Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002299 Transcriptional activation of mitochondrial biogenesis Reactome Homo sapiens 43 230
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
ALAS1 ENSG00000023330 211 Cytoplasm 0.014285714 19.0 16.45915 0.45614035
C10orf2 ENSG00000107815 56652 Cytoplasm 0.010416667 3.0 4.977936 0.33333333
CYCS ENSG00000172115 54205 Cytoplasm 0.011363636 3.0 0.3625176 0.66666667
POLG2 ENSG00000256525 11232 Cytoplasm 0.011363636 4.0 1.544217 0.16666667
POLRMT ENSG00000099821 5442 Cytoplasm 0.01 6.0 0.2 0.6
SIRT3 ENSG00000142082 23410 Cytoplasm 0.013888889 10.0 10.2866 0.48888889
TFB1M ENSG00000029639 51106 Cytoplasm 0.012820513 8.0 2.489123 0.78571429
TFB2M ENSG00000162851 64216 Cytoplasm 0.012820513 10.0 4.848002 0.48888889
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 0.014492754 18.0 33.20486 0.23529412
ATP5B ENSG00000110955 506 Cytoplasm/Nucleus 0.011627907 5.0 2.445612 0.2
CHD9 ENSG00000177200 80205 Cytoplasm/Nucleus 0.011764706 10.0 13.14743 0.26666667
GABPA ENSG00000154727 2551 Cytoplasm/Nucleus 0.015151515 23.0 103.6798 0.15019763
MEF2D ENSG00000116604 4209 Cytoplasm/Nucleus 0.011904762 7.0 1.186215 0.38095238
NCOA6 ENSG00000198646 23054 Cytoplasm/Nucleus 0.013888889 19.0 8.125901 0.37426901
PPARA ENSG00000186951 5465 Cytoplasm/Nucleus 0.015873016 49.0 64.43871 0.0952381
SSBP1 ENSG00000106028 6742 Cytoplasm/Nucleus 0.009615385 2.0 0.0 1.0
TFAM ENSG00000108064 7019 Cytoplasm/Nucleus 0.013513514 12.0 8.743503 0.42424242
TGS1 ENSG00000137574 96764 Cytoplasm/Nucleus 0.012820513 12.0 0.3797019 0.63636364
HCFC1 ENSG00000172534 3054 Unknown 0.013333333 11.0 9.228077 0.38181818
HDAC3 ENSG00000171720 8841 Unknown 0.013888889 23.0 15.43959 0.17786561
HELZ2 ENSG00000130589 85441 Unknown 0.012820513 12.0 0.3797019 0.63636364
MTERF1 ENSG00000127989 7978 Unknown 0.009615385 2.0 0.0 1.0
NCOR1 ENSG00000141027 9611 Unknown 0.013888889 22.0 22.09175 0.2034632
SMARCD3 ENSG00000082014 6604 Unknown 0.0125 12.0 2.247503 0.28787879
USP46 ENSG00000109189 64854 Unknown 0.011235955 4.0 0.0 1.0
CARM1 ENSG00000142453 10498 Nucleus 0.011764706 13.0 2.983784 0.38461538
CREB1 ENSG00000118260 1385 Nucleus 0.012345679 9.0 1.441251 0.27777778
CREBBP ENSG00000005339 1387 Nucleus 0.016393443 36.0 47.6523 0.16984127
ESRRA ENSG00000173153 2101 Nucleus 0.014492754 18.0 21.70929 0.22875817
GABPB1 ENSG00000104064 2553 Nucleus 0.014084507 17.0 39.52327 0.25735294
MED1 ENSG00000125686 5469 Nucleus 0.015625 25.0 15.57192 0.3
MEF2C ENSG00000081189 4208 Nucleus 0.011764706 7.0 0.3392256 0.33333333
NCOA1 ENSG00000084676 8648 Nucleus 0.014285714 24.0 4.295362 0.31884058
NCOA2 ENSG00000140396 10499 Nucleus 0.01369863 23.0 8.791588 0.26482213
