Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002624 Insulin signaling pathway KEGG Homo sapiens 134 1756
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
BAD ENSG00000002330 572 Cytoplasm 0.00390625 111.0 30.0 0.030630631
BRAF ENSG00000157764 673 Cytoplasm 0.004065041 196.0 56.8 0.008529566
CBLC ENSG00000142273 23624 Cytoplasm 0.003267974 25.0 0.887 0.266666667
EIF4E1B ENSG00000175766 253314 Cytoplasm 0.002493766 4.0 0.0583 0.166666667
EIF4E2 ENSG00000135930 9470 Cytoplasm 0.002493766 5.0 0.081 0.1
EXOC7 ENSG00000182473 23265 Cytoplasm 0.003484321 13.0 1.84 0.102564103
FBP1 ENSG00000165140 2203 Cytoplasm 0.003424658 26.0 42.9 0.184615385
FBP2 ENSG00000130957 8789 Cytoplasm 0.003058104 4.0 1.55 0.333333333
G6PC ENSG00000131482 2538 Cytoplasm 0.003378378 30.0 19.0 0.245977011
G6PC2 ENSG00000152254 57818 Cytoplasm 0.003257329 26.0 11.6 0.276923077
GYS2 ENSG00000111713 2998 Cytoplasm 0.003205128 25.0 6.22 0.096666667
HK1 ENSG00000156515 3098 Cytoplasm 0.003787879 26.0 14.1 0.224615385
HK2 ENSG00000159399 3099 Cytoplasm 0.003311258 28.0 11.5 0.187830688
HK3 ENSG00000160883 3101 Cytoplasm 0.003311258 25.0 7.1 0.236666667
INPP5D ENSG00000168918 3635 Cytoplasm 0.004032258 89.0 23.2 0.073544433
IRS1 ENSG00000169047 3667 Cytoplasm 0.004273504 174.0 189.0 0.034482759
IRS4 ENSG00000133124 8471 Cytoplasm 0.003968254 87.0 65.4 0.053996258
KRAS ENSG00000133703 3845 Cytoplasm 0.004237288 289.0 111.0 0.010068243
MAP2K1 ENSG00000169032 5604 Cytoplasm 0.003984064 238.0 12.8 0.010353508
MAPK10 ENSG00000109339 5602 Cytoplasm 0.003759398 45.0 6.56 0.103030303
PCK1 ENSG00000124253 5105 Cytoplasm 0.003676471 19.0 13.4 0.204678363
PCK2 ENSG00000100889 5106 Cytoplasm 0.003759398 27.0 18.1 0.282051282
PDE3B ENSG00000152270 5140 Cytoplasm 0.003636364 33.0 8.13 0.126893939
PHKA1 ENSG00000067177 5255 Cytoplasm 0.003412969 39.0 12.5 0.209176788
PHKG1 ENSG00000164776 5260 Cytoplasm 0.003412969 41.0 12.3 0.18902439
PHKG2 ENSG00000156873 5261 Cytoplasm 0.003546099 41.0 38.2 0.215853659
PKLR ENSG00000143627 5313 Cytoplasm 0.003703704 29.0 27.4 0.150246305
PPP1R3A ENSG00000154415 5506 Cytoplasm 0.003816794 22.0 22.5 0.376623377
PPP1R3C ENSG00000119938 5507 Cytoplasm 0.003802281 26.0 18.2 0.356923077
PPP1R3D ENSG00000132825 5509 Cytoplasm 0.003690037 19.0 6.19 0.549707602
PRKAA1 ENSG00000132356 5562 Cytoplasm 0.004347826 73.0 149.0 0.107305936
PRKAB1 ENSG00000111725 5564 Cytoplasm 0.00390625 41.0 30.1 0.191463415
PRKAB2 ENSG00000131791 5565 Cytoplasm 0.003875969 39.0 30.3 0.20782726
PRKACB ENSG00000142875 5567 Cytoplasm 0.004115226 54.0 82.7 0.163522013
PRKACG ENSG00000165059 5568 Cytoplasm 0.003802281 41.0 28.3 0.185365854
PRKAR1A ENSG00000108946 5573 Cytoplasm 0.003952569 35.0 18.4 0.210084034
PRKAR1B ENSG00000188191 5575 Cytoplasm 0.003597122 23.0 1.17 0.308300395
PRKX ENSG00000183943 5613 Cytoplasm 0.003144654 12.0 0.931 0.333333333
PTPN1 ENSG00000196396 5770 Cytoplasm 0.003745318 41.0 0.99 0.113414634
PYGM ENSG00000068976 5837 Cytoplasm 0.003802281 51.0 132.0 0.098039216
RAPGEF1 ENSG00000107263 2889 Cytoplasm 0.003484321 37.0 16.6 0.075075075
SHC3 ENSG00000148082 53358 Cytoplasm 0.003649635 34.0 2.41 0.222816399
SHC4 ENSG00000185634 399694 Cytoplasm 0.003154574 13.0 8.26 0.025641026
SOCS1 ENSG00000185338 8651 Cytoplasm 0.003278689 17.0 0.784 0.316176471
SOCS2 ENSG00000120833 8835 Cytoplasm 0.003174603 10.0 3.08 0.288888889
SOS1 ENSG00000115904 6654 Cytoplasm 0.004291845 203.0 29.2 0.026483929
SOS2 ENSG00000100485 6655 Cytoplasm 0.003891051 138.0 9.0 0.035650058
TSC1 ENSG00000165699 7248 Cytoplasm 0.003703704 40.0 4.29 0.16025641
ACACB ENSG00000076555 32 Cytoplasm/Nucleus 0.003095975 25.0 4.54 0.1
AKT2 ENSG00000105221 208 Cytoplasm/Nucleus 0.005102041 481.0 445.0 0.006470894
