Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002044 Signaling mediated by p38-alpha and p38-beta PID Homo sapiens 35 174
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
GDI1 ENSG00000203879 2664 Cytoplasm 0.01587302 8.0 1.61951 0.25
KRT19 ENSG00000171345 3880 Cytoplasm 0.015625 7.0 0.0 0.28571429
NOS2 ENSG00000007171 4843 Cytoplasm 0.01666667 8.0 0.1483946 0.89285714
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 0.02040816 44.0 7.519403 0.08773784
ATF6 ENSG00000118217 22926 Cytoplasm/Nucleus 0.01538462 9.0 0.05263158 0.13888889
CEBPB ENSG00000172216 1051 Cytoplasm/Nucleus 0.01754386 24.0 1.541426 0.14130435
EIF4E ENSG00000151247 1977 Cytoplasm/Nucleus 0.01639344 16.0 1.181342 0.125
EIF4EBP1 ENSG00000187840 1978 Cytoplasm/Nucleus 0.01612903 12.0 1.065369 0.10606061
ESR1 ENSG00000091831 2099 Cytoplasm/Nucleus 0.01851852 39.0 6.002004 0.07557355
HSPB1 ENSG00000106211 3315 Cytoplasm/Nucleus 0.01666667 25.0 1.794972 0.09
JUN ENSG00000177606 3725 Cytoplasm/Nucleus 0.02272727 49.0 47.73048 0.07908163
KRT8 ENSG00000170421 3856 Cytoplasm/Nucleus 0.01639344 11.0 0.2095912 0.32727273
MAPK11 ENSG00000185386 5600 Cytoplasm/Nucleus 0.02702703 95.0 118.4363 0.02665174
MAPKAPK2 ENSG00000162889 9261 Cytoplasm/Nucleus 0.01666667 33.0 1.771987 0.04545455
MAPKAPK3 ENSG00000114738 7867 Cytoplasm/Nucleus 0.01612903 20.0 0.387324 0.06315789
MAPKAPK5 ENSG00000089022 8550 Cytoplasm/Nucleus 0.01754386 24.0 2.630662 0.11594203
MITF ENSG00000187098 4286 Cytoplasm/Nucleus 0.01639344 11.0 0.0 0.38181818
PLA2G4A ENSG00000116711 5321 Cytoplasm/Nucleus 0.01639344 14.0 0.9735718 0.13186813
PTGS2 ENSG00000073756 5743 Cytoplasm/Nucleus 0.01666667 11.0 0.5801821 0.38181818
RPS6KA5 ENSG00000100784 9252 Cytoplasm/Nucleus 0.01639344 23.0 3.311042 0.06719368
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 0.01960784 32.0 4.551446 0.15120968
RAB5A ENSG00000144566 5868 Membrane 0.01388889 3.0 0.06722689 0.33333333
SLC9A1 ENSG00000090020 6548 Membrane 0.01538462 6.0 0.0 0.2
MAPK14 ENSG00000112062 1432 Unknown 0.02857143 119.0 213.6892 0.01894317
MKNK1 ENSG00000079277 8569 Unknown 0.01612903 20.0 7.30084 0.03684211
ATF1 ENSG00000123268 466 Nucleus 0.01724138 18.0 1.710506 0.16993464
CREB1 ENSG00000118260 1385 Nucleus 0.01886792 29.0 4.755426 0.1453202
DDIT3 ENSG00000175197 1649 Nucleus 0.01724138 21.0 2.054284 0.13809524
ELK4 ENSG00000158711 2005 Nucleus 0.01492537 8.0 0.0 0.03571429
HBP1 ENSG00000105856 26959 Nucleus 0.01492537 4.0 0.0 0.16666667
MEF2A ENSG00000068305 4205 Nucleus 0.01612903 11.0 0.05063911 0.2
MEF2C ENSG00000081189 4208 Nucleus 0.01612903 15.0 0.1309524 0.12380952
PPARGC1A ENSG00000109819 10891 Nucleus 0.01724138 19.0 0.6755912 0.19298246
