Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002605 Cytosolic DNA-sensing pathway KEGG Homo sapiens 56 233
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
AIM2 ENSG00000163568 9447 Cytoplasm 0.006535948 6.0 5.135529 0.066666667
CHUK ENSG00000213341 1147 Cytoplasm 0.011494253 80.0 168.9265 0.022468354
DDX58 ENSG00000107201 23586 Cytoplasm 0.009174312 29.0 2.661511 0.083743842
IKBKE ENSG00000263528 9641 Cytoplasm 0.009708738 40.0 8.51235 0.062820513
PYCARD ENSG00000103490 29108 Cytoplasm 0.008196721 16.0 50.20017 0.075
RIPK1 ENSG00000137275 8737 Cytoplasm 0.008474576 30.0 6.442248 0.066666667
RIPK3 ENSG00000129465 11035 Cytoplasm 0.007692308 14.0 0.0 0.10989011
TBK1 ENSG00000183735 29110 Cytoplasm 0.01010101 49.0 45.76374 0.053571429
ZBP1 ENSG00000124256 81030 Cytoplasm 0.009174312 29.0 21.35125 0.071428571
ADAR ENSG00000160710 103 Cytoplasm/Nucleus 0.00729927 2.0 16.65975 0.0
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 0.011363636 89.0 96.94801 0.018386108
IKBKG ENSG00000269335 8517 Cytoplasm/Nucleus 0.011764706 81.0 153.0944 0.024691358
IRF7 ENSG00000185507 3665 Cytoplasm/Nucleus 0.010752688 67.0 358.7882 0.021709634
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 0.009708738 132.0 55.5116 0.005667361
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 0.008547009 174.0 3.546555 0.002391868
NFKBIB ENSG00000104825 4793 Cytoplasm/Nucleus 0.009009009 99.0 31.20857 0.005565863
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 0.011494253 142.0 210.9209 0.006392968
CASP1 ENSG00000137752 834 Unknown 0.006329114 15.0 8.590437 0.028571429
MAVS ENSG00000088888 57506 Unknown 0.009803922 38.0 12.77073 0.076813656
POLR3A ENSG00000148606 11128 Unknown 0.008547009 39.0 27.64499 0.062078273
POLR3G ENSG00000113356 10622 Unknown 0.006756757 36.0 0.0 0.071428571
POLR3GL ENSG00000121851 84265 Unknown 0.006756757 31.0 0.0 0.096774194
TMEM173 ENSG00000184584 340061 Unknown 0.007874016 21.0 0.8916173 0.071428571
IL33 ENSG00000137033 90865 Nucleus 0.007751938 5.0 1.119489 0.4
IRF3 ENSG00000126456 3661 Nucleus 0.011235955 64.0 258.2054 0.030753968
POLR1C ENSG00000171453 9533 Nucleus 0.006993007 40.0 3.904863 0.058974359
POLR1D ENSG00000186184 51082 Nucleus 0.009433962 48.0 322.5679 0.054964539
POLR3B ENSG00000013503 55703 Nucleus 0.006756757 38.0 0.0 0.06401138
POLR3C ENSG00000186141 10623 Nucleus 0.006756757 39.0 0.0 0.060728745
POLR3D ENSG00000168495 661 Nucleus 0.006756757 39.0 0.0 0.060728745
POLR3F ENSG00000132664 10621 Nucleus 0.006756757 38.0 0.0 0.06401138
POLR3H ENSG00000100413 171568 Nucleus 0.006756757 37.0 0.0 0.067567568
POLR3K ENSG00000161980 51728 Nucleus 0.006756757 33.0 0.0 0.085227273
TREX1 ENSG00000213689 11277 Nucleus 0.007518797 5.0 0.0 0.3
CCL5 ENSG00000271503 6352 Secreted 0.007518797 9.0 0.0 0.083333333
CXCL10 ENSG00000169245 3627 Secreted 0.009259259 9.0 6.692856 0.333333333
IFNA1 ENSG00000197919 3439 Secreted 0.007462687 6.0 0.1428571 0.333333333
IFNA10 ENSG00000186803 3446 Secreted 0.007352941 3.0 0.0 0.333333333
IFNA13 ENSG00000233816 3447 Secreted 0.007462687 6.0 0.1428571 0.333333333
IFNA14 ENSG00000228083 3448 Secreted 0.007352941 3.0 0.0 0.333333333
IFNA16 ENSG00000147885 3449 Secreted 0.007352941 3.0 0.0 0.333333333
IFNA17 ENSG00000234829 3451 Secreted 0.007407407 4.0 0.0 0.5
IFNA2 ENSG00000188379 3440 Secreted 0.007692308 4.0 10.04433 0.166666667
IFNA21 ENSG00000137080 3452 Secreted 0.007352941 3.0 0.0 0.333333333
IFNA4 ENSG00000236637 3441 Secreted 0.007407407 4.0 0.0 0.5
IFNA5 ENSG00000147873 3442 Secreted 0.007633588 8.0 1.333333 0.392857143
IFNA6 ENSG00000120235 3443 Secreted 0.007407407 4.0 0.0 0.5
IFNA7 ENSG00000214042 3444 Secreted 0.007352941 3.0 0.0 0.333333333
IFNA8 ENSG00000120242 3445 Secreted 0.007462687 5.0 0.08333333 0.5
IFNB1 ENSG00000171855 3456 Secreted 0.008695652 7.0 0.09456681 0.095238095
IL18 ENSG00000150782 3606 Secreted 0.007633588 10.0 6.476262 0.022222222
IL6 ENSG00000136244 3569 Secreted 0.0078125 16.0 10.386 0.041666667
IL1B ENSG00000125538 3553 Secreted/Nucleus 0.008474576 30.0 25.23683 0.03908046
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
AIM2 ENSG00000163568 9447 Cytoplasm 11.0 20.77546 1.53E-6 0.018181818
CHUK ENSG00000213341 1147 Cytoplasm 9301.0 163422.9 1.56E-6 1.34521E-4
DDX58 ENSG00000107201 23586 Cytoplasm 424.0 16248.48 1.55E-6 0.004025603
IKBKE ENSG00000263528 9641 Cytoplasm 626.0 10541.6 1.55E-6 0.006446006
PYCARD ENSG00000103490 29108 Cytoplasm 131.0 43327.24 1.55E-6 0.007985907
RIPK1 ENSG00000137275 8737 Cytoplasm 2320.0 15130.51 1.56E-6 8.73965E-4
RIPK3 ENSG00000129465 11035 Cytoplasm 318.0 2805.618 1.55E-6 0.008193957
TBK1 ENSG00000183735 29110 Cytoplasm 640.0 30783.72 1.55E-6 0.004088419
ZBP1 ENSG00000124256 81030 Cytoplasm 93.0 69.51932 1.54E-6 0.008648901
ADAR ENSG00000160710 103 Cytoplasm/Nucleus 5.0 38.79019 1.53E-6 0.1
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 10428.0 206047.6 1.56E-6 1.0306E-4
IKBKG ENSG00000269335 8517 Cytoplasm/Nucleus 7020.0 200834.7 1.56E-6 2.06887E-4
IRF7 ENSG00000185507 3665 Cytoplasm/Nucleus 775.0 27409.34 1.55E-6 0.001623739
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 11386.0 279636.5 1.56E-6 2.06234E-4
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 12604.0 63578.71 1.56E-6 3.76E-5
NFKBIB ENSG00000104825 4793 Cytoplasm/Nucleus 3015.0 7652.721 1.56E-6 2.2207E-4
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 11059.0 663081.0 1.57E-6 3.07612E-4
CASP1 ENSG00000137752 834 Unknown 236.0 25741.57 1.55E-6 0.006815723
MAVS ENSG00000088888 57506 Unknown 423.0 11521.3 1.55E-6 0.004145519
POLR3A ENSG00000148606 11128 Unknown 812.0 2356.073 1.54E-6 0.00700953
POLR3G ENSG00000113356 10622 Unknown 750.0 1444.304 1.54E-6 0.008145972
POLR3GL ENSG00000121851 84265 Unknown 698.0 1444.271 1.54E-6 0.009405845
TMEM173 ENSG00000184584 340061 Unknown 110.0 20734.07 1.54E-6 0.010175146
IL33 ENSG00000137033 90865 Nucleus 8.0 575.3722 1.54E-6 0.285714286
IRF3 ENSG00000126456 3661 Nucleus 760.0 29345.83 1.55E-6 0.001608765
POLR1C ENSG00000171453 9533 Nucleus 1421.0 7687.888 1.55E-6 0.006716159
POLR1D ENSG00000186184 51082 Nucleus 1410.0 19637.03 1.55E-6 0.007198909
POLR3B ENSG00000013503 55703 Nucleus 799.0 1475.466 1.54E-6 0.007176891
POLR3C ENSG00000186141 10623 Nucleus 826.0 1872.943 1.54E-6 0.006715093
POLR3D ENSG00000168495 661 Nucleus 822.0 2949.222 1.55E-6 0.006801391
POLR3F ENSG00000132664 10621 Nucleus 802.0 1731.316 1.54E-6 0.007123266
POLR3H ENSG00000100413 171568 Nucleus 783.0 1473.068 1.54E-6 0.007473388
POLR3K ENSG00000161980 51728 Nucleus 798.0 7746.247 1.54E-6 0.008830105
TREX1 ENSG00000213689 11277 Nucleus 11.0 0.0 1.53E-6 0.109090909
CCL5 ENSG00000271503 6352 Secreted 554.0 19565.22 1.56E-6 0.00904812
CXCL10 ENSG00000169245 3627 Secreted 440.0 4059.904 1.55E-6 0.014091945
IFNA1 ENSG00000197919 3439 Secreted 770.0 40253.93 1.55E-6 0.006143921
IFNA10 ENSG00000186803 3446 Secreted 562.0 612.5992 1.55E-6 0.008107028
IFNA13 ENSG00000233816 3447 Secreted 770.0 40253.93 1.55E-6 0.006143921
IFNA14 ENSG00000228083 3448 Secreted 567.0 2378.315 1.55E-6 0.008026873
IFNA16 ENSG00000147885 3449 Secreted 562.0 612.5992 1.55E-6 0.008107028
IFNA17 ENSG00000234829 3451 Secreted 587.0 612.5992 1.55E-6 0.007930648
IFNA2 ENSG00000188379 3440 Secreted 652.0 6388.141 1.55E-6 0.007463742
IFNA21 ENSG00000137080 3452 Secreted 562.0 612.5992 1.55E-6 0.008107028
IFNA4 ENSG00000236637 3441 Secreted 587.0 612.5992 1.55E-6 0.007930648
IFNA5 ENSG00000147873 3442 Secreted 704.0 1827.21 1.55E-6 0.00694669
IFNA6 ENSG00000120235 3443 Secreted 587.0 612.5992 1.55E-6 0.007930648
IFNA7 ENSG00000214042 3444 Secreted 571.0 10991.75 1.55E-6 0.008043752
IFNA8 ENSG00000120242 3445 Secreted 657.0 1478.211 1.55E-6 0.00700245
IFNB1 ENSG00000171855 3456 Secreted 649.0 3562.363 1.55E-6 0.006596093
IL18 ENSG00000150782 3606 Secreted 568.0 43835.48 1.55E-6 0.012370519
IL6 ENSG00000136244 3569 Secreted 1764.0 36120.77 1.56E-6 0.003841242
IL1B ENSG00000125538 3553 Secreted/Nucleus 2345.0 54296.22 1.56E-6 0.001728316
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
AIM2 ENSG00000163568 9447 Cytoplasm 6.0 17.1 4.08E-6 0.066666667
CHUK ENSG00000213341 1147 Cytoplasm 2599.0 36200.0 4.21E-6 6.51047E-4
DDX58 ENSG00000107201 23586 Cytoplasm 139.0 7170.0 4.16E-6 0.018454801
IKBKE ENSG00000263528 9641 Cytoplasm 225.0 2820.0 4.17E-6 0.01234127
PYCARD ENSG00000103490 29108 Cytoplasm 53.0 11400.0 4.15E-6 0.027576197
RIPK1 ENSG00000137275 8737 Cytoplasm 323.0 1010.0 4.18E-6 0.013076169
RIPK3 ENSG00000129465 11035 Cytoplasm 14.0 0.0 4.14E-6 0.10989011
TBK1 ENSG00000183735 29110 Cytoplasm 230.0 10700.0 4.17E-6 0.011239795
ZBP1 ENSG00000124256 81030 Cytoplasm 29.0 8.05 4.14E-6 0.071428571
ADAR ENSG00000160710 103 Cytoplasm/Nucleus 2.0 25.8 4.08E-6 0.0
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 3098.0 92800.0 4.21E-6 5.24884E-4
IKBKG ENSG00000269335 8517 Cytoplasm/Nucleus 2435.0 52500.0 4.21E-6 7.02235E-4
IRF7 ENSG00000185507 3665 Cytoplasm/Nucleus 335.0 6300.0 4.16E-6 0.004683171
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 3288.0 55500.0 4.21E-6 4.9687E-4
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 3700.0 14800.0 4.21E-6 1.59868E-4
NFKBIB ENSG00000104825 4793 Cytoplasm/Nucleus 1068.0 1680.0 4.19E-6 4.47543E-4
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 3598.0 133000.0 4.22E-6 6.77638E-4
CASP1 ENSG00000137752 834 Unknown 61.0 5880.0 4.16E-6 0.033333333
MAVS ENSG00000088888 57506 Unknown 183.0 9810.0 4.17E-6 0.018074821
POLR3A ENSG00000148606 11128 Unknown 328.0 2850.0 4.17E-6 0.032128739
POLR3G ENSG00000113356 10622 Unknown 308.0 107.0 4.16E-6 0.03612674
POLR3GL ENSG00000121851 84265 Unknown 291.0 107.0 4.16E-6 0.04047873
TMEM173 ENSG00000184584 340061 Unknown 41.0 18.1 4.13E-6 0.031707317
IL33 ENSG00000137033 90865 Nucleus 5.0 0.145 4.14E-6 0.4
IRF3 ENSG00000126456 3661 Nucleus 282.0 4500.0 4.18E-6 0.006360264
POLR1C ENSG00000171453 9533 Nucleus 344.0 319.0 4.16E-6 0.028968066
POLR1D ENSG00000186184 51082 Nucleus 340.0 23300.0 4.18E-6 0.029932327
POLR3B ENSG00000013503 55703 Nucleus 322.0 107.0 4.16E-6 0.033048896