NR1D1 ENSG00000126368 9572 Nucleus 0.012820513 15.0 3.290734 0.16190476
NRF1 ENSG00000106459 4899 Nucleus 0.014705882 21.0 46.84893 0.15238095
PPARGC1A ENSG00000109819 10891 Nucleus 0.018181818 52.0 212.4092 0.07918552
PPARGC1B ENSG00000155846 133522 Nucleus 0.011764706 7.0 4.87508 0.23809524
PPRC1 ENSG00000148840 23082 Nucleus 0.013157895 11.0 4.686414 0.38181818
RXRA ENSG00000186350 6256 Nucleus 0.014492754 30.0 12.28994 0.20689655
TBL1X ENSG00000101849 6907 Nucleus 0.013888889 22.0 7.538397 0.37229437
TBL1XR1 ENSG00000177565 79718 Nucleus 0.01369863 22.0 6.847385 0.37662338
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
ALAS1 ENSG00000023330 211 Cytoplasm 189.0 47900.0 1.55E-6 0.016548463
C10orf2 ENSG00000107815 56652 Cytoplasm 3.0 5.23 1.53E-6 0.333333333
CYCS ENSG00000172115 54205 Cytoplasm 717.0 113000.0 1.55E-6 0.001527158
POLG2 ENSG00000256525 11232 Cytoplasm 4.0 25.3 1.54E-6 0.166666667
POLRMT ENSG00000099821 5442 Cytoplasm 10.0 0.222 1.53E-6 0.2
SIRT3 ENSG00000142082 23410 Cytoplasm 33.0 2270.0 1.55E-6 0.142045455
TFB1M ENSG00000029639 51106 Cytoplasm 8.0 17.7 1.53E-6 0.785714286
TFB2M ENSG00000162851 64216 Cytoplasm 18.0 135.0 1.53E-6 0.14379085
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 2727.0 293000.0 1.56E-6 0.004011675
ATP5B ENSG00000110955 506 Cytoplasm/Nucleus 299.0 65600.0 1.55E-6 0.01476959
CHD9 ENSG00000177200 80205 Cytoplasm/Nucleus 124.0 4510.0 1.55E-6 0.029766588
GABPA ENSG00000154727 2551 Cytoplasm/Nucleus 57.0 39400.0 1.55E-6 0.04197995
MEF2D ENSG00000116604 4209 Cytoplasm/Nucleus 74.0 477.0 1.55E-6 0.050721955
NCOA6 ENSG00000198646 23054 Cytoplasm/Nucleus 388.0 17500.0 1.56E-6 0.083553105
PPARA ENSG00000186951 5465 Cytoplasm/Nucleus 739.0 80300.0 1.56E-6 0.006135149
SSBP1 ENSG00000106028 6742 Cytoplasm/Nucleus 2.0 0.0 1.53E-6 1.0
TFAM ENSG00000108064 7019 Cytoplasm/Nucleus 26.0 3120.0 1.55E-6 0.101538462
TGS1 ENSG00000137574 96764 Cytoplasm/Nucleus 183.0 16400.0 1.55E-6 0.033087131
HCFC1 ENSG00000172534 3054 Unknown 41.0 1460.0 1.54E-6 0.395121951
HDAC3 ENSG00000171720 8841 Unknown 1077.0 29900.0 1.56E-6 0.014205438
HELZ2 ENSG00000130589 85441 Unknown 231.0 1970.0 1.55E-6 0.059288538
MTERF1 ENSG00000127989 7978 Unknown 2.0 0.0 1.53E-6 1.0
NCOR1 ENSG00000141027 9611 Unknown 1027.0 49300.0 1.56E-6 0.014197562
SMARCD3 ENSG00000082014 6604 Unknown 259.0 6820.0 1.55E-6 0.055460776
USP46 ENSG00000109189 64854 Unknown 12.0 0.737 1.54E-6 0.090909091
CARM1 ENSG00000142453 10498 Nucleus 279.0 5410.0 1.55E-6 0.026430469
CREB1 ENSG00000118260 1385 Nucleus 1632.0 139000.0 1.56E-6 0.00288302
CREBBP ENSG00000005339 1387 Nucleus 4940.0 1650000.0 1.57E-6 0.001769605
ESRRA ENSG00000173153 2101 Nucleus 75.0 1590.0 1.55E-6 0.068108108
GABPB1 ENSG00000104064 2553 Nucleus 17.0 255.0 1.53E-6 0.257352941
MED1 ENSG00000125686 5469 Nucleus 683.0 494000.0 1.56E-6 0.010927296
MEF2C ENSG00000081189 4208 Nucleus 316.0 28200.0 1.55E-6 0.009222423
NCOA1 ENSG00000084676 8648 Nucleus 813.0 64700.0 1.56E-6 0.009594702
NCOA2 ENSG00000140396 10499 Nucleus 654.0 29000.0 1.56E-6 0.013946453
NR1D1 ENSG00000126368 9572 Nucleus 216.0 3440.0 1.55E-6 0.005512489
NRF1 ENSG00000106459 4899 Nucleus 93.0 10900.0 1.55E-6 0.021972885
PPARGC1A ENSG00000109819 10891 Nucleus 604.0 39600.0 1.56E-6 0.010032618
PPARGC1B ENSG00000155846 133522 Nucleus 16.0 1350.0 1.54E-6 0.041666667
PPRC1 ENSG00000148840 23082 Nucleus 22.0 171.0 1.54E-6 0.090909091
RXRA ENSG00000186350 6256 Nucleus 1193.0 410000.0 1.56E-6 0.012691483
TBL1X ENSG00000101849 6907 Nucleus 503.0 14500.0 1.55E-6 0.033274457
TBL1XR1 ENSG00000177565 79718 Nucleus 496.0 12800.0 1.55E-6 0.035288368
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
ALAS1 ENSG00000023330 211 Cytoplasm 45.0 82200.0 3.99E-7 0.176767677
C10orf2 ENSG00000107815 56652 Cytoplasm 3.0 6.73 3.98E-7 0.333333333
CYCS ENSG00000172115 54205 Cytoplasm 90.0 148000.0 3.99E-7 0.043945069
POLG2 ENSG00000256525 11232 Cytoplasm 4.0 18.2 3.98E-7 0.166666667
POLRMT ENSG00000099821 5442 Cytoplasm 6.0 0.2 3.97E-7 0.6
SIRT3 ENSG00000142082 23410 Cytoplasm 10.0 3490.0 3.99E-7 0.488888889
TFB1M ENSG00000029639 51106 Cytoplasm 8.0 238.0 3.98E-7 0.785714286
TFB2M ENSG00000162851 64216 Cytoplasm 10.0 474.0 3.98E-7 0.488888889
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 257.0 106000.0 3.99E-7 0.110074173
ATP5B ENSG00000110955 506 Cytoplasm/Nucleus 68.0 128000.0 3.98E-7 0.131255487
CHD9 ENSG00000177200 80205 Cytoplasm/Nucleus 124.0 15900.0 3.99E-7 0.029504327
GABPA ENSG00000154727 2551 Cytoplasm/Nucleus 23.0 23600.0 3.99E-7 0.150197628
MEF2D ENSG00000116604 4209 Cytoplasm/Nucleus 35.0 5900.0 3.99E-7 0.105882353
NCOA6 ENSG00000198646 23054 Cytoplasm/Nucleus 343.0 51000.0 3.99E-7 0.098699129
PPARA ENSG00000186951 5465 Cytoplasm/Nucleus 569.0 120000.0 3.99E-7 0.006596698
SSBP1 ENSG00000106028 6742 Cytoplasm/Nucleus 2.0 0.0 3.97E-7 1.0
TFAM ENSG00000108064 7019 Cytoplasm/Nucleus 12.0 1260.0 3.98E-7 0.424242424
TGS1 ENSG00000137574 96764 Cytoplasm/Nucleus 174.0 35500.0 3.99E-7 0.035878015
HCFC1 ENSG00000172534 3054 Unknown 41.0 4650.0 3.98E-7 0.395121951
HDAC3 ENSG00000171720 8841 Unknown 709.0 143000.0 3.99E-7 0.022248253
HELZ2 ENSG00000130589 85441 Unknown 231.0 20100.0 3.99E-7 0.059175607
MTERF1 ENSG00000127989 7978 Unknown 2.0 0.0 3.97E-7 1.0
NCOR1 ENSG00000141027 9611 Unknown 674.0 63900.0 3.99E-7 0.022627766
