Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002282 TRAF6 mediated IRF7 activation Reactome Homo sapiens 33 184
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
DDX58 ENSG00000107201 23586 Cytoplasm 0.01923077 32.0 6.979896 0.09475806
IFIH1 ENSG00000115267 64135 Cytoplasm 0.01851852 16.0 1.244018 0.26666667
IKBKE ENSG00000263528 9641 Cytoplasm 0.02 41.0 21.671 0.06829268
TANK ENSG00000136560 10010 Cytoplasm 0.01886792 19.0 0.1615205 0.29824561
TBK1 ENSG00000183735 29110 Cytoplasm 0.01923077 38.0 15.76702 0.07396871
TRAF2 ENSG00000127191 7186 Cytoplasm 0.02 22.0 2.454067 0.26406926
TRAF6 ENSG00000175104 7189 Cytoplasm 0.02 26.0 4.547295 0.18769231
EP300 ENSG00000100393 2033 Cytoplasm/Nucleus 0.02272727 25.0 12.56204 0.3
IRF1 ENSG00000125347 3659 Cytoplasm/Nucleus 0.02173913 23.0 11.73329 0.20948617
IRF7 ENSG00000185507 3665 Cytoplasm/Nucleus 0.02941176 85.0 194.7968 0.03613445
MYD88 ENSG00000172936 4615 Cytoplasm/Nucleus 0.01694915 14.0 0.6253498 0.07692308
TRIM25 ENSG00000121060 7706 Cytoplasm/Nucleus 0.01818182 16.0 0.0 0.3
DHX36 ENSG00000174953 170506 Membrane 0.015625 3.0 0.0 0.33333333
MAVS ENSG00000088888 57506 Unknown 0.01886792 32.0 0.9460819 0.10282258
RNF135 ENSG00000181481 84282 Unknown 0.01818182 13.0 0.0 0.46153846
SIKE1 ENSG00000052723 80143 Unknown 0.0125 7.0 0.0 0.04761905
CREBBP ENSG00000005339 1387 Nucleus 0.02222222 24.0 12.01819 0.26811594
IRF2 ENSG00000168310 3660 Nucleus 0.0212766 23.0 14.22987 0.20948617
IRF3 ENSG00000126456 3661 Nucleus 0.02702703 60.0 61.63723 0.06158192
IFNA1 ENSG00000197919 3439 Secreted 0.01785714 12.0 1.278868 0.37878788
IFNA10 ENSG00000186803 3446 Secreted 0.01694915 7.0 0.1632708 0.52380952
IFNA13 ENSG00000233816 3447 Secreted 0.01785714 12.0 1.278868 0.37878788
IFNA14 ENSG00000228083 3448 Secreted 0.01694915 7.0 0.1632708 0.52380952
IFNA16 ENSG00000147885 3449 Secreted 0.01694915 7.0 0.1632708 0.52380952
IFNA17 ENSG00000234829 3451 Secreted 0.01724138 8.0 0.1632708 0.60714286
IFNA2 ENSG00000188379 3440 Secreted 0.01694915 8.0 0.2387694 0.39285714
IFNA21 ENSG00000137080 3452 Secreted 0.01694915 7.0 0.1632708 0.52380952
IFNA4 ENSG00000236637 3441 Secreted 0.01724138 8.0 0.1632708 0.60714286
IFNA5 ENSG00000147873 3442 Secreted 0.01851852 12.0 0.9748093 0.62121212
IFNA6 ENSG00000120235 3443 Secreted 0.01724138 8.0 0.1632708 0.60714286
IFNA7 ENSG00000214042 3444 Secreted 0.01694915 7.0 0.1632708 0.52380952
IFNA8 ENSG00000120242 3445 Secreted 0.01754386 9.0 0.2132708 0.63888889
IFNB1 ENSG00000171855 3456 Secreted 0.01694915 11.0 0.3355707 0.2
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
DDX58 ENSG00000107201 23586 Cytoplasm 424.0 16248.48 1.55E-6 0.004025603
IFIH1 ENSG00000115267 64135 Cytoplasm 175.0 17666.85 1.55E-6 0.009655172
IKBKE ENSG00000263528 9641 Cytoplasm 626.0 10541.6 1.55E-6 0.006446006
