Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002340 Trk receptor signaling mediated by the MAPK pathway PID Homo sapiens 34 175
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
BRAF ENSG00000157764 673 Cytoplasm 0.01960784 161.0 59.63431 0.004658385
KRAS ENSG00000133703 3845 Cytoplasm 0.01886792 87.0 8.111254 0.015503876
MAP2K1 ENSG00000169032 5604 Cytoplasm 0.01960784 188.0 49.28261 0.00324269
PRKCD ENSG00000163932 5580 Cytoplasm 0.01587302 14.0 0.3917717 0.175824176
TRPV1 ENSG00000196689 7442 Cytoplasm 0.01470588 8.0 0.09687467 0.25
CDK5 ENSG00000164885 1020 Cytoplasm/Nucleus 0.01388889 8.0 13.99309 0.035714286
CDK5R1 ENSG00000176749 8851 Cytoplasm/Nucleus 0.01111111 5.0 0.7381903 0.0
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 0.01923077 68.0 21.6051 0.022827041
FOS ENSG00000170345 2353 Cytoplasm/Nucleus 0.01785714 47.0 2.092658 0.043478261
MAP2K3 ENSG00000034152 5606 Cytoplasm/Nucleus 0.01694915 26.0 6.84377 0.073846154
MAP2K5 ENSG00000137764 5607 Cytoplasm/Nucleus 0.01470588 19.0 1.106676 0.01754386
MAP2K6 ENSG00000108984 5608 Cytoplasm/Nucleus 0.01694915 21.0 4.977671 0.1
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 0.02272727 146.0 57.66878 0.009730751
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 0.02222222 137.0 48.50526 0.010519536
MAPK7 ENSG00000166484 5598 Cytoplasm/Nucleus 0.01724138 36.0 17.24421 0.038095238
MAPKAPK2 ENSG00000162889 9261 Cytoplasm/Nucleus 0.01666667 35.0 2.007391 0.040336134
RAP1A ENSG00000116473 5906 Cytoplasm/Nucleus 0.01694915 24.0 4.82127 0.108695652
RAP1B ENSG00000127314 5908 Cytoplasm/Nucleus 0.01666667 21.0 4.204095 0.133333333
RPS6KA5 ENSG00000100784 9252 Cytoplasm/Nucleus 0.01639344 26.0 0.5284126 0.067692308
RUSC1 ENSG00000160753 23623 Cytoplasm/Nucleus 0.01369863 4.0 0.01327434 0.0
HRAS ENSG00000174775 3265 Membrane 0.02083333 97.0 24.8413 0.01847079
NRAS ENSG00000213281 4893 Membrane 0.01960784 85.0 10.89558 0.019607843
RAF1 ENSG00000132155 5894 Membrane 0.01851852 172.0 9.687575 0.003943968
RIT1 ENSG00000143622 6016 Membrane 0.01265823 4.0 0.0326087 0.0
RIT2 ENSG00000152214 6014 Membrane 0.01369863 5.0 0.0326087 0.2
MAP3K2 ENSG00000169967 10746 Unknown 0.01388889 15.0 3.324764 0.019047619
MAPK14 ENSG00000112062 1432 Unknown 0.02222222 74.0 57.97584 0.032580526
NTF3 ENSG00000185652 4908 Unknown 0.01666667 10.0 10.44176 0.244444444
CREB1 ENSG00000118260 1385 Nucleus 0.01886792 24.0 18.49006 0.137681159
EGR1 ENSG00000120738 1958 Nucleus 0.01639344 12.0 17.75343 0.196969697
MEF2C ENSG00000081189 4208 Nucleus 0.01492537 10.0 2.19337 0.044444444
RPS6KA1 ENSG00000117676 6195 Nucleus 0.01694915 34.0 1.574858 0.046345811
SRF ENSG00000112658 6722 Nucleus 0.01785714 37.0 3.712213 0.048048048
EHD4 ENSG00000103966 30844 Secreted 0.01388889 4.0 0.1773704 0.166666667