ARAF ENSG00000078061 369 Cytoplasm/Nucleus 0.003773585 145.0 5.78 0.014846743
CALM1 ENSG00000198668 801 Cytoplasm/Nucleus 0.00456621 85.0 223.0 0.084033613
CALM2 ENSG00000143933 805 Cytoplasm/Nucleus 0.004545455 84.0 216.0 0.081755594
CALM3 ENSG00000160014 808 Cytoplasm/Nucleus 0.004545455 84.0 216.0 0.081755594
CALML3 ENSG00000178363 810 Cytoplasm/Nucleus 0.003448276 25.0 5.63 0.256666667
CBL ENSG00000110395 867 Cytoplasm/Nucleus 0.004255319 98.0 73.0 0.063538818
CBLB ENSG00000114423 868 Cytoplasm/Nucleus 0.003831418 54.0 9.48 0.125786164
CRK ENSG00000167193 1398 Cytoplasm/Nucleus 0.004098361 80.0 44.3 0.084810127
CRKL ENSG00000099942 1399 Cytoplasm/Nucleus 0.003717472 57.0 12.9 0.138471178
EIF4E ENSG00000151247 1977 Cytoplasm/Nucleus 0.003225806 22.0 6.83 0.077922078
EIF4EBP1 ENSG00000187840 1978 Cytoplasm/Nucleus 0.003623188 48.0 185.0 0.041666667
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 0.004115226 74.0 58.2 0.038504258
FASN ENSG00000169710 2194 Cytoplasm/Nucleus 0.003816794 22.0 27.5 0.077922078
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 0.003891051 48.0 95.6 0.040780142
GCK ENSG00000106633 2645 Cytoplasm/Nucleus 0.003649635 26.0 28.4 0.203076923
GYS1 ENSG00000104812 2997 Cytoplasm/Nucleus 0.003546099 35.0 49.9 0.08907563
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 0.004081633 85.0 65.6 0.041176471
IRS2 ENSG00000185950 8660 Cytoplasm/Nucleus 0.004098361 111.0 46.6 0.062244062
LIPE ENSG00000079435 3991 Cytoplasm/Nucleus 0.003436426 19.0 4.67 0.175438596
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 0.003861004 231.0 7.32 0.008770939
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 0.004545455 243.0 330.0 0.012889841
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 0.004405286 215.0 201.0 0.013866551
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 0.004424779 94.0 111.0 0.081674674
MAPK9 ENSG00000050748 5601 Cytoplasm/Nucleus 0.004032258 56.0 10.7 0.142207792
MKNK2 ENSG00000099875 2872 Cytoplasm/Nucleus 0.003021148 18.0 23.4 0.019607843
PPP1CC ENSG00000186298 5501 Cytoplasm/Nucleus 0.004166667 41.0 41.6 0.319512195
PRKAA2 ENSG00000162409 5563 Cytoplasm/Nucleus 0.004098361 63.0 98.6 0.131592422
PRKAG2 ENSG00000106617 51422 Cytoplasm/Nucleus 0.003816794 37.0 26.1 0.1996997
PRKAR2A ENSG00000114302 5576 Cytoplasm/Nucleus 0.003717472 28.0 5.93 0.298941799
PRKAR2B ENSG00000005249 5577 Cytoplasm/Nucleus 0.003703704 30.0 5.69 0.268965517
PRKCI ENSG00000163558 5584 Cytoplasm/Nucleus 0.004115226 66.0 30.8 0.144055944
PYGB ENSG00000100994 5834 Cytoplasm/Nucleus 0.003436426 34.0 19.2 0.121212121
RPS6 ENSG00000137154 6194 Cytoplasm/Nucleus 0.003597122 28.0 17.2 0.063492063
RPS6KB1 ENSG00000108443 6198 Cytoplasm/Nucleus 0.004016064 90.0 33.6 0.045692884
SOCS3 ENSG00000184557 9021 Cytoplasm/Nucleus 0.003184713 17.0 2.4 0.176470588
TRIP10 ENSG00000125733 9322 Cytoplasm/Nucleus 0.003322259 11.0 0.987 0.145454545
PIK3CD ENSG00000171608 5293 Cytoskeleton 0.004201681 254.0 29.3 0.014938844
PPP1CA ENSG00000172531 5499 Cytoskeleton/Nucleus 0.004347826 51.0 109.0 0.256470588
AKT1 ENSG00000142208 207 Membrane 0.005405405 604.0 1110.0 0.005035529
AKT3 ENSG00000117020 10000 Membrane 0.005050505 477.0 426.0 0.005575815
HRAS ENSG00000174775 3265 Membrane 0.004484305 289.0 160.0 0.013648597
INSR ENSG00000171105 3643 Membrane 0.004484305 134.0 227.0 0.053866008
MTOR ENSG00000198793 2475 Membrane 0.004608295 173.0 229.0 0.033539454
NRAS ENSG00000213281 4893 Membrane 0.004273504 247.0 157.0 0.013034462
PDE3A ENSG00000172572 5139 Membrane 0.003745318 32.0 12.9 0.137096774
PIK3CA ENSG00000121879 5290 Membrane 0.004329004 286.0 147.0 0.013029076
PIK3CG ENSG00000105851 5294 Membrane 0.004237288 258.0 44.5 0.01459898
PIK3R1 ENSG00000145675 5295 Membrane 0.004405286 292.0 92.7 0.01245116
PIK3R2 ENSG00000105647 5296 Membrane 0.004219409 254.0 68.2 0.013662818
PIK3R5 ENSG00000141506 23533 Membrane 0.004065041 201.0 20.4 0.013930348
PTPRF ENSG00000142949 5792 Membrane 0.003424658 13.0 2.68 0.217948718
RAF1 ENSG00000132155 5894 Membrane 0.004149378 241.0 62.8 0.007745505
RHEB ENSG00000106615 6009 Membrane 0.003703704 36.0 9.56 0.133333333
RHOQ ENSG00000119729 23433 Membrane 0.003636364 30.0 27.7 0.142528736
SH2B2 ENSG00000160999 10603 Membrane 0.003546099 23.0 2.38 0.205533597
SHC1 ENSG00000160691 6464 Membrane 0.004484305 135.0 64.1 0.062797125
SLC2A4 ENSG00000181856 6517 Membrane 0.004273504 45.0 188.0 0.219191919
SORBS1 ENSG00000095637 10580 Membrane 0.003663004 17.0 5.18 0.323529412
PRKCZ ENSG00000067606 5590 Membrane/Nucleus 0.004504505 110.0 57.5 0.093077565
ACACA ENSG00000278540 31 Unknown 0.003846154 41.0 71.1 0.146341463
CALML6 ENSG00000169885 163688 Unknown 0.003448276 23.0 5.22 0.304347826
GRB2 ENSG00000177885 2885 Unknown 0.00462963 286.0 322.0 0.015458226
GSK3B ENSG00000082701 2932 Unknown 0.004255319 125.0 182.0 0.023354839
MKNK1 ENSG00000079277 8569 Unknown 0.003496503 28.0 70.9 0.066137566
PDPK1 ENSG00000140992 5170 Unknown 0.0041841 198.0 24.7 0.019996924
PHKA2 ENSG00000044446 5256 Unknown 0.003508772 37.0 11.1 0.208708709
PHKB ENSG00000102893 5257 Unknown 0.003584229 47.0 22.7 0.166512488
PIK3CB ENSG00000051382 5291 Unknown 0.004201681 259.0 29.9 0.014366526
PIK3R3 ENSG00000117461 8503 Unknown 0.004166667 229.0 52.7 0.015858423
PPP1R3B ENSG00000173281 79660 Unknown 0.003717472 21.0 7.98 0.423809524
PRKACA ENSG00000072062 5566 Unknown 0.0041841 78.0 144.0 0.080586081
PRKAG1 ENSG00000181929 5571 Unknown 0.003875969 36.0 20.4 0.215873016
PRKAG3 ENSG00000115592 53632 Unknown 0.003703704 31.0 13.3 0.230107527
PYGL ENSG00000100504 5836 Unknown 0.00390625 42.0 62.7 0.132404181
RPS6KB2 ENSG00000175634 6199 Unknown 0.003571429 40.0 3.66 0.066666667
RPTOR ENSG00000141564 57521 Unknown 0.003937008 56.0 38.2 0.105194805
SHC2 ENSG00000129946 25759 Unknown 0.003649635 36.0 2.46 0.198412698
SOCS4 ENSG00000180008 122809 Unknown 0.003125 9.0 0.00984 0.361111111
SREBF1 ENSG00000072310 6720 Unknown 0.004032258 42.0 169.0 0.089430894
TSC2 ENSG00000103197 7249 Unknown 0.004016064 69.0 26.5 0.066496164
PPARGC1A ENSG00000109819 10891 Nucleus 0.003496503 28.0 4.16 0.111111111
PPP1CB ENSG00000213639 5500 Nucleus 0.004048583 35.0 30.9 0.31092437
CALML5 ENSG00000178372 51806 Secreted 0.003448276 23.0 5.22 0.304347826
INS ENSG00000254647 3630 Secreted 0.004464286 91.0 67.3 0.101831502
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BAD ENSG00000002330 572 Cytoplasm 4485.0 12100.0 1.55E-6 8.39E-5
BRAF ENSG00000157764 673 Cytoplasm 12094.0 42600.0 1.56E-6 4.04E-5
CBLC ENSG00000142273 23624 Cytoplasm 396.0 489.0 1.55E-6 0.0192
EIF4E1B ENSG00000175766 253314 Cytoplasm 14.0 0.521 1.53E-6 0.044
EIF4E2 ENSG00000135930 9470 Cytoplasm 37.0 126.0 1.54E-6 0.0631
EXOC7 ENSG00000182473 23265 Cytoplasm 175.0 4360.0 1.55E-6 0.0331
FBP1 ENSG00000165140 2203 Cytoplasm 686.0 10400.0 1.54E-6 0.00132
FBP2 ENSG00000130957 8789 Cytoplasm 311.0 828.0 1.54E-6 0.00226
G6PC ENSG00000131482 2538 Cytoplasm 446.0 41000.0 1.55E-6 0.0036
G6PC2 ENSG00000152254 57818 Cytoplasm 166.0 4530.0 1.54E-6 0.0188
GYS2 ENSG00000111713 2998 Cytoplasm 210.0 43900.0 1.55E-6 0.00488
HK1 ENSG00000156515 3098 Cytoplasm 606.0 195000.0 1.55E-6 0.00334
HK2 ENSG00000159399 3099 Cytoplasm 784.0 36800.0 1.54E-6 0.00199
HK3 ENSG00000160883 3101 Cytoplasm 400.0 13100.0 1.54E-6 0.00654
INPP5D ENSG00000168918 3635 Cytoplasm 2133.0 15300.0 1.55E-6 0.00195
IRS1 ENSG00000169047 3667 Cytoplasm 4154.0 22000.0 1.56E-6 7.58E-4
IRS4 ENSG00000133124 8471 Cytoplasm 554.0 1020.0 1.55E-6 0.00464
KRAS ENSG00000133703 3845 Cytoplasm 15339.0 61700.0 1.56E-6 8.92E-5
MAP2K1 ENSG00000169032 5604 Cytoplasm 23272.0 37700.0 1.56E-6 1.47E-5
MAPK10 ENSG00000109339 5602 Cytoplasm 3333.0 15900.0 1.56E-6 3.89E-4
PCK1 ENSG00000124253 5105 Cytoplasm 447.0 33800.0 1.55E-6 0.0102
PCK2 ENSG00000100889 5106 Cytoplasm 159.0 19700.0 1.55E-6 0.0234
PDE3B ENSG00000152270 5140 Cytoplasm 229.0 11400.0 1.55E-6 0.023
PHKA1 ENSG00000067177 5255 Cytoplasm 102.0 425.0 1.54E-6 0.0326
PHKG1 ENSG00000164776 5260 Cytoplasm 108.0 408.0 1.54E-6 0.0291
PHKG2 ENSG00000156873 5261 Cytoplasm 107.0 624.0 1.54E-6 0.0339
PKLR ENSG00000143627 5313 Cytoplasm 861.0 198000.0 1.55E-6 0.00887
PPP1R3A ENSG00000154415 5506 Cytoplasm 33.0 72.1 1.55E-6 0.165
PPP1R3C ENSG00000119938 5507 Cytoplasm 55.0 7120.0 1.55E-6 0.0902
PPP1R3D ENSG00000132825 5509 Cytoplasm 19.0 5.16 1.54E-6 0.55
PRKAA1 ENSG00000132356 5562 Cytoplasm 975.0 36500.0 1.56E-6 0.00331
PRKAB1 ENSG00000111725 5564 Cytoplasm 534.0 8570.0 1.55E-6 0.00576
PRKAB2 ENSG00000131791 5565 Cytoplasm 504.0 5270.0 1.55E-6 0.00648
PRKACB ENSG00000142875 5567 Cytoplasm 6037.0 134000.0 1.56E-6 1.64E-4
PRKACG ENSG00000165059 5568 Cytoplasm 5482.0 69200.0 1.56E-6 1.33E-4
PRKAR1A ENSG00000108946 5573 Cytoplasm 1071.0 33900.0 1.56E-6 0.0016
PRKAR1B ENSG00000188191 5575 Cytoplasm 499.0 11300.0 1.56E-6 0.0053
PRKX ENSG00000183943 5613 Cytoplasm 2758.0 10600.0 1.55E-6 2.09E-4
PTPN1 ENSG00000196396 5770 Cytoplasm 1033.0 23200.0 1.56E-6 0.00642
PYGM ENSG00000068976 5837 Cytoplasm 141.0 8530.0 1.55E-6 0.0211
RAPGEF1 ENSG00000107263 2889 Cytoplasm 1033.0 22500.0 1.55E-6 8.99E-4
SHC3 ENSG00000148082 53358 Cytoplasm 1052.0 3700.0 1.55E-6 0.0118
SHC4 ENSG00000185634 399694 Cytoplasm 146.0 151.0 1.55E-6 0.0152
SOCS1 ENSG00000185338 8651 Cytoplasm 1341.0 27000.0 1.56E-6 0.00394
SOCS2 ENSG00000120833 8835 Cytoplasm 265.0 600.0 1.55E-6 0.0365
SOS1 ENSG00000115904 6654 Cytoplasm 23511.0 177000.0 1.56E-6 6.54E-5
SOS2 ENSG00000100485 6655 Cytoplasm 6309.0 10000.0 1.56E-6 2.71E-4
TSC1 ENSG00000165699 7248 Cytoplasm 363.0 187.0 1.55E-6 0.00793
ACACB ENSG00000076555 32 Cytoplasm/Nucleus 144.0 5200.0 1.55E-6 0.0193
AKT2 ENSG00000105221 208 Cytoplasm/Nucleus 23612.0 163000.0 1.56E-6 4.86E-5
ARAF ENSG00000078061 369 Cytoplasm/Nucleus 6326.0 11300.0 1.55E-6 1.03E-4
CALM1 ENSG00000198668 801 Cytoplasm/Nucleus 10151.0 520000.0 1.56E-6 2.69E-4
CALM2 ENSG00000143933 805 Cytoplasm/Nucleus 9810.0 489000.0 1.56E-6 2.85E-4
CALM3 ENSG00000160014 808 Cytoplasm/Nucleus 9815.0 493000.0 1.56E-6 2.85E-4
CALML3 ENSG00000178363 810 Cytoplasm/Nucleus 1246.0 3000.0 1.55E-6 0.00285
CBL ENSG00000110395 867 Cytoplasm/Nucleus 5209.0 92900.0 1.56E-6 8.8E-4
CBLB ENSG00000114423 868 Cytoplasm/Nucleus 1299.0 34900.0 1.56E-6 0.00669
CRK ENSG00000167193 1398 Cytoplasm/Nucleus 4161.0 46800.0 1.56E-6 8.51E-4
CRKL ENSG00000099942 1399 Cytoplasm/Nucleus 2208.0 9050.0 1.55E-6 0.00119
EIF4E ENSG00000151247 1977 Cytoplasm/Nucleus 833.0 61900.0 1.55E-6 0.00865
EIF4EBP1 ENSG00000187840 1978 Cytoplasm/Nucleus 1189.0 11000.0 1.55E-6 4.81E-4
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 3468.0 49000.0 1.56E-6 3.9E-4
FASN ENSG00000169710 2194 Cytoplasm/Nucleus 120.0 38400.0 1.55E-6 0.0176
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 1320.0 45800.0 1.56E-6 0.00162
GCK ENSG00000106633 2645 Cytoplasm/Nucleus 534.0 147000.0 1.55E-6 0.00696
GYS1 ENSG00000104812 2997 Cytoplasm/Nucleus 147.0 27800.0 1.55E-6 0.0145
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 10428.0 206000.0 1.56E-6 1.03E-4
IRS2 ENSG00000185950 8660 Cytoplasm/Nucleus 2517.0 13000.0 1.56E-6 0.00167
LIPE ENSG00000079435 3991 Cytoplasm/Nucleus 53.0 68300.0 1.54E-6 0.0595
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 22859.0 10500.0 1.55E-6 9.5E-6
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 33563.0 1130000.0 1.56E-6 2.83E-5
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 29207.0 850000.0 1.56E-6 3.17E-5
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 11158.0 360000.0 1.56E-6 1.42E-4
MAPK9 ENSG00000050748 5601 Cytoplasm/Nucleus 6317.0 61100.0 1.56E-6 1.86E-4
MKNK2 ENSG00000099875 2872 Cytoplasm/Nucleus 78.0 209.0 1.54E-6 0.00666
PPP1CC ENSG00000186298 5501 Cytoplasm/Nucleus 818.0 37600.0 1.56E-6 0.0197
PRKAA2 ENSG00000162409 5563 Cytoplasm/Nucleus 811.0 20600.0 1.55E-6 0.00343
PRKAG2 ENSG00000106617 51422 Cytoplasm/Nucleus 391.0 3150.0 1.55E-6 0.00896
PRKAR2A ENSG00000114302 5576 Cytoplasm/Nucleus 594.0 13300.0 1.55E-6 0.00471
PRKAR2B ENSG00000005249 5577 Cytoplasm/Nucleus 1243.0 48400.0 1.55E-6 0.00823
PRKCI ENSG00000163558 5584 Cytoplasm/Nucleus 1334.0 16500.0 1.56E-6 0.00384
PYGB ENSG00000100994 5834 Cytoplasm/Nucleus 137.0 9120.0 1.55E-6 0.0162
RPS6 ENSG00000137154 6194 Cytoplasm/Nucleus 2882.0 391000.0 1.56E-6 0.0031
RPS6KB1 ENSG00000108443 6198 Cytoplasm/Nucleus 3539.0 54900.0 1.56E-6 3.46E-4
SOCS3 ENSG00000184557 9021 Cytoplasm/Nucleus 2446.0 25700.0 1.56E-6 0.00128
TRIP10 ENSG00000125733 9322 Cytoplasm/Nucleus 58.0 191.0 1.54E-6 0.0635
PIK3CD ENSG00000171608 5293 Cytoskeleton 14967.0 29900.0 1.56E-6 1.22E-4
PPP1CA ENSG00000172531 5499 Cytoskeleton/Nucleus 532.0 19200.0 1.56E-6 0.0137
AKT1 ENSG00000142208 207 Membrane 52751.0 2150000.0 1.57E-6 1.74E-5
AKT3 ENSG00000117020 10000 Membrane 22158.0 86500.0 1.56E-6 5.25E-5
HRAS ENSG00000174775 3265 Membrane 21752.0 305000.0 1.56E-6 6.79E-5
INSR ENSG00000171105 3643 Membrane 1576.0 21600.0 1.56E-6 0.00205
MTOR ENSG00000198793 2475 Membrane 6209.0 146000.0 1.56E-6 2.1E-4
NRAS ENSG00000213281 4893 Membrane 14710.0 64200.0 1.56E-6 1.13E-4
PDE3A ENSG00000172572 5139 Membrane 230.0 13300.0 1.55E-6 0.0239
PIK3CA ENSG00000121879 5290 Membrane 27859.0 414000.0 1.56E-6 5.51E-5
PIK3CG ENSG00000105851 5294 Membrane 13674.0 58900.0 1.56E-6 1.37E-4
PIK3R1 ENSG00000145675 5295 Membrane 31452.0 734000.0 1.56E-6 4.03E-5
PIK3R2 ENSG00000105647 5296 Membrane 17436.0 144000.0 1.56E-6 9.14E-5
PIK3R5 ENSG00000141506 23533 Membrane 7488.0 14200.0 1.56E-6 3.32E-4
PTPRF ENSG00000142949 5792 Membrane 48.0 14300.0 1.55E-6 0.107
RAF1 ENSG00000132155 5894 Membrane 23706.0 140000.0 1.56E-6 1.64E-5
RHEB ENSG00000106615 6009 Membrane 451.0 579.0 1.55E-6 0.00455
RHOQ ENSG00000119729 23433 Membrane 238.0 4450.0 1.55E-6 0.0222
SH2B2 ENSG00000160999 10603 Membrane 180.0 33.5 1.55E-6 0.0169
SHC1 ENSG00000160691 6464 Membrane 13549.0 312000.0 1.56E-6 2.6E-4
SLC2A4 ENSG00000181856 6517 Membrane 256.0 35300.0 1.55E-6 0.0126
SORBS1 ENSG00000095637 10580 Membrane 79.0 2660.0 1.55E-6 0.154
PRKCZ ENSG00000067606 5590 Membrane/Nucleus 3319.0 59100.0 1.56E-6 0.00138
ACACA ENSG00000278540 31 Unknown 320.0 41400.0 1.55E-6 0.00594
CALML6 ENSG00000169885 163688 Unknown 1168.0 1520.0 1.55E-6 0.00322
GRB2 ENSG00000177885 2885 Unknown 29079.0 822000.0 1.57E-6 5.64E-5
GSK3B ENSG00000082701 2932 Unknown 9387.0 367000.0 1.56E-6 1.84E-4
MKNK1 ENSG00000079277 8569 Unknown 491.0 2300.0 1.55E-6 0.00238
PDPK1 ENSG00000140992 5170 Unknown 7752.0 22600.0 1.56E-6 2.91E-4
PHKA2 ENSG00000044446 5256 Unknown 96.0 1480.0 1.55E-6 0.0338
PHKB ENSG00000102893 5257 Unknown 125.0 473.0 1.54E-6 0.0265
PIK3CB ENSG00000051382 5291 Unknown 17496.0 62500.0 1.56E-6 1.07E-4
PIK3R3 ENSG00000117461 8503 Unknown 10628.0 40100.0 1.56E-6 1.94E-4
PPP1R3B ENSG00000173281 79660 Unknown 21.0 9.79 1.54E-6 0.424
PRKACA ENSG00000072062 5566 Unknown 11354.0 1170000.0 1.56E-6 1.85E-4
PRKAG1 ENSG00000181929 5571 Unknown 449.0 6870.0 1.55E-6 0.00782
PRKAG3 ENSG00000115592 53632 Unknown 339.0 2430.0 1.55E-6 0.0105
PYGL ENSG00000100504 5836 Unknown 280.0 27100.0 1.55E-6 0.00466
RPS6KB2 ENSG00000175634 6199 Unknown 805.0 612.0 1.55E-6 0.00197
RPTOR ENSG00000141564 57521 Unknown 582.0 2580.0 1.55E-6 0.0051
SHC2 ENSG00000129946 25759 Unknown 1261.0 3710.0 1.55E-6 0.00739
SOCS4 ENSG00000180008 122809 Unknown 118.0 65.3 1.55E-6 0.161
SREBF1 ENSG00000072310 6720 Unknown 309.0 119000.0 1.55E-6 0.0165
TSC2 ENSG00000103197 7249 Unknown 891.0 1720.0 1.55E-6 0.00219
PPARGC1A ENSG00000109819 10891 Nucleus 604.0 39600.0 1.56E-6 0.01
PPP1CB ENSG00000213639 5500 Nucleus 406.0 5720.0 1.56E-6 0.0132
CALML5 ENSG00000178372 51806 Secreted 1172.0 2160.0 1.55E-6 0.0032
INS ENSG00000254647 3630 Secreted 1834.0 510000.0 1.56E-6 0.00309
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BAD ENSG00000002330 572 Cytoplasm 1742.0 10700.0 4.2E-6 3.79E-4
BRAF ENSG00000157764 673 Cytoplasm 3972.0 6130.0 4.2E-6 2.06E-4
CBLC ENSG00000142273 23624 Cytoplasm 274.0 1120.0 4.18E-6 0.035
EIF4E1B ENSG00000175766 253314 Cytoplasm 14.0 93.7 4.1E-6 0.044
EIF4E2 ENSG00000135930 9470 Cytoplasm 24.0 2660.0 4.11E-6 0.123
EXOC7 ENSG00000182473 23265 Cytoplasm 13.0 7.13 4.17E-6 0.103
FBP1 ENSG00000165140 2203 Cytoplasm 255.0 54800.0 4.18E-6 0.00824
FBP2 ENSG00000130957 8789 Cytoplasm 214.0 15800.0 4.16E-6 0.00443
G6PC ENSG00000131482 2538 Cytoplasm 141.0 66500.0 4.17E-6 0.0293
G6PC2 ENSG00000152254 57818 Cytoplasm 129.0 48100.0 4.16E-6 0.0291
GYS2 ENSG00000111713 2998 Cytoplasm 63.0 56300.0 4.16E-6 0.0369
HK1 ENSG00000156515 3098 Cytoplasm 253.0 178000.0 4.18E-6 0.0141
HK2 ENSG00000159399 3099 Cytoplasm 255.0 31700.0 4.16E-6 0.0138
HK3 ENSG00000160883 3101 Cytoplasm 248.0 23100.0 4.16E-6 0.0143
INPP5D ENSG00000168918 3635 Cytoplasm 417.0 1560.0 4.18E-6 0.018
IRS1 ENSG00000169047 3667 Cytoplasm 567.0 5780.0 4.19E-6 0.00666
IRS4 ENSG00000133124 8471 Cytoplasm 321.0 1030.0 4.19E-6 0.00909
KRAS ENSG00000133703 3845 Cytoplasm 6144.0 82900.0 4.22E-6 3.01E-4
MAP2K1 ENSG00000169032 5604 Cytoplasm 7272.0 15700.0 4.21E-6 8.17E-5
MAPK10 ENSG00000109339 5602 Cytoplasm 1320.0 10800.0 4.2E-6 0.00164
PCK1 ENSG00000124253 5105 Cytoplasm 114.0 32100.0 4.18E-6 0.0144
PCK2 ENSG00000100889 5106 Cytoplasm 126.0 45400.0 4.18E-6 0.0278
PDE3B ENSG00000152270 5140 Cytoplasm 145.0 33900.0 4.19E-6 0.0456
PHKA1 ENSG00000067177 5255 Cytoplasm 64.0 55.4 4.17E-6 0.0769
PHKG1 ENSG00000164776 5260 Cytoplasm 68.0 44.9 4.17E-6 0.068
PHKG2 ENSG00000156873 5261 Cytoplasm 68.0 859.0 4.17E-6 0.0777
PKLR ENSG00000143627 5313 Cytoplasm 404.0 577000.0 4.2E-6 0.0386
PPP1R3A ENSG00000154415 5506 Cytoplasm 22.0 85.9 4.17E-6 0.377
PPP1R3C ENSG00000119938 5507 Cytoplasm 26.0 196.0 4.17E-6 0.357
PPP1R3D ENSG00000132825 5509 Cytoplasm 19.0 32.6 4.17E-6 0.55
PRKAA1 ENSG00000132356 5562 Cytoplasm 198.0 26700.0 4.19E-6 0.0204
PRKAB1 ENSG00000111725 5564 Cytoplasm 93.0 2430.0 4.17E-6 0.0496
PRKAB2 ENSG00000131791 5565 Cytoplasm 88.0 2610.0 4.17E-6 0.0546
PRKACB ENSG00000142875 5567 Cytoplasm 2788.0 208000.0 4.22E-6 4.6E-4
PRKACG ENSG00000165059 5568 Cytoplasm 2664.0 37400.0 4.2E-6 3.54E-4
PRKAR1A ENSG00000108946 5573 Cytoplasm 54.0 51.5 4.19E-6 0.0957
PRKAR1B ENSG00000188191 5575 Cytoplasm 38.0 2.71 4.17E-6 0.111
PRKX ENSG00000183943 5613 Cytoplasm 2375.0 18600.0 4.2E-6 2.16E-4
PTPN1 ENSG00000196396 5770 Cytoplasm 85.0 21.5 4.19E-6 0.0782
PYGM ENSG00000068976 5837 Cytoplasm 85.0 16600.0 4.18E-6 0.049
RAPGEF1 ENSG00000107263 2889 Cytoplasm 173.0 114.0 4.17E-6 0.0202
SHC3 ENSG00000148082 53358 Cytoplasm 441.0 849.0 4.19E-6 0.0232
SHC4 ENSG00000185634 399694 Cytoplasm 146.0 1550.0 4.17E-6 0.0105
SOCS1 ENSG00000185338 8651 Cytoplasm 222.0 449.0 4.17E-6 0.0847
SOCS2 ENSG00000120833 8835 Cytoplasm 89.0 167.0 4.16E-6 0.282
SOS1 ENSG00000115904 6654 Cytoplasm 4893.0 29700.0 4.2E-6 7.29E-4
SOS2 ENSG00000100485 6655 Cytoplasm 3065.0 6030.0 4.19E-6 6.63E-4
TSC1 ENSG00000165699 7248 Cytoplasm 68.0 27.3 4.17E-6 0.0658
ACACB ENSG00000076555 32 Cytoplasm/Nucleus 73.0 4730.0 4.15E-6 0.0472
AKT2 ENSG00000105221 208 Cytoplasm/Nucleus 12922.0 78100.0 4.22E-6 9.13E-5
ARAF ENSG00000078061 369 Cytoplasm/Nucleus 2172.0 2010.0 4.19E-6 3.38E-4
CALM1 ENSG00000198668 801 Cytoplasm/Nucleus 2322.0 145000.0 4.23E-6 0.00163
CALM2 ENSG00000143933 805 Cytoplasm/Nucleus 2268.0 144000.0 4.23E-6 0.0017
CALM3 ENSG00000160014 808 Cytoplasm/Nucleus 2268.0 144000.0 4.23E-6 0.0017
CALML3 ENSG00000178363 810 Cytoplasm/Nucleus 1239.0 10600.0 4.19E-6 0.00281
CBL ENSG00000110395 867 Cytoplasm/Nucleus 912.0 35700.0 4.2E-6 0.0129
CBLB ENSG00000114423 868 Cytoplasm/Nucleus 489.0 4300.0 4.19E-6 0.0216
CRK ENSG00000167193 1398 Cytoplasm/Nucleus 1184.0 12200.0 4.21E-6 0.00506
CRKL ENSG00000099942 1399 Cytoplasm/Nucleus 831.0 3250.0 4.2E-6 0.006
EIF4E ENSG00000151247 1977 Cytoplasm/Nucleus 116.0 27300.0 4.14E-6 0.119
EIF4EBP1 ENSG00000187840 1978 Cytoplasm/Nucleus 164.0 12300.0 4.18E-6 0.00531
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 610.0 8360.0 4.21E-6 0.00461
FASN ENSG00000169710 2194 Cytoplasm/Nucleus 37.0 12100.0 4.18E-6 0.033
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 193.0 24600.0 4.19E-6 0.0204
GCK ENSG00000106633 2645 Cytoplasm/Nucleus 185.0 91100.0 4.18E-6 0.0211
GYS1 ENSG00000104812 2997 Cytoplasm/Nucleus 59.0 10100.0 4.17E-6 0.0596
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 3098.0 92800.0 4.21E-6 5.25E-4
IRS2 ENSG00000185950 8660 Cytoplasm/Nucleus 409.0 511.0 4.19E-6 0.0101
LIPE ENSG00000079435 3991 Cytoplasm/Nucleus 19.0 25.0 4.17E-6 0.175
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 7076.0 6360.0 4.2E-6 5.76E-5
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 9283.0 714000.0 4.23E-6 1.78E-4
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 8670.0 340000.0 4.23E-6 1.73E-4
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 2163.0 200000.0 4.22E-6 0.00165
MAPK9 ENSG00000050748 5601 Cytoplasm/Nucleus 1691.0 46700.0 4.21E-6 0.00157
MKNK2 ENSG00000099875 2872 Cytoplasm/Nucleus 18.0 462.0 4.16E-6 0.0196
PPP1CC ENSG00000186298 5501 Cytoplasm/Nucleus 260.0 9700.0 4.2E-6 0.0287
PRKAA2 ENSG00000162409 5563 Cytoplasm/Nucleus 167.0 17100.0 4.18E-6 0.0253
PRKAG2 ENSG00000106617 51422 Cytoplasm/Nucleus 80.0 2380.0 4.17E-6 0.0573
PRKAR2A ENSG00000114302 5576 Cytoplasm/Nucleus 46.0 9.34 4.18E-6 0.12
PRKAR2B ENSG00000005249 5577 Cytoplasm/Nucleus 51.0 30.8 4.18E-6 0.1
PRKCI ENSG00000163558 5584 Cytoplasm/Nucleus 155.0 7920.0 4.19E-6 0.0628
PYGB ENSG00000100994 5834 Cytoplasm/Nucleus 60.0 5210.0 4.16E-6 0.0548
RPS6 ENSG00000137154 6194 Cytoplasm/Nucleus 60.0 4910.0 4.17E-6 0.0209
RPS6KB1 ENSG00000108443 6198 Cytoplasm/Nucleus 395.0 10400.0 4.2E-6 0.00766
SOCS3 ENSG00000184557 9021 Cytoplasm/Nucleus 424.0 3020.0 4.18E-6 0.0227
TRIP10 ENSG00000125733 9322 Cytoplasm/Nucleus 11.0 7.69 4.16E-6 0.145
PIK3CD ENSG00000171608 5293 Cytoskeleton 7623.0 27500.0 4.21E-6 2.8E-4
PPP1CA ENSG00000172531 5499 Cytoskeleton/Nucleus 257.0 16600.0 4.2E-6 0.0269
AKT1 ENSG00000142208 207 Membrane 15717.0 483000.0 4.23E-6 9.3E-5
AKT3 ENSG00000117020 10000 Membrane 12844.0 58500.0 4.22E-6 8.89E-5
HRAS ENSG00000174775 3265 Membrane 5956.0 121000.0 4.22E-6 4.77E-4
INSR ENSG00000171105 3643 Membrane 294.0 1030.0 4.19E-6 0.0171
MTOR ENSG00000198793 2475 Membrane 1046.0 26800.0 4.2E-6 0.00265
NRAS ENSG00000213281 4893 Membrane 4978.0 69500.0 4.21E-6 5.26E-4
PDE3A ENSG00000172572 5139 Membrane 142.0 28300.0 4.19E-6 0.05
