasm/Nucleus 636.0 10200.67 1.56E-6 0.0266
NRIP1 ENSG00000180530 8204 Cytoplasm/Nucleus 141.0 458.9925 1.55E-6 0.0323
PRKCA ENSG00000154229 5578 Cytoplasm/Nucleus 10261.0 710244.0 1.56E-6 2.96E-4
RARB ENSG00000077092 5915 Cytoplasm/Nucleus 255.0 2612.655 1.56E-6 0.175
VDR ENSG00000111424 7421 Cytoplasm/Nucleus 157.0 7347.984 1.56E-6 0.0471
AKT1 ENSG00000142208 207 Membrane 52751.0 2150216.0 1.57E-6 1.74E-5
PRKCG ENSG00000126583 5582 Membrane/Nucleus 5825.0 68771.35 1.56E-6 5.68E-4
HDAC3 ENSG00000171720 8841 Unknown 1077.0 29858.58 1.56E-6 0.0142
MAPK14 ENSG00000112062 1432 Unknown 9287.0 426504.4 1.56E-6 2.57E-4
PRKACA ENSG00000072062 5566 Unknown 11354.0 1165923.0 1.56E-6 1.85E-4
CCNH ENSG00000134480 902 Nucleus 2243.0 14216.22 1.55E-6 0.00223
CREBBP ENSG00000005339 1387 Nucleus 4940.0 1649017.0 1.57E-6 0.00177
HDAC1 ENSG00000116478 3065 Nucleus 3183.0 335630.1 1.56E-6 0.00344
KAT2B ENSG00000114166 8850 Nucleus 1184.0 53639.25 1.56E-6 0.012
NCOA1 ENSG00000084676 8648 Nucleus 813.0 64652.71 1.56E-6 0.00959
NCOA2 ENSG00000140396 10499 Nucleus 654.0 29031.22 1.56E-6 0.0139
RARA ENSG00000131759 5914 Nucleus 385.0 11755.52 1.56E-6 0.0894
RARG ENSG00000172819 5916 Nucleus 182.0 1431.724 1.55E-6 0.276
RXRA ENSG00000186350 6256 Nucleus 1193.0 410424.8 1.56E-6 0.0127
RXRB ENSG00000204231 6257 Nucleus 309.0 36707.6 1.56E-6 0.0177
RXRG ENSG00000143171 6258 Nucleus 253.0 21386.04 1.55E-6 0.0186
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
RBP1 ENSG00000114115 5947 Cytoplasm 3.0 0.00901 1.35685E-4 0.0
CDK1 ENSG00000170312 983 Cytoplasm/Nucleus 355.0 19300.0 1.66639E-4 0.018747513
CDK7 ENSG00000134058 1022 Cytoplasm/Nucleus 21.0 3.7 1.40509E-4 0.133333333
EP300 ENSG00000100393 2033 Cytoplasm/Nucleus 1723.0 164000.0 1.88644E-4 0.004008081
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 5647.0 122000.0 1.91571E-4 4.01908E-4
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 5295.0 94900.0 1.89179E-4 3.9334E-4
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 2657.0 58300.0 1.84366E-4 0.001118607
MNAT1 ENSG00000020426 4331 Cytoplasm/Nucleus 15.0 1.33 1.39063E-4 0.190476191
NCOA3 ENSG00000124151 8202 Cytoplasm/Nucleus 111.0 334.0 1.5758E-4 0.070925471
NCOR2 ENSG00000196498 9612 Cytoplasm/Nucleus 256.0 4780.0 1.64366E-4 0.044362745