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BRAF ENSG00000157764 673 Cytoplasm 12094.0 42600.0 1.56E-6 4.04E-5
KRAS ENSG00000133703 3845 Cytoplasm 15339.0 61700.0 1.56E-6 8.92E-5
MAP2K1 ENSG00000169032 5604 Cytoplasm 23272.0 37700.0 1.56E-6 1.47E-5
PRKCD ENSG00000163932 5580 Cytoplasm 4033.0 210000.0 1.56E-6 0.00131
TRPV1 ENSG00000196689 7442 Cytoplasm 35.0 20400.0 1.55E-6 0.153
CDK5 ENSG00000164885 1020 Cytoplasm/Nucleus 754.0 36300.0 1.56E-6 0.00347
CDK5R1 ENSG00000176749 8851 Cytoplasm/Nucleus 89.0 711.0 1.55E-6 0.0312
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 3468.0 49000.0 1.56E-6 3.9E-4
FOS ENSG00000170345 2353 Cytoplasm/Nucleus 3623.0 68600.0 1.56E-6 7.3E-4
MAP2K3 ENSG00000034152 5606 Cytoplasm/Nucleus 2871.0 8580.0 1.56E-6 3.52E-4
MAP2K5 ENSG00000137764 5607 Cytoplasm/Nucleus 762.0 218.0 1.55E-6 0.00185
MAP2K6 ENSG00000108984 5608 Cytoplasm/Nucleus 2682.0 7380.0 1.56E-6 3.98E-4
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 33563.0 1130000.0 1.56E-6 2.83E-5
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 29207.0 850000.0 1.56E-6 3.17E-5
MAPK7 ENSG00000166484 5598 Cytoplasm/Nucleus 1164.0 3380.0 1.56E-6 0.00133
MAPKAPK2 ENSG00000162889 9261 Cytoplasm/Nucleus 1421.0 8100.0 1.55E-6 4.69E-4
RAP1A ENSG00000116473 5906 Cytoplasm/Nucleus 1544.0 17600.0 1.56E-6 0.00137
RAP1B ENSG00000127314 5908 Cytoplasm/Nucleus 1262.0 9880.0 1.55E-6 0.00172
RPS6KA5 ENSG00000100784 9252 Cytoplasm/Nucleus 627.0 4510.0 1.55E-6 0.00267
RUSC1 ENSG00000160753 23623 Cytoplasm/Nucleus 4.0 4.36E-5 1.54E-6 0.0
HRAS ENSG00000174775 3265 Membrane 21752.0 305000.0 1.56E-6 6.79E-5
NRAS ENSG00000213281 4893 Membrane 14710.0 64200.0 1.56E-6 1.13E-4
RAF1 ENSG00000132155 5894 Membrane 23706.0 140000.0 1.56E-6 1.64E-5
RIT1 ENSG00000143622 6016 Membrane 25.0 8.53 1.54E-6 0.0767
RIT2 ENSG00000152214 6014 Membrane 24.0 0.0944 1.54E-6 0.13
MAP3K2 ENSG00000169967 10746 Unknown 725.0 162.0 1.55E-6 0.00209
MAPK14 ENSG00000112062 1432 Unknown 9287.0 427000.0 1.56E-6 2.57E-4
NTF3 ENSG00000185652 4908 Unknown 412.0 1110.0 1.55E-6 0.00298
CREB1 ENSG00000118260 1385 Nucleus 1632.0 139000.0 1.56E-6 0.00288
EGR1 ENSG00000120738 1958 Nucleus 229.0 1580.0 1.56E-6 0.0265
MEF2C ENSG00000081189 4208 Nucleus 316.0 28200.0 1.55E-6 0.00922
RPS6KA1 ENSG00000117676 6195 Nucleus 1675.0 7420.0 1.56E-6 6.33E-4
SRF ENSG00000112658 6722 Nucleus 617.0 15200.0 1.56E-6 0.00547
EHD4 ENSG00000103966 30844 Secreted 28.0 5.43 1.55E-6 0.0926
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BRAF ENSG00000157764 673 Cytoplasm 1459.0 1480.0 1.61421E-4 9.88143E-4
KRAS ENSG00000133703 3845 Cytoplasm 2404.0 6010.0 1.70126E-4 0.001302449
MAP2K1 ENSG00000169032 5604 Cytoplasm 4166.0 11800.0 1.71821E-4 2.38252E-4
PRKCD ENSG00000163932 5580 Cytoplasm 838.0 17600.0 1.77715E-4 0.008328985