POLR3C ENSG00000186141 10623 Nucleus 323.0 107.0 4.16E-6 0.032844259
POLR3D ENSG00000168495 661 Nucleus 321.0 107.0 4.16E-6 0.033255452
POLR3F ENSG00000132664 10621 Nucleus 316.0 107.0 4.16E-6 0.034317862
POLR3H ENSG00000100413 171568 Nucleus 313.0 107.0 4.16E-6 0.03497993
POLR3K ENSG00000161980 51728 Nucleus 363.0 4120.0 4.16E-6 0.033894952
TREX1 ENSG00000213689 11277 Nucleus 5.0 0.0 4.1E-6 0.3
CCL5 ENSG00000271503 6352 Secreted 264.0 5060.0 4.19E-6 0.022871299
CXCL10 ENSG00000169245 3627 Secreted 195.0 1950.0 4.19E-6 0.043986254
IFNA1 ENSG00000197919 3439 Secreted 248.0 6240.0 4.16E-6 0.049333943
IFNA10 ENSG00000186803 3446 Secreted 169.0 131.0 4.16E-6 0.081501832
IFNA13 ENSG00000233816 3447 Secreted 248.0 6240.0 4.16E-6 0.049333943
IFNA14 ENSG00000228083 3448 Secreted 171.0 610.0 4.16E-6 0.079738562
IFNA16 ENSG00000147885 3449 Secreted 169.0 131.0 4.16E-6 0.081501832
IFNA17 ENSG00000234829 3451 Secreted 178.0 131.0 4.16E-6 0.076937726
IFNA2 ENSG00000188379 3440 Secreted 208.0 3580.0 4.18E-6 0.061269045
IFNA21 ENSG00000137080 3452 Secreted 169.0 131.0 4.16E-6 0.081501832
IFNA4 ENSG00000236637 3441 Secreted 178.0 131.0 4.16E-6 0.076937726
IFNA5 ENSG00000147873 3442 Secreted 221.0 622.0 4.16E-6 0.059152612
IFNA6 ENSG00000120235 3443 Secreted 178.0 131.0 4.16E-6 0.076937726
IFNA7 ENSG00000214042 3444 Secreted 169.0 131.0 4.16E-6 0.081501832
IFNA8 ENSG00000120242 3445 Secreted 210.0 501.0 4.17E-6 0.05914787
IFNB1 ENSG00000171855 3456 Secreted 236.0 434.0 4.17E-6 0.044284169
IL18 ENSG00000150782 3606 Secreted 92.0 3980.0 4.17E-6 0.227902532
IL6 ENSG00000136244 3569 Secreted 455.0 7980.0 4.2E-6 0.021358377
IL1B ENSG00000125538 3553 Secreted/Nucleus 791.0 39400.0 4.21E-6 0.007722959
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
AIM2 PYCARD 4
CASP1 IL18 5
CASP1 IL1B 6
CASP1 PYCARD 4
CHUK IKBKB 11
CHUK IKBKE 3
CHUK IKBKG 10
CHUK IRF7 4
CHUK NFKB1 10
CHUK NFKBIA 14
CHUK NFKBIB 9
CHUK POLR1D 2
CHUK RELA 11
DDX58 CHUK 1
DDX58 IKBKB 1
DDX58 IKBKE 2
DDX58 IKBKG 2
DDX58 IRF3 2
DDX58 MAVS 8
DDX58 TBK1 2
IKBKB IKBKG 12
IKBKB IRF3 2
IKBKB MAVS 3
IKBKB NFKB1 9
IKBKB NFKBIA 14
IKBKB NFKBIB 12
IKBKB POLR1D 2
IKBKB RELA 11
IKBKE IRF3 7
IKBKE IRF7 4
IKBKE MAVS 4
IKBKE NFKBIA 4
IKBKE RELA 4
IKBKE TBK1 4
IKBKG MAVS 3
IKBKG NFKB1 8
IKBKG NFKBIA 11
IKBKG NFKBIB 9
IKBKG POLR1D 2
IKBKG RELA 6
IKBKG RIPK1 5
IKBKG TBK1 6
IL18 RELA 2
IL1B CCL5 1
IL1B IL6 1
IL1B NFKB1 3
IL1B NFKBIA 1
IL1B RELA 3
IL33 RELA 1
IRF3 IFNB1 2
IRF3 IRF7 3
IRF3 MAVS 4
IRF3 TBK1 5