NRIP1 ENSG00000180530 8204 Cytoplasm/Nucleus 62.0 143.0 1.55788E-4 0.096774194
PRKCA ENSG00000154229 5578 Cytoplasm/Nucleus 1524.0 27000.0 1.76274E-4 0.003369162
RARB ENSG00000077092 5915 Cytoplasm/Nucleus 47.0 129.0 1.46434E-4 0.130434783
VDR ENSG00000111424 7421 Cytoplasm/Nucleus 98.0 439.0 1.58053E-4 0.069640227
AKT1 ENSG00000142208 207 Membrane 9285.0 328000.0 1.9976E-4 2.07281E-4
PRKCG ENSG00000126583 5582 Membrane/Nucleus 407.0 445.0 1.60411E-4 0.008823423
HDAC3 ENSG00000171720 8841 Unknown 290.0 2660.0 1.60849E-4 0.039327049
MAPK14 ENSG00000112062 1432 Unknown 1830.0 65300.0 1.85494E-4 0.002225827
PRKACA ENSG00000072062 5566 Unknown 847.0 45000.0 1.78285E-4 0.005216576
CCNH ENSG00000134480 902 Nucleus 22.0 4.01 1.39198E-4 0.121212121
CREBBP ENSG00000005339 1387 Nucleus 1251.0 92700.0 1.87512E-4 0.006373142
HDAC1 ENSG00000116478 3065 Nucleus 930.0 43900.0 1.76647E-4 0.010037386
KAT2B ENSG00000114166 8850 Nucleus 334.0 3330.0 1.68492E-4 0.02609196
NCOA1 ENSG00000084676 8648 Nucleus 246.0 5960.0 1.5977E-4 0.02402522
NCOA2 ENSG00000140396 10499 Nucleus 182.0 2040.0 1.61368E-4 0.026835043
RARA ENSG00000131759 5914 Nucleus 85.0 710.0 1.51194E-4 0.067787115
RARG ENSG00000172819 5916 Nucleus 57.0 283.0 1.47754E-4 0.125313283
RXRA ENSG00000186350 6256 Nucleus 117.0 5320.0 1.58907E-4 0.049955791
RXRB ENSG00000204231 6257 Nucleus 78.0 1270.0 1.49165E-4 0.065601066
RXRG ENSG00000143171 6258 Nucleus 67.0 787.0 1.50128E-4 0.074174582
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
AKT1 CREBBP 4
AKT1 EP300 6
AKT1 NCOR2 2
AKT1 NRIP1 1
AKT1 RARA 4
CCNH AKT1 1
CCNH CDK1 3
CCNH CDK7 7
CCNH EP300 3
CCNH MNAT1 7
CCNH RARA 2
CCNH RARG 1
CDK1 AKT1 1
CDK1 CDK7 4
CDK1 MAPK3 1
CDK1 NCOA3 1
CDK1 RXRA 1
CDK7 AKT1 1
CDK7 MNAT1 7
CDK7 RARA 4
CDK7 RARG 2
CREBBP EP300 5
CREBBP HDAC1 3
CREBBP HDAC3 3
CREBBP KAT2B 6
CREBBP MAPK3 2
CREBBP NCOA1 8
CREBBP NCOA2 6
CREBBP NCOA3 7
CREBBP RARA 5
CREBBP RARB 3
CREBBP RXRA 3
CREBBP VDR 3
EP300 HDAC1 4
EP300 HDAC3 2
EP300 KAT2B 7
EP300 NCOA1 6
EP300 NCOA2 5
EP300 NCOA3 7
EP300 RARA 3
EP300 RXRA 2
EP300 VDR 2
HDAC1 HDAC3 3
HDAC1 NCOR2 7
HDAC1 NRIP1 3
HDAC1 RARA 2
HDAC1 RARB 2
HDAC3 KAT2B 2
HDAC3 NCOR2 7
HDAC3 NRIP1 4
HDAC3 RARA 4
HDAC3 RARB 2
HDAC3 RXRA 3
KAT2B MAPK3 3
KAT2B NCOA1 4
KAT2B NCOA2 1
KAT2B NCOA3 5
KAT2B RARA 4
KAT2B RARB 2
KAT2B RARG 2
MAPK14 MAPK3 5
MAPK14 NCOA3 5