TRPV1 ENSG00000196689 7442 Cytoplasm 26.0 0.168 1.40984E-4 0.144615385
CDK5 ENSG00000164885 1020 Cytoplasm/Nucleus 90.0 5370.0 1.52602E-4 0.02721598
CDK5R1 ENSG00000176749 8851 Cytoplasm/Nucleus 33.0 66.2 1.43596E-4 0.043560606
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 573.0 2890.0 1.6714E-4 0.003801609
FOS ENSG00000170345 2353 Cytoplasm/Nucleus 1367.0 21000.0 1.80245E-4 0.00258445
MAP2K3 ENSG00000034152 5606 Cytoplasm/Nucleus 445.0 5260.0 1.56593E-4 0.005496508
MAP2K5 ENSG00000137764 5607 Cytoplasm/Nucleus 61.0 2.96 1.45964E-4 0.068852459
MAP2K6 ENSG00000108984 5608 Cytoplasm/Nucleus 462.0 6000.0 1.60927E-4 0.005953555
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 5647.0 122000.0 1.91571E-4 4.01908E-4
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 5295.0 94900.0 1.89179E-4 3.9334E-4
MAPK7 ENSG00000166484 5598 Cytoplasm/Nucleus 98.0 65.6 1.51217E-4 0.044182622
MAPKAPK2 ENSG00000162889 9261 Cytoplasm/Nucleus 201.0 377.0 1.53327E-4 0.009452736
RAP1A ENSG00000116473 5906 Cytoplasm/Nucleus 498.0 2560.0 1.58303E-4 0.007757388
RAP1B ENSG00000127314 5908 Cytoplasm/Nucleus 384.0 1030.0 1.55739E-4 0.009927111
RPS6KA5 ENSG00000100784 9252 Cytoplasm/Nucleus 87.0 44.3 1.44488E-4 0.027800054
RUSC1 ENSG00000160753 23623 Cytoplasm/Nucleus 4.0 6.96E-4 1.25063E-4 0.0
HRAS ENSG00000174775 3265 Membrane 4283.0 43500.0 1.85185E-4 7.45373E-4
NRAS ENSG00000213281 4893 Membrane 2219.0 11100.0 1.7584E-4 0.001738409
RAF1 ENSG00000132155 5894 Membrane 4276.0 9490.0 1.70271E-4 2.22211E-4
RIT1 ENSG00000143622 6016 Membrane 14.0 0.287 1.2875E-4 0.21978022
RIT2 ENSG00000152214 6014 Membrane 17.0 0.314 1.321E-4 0.25
MAP3K2 ENSG00000169967 10746 Unknown 51.0 8.12 1.46886E-4 0.08627451
MAPK14 ENSG00000112062 1432 Unknown 1830.0 65300.0 1.85494E-4 0.002225827
NTF3 ENSG00000185652 4908 Unknown 111.0 131.0 1.41643E-4 0.032268632
CREB1 ENSG00000118260 1385 Nucleus 476.0 19700.0 1.76491E-4 0.012976559
EGR1 ENSG00000120738 1958 Nucleus 163.0 1500.0 1.69233E-4 0.035067788
MEF2C ENSG00000081189 4208 Nucleus 93.0 1460.0 1.51194E-4 0.0514259
RPS6KA1 ENSG00000117676 6195 Nucleus 147.0 767.0 1.51722E-4 0.014816886
SRF ENSG00000112658 6722 Nucleus 231.0 6970.0 1.55715E-4 0.014041031
EHD4 ENSG00000103966 30844 Secreted 21.0 1.86 1.30378E-4 0.123809524
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
BRAF HRAS 7
BRAF MAP2K1 12
BRAF MAP2K3 2
BRAF MAP2K6 1
BRAF MAPK1 6
BRAF MAPK3 6
BRAF NRAS 5
BRAF RAF1 9
CDK5 CDK5R1 8
CDK5 MAP2K1 2
EHD4 NTF3 1
ELK1 EGR1 3
ELK1 FOS 5
ELK1 SRF 6
HRAS FOS 1
HRAS MAP2K1 4
HRAS MAPK1 3
HRAS MAPK3 3
HRAS RAF1 14
HRAS RAP1B 2
HRAS TRPV1 1
KRAS BRAF 5
KRAS FOS 1
KRAS MAPK1 3
KRAS MAPK3 2
KRAS RAF1 10
KRAS TRPV1 1
MAP2K1 MAPK1 13
MAP2K1 MAPK14 4
MAP2K1 MAPK3 12
MAP2K1 MAPK7 1
MAP2K1 NRAS 2