SMARCD3 ENSG00000082014 6604 Unknown 214.0 23800.0 3.99E-7 0.058180861
USP46 ENSG00000109189 64854 Unknown 12.0 4.15 3.99E-7 0.090909091
CARM1 ENSG00000142453 10498 Nucleus 226.0 35100.0 3.99E-7 0.030442478
CREB1 ENSG00000118260 1385 Nucleus 206.0 106000.0 3.99E-7 0.010561212
CREBBP ENSG00000005339 1387 Nucleus 1505.0 1380000.0 4.0E-7 0.009085849
ESRRA ENSG00000173153 2101 Nucleus 61.0 18800.0 3.99E-7 0.086338798
GABPB1 ENSG00000104064 2553 Nucleus 17.0 1280.0 3.98E-7 0.257352941
MED1 ENSG00000125686 5469 Nucleus 591.0 932000.0 3.99E-7 0.012159798
MEF2C ENSG00000081189 4208 Nucleus 57.0 8420.0 3.99E-7 0.043233083
NCOA1 ENSG00000084676 8648 Nucleus 413.0 84800.0 3.99E-7 0.022320694
NCOA2 ENSG00000140396 10499 Nucleus 421.0 62200.0 3.99E-7 0.02425065
NR1D1 ENSG00000126368 9572 Nucleus 186.0 13000.0 3.99E-7 0.005928509
NRF1 ENSG00000106459 4899 Nucleus 39.0 6680.0 3.98E-7 0.060728745
PPARGC1A ENSG00000109819 10891 Nucleus 349.0 123000.0 3.99E-7 0.023630735
PPARGC1B ENSG00000155846 133522 Nucleus 11.0 2300.0 3.98E-7 0.090909091
PPRC1 ENSG00000148840 23082 Nucleus 11.0 53.4 3.98E-7 0.381818182
RXRA ENSG00000186350 6256 Nucleus 731.0 1020000.0 3.99E-7 0.027712085
TBL1X ENSG00000101849 6907 Nucleus 413.0 32900.0 3.99E-7 0.040715579
TBL1XR1 ENSG00000177565 79718 Nucleus 418.0 42400.0 3.99E-7 0.040228105
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
ATF2 CREB1 3
ATF2 NR1D1 2
ATF2 PPARGC1A 4
CARM1 CREBBP 3
CARM1 NCOA2 3
CARM1 PPARA 1
CHD9 PPARA 4
CHD9 RXRA 3
CREB1 CREBBP 8
CREBBP HDAC3 3
CREBBP MED1 3
CREBBP NCOA1 8
CREBBP NCOA2 6
CREBBP NCOA6 4
CREBBP NCOR1 2
CREBBP PPARA 2
CREBBP PPARGC1A 3
CREBBP RXRA 3
ESRRA PPARGC1A 4
GABPA GABPB1 3
GABPA HCFC1 4
GABPB1 HCFC1 3
HDAC3 NCOR1 7
HDAC3 NR1D1 3
HDAC3 RXRA 3
HDAC3 TBL1X 6
HDAC3 TBL1XR1 5
HELZ2 PPARA 3
MED1 NCOA1 2
MED1 PPARA 2
MED1 PPARGC1A 3
MED1 RXRA 6
MEF2C NCOA2 3
MEF2C PPARGC1A 1
MEF2D PPARGC1A 1
NCOA1 NCOA2 5
NCOA1 PPARA 3
NCOA1 PPARGC1A 3
NCOA1 RXRA 6
NCOA2 PPARA 2
NCOA2 RXRA 5
NCOA6 PPARA 2
NCOA6 RXRA 4
NCOR1 NR1D1 5
NCOR1 PPARA 4
NCOR1 RXRA 2
NCOR1 TBL1X 5
NCOR1 TBL1XR1 5
NRF1 PPARGC1A 4
NRF1 PPRC1 5
NRF1 TFAM 2
POLRMT TFB2M 3
PPARA PPARGC1A 3
PPARA RXRA 7
PPARA TGS1 2
PPARGC1A GABPA 2
PPARGC1A RXRA 3
RXRA SMARCD3 3
SMARCD3 TBL1X 2
SMARCD3 TBL1XR1 2
TBL1X TBL1XR1 6
TFAM TFB2M 4
ALAS1 NRF1 1
ATF2 ATP5B 2
ATF2 CHD9 1
ATF2 CREBBP 2
ATF2 HDAC3 1
ATF2 MED1 1
ATF2 NCOA6 2
ATF2 POLG2 1
ATF2 PPARA 1
ATF2 PPRC1 1
ATF2 SIRT3 1
ATF2 TBL1X 1
ATF2 TFAM 1
ATP5B NRF1 1
ATP5B PPARGC1B 1
ATP5B SIRT3 2
C10orf2 CHD9 2
CARM1 ALAS1 1
CARM1 CREB1 1
CARM1 MEF2D 1
CARM1 NCOA1 2
CARM1 RXRA 1
CARM1 TBL1X 1
CARM1 TBL1XR1 1
CHD9 ALAS1 1
CHD9 TBL1X 1
