Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002140 Surfactant metabolism Reactome Homo sapiens 30 71
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
NAPSA ENSG00000131400 9476 Cytoplasm 0.01724138 2.0 0.0 1.0
ABCA3 ENSG00000167972 21 Membrane 0.01408451 6.0 1.666667 0.0
ADORA2A ENSG00000128271 135 Membrane 0.01785714 5.0 3.333333 0.1
ADORA2B ENSG00000170425 136 Membrane 0.01785714 5.0 3.333333 0.1
ADRA2C ENSG00000184160 152 Membrane 0.01785714 5.0 3.333333 0.1
CKAP4 ENSG00000136026 10970 Membrane 0.015625 4.0 25.225 0.16666667
CSF2RB ENSG00000100368 1439 Membrane 0.02083333 9.0 0.225 0.52777778
DMBT1 ENSG00000187908 1755 Membrane 0.01538462 6.0 0.325 0.26666667
P2RY2 ENSG00000175591 5029 Membrane 0.01785714 5.0 3.333333 0.1
SFTPC ENSG00000168484 6440 Membrane 0.02941176 26.0 114.3917 0.10153846
ZDHHC2 ENSG00000104219 51201 Membrane 0.01123596 1.0 0.0 0.0
ADRA2A ENSG00000150594 150 Membrane/Nucleus 0.01785714 5.0 3.333333 0.1
CTSH ENSG00000103811 1512 Membrane/Nucleus 0.01724138 3.0 0.0 0.33333333
ADGRF5 ENSG00000069122 221395 Unknown 0.01785714 5.0 3.333333 0.1
CCDC59 ENSG00000133773 29080 Unknown 0.01754386 3.0 0.0 1.0
CSF2RA ENSG00000198223 1438 Unknown 0.02083333 9.0 0.225 0.52777778
LMCD1 ENSG00000071282 29995 Unknown 0.01123596 1.0 0.0 0.0
PGA3 ENSG00000229859 643834 Unknown 0.01724138 2.0 0.0 1.0
PGA4 ENSG00000229183 643847 Unknown 0.01724138 2.0 0.0 1.0
SFTA3 ENSG00000229415 253970 Unknown 0.02222222 8.0 30.33333 0.39285714
GATA6 ENSG00000141448 2627 Nucleus 0.015625 4.0 25.225 0.16666667
TTF1 ENSG00000125482 7270 Nucleus 0.01754386 3.0 0.0 1.0
PGA5 ENSG00000256713 5222 Secreted 0.01724138 2.0 0.0 1.0
SFTPA1 ENSG00000122852 653509 Secreted 0.02272727 12.0 35.33333 0.28787879
SFTPA2 ENSG00000185303 729238 Secreted 0.02272727 10.0 30.33333 0.42222222
SFTPB ENSG00000168878 6439 Secreted 0.02941176 27.0 122.3917 0.09401709
SFTPD ENSG00000133661 6441 Secreted 0.0212766 10.0 6.325 0.48888889
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
NAPSA ENSG00000131400 9476 Cytoplasm 3.0 38.1 1.53E-6 0.333333333
ABCA3 ENSG00000167972 21 Membrane 8.0 3780.0 1.54E-6 0.035714286
ADORA2A ENSG00000128271 135 Membrane 1322.0 24200.0 1.55E-6 0.003520461
ADORA2B ENSG00000170425 136 Membrane 1276.0 23500.0 1.55E-6 0.003015551
ADRA2C ENSG00000184160 152 Membrane 169.0 2700.0 1.54E-6 0.020710059