MAPK14 RARG 1
MAPK1 AKT1 2
MAPK1 CREBBP 1
MAPK1 MAPK3 4
MAPK1 NCOA1 2
MAPK1 NCOA2 1
MAPK1 NCOR2 1
MAPK1 NRIP1 1
MAPK1 RARA 3
MAPK1 RXRA 5
MAPK1 VDR 2
MAPK3 AKT1 1
MAPK3 NCOA1 1
MAPK3 NCOA2 1
MAPK3 NCOR2 1
MAPK3 NRIP1 1
MAPK3 RARG 2
MAPK3 RXRA 4
MAPK3 VDR 2
MAPK8 NCOA3 2
MAPK8 RARA 2
MAPK8 RXRA 2
MNAT1 AKT1 1
MNAT1 CDK1 1
MNAT1 RARA 1
MNAT1 RARG 1
NCOA1 NCOA2 5
NCOA1 NCOA3 3
NCOA1 RARA 6
NCOA1 RARB 4
NCOA1 RARG 4
NCOA1 RXRA 6
NCOA1 RXRB 5
NCOA1 VDR 5
NCOA2 NCOA3 4
NCOA2 RARA 5
NCOA2 RXRA 5
NCOA3 RARA 6
NCOA3 RARB 3
NCOA3 RARG 5
NCOA3 RXRA 4
NCOA3 VDR 3
NCOR2 RARA 6
NCOR2 RARB 4
NCOR2 RARG 4
NCOR2 RXRA 5
NCOR2 RXRG 4
NCOR2 VDR 2
NRIP1 RARA 4
NRIP1 RXRA 3
NRIP1 RXRB 3
PRKACA AKT1 1
PRKACA NCOA3 1
PRKACA RARA 3
PRKACA RARG 1
PRKACA RXRA 1
PRKACA VDR 1
PRKCA AKT1 2
PRKCA EP300 1
PRKCA MAPK1 1
PRKCA MAPK3 1
PRKCA RARA 2
PRKCA VDR 1
PRKCG AKT1 1
PRKCG RARA 1
RARA RXRA 10
RARA RXRB 5
RARA RXRG 5
RARB AKT1 1
RARB RXRA 5
RARB RXRB 6
RARB RXRG 5
RARG AKT1 1
RARG RXRA 5
RARG RXRB 4
RARG RXRG 6
RBP1 AKT1 1
RXRA VDR 8
RXRB VDR 5
RXRG VDR 4
AKT1 HDAC3 1
AKT1 KAT2B 2
AKT1 MAPK14 3
AKT1 MAPK8 2
AKT1 NCOA2 1
AKT1 RXRA 1
AKT1 RXRB 1
AKT1 RXRG 1
CCNH RARB 2
CCNH RXRA 1
CDK1 EP300 1
CDK1 NCOA2 2
CDK1 PRKACA 1
CDK1 RARA 2
CDK7 CREBBP 1
CDK7 EP300 2
CDK7 VDR 2
CREBBP NCOR2 2
CREBBP RARG 1
CREBBP RXRG 1
EP300 MAPK1 2
EP300 MAPK8 1
EP300 MNAT1 1
EP300 NCOR2 1
EP300 NRIP1 1
EP300 RARB 2
EP300 RARG 2
HDAC1 MAPK14 1
HDAC1 MAPK8 1
HDAC1 PRKACA 2
HDAC1 RARG 1
HDAC1 RBP1 1
HDAC1 RXRA 1
HDAC1 RXRB 1
HDAC1 RXRG 1
HDAC3 MAPK14 1
HDAC3 RARG 2
HDAC3 RXRB 1
HDAC3 RXRG 1
KAT2B HDAC1 1
KAT2B NRIP1 1
MAPK14 CREBBP 1
MAPK14 EP300 1
MAPK14 KAT2B 1
MAPK14 MAPK8 2
MAPK14 RARA 1
MAPK14 RARB 1
MAPK1 MAPK14 4
MAPK1 MAPK8 2
MAPK1 NCOA3 2
MAPK1 RARB 1
MAPK1 RARG 1
MAPK1 RXRB 1
MAPK1 RXRG 1
MAPK3 MAPK8 1
MAPK3 RARA 1
MAPK3 RARB 1
MAPK3 RXRB 1
MAPK3 RXRG 1
NCOA1 HDAC1 1
NCOA1 HDAC3 1
NCOA2 RARB 1
NCOA2 RARG 1
NCOA2 VDR 4
NCOA3 HDAC1 1
NCOA3 HDAC3 1
NCOA3 NCOR2 2
NCOA3 NRIP1 1
NCOA3 RXRB 2
NCOR2 RXRB 1
NRIP1 VDR 3
PRKACA CREBBP 1
PRKACA EP300 1
PRKACA MAPK1 1
PRKACA MAPK3 1
PRKCA PRKACA 1
PRKCA RXRA 1
PRKCA RXRB 1
PRKCA RXRG 1
PRKCG PRKACA 1
PRKCG RXRA 1
PRKCG RXRB 1
PRKCG RXRG 1
RARA RARG 1
RARA VDR 1
RARB NRIP1 1
RARB VDR 1
RARG NRIP1 1
RARG VDR 1
RXRG NRIP1 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail