Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0001940 RORA activates gene expression Reactome Homo sapiens 27 204
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
CPT1A ENSG00000110090 1374 Cytoplasm 0.02777778 21.0 2.664427 0.4047619
ARNTL ENSG00000133794 406 Cytoplasm/Nucleus 0.02564103 32.0 2.856125 0.11693548
CHD9 ENSG00000177200 80205 Cytoplasm/Nucleus 0.02173913 9.0 0.025 0.38888889
EP300 ENSG00000100393 2033 Cytoplasm/Nucleus 0.03448276 44.0 19.19041 0.15010571
NCOA6 ENSG00000198646 23054 Cytoplasm/Nucleus 0.02564103 19.0 0.3388009 0.40935673
NRIP1 ENSG00000180530 8204 Cytoplasm/Nucleus 0.02380952 16.0 0.8723005 0.28333333
PPARA ENSG00000186951 5465 Cytoplasm/Nucleus 0.03703704 59.0 36.98179 0.09760374
SIRT1 ENSG00000096717 23411 Cytoplasm/Nucleus 0.02272727 18.0 1.322198 0.13071895
TGS1 ENSG00000137574 96764 Cytoplasm/Nucleus 0.025 14.0 0.2415158 0.64835165
HDAC3 ENSG00000171720 8841 Unknown 0.02631579 31.0 5.613893 0.14193548
HELZ2 ENSG00000130589 85441 Unknown 0.025 14.0 0.2415158 0.64835165
NCOR1 ENSG00000141027 9611 Unknown 0.02777778 27.0 4.731634 0.23361823
SMARCD3 ENSG00000082014 6604 Unknown 0.02380952 14.0 1.236711 0.36263736
SREBF1 ENSG00000072310 6720 Unknown 0.02380952 18.0 1.553286 0.19607843
CARM1 ENSG00000142453 10498 Nucleus 0.02439024 15.0 0.6492071 0.42857143
CLOCK ENSG00000134852 9575 Nucleus 0.02380952 25.0 1.650805 0.12
CREBBP ENSG00000005339 1387 Nucleus 0.03125 35.0 7.054877 0.21512605
MED1 ENSG00000125686 5469 Nucleus 0.03030303 28.0 4.233256 0.30687831
NCOA1 ENSG00000084676 8648 Nucleus 0.02941176 27.0 2.463446 0.32763533
NCOA2 ENSG00000140396 10499 Nucleus 0.02777778 25.0 2.355133 0.29666667
NPAS2 ENSG00000170485 4862 Nucleus 0.03225806 37.0 11.95968 0.18468468
NR1D1 ENSG00000126368 9572 Nucleus 0.025 33.0 2.799675 0.09469697
PPARGC1A ENSG00000109819 10891 Nucleus 0.02941176 35.0 7.726253 0.15798319
RORA ENSG00000069667 6095 Nucleus 0.02631579 29.0 6.096077 0.13546798
RXRA ENSG00000186350 6256 Nucleus 0.03448276 41.0 17.29249 0.17804878
TBL1X ENSG00000101849 6907 Nucleus 0.02857143 22.0 3.424742 0.41125541
TBL1XR1 ENSG00000177565 79718 Nucleus 0.02857143 22.0 3.424742 0.41125541
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
CPT1A ENSG00000110090 1374 Cytoplasm 415.0 13300.09 1.55E-6 0.008544322
ARNTL ENSG00000133794 406 Cytoplasm/Nucleus 423.0 18601.47 1.55E-6 0.002207209
CHD9 ENSG00000177200 80205 Cytoplasm/Nucleus 124.0 4512.832 1.55E-6 0.029766588
EP300 ENSG00000100393 2033 Cytoplasm/Nucleus 6386.0 1381818.0 1.56E-6 0.00143089