TANK ENSG00000136560 10010 Cytoplasm 176.0 255.691 1.55E-6 0.024675325
TBK1 ENSG00000183735 29110 Cytoplasm 640.0 30783.72 1.55E-6 0.004088419
TRAF2 ENSG00000127191 7186 Cytoplasm 2474.0 66199.67 1.56E-6 0.001881925
TRAF6 ENSG00000175104 7189 Cytoplasm 4812.0 283172.4 1.56E-6 6.24089E-4
EP300 ENSG00000100393 2033 Cytoplasm/Nucleus 6386.0 1381818.0 1.56E-6 0.00143089
IRF1 ENSG00000125347 3659 Cytoplasm/Nucleus 243.0 28498.99 1.56E-6 0.029758868
IRF7 ENSG00000185507 3665 Cytoplasm/Nucleus 775.0 27409.34 1.55E-6 0.001623739
MYD88 ENSG00000172936 4615 Cytoplasm/Nucleus 1850.0 15234.64 1.55E-6 3.52565E-4
TRIM25 ENSG00000121060 7706 Cytoplasm/Nucleus 243.0 10658.76 1.55E-6 0.015270551
DHX36 ENSG00000174953 170506 Membrane 9.0 0.0 1.53E-6 0.027777778
MAVS ENSG00000088888 57506 Unknown 423.0 11521.3 1.55E-6 0.004145519
RNF135 ENSG00000181481 84282 Unknown 86.0 532.9474 1.54E-6 0.040492476
SIKE1 ENSG00000052723 80143 Unknown 21.0 0.0 1.53E-6 0.004761905
CREBBP ENSG00000005339 1387 Nucleus 4940.0 1649017.0 1.57E-6 0.001769605
IRF2 ENSG00000168310 3660 Nucleus 97.0 3725.63 1.55E-6 0.025343643
IRF3 ENSG00000126456 3661 Nucleus 760.0 29345.83 1.55E-6 0.001608765
IFNA1 ENSG00000197919 3439 Secreted 770.0 40253.93 1.55E-6 0.006143921
IFNA10 ENSG00000186803 3446 Secreted 562.0 612.5992 1.55E-6 0.008107028
IFNA13 ENSG00000233816 3447 Secreted 770.0 40253.93 1.55E-6 0.006143921
IFNA14 ENSG00000228083 3448 Secreted 567.0 2378.315 1.55E-6 0.008026873
IFNA16 ENSG00000147885 3449 Secreted 562.0 612.5992 1.55E-6 0.008107028
IFNA17 ENSG00000234829 3451 Secreted 587.0 612.5992 1.55E-6 0.007930648
IFNA2 ENSG00000188379 3440 Secreted 652.0 6388.141 1.55E-6 0.007463742
IFNA21 ENSG00000137080 3452 Secreted 562.0 612.5992 1.55E-6 0.008107028
IFNA4 ENSG00000236637 3441 Secreted 587.0 612.5992 1.55E-6 0.007930648
IFNA5 ENSG00000147873 3442 Secreted 704.0 1827.21 1.55E-6 0.00694669
IFNA6 ENSG00000120235 3443 Secreted 587.0 612.5992 1.55E-6 0.007930648
IFNA7 ENSG00000214042 3444 Secreted 571.0 10991.75 1.55E-6 0.008043752
IFNA8 ENSG00000120242 3445 Secreted 657.0 1478.211 1.55E-6 0.00700245
IFNB1 ENSG00000171855 3456 Secreted 649.0 3562.363 1.55E-6 0.006596093
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
DDX58 ENSG00000107201 23586 Cytoplasm 248.0 15500.0 3.99E-7 0.00963171
IFIH1 ENSG00000115267 64135 Cytoplasm 106.0 24700.0 3.99E-7 0.020125786
IKBKE ENSG00000263528 9641 Cytoplasm 147.0 3130.0 3.99E-7 0.015003262
TANK ENSG00000136560 10010 Cytoplasm 42.0 8.98 3.98E-7 0.141695703
TBK1 ENSG00000183735 29110 Cytoplasm 236.0 11900.0 3.99E-7 0.006671475
TRAF2 ENSG00000127191 7186 Cytoplasm 608.0 21300.0 3.99E-7 0.01466986
TRAF6 ENSG00000175104 7189 Cytoplasm 1432.0 387000.0 3.99E-7 0.001792902
EP300 ENSG00000100393 2033 Cytoplasm/Nucleus 2106.0 1670000.0 4.0E-7 0.007161531
IRF1 ENSG00000125347 3659 Cytoplasm/Nucleus 112.0 59300.0 3.99E-7 0.031370656