CHD9 TBL1XR1 1
CREB1 NCOR1 1
CREB1 PPARGC1A 2
CREB1 SIRT3 1
CREBBP ALAS1 1
CREBBP GABPA 1
CREBBP HELZ2 1
CREBBP MEF2D 1
CREBBP SIRT3 1
CREBBP SMARCD3 1
CREBBP TBL1X 1
CREBBP TBL1XR1 1
CREBBP TGS1 2
CYCS NRF1 1
CYCS PPARGC1B 1
ESRRA ALAS1 1
ESRRA ATP5B 1
ESRRA GABPA 1
ESRRA MED1 1
ESRRA MEF2C 1
ESRRA MEF2D 1
ESRRA NCOA1 3
ESRRA NCOA6 1
ESRRA SMARCD3 1
ESRRA TBL1XR1 1
GABPA C10orf2 1
GABPA MED1 1
GABPA MTERF1 1
GABPA NRF1 1
GABPA POLG2 1
GABPA POLRMT 1
GABPA PPRC1 1
GABPA SSBP1 1
GABPA TFAM 1
GABPA TFB1M 1
GABPA TFB2M 1
GABPB1 C10orf2 1
GABPB1 MTERF1 1
GABPB1 NRF1 1
GABPB1 POLG2 1
GABPB1 POLRMT 1
GABPB1 PPARGC1A 1
GABPB1 PPRC1 1
GABPB1 SIRT3 1
GABPB1 SSBP1 1
GABPB1 TFAM 1
GABPB1 TFB1M 1
GABPB1 TFB2M 1
HCFC1 NCOA6 2
HCFC1 NRF1 1
HCFC1 PPARGC1A 2
HCFC1 PPARGC1B 1
HCFC1 PPRC1 1
HCFC1 TFB1M 1
HCFC1 TFB2M 1
HDAC3 MEF2C 1
HDAC3 MEF2D 1
HDAC3 PPARA 1
HDAC3 PPARGC1A 1
HDAC3 SIRT3 1
HDAC3 USP46 1
HELZ2 ALAS1 1
HELZ2 MED1 1
HELZ2 NCOA1 1
HELZ2 NCOA2 1
HELZ2 PPARGC1A 1
HELZ2 RXRA 1
HELZ2 TBL1X 1
HELZ2 TBL1XR1 1
MED1 ALAS1 1
MED1 NCOA2 1
MED1 NCOA6 2
MED1 NCOR1 1
MED1 NR1D1 1
MED1 SIRT3 1
MED1 TBL1X 1
MED1 TBL1XR1 1
MED1 TGS1 2
MEF2C MEF2D 1
NCOA1 ALAS1 1
NCOA1 HDAC3 1
NCOA1 NCOA6 3
NCOA1 NCOR1 1
NCOA1 TBL1X 1
NCOA1 TBL1XR1 1
NCOA1 TGS1 1
NCOA2 ALAS1 1
NCOA2 ESRRA 1
NCOA2 NCOA6 1
NCOA2 PPARGC1A 1
NCOA2 TBL1X 1
NCOA2 TBL1XR1 1
NCOA6 ALAS1 1
NCOA6 PPARGC1A 2
NCOA6 TBL1X 1
NCOA6 TBL1XR1 1
NCOA6 TGS1 2
NCOR1 POLG2 1
NCOR1 PPARGC1A 1
NCOR1 SIRT3 1
NCOR1 USP46 1
NR1D1 USP46 1
NRF1 NR1D1 1
NRF1 PPARGC1B 1
NRF1 SMARCD3 1
NRF1 TFB1M 1
NRF1 TFB2M 1
POLRMT TFAM 1
POLRMT TFB1M 3
PPARA ALAS1 2
PPARA ESRRA 1
PPARA NR1D1 1
PPARA PPARGC1B 1
PPARA PPRC1 1
PPARGC1A CYCS 1
PPARGC1A NR1D1 1
PPARGC1A SIRT3 1
PPARGC1A TFAM 1
PPARGC1A TFB1M 1
PPARGC1A TFB2M 1
PPARGC1A TGS1 1
PPARGC1B ALAS1 1
PPRC1 TFAM 1
PPRC1 TFB1M 1
PPRC1 TFB2M 1
RXRA ALAS1 1
RXRA TBL1X 1
RXRA TBL1XR1 1
RXRA TGS1 1
SIRT3 TFAM 1
SMARCD3 ALAS1 1
SMARCD3 PPARA 1
TBL1X ALAS1 1
TBL1X PPARA 1
TBL1XR1 ALAS1 1
TBL1XR1 PPARA 1
TBL1XR1 TGS1 1
TBL1X TGS1 1
TFAM TFB1M 3
TGS1 ALAS1 1
USP46 PPARGC1A 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002299 pathway0002823 9 0.8181818 Hs_Mitochondrial_Gene_Expression_WP391_71373 WikiPathways 11 23
pathway0002299 pathway0001846 16 0.8 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Reactome 20 122
pathway0002299 pathway0001940 18 0.6666667 RORA activates gene expression Reactome 27 204
pathway0002299 pathway0000430 23 0.5348837 Circadian Clock Reactome 49 389
pathway0002299 pathway0001704 22 0.5116279 PPARA activates gene expression Reactome 113 1887
pathway0002299 pathway0001527 4 0.5 NR1D1 (REV-ERBA) represses gene expression Reactome 8 21