RPS6KA4 ENSG00000162302 8986 Nucleus 0.01612903 16.0 1.057666 0.08333333
USF1 ENSG00000158773 7391 Nucleus 0.01538462 6.0 0.0 0.4
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
GDI1 ENSG00000203879 2664 Cytoplasm 41.0 574.0 1.55E-6 0.065853659
KRT19 ENSG00000171345 3880 Cytoplasm 7.0 0.0 1.55E-6 0.285714286
NOS2 ENSG00000007171 4843 Cytoplasm 420.0 34300.0 1.56E-6 0.009853392
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 2727.0 293000.0 1.56E-6 0.004011675
ATF6 ENSG00000118217 22926 Cytoplasm/Nucleus 75.0 15200.0 1.55E-6 0.023423423
CEBPB ENSG00000172216 1051 Cytoplasm/Nucleus 740.0 78400.0 1.56E-6 0.018662912
EIF4E ENSG00000151247 1977 Cytoplasm/Nucleus 833.0 61900.0 1.55E-6 0.008648652
EIF4EBP1 ENSG00000187840 1978 Cytoplasm/Nucleus 1189.0 11000.0 1.55E-6 4.81405E-4
ESR1 ENSG00000091831 2099 Cytoplasm/Nucleus 1715.0 361000.0 1.56E-6 0.005537658
HSPB1 ENSG00000106211 3315 Cytoplasm/Nucleus 611.0 25100.0 1.56E-6 0.007222774
JUN ENSG00000177606 3725 Cytoplasm/Nucleus 12667.0 3720000.0 1.57E-6 4.67389E-4
KRT8 ENSG00000170421 3856 Cytoplasm/Nucleus 80.0 278.0 1.56E-6 0.194936709
MAPK11 ENSG00000185386 5600 Cytoplasm/Nucleus 3606.0 96400.0 1.56E-6 9.00487E-4
MAPKAPK2 ENSG00000162889 9261 Cytoplasm/Nucleus 1421.0 8100.0 1.55E-6 4.68823E-4
MAPKAPK3 ENSG00000114738 7867 Cytoplasm/Nucleus 596.0 900.0 1.55E-6 0.017037956
MAPKAPK5 ENSG00000089022 8550 Cytoplasm/Nucleus 340.0 5340.0 1.55E-6 0.006125282
MITF ENSG00000187098 4286 Cytoplasm/Nucleus 271.0 5930.0 1.55E-6 0.017329507
PLA2G4A ENSG00000116711 5321 Cytoplasm/Nucleus 1333.0 269000.0 1.56E-6 0.003151689
PTGS2 ENSG00000073756 5743 Cytoplasm/Nucleus 1253.0 121000.0 1.56E-6 0.001045414
RPS6KA5 ENSG00000100784 9252 Cytoplasm/Nucleus 627.0 4510.0 1.55E-6 0.00267005
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 8418.0 2450000.0 1.57E-6 7.35566E-4
RAB5A ENSG00000144566 5868 Membrane 237.0 34000.0 1.55E-6 0.010298219
SLC9A1 ENSG00000090020 6548 Membrane 184.0 100000.0 1.55E-6 0.01318603
MAPK14 ENSG00000112062 1432 Unknown 9287.0 427000.0 1.56E-6 2.56589E-4
MKNK1 ENSG00000079277 8569 Unknown 491.0 2300.0 1.55E-6 0.002377489
ATF1 ENSG00000123268 466 Nucleus 146.0 409.0 1.55E-6 0.025129901
CREB1 ENSG00000118260 1385 Nucleus 1632.0 139000.0 1.56E-6 0.00288302
DDIT3 ENSG00000175197 1649 Nucleus 166.0 9880.0 1.55E-6 0.024096386
ELK4 ENSG00000158711 2005 Nucleus 277.0 134.0 1.55E-6 0.001805054
HBP1 ENSG00000105856 26959 Nucleus 34.0 2.12 1.55E-6 0.167557932
MEF2A ENSG00000068305 4205 Nucleus 69.0 1840.0 1.55E-6 0.057544757
MEF2C ENSG00000081189 4208 Nucleus 316.0 28200.0 1.55E-6 0.009222423
PPARGC1A ENSG00000109819 10891 Nucleus 604.0 39600.0 1.56E-6 0.010032618
RPS6KA4 ENSG00000162302 8986 Nucleus 165.0 104.0 1.55E-6 0.008499631