IRF7 ENSG00000185507 3665 Cytoplasm/Nucleus 302.0 40000.0 3.99E-7 0.006512508
MYD88 ENSG00000172936 4615 Cytoplasm/Nucleus 536.0 17300.0 3.99E-7 0.002517785
TRIM25 ENSG00000121060 7706 Cytoplasm/Nucleus 167.0 13100.0 3.99E-7 0.02712647
DHX36 ENSG00000174953 170506 Membrane 9.0 0.0 3.98E-7 0.027777778
MAVS ENSG00000088888 57506 Unknown 201.0 12900.0 3.99E-7 0.011094527
RNF135 ENSG00000181481 84282 Unknown 86.0 892.0 3.98E-7 0.032831737
SIKE1 ENSG00000052723 80143 Unknown 14.0 0.0 3.97E-7 0.010989011
CREBBP ENSG00000005339 1387 Nucleus 1505.0 1380000.0 4.0E-7 0.009085849
IRF2 ENSG00000168310 3660 Nucleus 83.0 9990.0 3.99E-7 0.031148986
IRF3 ENSG00000126456 3661 Nucleus 388.0 57800.0 3.99E-7 0.003796052
IFNA1 ENSG00000197919 3439 Secreted 111.0 36000.0 3.99E-7 0.023751024
IFNA10 ENSG00000186803 3446 Secreted 67.0 743.0 3.99E-7 0.033469019
IFNA13 ENSG00000233816 3447 Secreted 111.0 36000.0 3.99E-7 0.023751024
IFNA14 ENSG00000228083 3448 Secreted 70.0 2680.0 3.99E-7 0.034782609
IFNA16 ENSG00000147885 3449 Secreted 67.0 743.0 3.99E-7 0.033469019
IFNA17 ENSG00000234829 3451 Secreted 71.0 743.0 3.99E-7 0.037022133
IFNA2 ENSG00000188379 3440 Secreted 77.0 5950.0 3.99E-7 0.028024607
IFNA21 ENSG00000137080 3452 Secreted 67.0 743.0 3.99E-7 0.033469019
IFNA4 ENSG00000236637 3441 Secreted 71.0 743.0 3.99E-7 0.037022133
IFNA5 ENSG00000147873 3442 Secreted 91.0 1500.0 3.99E-7 0.042735043
IFNA6 ENSG00000120235 3443 Secreted 71.0 743.0 3.99E-7 0.037022133
IFNA7 ENSG00000214042 3444 Secreted 67.0 743.0 3.99E-7 0.033469019
IFNA8 ENSG00000120242 3445 Secreted 81.0 2020.0 3.99E-7 0.037037037
IFNB1 ENSG00000171855 3456 Secreted 109.0 5280.0 3.99E-7 0.014441047
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
CREBBP EP300 5
CREBBP IRF1 2
CREBBP IRF3 6
CREBBP IRF7 3
DDX58 IKBKE 2
DDX58 IRF3 2
DDX58 MAVS 8
DDX58 RNF135 2
DDX58 TBK1 2
DDX58 TRAF6 3
DDX58 TRIM25 4
DHX36 IRF7 1
EP300 IRF1 4
EP300 IRF3 5
EP300 IRF7 3
IFIH1 IKBKE 2
IFIH1 IRF3 1
IFIH1 IRF7 1
IFIH1 MAVS 7
IKBKE IRF1 1
IKBKE IRF3 7
IKBKE IRF7 4
IKBKE MAVS 4
IKBKE SIKE1 2
IKBKE TANK 6
IKBKE TBK1 4
IKBKE TRAF2 3
IRF1 IRF2 2
IRF2 IFNA2 2
IRF2 IFNB1 3
IRF3 IFNB1 2
IRF3 IRF7 3
IRF3 MAVS 4
IRF3 TBK1 5
IRF7 IFNA1 2
IRF7 IFNA10 2
IRF7 IFNA13 2
IRF7 IFNA14 2
IRF7 IFNA16 2
IRF7 IFNA17 2
IRF7 IFNA2 2
IRF7 IFNA21 2
IRF7 IFNA4 2
IRF7 IFNA5 2
IRF7 IFNA6 2
IRF7 IFNA7 2
IRF7 IFNA8 2
IRF7 IFNB1 4
IRF7 MAVS 3
IRF7 MYD88 4
IRF7 TANK 2
IRF7 TBK1 4
IRF7 TRAF6 4
MAVS TBK1 5
MAVS TRAF2 5
MAVS TRAF6 6
MYD88 TRAF6 7
SIKE1 TBK1 2
TANK IRF3 2
TANK TBK1 8
TANK TRAF2 7
TBK1 TRAF2 7
TBK1 TRAF6 2
TRAF6 TRIM25 3
CREBBP IFNA1 1
CREBBP IFNA10 1
CREBBP IFNA13 1
CREBBP IFNA14 1
CREBBP IFNA16 1
CREBBP IFNA17 1
CREBBP IFNA2 1
CREBBP IFNA21 1
CREBBP IFNA4 1
CREBBP IFNA5 1
CREBBP IFNA6 1
CREBBP IFNA7 1
CREBBP IFNA8 1
CREBBP IFNB1 1
CREBBP TRAF2 2
CREBBP TRAF6 1
DDX58 TANK 1
DDX58 TRAF2 1
DHX36 MYD88 1