MAP2K1 RAF1 10
MAP2K1 RUSC1 1
MAP2K3 MAPK1 1
MAP2K3 MAPK14 12
MAP2K3 MAPK3 4
MAP2K5 MAPK14 1
MAP2K5 MAPK7 10
MAP2K6 MAPK14 11
MAP2K6 MAPKAPK2 2
MAP3K2 MAP2K3 2
MAP3K2 MAP2K5 4
MAP3K2 MAP2K6 2
MAPK14 ELK1 5
MAPK14 FOS 3
MAPK14 MAPK3 5
MAPK14 MAPKAPK2 11
MAPK14 MEF2C 9
MAPK14 RPS6KA5 9
MAPK1 CREB1 1
MAPK1 ELK1 9
MAPK1 FOS 5
MAPK1 MAPK3 4
MAPK1 MAPK7 1
MAPK1 MAPKAPK2 4
MAPK1 RAF1 5
MAPK1 RPS6KA1 10
MAPK1 RPS6KA5 7
MAPK3 CREB1 1
MAPK3 ELK1 8
MAPK3 FOS 5
MAPK3 MAPK7 1
MAPK3 MAPKAPK2 3
MAPK3 PRKCD 3
MAPK3 RAF1 5
MAPK3 RPS6KA1 7
MAPK3 RPS6KA5 6
MAPK7 ELK1 1
MAPK7 MAPKAPK2 1
MAPK7 MEF2C 7
MAPK7 RPS6KA1 4
MAPK7 RPS6KA5 1
MAPKAPK2 CREB1 4
MAPKAPK2 SRF 5
NRAS FOS 1
NRAS MAPK1 3
NRAS MAPK3 3
NRAS RAF1 10
NRAS TRPV1 1
PRKCD BRAF 3
PRKCD MAP2K1 1
PRKCD RAF1 5
RAF1 MAP2K3 1
RAF1 RAP1A 5
RAP1A BRAF 4
RAP1A MAPK1 2
RAP1A MAPK3 2
RAP1B BRAF 5
RIT1 BRAF 1
RIT2 BRAF 1
RPS6KA1 CREB1 4
RPS6KA1 SRF 2
RPS6KA5 CREB1 4
RPS6KA5 ELK1 1
RPS6KA5 FOS 1
RPS6KA5 SRF 1
SRF EGR1 2
SRF FOS 3
BRAF MAPK14 1
CDK5 MAPK1 1
CREB1 BRAF 1
CREB1 EGR1 1
CREB1 EHD4 1
CREB1 FOS 2
CREB1 HRAS 1
CREB1 MAPK14 2
CREB1 NTF3 1
CREB1 RUSC1 1
CREB1 SRF 1
EGR1 CDK5R1 1
EGR1 MAPK1 1
EGR1 MAPK14 1
EGR1 MAPK3 1
EGR1 MEF2C 1
ELK1 EHD4 1
ELK1 HRAS 1
ELK1 MAP2K1 1
ELK1 MAP2K3 1
ELK1 MAP2K6 1
ELK1 MAPKAPK2 1
ELK1 NRAS 1
FOS MAPK7 1
FOS RPS6KA1 2
HRAS MAPK14 1
HRAS RAP1A 1
HRAS RIT2 1
HRAS SRF 1
KRAS HRAS 1
KRAS MAPK14 1
KRAS NRAS 1
KRAS RAP1A 1
KRAS RAP1B 1
MAP2K1 KRAS 1
MAP2K3 MAP2K6 2
MAP2K3 MAPKAPK2 1
MAP2K6 MAPK1 1
MAP3K2 MAPK7 1
MAPK14 NTF3 1
MAPK14 TRPV1 1
MAPK1 MAPK14 4
MAPK1 PRKCD 2
MAPK3 MAP2K5 1
MAPK7 RAF1 2
MEF2C NTF3 1
NRAS HRAS 1
NRAS MAPK14 1
NRAS RAP1A 1
NRAS RAP1B 1
NTF3 HRAS 1
NTF3 KRAS 1
NTF3 NRAS 1
NTF3 RIT1 1
NTF3 RIT2 1
PRKCD HRAS 1
RAF1 MAP2K6 1
RAF1 MAPK14 1
RAP1A MAP2K1 1
RAP1A MAP3K2 1
RAP1B MAP2K1 1
RAP1B MAP3K2 1
RAP1B MAPK1 1
RAP1B MAPK3 1
RAP1B RAF1 1
RPS6KA1 HRAS 1
RPS6KA1 KRAS 1
RPS6KA1 NRAS 1
SRF MAP2K6 1
SRF MAPK14 1
SRF NRAS 1
SRF RAP1A 1
TRPV1 PRKCD 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002340 pathway0000700 5 0.8333333 ERK cascade ( EGF signaling pathway Diagram ) INOH 6 15
pathway0002340 pathway0000708 5 0.8333333 ERK cascade ( HGF signaling pathway ) INOH 6 15
pathway0002340 pathway0000714 5 0.8333333 ERK cascade ( VEGF signaling pathway ) INOH 6 15
pathway0002340 pathway0001446 5 0.8333333 Negative feedback regulation of MAPK pathway Reactome 6 16
pathway0002340 pathway0002466 4 0.8 ERK cascade ( Integrin signaling pathway ) INOH 5 11
pathway0002340 pathway0000704 4 0.8 ERK cascade ( GPCR Adenosine A2A receptor signaling pathway ) INOH 5 11
pathway0002340 pathway0000707 4 0.8 ERK cascade ( GPCR signaling (G alpha s, Epac and ERK) ) INOH 5 11
pathway0002340 pathway0000701 6 0.75 ERK cascade ( FGF signaling pathway ) INOH 8 26