USF1 ENSG00000158773 7391 Nucleus 6.0 0.0 1.54E-6 0.4
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
GDI1 ENSG00000203879 2664 Cytoplasm 8.0 0.0607 1.38274E-4 0.25
KRT19 ENSG00000171345 3880 Cytoplasm 7.0 0.0 1.37571E-4 0.285714286
NOS2 ENSG00000007171 4843 Cytoplasm 106.0 838.0 1.59898E-4 0.059119497
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 579.0 16500.0 1.81917E-4 0.015998231
ATF6 ENSG00000118217 22926 Cytoplasm/Nucleus 9.0 0.0262 1.28189E-4 0.138888889
CEBPB ENSG00000172216 1051 Cytoplasm/Nucleus 287.0 7820.0 1.67392E-4 0.025706001
EIF4E ENSG00000151247 1977 Cytoplasm/Nucleus 66.0 489.0 1.51791E-4 0.067132867
EIF4EBP1 ENSG00000187840 1978 Cytoplasm/Nucleus 106.0 101.0 1.41985E-4 0.019586703
ESR1 ENSG00000091831 2099 Cytoplasm/Nucleus 746.0 61600.0 1.8352E-4 0.010896594
HSPB1 ENSG00000106211 3315 Cytoplasm/Nucleus 46.0 19.0 1.41503E-4 0.057004831
JUN ENSG00000177606 3725 Cytoplasm/Nucleus 3540.0 384000.0 2.07297E-4 0.001375153
KRT8 ENSG00000170421 3856 Cytoplasm/Nucleus 11.0 1.13 1.42126E-4 0.327272727
MAPK11 ENSG00000185386 5600 Cytoplasm/Nucleus 707.0 11900.0 1.75377E-4 0.006070417
MAPKAPK2 ENSG00000162889 9261 Cytoplasm/Nucleus 201.0 377.0 1.53327E-4 0.009452736
MAPKAPK3 ENSG00000114738 7867 Cytoplasm/Nucleus 40.0 3.83 1.38908E-4 0.023076923
MAPKAPK5 ENSG00000089022 8550 Cytoplasm/Nucleus 24.0 3.08 1.42878E-4 0.115942029
MITF ENSG00000187098 4286 Cytoplasm/Nucleus 88.0 433.0 1.58153E-4 0.088819227
PLA2G4A ENSG00000116711 5321 Cytoplasm/Nucleus 131.0 189.0 1.50807E-4 0.038167939
PTGS2 ENSG00000073756 5743 Cytoplasm/Nucleus 61.0 515.0 1.57704E-4 0.106010929
RPS6KA5 ENSG00000100784 9252 Cytoplasm/Nucleus 87.0 44.3 1.44488E-4 0.027800053
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 1240.0 161000.0 1.88751E-4 0.006070192
RAB5A ENSG00000144566 5868 Membrane 108.0 719.0 1.53633E-4 0.027345102
SLC9A1 ENSG00000090020 6548 Membrane 51.0 882.0 1.50083E-4 0.065882353
MAPK14 ENSG00000112062 1432 Unknown 1830.0 65300.0 1.85494E-4 0.002225827
MKNK1 ENSG00000079277 8569 Unknown 20.0 1.11 1.26695E-4 0.036842105
ATF1 ENSG00000123268 466 Nucleus 36.0 4.69 1.46994E-4 0.103174603
CREB1 ENSG00000118260 1385 Nucleus 476.0 19700.0 1.76491E-4 0.012976559
DDIT3 ENSG00000175197 1649 Nucleus 59.0 144.0 1.50625E-4 0.098188194
ELK4 ENSG00000158711 2005 Nucleus 8.0 0.0 1.2536E-4 0.035714286
HBP1 ENSG00000105856 26959 Nucleus 34.0 21.2 1.47145E-4 0.142602496
MEF2A ENSG00000068305 4205 Nucleus 11.0 0.0171 1.37836E-4 0.2
MEF2C ENSG00000081189 4208 Nucleus 93.0 1460.0 1.51194E-4 0.0514259
PPARGC1A ENSG00000109819 10891 Nucleus 75.0 116.0 1.49768E-4 0.043603604
RPS6KA4 ENSG00000162302 8986 Nucleus 39.0 2.96 1.44051E-4 0.056680162