EP300 IFNA1 1
EP300 IFNA10 1
EP300 IFNA13 1
EP300 IFNA14 1
EP300 IFNA16 1
EP300 IFNA17 1
EP300 IFNA2 1
EP300 IFNA21 1
EP300 IFNA4 1
EP300 IFNA5 1
EP300 IFNA6 1
EP300 IFNA7 1
EP300 IFNA8 1
EP300 IFNB1 1
EP300 IRF2 2
EP300 TRAF2 2
EP300 TRAF6 1
IFIH1 TANK 1
IFIH1 TBK1 1
IFIH1 TRAF2 1
IFIH1 TRAF6 1
IFNA13 IFIH1 1
IFNA13 IFNA5 1
IFNA13 IFNA8 1
IFNA13 IRF2 1
IFNA17 IFNA5 1
IFNA1 IFIH1 1
IFNA1 IFNA5 1
IFNA1 IFNA8 1
IFNA1 IRF2 1
IFNA4 IFNA5 1
IFNA5 IFNA6 1
IKBKE MYD88 1
IKBKE RNF135 1
IKBKE TRAF6 1
IKBKE TRIM25 1
IRF1 DDX58 1
IRF1 IFNA1 1
IRF1 IFNA10 1
IRF1 IFNA13 1
IRF1 IFNA14 1
IRF1 IFNA16 1
IRF1 IFNA17 1
IRF1 IFNA2 1
IRF1 IFNA21 1
IRF1 IFNA4 1
IRF1 IFNA5 1
IRF1 IFNA6 1
IRF1 IFNA7 1
IRF1 IFNA8 1
IRF1 IFNB1 2
IRF2 DDX58 1
IRF2 IFNA10 1
IRF2 IFNA14 1
IRF2 IFNA16 1
IRF2 IFNA17 1
IRF2 IFNA21 1
IRF2 IFNA4 1
IRF2 IFNA5 1
IRF2 IFNA6 1
IRF2 IFNA7 1
IRF2 IFNA8 1
IRF3 IFNA1 1
IRF3 IFNA10 1
IRF3 IFNA13 1
IRF3 IFNA14 1
IRF3 IFNA16 1
IRF3 IFNA17 1
IRF3 IFNA2 1
IRF3 IFNA21 1
IRF3 IFNA4 1
IRF3 IFNA5 1
IRF3 IFNA6 1
IRF3 IFNA7 1
IRF3 IFNA8 1
IRF3 TRAF2 2
IRF3 TRAF6 2
IRF7 DDX58 1
IRF7 IRF2 1
MAVS RNF135 1
MAVS TANK 1
MAVS TRIM25 1
MYD88 TRAF2 1
RNF135 IRF3 1
RNF135 IRF7 1
RNF135 TANK 1
RNF135 TBK1 1
RNF135 TRAF2 1
RNF135 TRAF6 1
TANK TRAF6 1
TANK TRIM25 1
TBK1 TRIM25 1
TRAF2 IRF7 1
TRAF2 TRAF6 3
TRAF2 TRIM25 1
TRIM25 IRF3 1
TRIM25 IRF7 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002282 pathway0002278 13 0.9285714 TRAF3-dependent IRF activation pathway Reactome 14 55
pathway0002282 pathway0002604 26 0.7878788 RIG-I-like receptor signaling pathway KEGG 71 471
pathway0002282 pathway0001082 13 0.7222222 IFN alpha signaling pathway(JAK1 TYK2 STAT1) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) INOH 18 83
pathway0002282 pathway0001083 13 0.7222222 IFN alpha signaling pathway(JAK1 TYK2 STAT3) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) INOH 18 73
pathway0002282 pathway0002655 23 0.6969697 Hepatitis C KEGG 134 1627
pathway0002282 pathway0001081 13 0.6842105 IFN alpha signaling pathway(JAK1 TYK2 STAT1 STAT3) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) INOH 19 91
pathway0002282 pathway0001080 13 0.65 IFN alpha signaling pathway((JAK1 TYK2 STAT1 STAT2) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) INOH 20 106
pathway0002282 pathway0002602 20 0.6060606 Toll-like receptor signaling pathway KEGG 100 1158
pathway0002282 pathway0002605 20 0.6060606 Cytosolic DNA-sensing pathway KEGG 56 233
pathway0002282 pathway0000747 20 0.6060606 Factors involved in megakaryocyte development and platelet production Reactome 111 689
pathway0002282 pathway0001297 3 0.6 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Reactome 5 9
pathway0002282 pathway0001180 18 0.5454545 Interferon alpha/beta signaling Reactome 67 378
pathway0002282 pathway0001840 14 0.5384615 Regulation of IFNA signaling Reactome 26 216