NCOA6 ENSG00000198646 23054 Cytoplasm/Nucleus 388.0 17501.38 1.56E-6 0.083553105
NRIP1 ENSG00000180530 8204 Cytoplasm/Nucleus 141.0 458.9925 1.55E-6 0.032320162
PPARA ENSG00000186951 5465 Cytoplasm/Nucleus 739.0 80318.34 1.56E-6 0.006135149
SIRT1 ENSG00000096717 23411 Cytoplasm/Nucleus 674.0 56887.81 1.56E-6 0.023311185
TGS1 ENSG00000137574 96764 Cytoplasm/Nucleus 183.0 16362.52 1.55E-6 0.033087131
HDAC3 ENSG00000171720 8841 Unknown 1077.0 29858.58 1.56E-6 0.014205438
HELZ2 ENSG00000130589 85441 Unknown 231.0 1965.095 1.55E-6 0.059288538
NCOR1 ENSG00000141027 9611 Unknown 1027.0 49276.93 1.56E-6 0.014197562
SMARCD3 ENSG00000082014 6604 Unknown 259.0 6815.993 1.55E-6 0.055460776
SREBF1 ENSG00000072310 6720 Unknown 309.0 119059.6 1.55E-6 0.016475434
CARM1 ENSG00000142453 10498 Nucleus 279.0 5414.089 1.55E-6 0.026430469
CLOCK ENSG00000134852 9575 Nucleus 409.0 16929.58 1.55E-6 0.007646579
CREBBP ENSG00000005339 1387 Nucleus 4940.0 1649017.0 1.57E-6 0.001769605
MED1 ENSG00000125686 5469 Nucleus 683.0 493974.1 1.56E-6 0.010927296
NCOA1 ENSG00000084676 8648 Nucleus 813.0 64652.71 1.56E-6 0.009594702
NCOA2 ENSG00000140396 10499 Nucleus 654.0 29031.22 1.56E-6 0.013946453
NPAS2 ENSG00000170485 4862 Nucleus 299.0 8877.309 1.55E-6 0.005791116
NR1D1 ENSG00000126368 9572 Nucleus 216.0 3443.745 1.55E-6 0.005512489
PPARGC1A ENSG00000109819 10891 Nucleus 604.0 39611.43 1.56E-6 0.010032618
RORA ENSG00000069667 6095 Nucleus 142.0 952.9313 1.55E-6 0.013585056
RXRA ENSG00000186350 6256 Nucleus 1193.0 410424.8 1.56E-6 0.012691483
TBL1X ENSG00000101849 6907 Nucleus 503.0 14512.85 1.55E-6 0.033274457
TBL1XR1 ENSG00000177565 79718 Nucleus 496.0 12799.37 1.55E-6 0.035288368
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
CPT1A ENSG00000110090 1374 Cytoplasm 81.0 14800.0 3.99E-7 0.088580247
ARNTL ENSG00000133794 406 Cytoplasm/Nucleus 230.0 27800.0 3.99E-7 0.005771787
CHD9 ENSG00000177200 80205 Cytoplasm/Nucleus 124.0 15900.0 3.99E-7 0.029504327
EP300 ENSG00000100393 2033 Cytoplasm/Nucleus 2106.0 1670000.0 4.0E-7 0.007161531
NCOA6 ENSG00000198646 23054 Cytoplasm/Nucleus 343.0 51000.0 3.99E-7 0.098699129
NRIP1 ENSG00000180530 8204 Cytoplasm/Nucleus 49.0 32.2 3.99E-7 0.032312925
PPARA ENSG00000186951 5465 Cytoplasm/Nucleus 569.0 120000.0 3.99E-7 0.006596698
SIRT1 ENSG00000096717 23411 Cytoplasm/Nucleus 227.0 31200.0 3.99E-7 0.090639741
TGS1 ENSG00000137574 96764 Cytoplasm/Nucleus 174.0 35500.0 3.99E-7 0.035878015
HDAC3 ENSG00000171720 8841 Unknown 709.0 143000.0 3.99E-7 0.022248253
HELZ2 ENSG00000130589 85441 Unknown 231.0 20100.0 3.99E-7 0.059175607