USF1 ENSG00000158773 7391 Nucleus 6.0 0.0 1.30395E-4 0.4
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
ATF1 JUN 3
ATF2 CEBPB 4
ATF2 CREB1 3
ATF2 DDIT3 3
ATF2 ESR1 2
ATF2 JUN 7
ATF2 PPARGC1A 4
ATF2 TP53 2
ATF6 DDIT3 2
CEBPB DDIT3 5
CEBPB ESR1 5
CEBPB JUN 2
CREB1 JUN 5
CREB1 MITF 2
EIF4E EIF4EBP1 9
ESR1 HSPB1 2
ESR1 JUN 7
ESR1 TP53 4
GDI1 JUN 2
JUN KRT19 3
JUN KRT8 2
JUN MEF2C 2
JUN PTGS2 2
JUN TP53 4
MAPK11 ATF2 8
MAPK11 ATF6 1
MAPK11 CEBPB 1
MAPK11 CREB1 1
MAPK11 DDIT3 3
MAPK11 EIF4E 1
MAPK11 ESR1 1
MAPK11 GDI1 1
MAPK11 HSPB1 1
MAPK11 JUN 2
MAPK11 KRT19 1
MAPK11 KRT8 1
MAPK11 MAPK14 3
MAPK11 MAPKAPK2 8
MAPK11 MAPKAPK3 7
MAPK11 MAPKAPK5 5
MAPK11 MEF2A 2
MAPK11 MEF2C 4
MAPK11 MITF 1
MAPK11 MKNK1 5
MAPK11 PLA2G4A 2
MAPK11 PPARGC1A 2
MAPK11 RPS6KA4 3
MAPK11 RPS6KA5 6
MAPK11 SLC9A1 1
MAPK11 TP53 6
MAPK11 USF1 1
MAPK14 ATF1 1
MAPK14 ATF2 8
MAPK14 ATF6 2
MAPK14 CEBPB 1
MAPK14 DDIT3 4
MAPK14 EIF4E 1
MAPK14 ELK4 2
MAPK14 ESR1 2
MAPK14 GDI1 1
MAPK14 HSPB1 2
MAPK14 JUN 3
MAPK14 KRT19 1
MAPK14 MAPKAPK2 11
MAPK14 MAPKAPK3 8
MAPK14 MAPKAPK5 7
MAPK14 MEF2A 6
MAPK14 MEF2C 9
MAPK14 MITF 3
MAPK14 MKNK1 8
MAPK14 PLA2G4A 4
MAPK14 PPARGC1A 4
MAPK14 RPS6KA4 7
MAPK14 RPS6KA5 9
MAPK14 SLC9A1 3
MAPK14 TP53 8
MAPK14 USF1 2
MAPKAPK2 CREB1 4
MAPKAPK2 HSPB1 5
MAPKAPK2 TP53 1
MAPKAPK5 TP53 5
MEF2C PPARGC1A 1
MKNK1 EIF4E 5
MKNK1 PLA2G4A 4
PLA2G4A PTGS2 3
RPS6KA4 ATF1 1
RPS6KA4 CREB1 2
RPS6KA4 EIF4EBP1 1
RPS6KA5 ATF1 5
RPS6KA5 CREB1 4
RPS6KA5 EIF4EBP1 1
ATF1 ATF2 2
ATF1 CREB1 4
ATF1 DDIT3 1
ATF1 ESR1 1
ATF2 GDI1 1
ATF2 HSPB1 2
ATF2 KRT8 3
ATF2 MAPKAPK3 1
ATF2 MAPKAPK5 1
ATF2 MITF 1
ATF2 NOS2 1
ATF2 PTGS2 1
ATF2 RPS6KA5 3
ATF6 CREB1 2
CEBPB CREB1 2
CEBPB MITF 1
CEBPB PLA2G4A 1
CEBPB RPS6KA5 1
CEBPB TP53 1
CREB1 ESR1 1
CREB1 MAPK14 2
CREB1 MAPKAPK5 1
CREB1 PPARGC1A 2
CREB1 TP53 3
DDIT3 JUN 2
DDIT3 MEF2C 1
DDIT3 PPARGC1A 1
EIF4EBP1 MAPK14 2
EIF4EBP1 MAPKAPK5 3
EIF4E MAPKAPK5 1
ELK4 MAPK11 2
ESR1 MAPKAPK2 2
ESR1 NOS2 1
ESR1 PPARGC1A 2
ESR1 USF1 2
GDI1 RAB5A 1
HBP1 MAPK11 1
HBP1 MAPK14 1
HSPB1 MAPKAPK3 3
HSPB1 MAPKAPK5 3
HSPB1 NOS2 1
HSPB1 TP53 3
JUN EIF4E 1
JUN MAPKAPK3 1
JUN MAPKAPK5 1
JUN MEF2A 2
JUN MITF 1
JUN NOS2 1
JUN PPARGC1A 1
JUN RAB5A 1
JUN RPS6KA4 1
JUN SLC9A1 1
KRT19 KRT8 1
KRT8 MAPK14 2
KRT8 NOS2 1
KRT8 TP53 1
MAPK11 NOS2 1
MAPK11 PTGS2 1
MAPK14 NOS2 1
MAPK14 PTGS2 1
MAPKAPK2 ATF1 1
MAPKAPK2 MAPKAPK5 1
MAPKAPK3 MEF2A 2
MAPKAPK5 PLA2G4A 2
MEF2A MAPKAPK2 1
MEF2A MEF2C 2
MKNK1 EIF4EBP1 1
MKNK1 RAB5A 2
NOS2 TP53 1
PLA2G4A RPS6KA5 2
PPARGC1A TP53 1
PPARGC1A USF1 2
PTGS2 ATF1 1
PTGS2 ESR1 1
PTGS2 TP53 3
TP53 DDIT3 1
TP53 EIF4E 1
TP53 MITF 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002044 pathway0000501 4 0.5714286 CREB phosphorylation Reactome 7 11