CKAP4 ENSG00000136026 10970 Membrane 20.0 12700.0 1.54E-6 0.110526316
CSF2RB ENSG00000100368 1439 Membrane 1703.0 41800.0 1.56E-6 0.004166974
DMBT1 ENSG00000187908 1755 Membrane 6.0 0.0693 1.52E-6 0.266666667
P2RY2 ENSG00000175591 5029 Membrane 27.0 710.0 1.54E-6 0.635327635
SFTPC ENSG00000168484 6440 Membrane 44.0 20800.0 1.54E-6 0.034883721
ZDHHC2 ENSG00000104219 51201 Membrane 1.0 0.0 1.51E-6 0.0
ADRA2A ENSG00000150594 150 Membrane/Nucleus 143.0 2570.0 1.54E-6 0.027775042
CTSH ENSG00000103811 1512 Membrane/Nucleus 16.0 521.0 1.53E-6 0.608333333
ADGRF5 ENSG00000069122 221395 Unknown 5.0 2.05 1.52E-6 0.1
CCDC59 ENSG00000133773 29080 Unknown 3.0 0.0 1.52E-6 1.0
CSF2RA ENSG00000198223 1438 Unknown 875.0 16400.0 1.55E-6 0.014315789
LMCD1 ENSG00000071282 29995 Unknown 1.0 0.0 1.52E-6 0.0
PGA3 ENSG00000229859 643834 Unknown 2.0 0.0 1.51E-6 1.0
PGA4 ENSG00000229183 643847 Unknown 2.0 0.0 1.51E-6 1.0
SFTA3 ENSG00000229415 253970 Unknown 18.0 490.0 1.53E-6 0.071895425
GATA6 ENSG00000141448 2627 Nucleus 43.0 13200.0 1.55E-6 0.069767442
TTF1 ENSG00000125482 7270 Nucleus 275.0 13900.0 1.54E-6 0.110205707
PGA5 ENSG00000256713 5222 Secreted 2.0 0.0 1.51E-6 1.0
SFTPA1 ENSG00000122852 653509 Secreted 52.0 2000.0 1.54E-6 0.020361991
SFTPA2 ENSG00000185303 729238 Secreted 36.0 776.0 1.54E-6 0.03968254
SFTPB ENSG00000168878 6439 Secreted 45.0 21000.0 1.54E-6 0.033333333
SFTPD ENSG00000133661 6441 Secreted 47.0 12200.0 1.55E-6 0.037002775
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
NAPSA ENSG00000131400 9476 Cytoplasm 2.0 0.0 3.97E-7 1.0
ABCA3 ENSG00000167972 21 Membrane 6.0 190.0 3.97E-7 0.0
ADORA2A ENSG00000128271 135 Membrane 43.0 6480.0 3.98E-7 0.50166113
ADORA2B ENSG00000170425 136 Membrane 41.0 2040.0 3.98E-7 0.55243902
ADRA2C ENSG00000184160 152 Membrane 125.0 5850.0 3.98E-7 0.02864516
CKAP4 ENSG00000136026 10970 Membrane 4.0 8170.0 3.97E-7 0.16666667
CSF2RB ENSG00000100368 1439 Membrane 456.0 45500.0 3.99E-7 0.01054559
DMBT1 ENSG00000187908 1755 Membrane 6.0 0.0461 3.97E-7 0.26666667
P2RY2 ENSG00000175591 5029 Membrane 27.0 4350.0 3.99E-7 0.63532764
SFTPC ENSG00000168484 6440 Membrane 44.0 23400.0 3.98E-7 0.03488372
ZDHHC2 ENSG00000104219 51201 Membrane 1.0 0.0 3.95E-7 0.0
ADRA2A ENSG00000150594 150 Membrane/Nucleus 139.0 7860.0 3.98E-7 0.02721301
CTSH ENSG00000103811 1512 Membrane/Nucleus 16.0 1740.0 3.98E-7 0.60833333