NCOR1 ENSG00000141027 9611 Unknown 674.0 63900.0 3.99E-7 0.022627766
SMARCD3 ENSG00000082014 6604 Unknown 214.0 23800.0 3.99E-7 0.058180861
SREBF1 ENSG00000072310 6720 Unknown 162.0 183000.0 3.99E-7 0.033893106
CARM1 ENSG00000142453 10498 Nucleus 226.0 35100.0 3.99E-7 0.030442478
CLOCK ENSG00000134852 9575 Nucleus 232.0 38100.0 3.99E-7 0.022204807
CREBBP ENSG00000005339 1387 Nucleus 1505.0 1380000.0 4.0E-7 0.009085849
MED1 ENSG00000125686 5469 Nucleus 591.0 932000.0 3.99E-7 0.012159798
NCOA1 ENSG00000084676 8648 Nucleus 413.0 84800.0 3.99E-7 0.022320694
NCOA2 ENSG00000140396 10499 Nucleus 421.0 62200.0 3.99E-7 0.02425065
NPAS2 ENSG00000170485 4862 Nucleus 225.0 33200.0 3.99E-7 0.009365079
NR1D1 ENSG00000126368 9572 Nucleus 186.0 13000.0 3.99E-7 0.005928509
PPARGC1A ENSG00000109819 10891 Nucleus 349.0 123000.0 3.99E-7 0.023630735
RORA ENSG00000069667 6095 Nucleus 127.0 5240.0 3.99E-7 0.013498313
RXRA ENSG00000186350 6256 Nucleus 731.0 1020000.0 3.99E-7 0.027712085
TBL1X ENSG00000101849 6907 Nucleus 413.0 32900.0 3.99E-7 0.040715579
TBL1XR1 ENSG00000177565 79718 Nucleus 418.0 42400.0 3.99E-7 0.040228105
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
ARNTL CLOCK 6
ARNTL EP300 2
ARNTL NPAS2 5
ARNTL PPARA 1
CARM1 CREBBP 3
CARM1 EP300 5
CARM1 NCOA2 3
CARM1 PPARA 1
CHD9 PPARA 4
CHD9 RXRA 3
CLOCK NPAS2 2
CLOCK NR1D1 3
CLOCK PPARA 1
CLOCK RORA 2
CREBBP EP300 5
CREBBP HDAC3 3
CREBBP MED1 3
CREBBP NCOA1 8
CREBBP NCOA2 6
CREBBP NCOA6 4
CREBBP NCOR1 2
CREBBP NPAS2 3
CREBBP PPARA 2
CREBBP PPARGC1A 3
CREBBP RXRA 3
EP300 HDAC3 2
EP300 MED1 3
EP300 NCOA1 6
EP300 NCOA2 5
EP300 NCOA6 3
EP300 NPAS2 3
EP300 NR1D1 1
EP300 PPARGC1A 4
EP300 RORA 3
EP300 RXRA 2
EP300 SIRT1 4
EP300 SREBF1 2
HDAC3 CLOCK 2
HDAC3 NCOR1 7
HDAC3 NPAS2 1
HDAC3 NR1D1 3
HDAC3 NRIP1 4
HDAC3 RXRA 3
HDAC3 TBL1X 6
HDAC3 TBL1XR1 5
HELZ2 PPARA 3
MED1 NCOA1 2
MED1 PPARA 2
MED1 PPARGC1A 3
MED1 RORA 2
MED1 RXRA 6
NCOA1 NCOA2 5
NCOA1 PPARA 3
NCOA1 PPARGC1A 3
NCOA1 RXRA 6
NCOA2 PPARA 2
NCOA2 RXRA 5
NCOA6 PPARA 2
NCOA6 RXRA 4
NCOR1 NPAS2 1
NCOR1 NR1D1 5
NCOR1 PPARA 4
NCOR1 RXRA 2
NCOR1 TBL1X 5
NCOR1 TBL1XR1 5
NPAS2 NR1D1 3
NR1D1 ARNTL 3
NRIP1 PPARGC1A 2
NRIP1 RXRA 3
PPARA CPT1A 3
PPARA PPARGC1A 3
PPARA RXRA 7
PPARA TGS1 2
PPARGC1A RXRA 3
PPARGC1A SIRT1 3
RORA ARNTL 3
RORA SREBF1 1
RXRA CPT1A 2
RXRA SMARCD3 3
SIRT1 SREBF1 3
SMARCD3 TBL1X 2
SMARCD3 TBL1XR1 2
TBL1X TBL1XR1 6
ARNTL CREBBP 1
ARNTL RXRA 1
CARM1 CPT1A 1
CARM1 NCOA1 2
CARM1 NPAS2 1
CARM1 NRIP1 2
CARM1 RXRA 1
CARM1 TBL1X 1
CARM1 TBL1XR1 1
CHD9 CPT1A 1
CHD9 NPAS2 1
CHD9 TBL1X 1
CHD9 TBL1XR1 1
CLOCK EP300 1
CLOCK RXRA 1
CPT1A EP300 1
CPT1A RORA 1