IRF3 TMEM173 2
IRF3 ZBP1 3
IRF7 IFNA1 2
IRF7 IFNA10 2
IRF7 IFNA13 2
IRF7 IFNA14 2
IRF7 IFNA16 2
IRF7 IFNA17 2
IRF7 IFNA2 2
IRF7 IFNA21 2
IRF7 IFNA4 2
IRF7 IFNA5 2
IRF7 IFNA6 2
IRF7 IFNA7 2
IRF7 IFNA8 2
IRF7 IFNB1 4
IRF7 MAVS 3
IRF7 TBK1 4
MAVS CHUK 2
MAVS TBK1 5
MAVS TMEM173 5
NFKB1 IL6 2
NFKB1 NFKBIA 12
NFKB1 NFKBIB 9
NFKB1 POLR1D 2
NFKB1 RELA 12
NFKBIA NFKBIB 7
NFKBIA RELA 14
NFKBIB POLR1D 5
NFKBIB RELA 11
POLR1C POLR1D 5
POLR1C POLR3A 3
POLR1C POLR3B 3
POLR1C POLR3C 3
POLR1C POLR3D 3
POLR1C POLR3F 3
POLR1C POLR3G 3
POLR1C POLR3GL 2
POLR1C POLR3H 3
POLR1C POLR3K 3
POLR1D POLR3A 3
POLR1D POLR3B 3
POLR1D POLR3C 2
POLR1D POLR3D 3
POLR1D POLR3F 3
POLR1D POLR3G 2
POLR1D POLR3GL 2
POLR1D POLR3H 3
POLR1D POLR3K 2
POLR1D RELA 2
POLR3A POLR3B 3
POLR3A POLR3C 3
POLR3A POLR3D 3
POLR3A POLR3F 4
POLR3A POLR3G 3
POLR3A POLR3GL 2
POLR3A POLR3H 3
POLR3A POLR3K 2
POLR3B POLR3C 3
POLR3B POLR3D 3
POLR3B POLR3F 3
POLR3B POLR3G 3
POLR3B POLR3GL 2
POLR3B POLR3H 3
POLR3B POLR3K 2
POLR3C POLR3D 3
POLR3C POLR3F 5
POLR3C POLR3G 5
POLR3C POLR3GL 3
POLR3C POLR3H 3
POLR3C POLR3K 3
POLR3D POLR3F 4
POLR3D POLR3G 4
POLR3D POLR3GL 2
POLR3D POLR3H 3
POLR3D POLR3K 3
POLR3F POLR3G 5
POLR3F POLR3GL 4
POLR3F POLR3H 2
POLR3F POLR3K 2
POLR3GL POLR3H 2
POLR3GL POLR3K 2
POLR3G POLR3H 3
POLR3G POLR3K 2
POLR3H POLR3K 2
RELA IL6 2
RIPK1 CHUK 4
RIPK1 IKBKB 4
RIPK1 RELA 1
RIPK1 RIPK3 5
RIPK1 ZBP1 3
RIPK3 CHUK 2
RIPK3 IKBKB 2
RIPK3 ZBP1 3
TBK1 NFKBIA 2
TBK1 TMEM173 6
TREX1 IRF3 1
TREX1 TBK1 1
ZBP1 CHUK 1
ZBP1 IKBKB 1
ZBP1 TBK1 2
ADAR AIM2 1
AIM2 CASP1 1
CASP1 IL33 2
CCL5 NFKB1 1
CCL5 RELA 2
CHUK CXCL10 1
CHUK PYCARD 2
CHUK TBK1 1
CXCL10 IKBKB 1
CXCL10 IRF3 1
CXCL10 NFKB1 1
CXCL10 RELA 1
DDX58 RIPK1 1
DDX58 TMEM173 3
IFNA13 IFNA5 1
IFNA13 IFNA8 1
IFNA17 IFNA5 1
IFNA1 IFNA5 1
IFNA1 IFNA8 1
IFNA2 IL6 1
IFNA4 IFNA5 1
IFNA5 IFNA6 1
IKBKB IKBKE 1
IKBKB PYCARD 2
IKBKB TBK1 2
IKBKE IKBKG 1
IKBKG IL1B 1
IKBKG IRF3 1
IKBKG IRF7 1
IKBKG POLR3A 1
IKBKG PYCARD 1
IL1B CXCL10 1
IL33 IL1B 1
IL33 IL6 1
IRF3 IFNA1 1
IRF3 IFNA10 1
IRF3 IFNA13 1
IRF3 IFNA14 1
IRF3 IFNA16 1
IRF3 IFNA17 1
IRF3 IFNA2 1
IRF3 IFNA21 1
IRF3 IFNA4 1
IRF3 IFNA5 1
IRF3 IFNA6 1
IRF3 IFNA7 1
IRF3 IFNA8 1
IRF3 RELA 1
IRF7 ADAR 1
IRF7 CXCL10 1
IRF7 DDX58 1
MAVS NFKB1 1
MAVS NFKBIA 1
MAVS RELA 1
MAVS RIPK1 1
NFKB1 IL18 1
NFKB1 TBK1 2
NFKBIB POLR1C 4
NFKBIB TBK1 1
POLR3G POLR3GL 1
PYCARD IL1B 1
PYCARD RIPK1 2
RELA IFNB1 1
RELA TBK1 3
RIPK1 NFKB1 1
RIPK3 IKBKG 1
TMEM173 IKBKE 1
TREX1 TMEM173 1
ZBP1 IKBKE 1
ZBP1 IKBKG 1
ZBP1 IRF7 1