ADGRF5 ENSG00000069122 221395 Unknown 5.0 13.4 3.97E-7 0.1
CCDC59 ENSG00000133773 29080 Unknown 3.0 0.0 3.97E-7 1.0
CSF2RA ENSG00000198223 1438 Unknown 302.0 31500.0 3.99E-7 0.0217377
LMCD1 ENSG00000071282 29995 Unknown 1.0 0.0 3.97E-7 0.0
PGA3 ENSG00000229859 643834 Unknown 2.0 0.0 3.97E-7 1.0
PGA4 ENSG00000229183 643847 Unknown 2.0 0.0 3.97E-7 1.0
SFTA3 ENSG00000229415 253970 Unknown 18.0 7120.0 3.98E-7 0.07189542
GATA6 ENSG00000141448 2627 Nucleus 19.0 22500.0 3.99E-7 0.11111111
TTF1 ENSG00000125482 7270 Nucleus 259.0 25700.0 3.99E-7 0.12424052
PGA5 ENSG00000256713 5222 Secreted 2.0 0.0 3.97E-7 1.0
SFTPA1 ENSG00000122852 653509 Secreted 34.0 8700.0 3.98E-7 0.033868090000000003
SFTPA2 ENSG00000185303 729238 Secreted 29.0 7200.0 3.98E-7 0.04679803
SFTPB ENSG00000168878 6439 Secreted 45.0 24300.0 3.98E-7 0.03333333
SFTPD ENSG00000133661 6441 Secreted 31.0 2260.0 3.98E-7 0.04731183
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
ADGRF5 SFTPB 1
ADGRF5 SFTPC 1
ADORA2A SFTPB 1
ADORA2A SFTPC 1
ADORA2B SFTPB 1
ADORA2B SFTPC 1
ADRA2A SFTPB 1
ADRA2A SFTPC 1
ADRA2C SFTPB 1
ADRA2C SFTPC 1
CSF2RA CSF2RB 5
CTSH SFTPB 3
DMBT1 SFTPA1 4
DMBT1 SFTPD 4
P2RY2 SFTPB 1
P2RY2 SFTPC 1
SFTPA1 SFTPA2 2
SFTPA1 SFTPD 2
ABCA3 ADGRF5 1
ABCA3 ADORA2A 1
ABCA3 ADORA2B 1
ABCA3 ADRA2A 1
ABCA3 ADRA2C 1
ABCA3 P2RY2 1
CCDC59 SFTPB 1
CCDC59 SFTPC 1
CCDC59 TTF1 1
CKAP4 SFTA3 1
CKAP4 SFTPA1 1
CKAP4 SFTPA2 1
CSF2RA SFTA3 1
CSF2RA SFTPA1 1
CSF2RA SFTPA2 1
CSF2RA SFTPB 1
CSF2RA SFTPC 1
CSF2RA SFTPD 1
CSF2RB SFTA3 1
CSF2RB SFTPA1 1
CSF2RB SFTPA2 1
CSF2RB SFTPB 1
CSF2RB SFTPC 1
CSF2RB SFTPD 1
CTSH SFTPC 1
DMBT1 SFTA3 1
DMBT1 SFTPA2 1
GATA6 LMCD1 1
GATA6 SFTA3 1
GATA6 SFTPA1 1
GATA6 SFTPA2 1
NAPSA SFTPB 1
NAPSA SFTPC 1
PGA3 SFTPB 1
PGA3 SFTPC 1
PGA4 SFTPB 1
PGA4 SFTPC 1
PGA5 SFTPB 1
PGA5 SFTPC 1
SFTA3 SFTPB 1
SFTA3 SFTPC 1
SFTA3 SFTPD 1
SFTPA1 SFTPB 1
SFTPA1 SFTPC 1
SFTPA2 SFTPB 1
SFTPA2 SFTPC 1
SFTPA2 SFTPD 1
SFTPB SFTPC 1
SFTPB SFTPD 1
SFTPB TTF1 1
SFTPC SFTPD 1
SFTPC TTF1 1
ZDHHC2 CKAP4 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002140 pathway0000554 5 1.0 Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3) Reactome 5 10
pathway0002140 pathway0000565 8 1.0 Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) Reactome 8 26
pathway0002140 pathway0000566 8 1.0 Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Reactome 8 26