CREBBP CPT1A 1
CREBBP HELZ2 1
CREBBP SMARCD3 1
CREBBP SREBF1 4
CREBBP TBL1X 1
CREBBP TBL1XR1 1
CREBBP TGS1 2
EP300 HELZ2 1
EP300 NCOR1 1
EP300 NRIP1 1
EP300 PPARA 2
EP300 SMARCD3 1
EP300 TGS1 2
HDAC3 ARNTL 1
HDAC3 PPARA 1
HDAC3 PPARGC1A 1
HELZ2 CPT1A 1
HELZ2 MED1 1
HELZ2 NCOA1 1
HELZ2 NCOA2 1
HELZ2 NPAS2 1
HELZ2 PPARGC1A 1
HELZ2 RXRA 1
HELZ2 TBL1X 1
HELZ2 TBL1XR1 1
MED1 CPT1A 1
MED1 NCOA2 1
MED1 NCOA6 2
MED1 NCOR1 1
MED1 NPAS2 1
MED1 NR1D1 1
MED1 NRIP1 1
MED1 SREBF1 4
MED1 TBL1X 1
MED1 TBL1XR1 1
MED1 TGS1 2
NCOA1 CPT1A 1
NCOA1 HDAC3 1
NCOA1 NCOA6 3
NCOA1 NCOR1 1
NCOA1 NPAS2 1
NCOA1 RORA 3
NCOA1 TBL1X 1
NCOA1 TBL1XR1 1
NCOA1 TGS1 1
NCOA2 CPT1A 1
NCOA2 NCOA6 1
NCOA2 NPAS2 1
NCOA2 PPARGC1A 1
NCOA2 RORA 1
NCOA2 TBL1X 1
NCOA2 TBL1XR1 1
NCOA6 CPT1A 1
NCOA6 NPAS2 1
NCOA6 PPARGC1A 2
NCOA6 TBL1X 1
NCOA6 TBL1XR1 1
NCOA6 TGS1 2
NCOR1 ARNTL 1
NCOR1 CLOCK 1
NCOR1 PPARGC1A 1
NCOR1 SIRT1 2
NCOR1 SREBF1 2
NRIP1 ARNTL 1
NRIP1 NR1D1 1
NRIP1 PPARA 2
NRIP1 RORA 1
PPARA NPAS2 2
PPARA NR1D1 1
PPARA RORA 1
PPARGC1A ARNTL 1
PPARGC1A NR1D1 1
PPARGC1A RORA 1
PPARGC1A TGS1 1
RORA NPAS2 2
RORA NR1D1 1
RORA SMARCD3 2
RXRA NPAS2 2
RXRA SREBF1 1
RXRA TBL1X 1
RXRA TBL1XR1 1
RXRA TGS1 1
SIRT1 ARNTL 1
SIRT1 CLOCK 1
SIRT1 NCOA2 1
SIRT1 PPARA 1
SMARCD3 CPT1A 1
SMARCD3 NPAS2 1
SMARCD3 PPARA 1
SMARCD3 SREBF1 2
SREBF1 NR1D1 1
SREBF1 PPARGC1A 1
TBL1X CPT1A 1
TBL1X NPAS2 1
TBL1X PPARA 1
TBL1XR1 CPT1A 1
TBL1XR1 NPAS2 1
TBL1XR1 PPARA 1
TBL1XR1 TGS1 1
TBL1X TGS1 1
TGS1 CPT1A 1
TGS1 NPAS2 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0001940 pathway0000430 25 0.9259259 Circadian Clock Reactome 49 389
pathway0001940 pathway0001704 25 0.9259259 PPARA activates gene expression Reactome 113 1887
pathway0001940 pathway0000316 24 0.8888889 BMAL1:CLOCK,NPAS2 activates circadian gene expression Reactome 42 282
pathway0001940 pathway0001846 16 0.8 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Reactome 20 122
pathway0001940 pathway0001527 6 0.75 NR1D1 (REV-ERBA) represses gene expression Reactome 8 21
pathway0001940 pathway0002302 19 0.7037037 Transcriptional regulation of white adipocyte differentiation Reactome 79 1522
pathway0001940 pathway0002299 18 0.6666667 Transcriptional activation of mitochondrial biogenesis Reactome 43 230
pathway0001940 pathway0002857 4 0.6666667 Hs_SREBF_and_miR33_in_cholesterol_and_lipid_homeostasis_WP2011_89947 WikiPathways 6 12
pathway0001940 pathway0000069 15 0.5555556 Activation of gene expression by SREBF (SREBP) Reactome 42 266
pathway0001940 pathway0002460 14 0.5185185 YAP1- and WWTR1 (TAZ)-stimulated gene expression Reactome 29 144