ZBP1 TMEM173 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002605 pathway0001090 7 0.875 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) Reactome 8 30
pathway0002605 pathway0001091 7 0.875 IKK-NF-kappaB cascade ( B cell receptor signaling ) INOH 8 30
pathway0002605 pathway0001092 7 0.875 IKK-NF-kappaB cascade ( CD4 T cell receptor signaling (NF-kB cascade) ) INOH 8 30
pathway0002605 pathway0001093 7 0.875 IKK-NF-kappaB cascade ( CD4 T cell receptor signaling ) INOH 8 30
pathway0002605 pathway0001089 6 0.8571429 IkBA variant leads to EDA-ID Reactome 7 23
pathway0002605 pathway0001094 9 0.8181818 IKK-NFkB cascade ( TNFR1 signaling pathway ) INOH 11 44
pathway0002605 pathway0001082 13 0.7222222 IFN alpha signaling pathway(JAK1 TYK2 STAT1) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) INOH 18 83
pathway0002605 pathway0001083 13 0.7222222 IFN alpha signaling pathway(JAK1 TYK2 STAT3) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) INOH 18 73
pathway0002605 pathway0001182 5 0.7142857 Interleukin-1 processing Reactome 7 19
pathway0002605 pathway0001081 13 0.6842105 IFN alpha signaling pathway(JAK1 TYK2 STAT1 STAT3) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) INOH 19 91
pathway0002605 pathway0000452 4 0.6666667 CLEC7A/inflammasome pathway Reactome 6 15
pathway0002605 pathway0001213 4 0.6666667 IRF3 mediated activation of type 1 IFN Reactome 6 16
pathway0002605 pathway0001080 13 0.65 IFN alpha signaling pathway((JAK1 TYK2 STAT1 STAT2) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) ) INOH 20 106
pathway0002605 pathway0001927 11 0.6111111 RNA Polymerase III Chain Elongation Reactome 18 153
pathway0002605 pathway0002282 20 0.6060606 TRAF6 mediated IRF7 activation Reactome 33 184
pathway0002605 pathway0001483 7 0.5833333 NF-kB signaling ( Toll-like receptor signaling pathway (trough NF-kappaB) ) INOH 12 64
pathway0002605 pathway0001840 14 0.5384615 Regulation of IFNA signaling Reactome 26 216
pathway0002605 pathway0002604 30 0.5357143 RIG-I-like receptor signaling pathway KEGG 71 471
pathway0002605 pathway0002602 29 0.5178571 Toll-like receptor signaling pathway KEGG 100 1158
pathway0002605 pathway0002845 4 0.5 Hs_TLR4_Signaling_and_Tolerance_WP3851_90114 WikiPathways 8 12
pathway0002605 pathway0000532 11 0.5 Cytosolic sensors of pathogen-associated DNA Reactome 22 166
pathway0002605 pathway0001481 6 0.5 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Reactome 12 63
pathway0002605 pathway0002278 7 0.5 TRAF3-dependent IRF activation pathway Reactome 14 55