pathway0002340 pathway0000709 6 0.75 ERK cascade ( IGF1 signaling pathway ) INOH 8 26
pathway0002340 pathway0000710 6 0.75 ERK cascade ( Insulin receptor signaling (D. melanogaster) ) INOH 8 26
pathway0002340 pathway0000711 6 0.75 ERK cascade ( Insulin receptor signaling (Mammal) ) INOH 8 26
pathway0002340 pathway0000713 6 0.75 ERK cascade ( NGF signaling pathway ) INOH 8 26
pathway0002340 pathway0002467 5 0.7142857 ERK cascade ( PDGF signaling pathway ) INOH 7 18
pathway0002340 pathway0000697 5 0.7142857 ERK cascade ( B cell receptor signaling ) INOH 7 22
pathway0002340 pathway0000699 5 0.7142857 ERK cascade ( CD4 T cell receptor signaling ) INOH 7 22
pathway0002340 pathway0000705 5 0.7142857 ERK cascade ( GPCR GroupI metabotropic glutamate receptor signaling pathway ) INOH 7 22
pathway0002340 pathway0000706 5 0.7142857 ERK cascade ( GPCR signaling (G alpha q) ) INOH 7 22
pathway0002340 pathway0000712 5 0.7142857 ERK cascade ( JAK-STAT pathway and regulation pathway Diagram ) INOH 7 22
pathway0002340 pathway0001796 5 0.7142857 Raf activation signaling (through RasGRP) ( CD4 T cell receptor signaling ) INOH 7 18
pathway0002340 pathway0001806 10 0.7142857 Ras signaling in the CD4+ TCR pathway PID 14 58
pathway0002340 pathway0002562 24 0.7058824 MAPK signaling pathway KEGG 264 4851
pathway0002340 pathway0001795 5 0.625 Raf activation signaling (through RasGRP) ( CD4 T cell receptor signaling (ERK cascade) ) INOH 8 25
pathway0002340 pathway0000077 3 0.6 Activation of RAS in B cells Reactome 5 9
pathway0002340 pathway0002059 3 0.6 Signalling to p38 via RIT and RIN Reactome 5 9
pathway0002340 pathway0000658 20 0.5882353 EGFR1 NetPath 475 10010
pathway0002340 pathway0000501 4 0.5714286 CREB phosphorylation Reactome 7 11
pathway0002340 pathway0000692 19 0.5588235 ErbB1 downstream signaling PID 105 1597
pathway0002340 pathway0000888 5 0.5555556 Gastrin-CREB signalling pathway via PKC and MAPK Reactome 9 21
pathway0002340 pathway0001791 5 0.5555556 Raf activation signaling (through Grb2 and Sos) ( B cell receptor signaling ) INOH 9 27
pathway0002340 pathway0001792 5 0.5555556 Raf activation signaling (through Grb2 and Sos) ( CD4 T cell receptor signaling (ERK cascade) ) INOH 9 27
pathway0002340 pathway0001793 5 0.5555556 Raf activation signaling (through Grb2 and Sos) ( CD4 T cell receptor signaling ) INOH 9 27
pathway0002340 pathway0001794 5 0.5555556 Raf activation signaling (through Grb2 and Sos) ( JAK-STAT pathway and regulation pathway Diagram ) INOH 9 27
pathway0002340 pathway0002750 8 0.5333333 Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 WikiPathways 15 37
pathway0002340 pathway0002617 17 0.5 Neurotrophin signaling pathway KEGG 126 2153
pathway0002340 pathway0000698 5 0.5 ERK cascade ( CD4 T cell receptor signaling (ERK cascade) ) INOH 10 42