PIK3CA ENSG00000121879 5290 Membrane 8869.0 407000.0 4.23E-6 3.0E-4
PIK3CG ENSG00000105851 5294 Membrane 7696.0 36500.0 4.21E-6 2.71E-4
PIK3R1 ENSG00000145675 5295 Membrane 9027.0 146000.0 4.22E-6 2.65E-4
PIK3R2 ENSG00000105647 5296 Membrane 7733.0 62100.0 4.21E-6 2.71E-4
PIK3R5 ENSG00000141506 23533 Membrane 6010.0 17400.0 4.21E-6 3.4E-4
PTPRF ENSG00000142949 5792 Membrane 23.0 4.53 4.17E-6 0.15
RAF1 ENSG00000132155 5894 Membrane 6431.0 23300.0 4.21E-6 1.06E-4
RHEB ENSG00000106615 6009 Membrane 70.0 361.0 4.16E-6 0.041
RHOQ ENSG00000119729 23433 Membrane 30.0 80.7 4.17E-6 0.143
SH2B2 ENSG00000160999 10603 Membrane 40.0 16.9 4.17E-6 0.108
SHC1 ENSG00000160691 6464 Membrane 1385.0 23000.0 4.21E-6 0.00641
SLC2A4 ENSG00000181856 6517 Membrane 86.0 12700.0 4.18E-6 0.067
SORBS1 ENSG00000095637 10580 Membrane 35.0 185.0 4.18E-6 0.136
PRKCZ ENSG00000067606 5590 Membrane/Nucleus 230.0 11700.0 4.2E-6 0.0574
ACACA ENSG00000278540 31 Unknown 96.0 67400.0 4.18E-6 0.0469
CALML6 ENSG00000169885 163688 Unknown 1168.0 6590.0 4.19E-6 0.00314
GRB2 ENSG00000177885 2885 Unknown 5947.0 100000.0 4.22E-6 5.35E-4
GSK3B ENSG00000082701 2932 Unknown 1991.0 174000.0 4.21E-6 0.00115
MKNK1 ENSG00000079277 8569 Unknown 28.0 773.0 4.17E-6 0.0661
PDPK1 ENSG00000140992 5170 Unknown 1246.0 3680.0 4.2E-6 0.00166
PHKA2 ENSG00000044446 5256 Unknown 62.0 31.9 4.17E-6 0.0756
PHKB ENSG00000102893 5257 Unknown 77.0 54.4 4.17E-6 0.0649
PIK3CB ENSG00000051382 5291 Unknown 7887.0 42600.0 4.21E-6 3.07E-4
PIK3R3 ENSG00000117461 8503 Unknown 7005.0 28500.0 4.21E-6 3.03E-4
PPP1R3B ENSG00000173281 79660 Unknown 21.0 63.8 4.17E-6 0.424
PRKACA ENSG00000072062 5566 Unknown 3252.0 490000.0 4.23E-6 5.84E-4
PRKAG1 ENSG00000181929 5571 Unknown 82.0 2790.0 4.17E-6 0.0557
PRKAG3 ENSG00000115592 53632 Unknown 70.0 1820.0 4.17E-6 0.0609
PYGL ENSG00000100504 5836 Unknown 71.0 26400.0 4.19E-6 0.0588
RPS6KB2 ENSG00000175634 6199 Unknown 189.0 1240.0 4.19E-6 0.0159
RPTOR ENSG00000141564 57521 Unknown 104.0 2560.0 4.17E-6 0.0403
SHC2 ENSG00000129946 25759 Unknown 459.0 830.0 4.19E-6 0.0201
SOCS4 ENSG00000180008 122809 Unknown 76.0 50.8 4.16E-6 0.362
SREBF1 ENSG00000072310 6720 Unknown 42.0 6670.0 4.19E-6 0.0894
TSC2 ENSG00000103197 7249 Unknown 134.0 1230.0 4.18E-6 0.0274
PPARGC1A ENSG00000109819 10891 Nucleus 82.0 3500.0 4.18E-6 0.0385
PPP1CB ENSG00000213639 5500 Nucleus 242.0 8360.0 4.2E-6 0.0207
CALML5 ENSG00000178372 51806 Secreted 1172.0 8330.0 4.19E-6 0.00311
INS ENSG00000254647 3630 Secreted 449.0 32800.0 4.21E-6 0.0125
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
ACACA ACACB 3
ACACA FASN 5
ACACB FASN 3
AKT1 AKT2 2
AKT1 BAD 10
AKT1 BRAF 4
AKT1 CALM1 2
AKT1 CALM2 2
AKT1 CALM3 2
AKT1 EIF4EBP1 4
AKT1 FOXO1 13
AKT1 GSK3B 13
AKT1 IKBKB 7
AKT1 IRS1 3
AKT1 MTOR 11
AKT1 PDE3A 2
AKT1 PDE3B 2
AKT1 PPP1CA 4
AKT1 PPP1CB 3
AKT1 PPP1CC 2
AKT1 PRKCZ 4
AKT1 PTPN1 3
AKT1 RAF1 6
AKT1 RPS6KB1 6
AKT1 RPS6KB2 2
AKT1 RPTOR 3
AKT1 TSC1 5
AKT1 TSC2 10
AKT2 BAD 4
AKT2 FOXO1 4
AKT2 GSK3B 8
AKT2 IKBKB 2
AKT2 PDE3A 1
AKT2 PDE3B 2
AKT2 RPS6KB2 2
AKT2 SLC2A4 2
AKT2 TSC1 2
AKT2 TSC2 5
AKT3 BAD 4
AKT3 FOXO1 5
AKT3 GSK3B 6
AKT3 IKBKB 2
AKT3 PDE3A 1
AKT3 PDE3B 1
AKT3 PRKCZ 4
AKT3 RPS6KB2 2
AKT3 TSC2 6
ARAF AKT1 1
ARAF AKT2 1
ARAF AKT3 1
ARAF BAD 2
ARAF BRAF 4
ARAF HRAS 8
ARAF KRAS 4
ARAF MAP2K1 10
ARAF MAP2K2 8
ARAF MAPK1 2
ARAF MAPK3 2
ARAF RAF1 2
BRAF AKT2 1
BRAF AKT3 1
BRAF BAD 1
BRAF CRK 2
BRAF HRAS 7
BRAF MAP2K1 12
BRAF MAP2K2 11
BRAF MAPK1 6
BRAF MAPK3 6
BRAF NRAS 5
BRAF RAF1 9
CALM1 HRAS 3
CALM1 KRAS 6
CALM1 NRAS 3
CALM1 PHKA1 2
CALM1 PHKA2 2
CALM1 PHKB 3
CALM1 PHKG1 3
CALM1 PHKG2 2
CALM1 PRKACA 3
CALM1 PYGB 2
CALM1 PYGL 2
CALM1 PYGM 2
CALM2 HRAS 3
CALM2 KRAS 6
CALM2 NRAS 3
CALM2 PHKA1 2
CALM2 PHKA2 2
CALM2 PHKB 3
CALM2 PHKG1 3
CALM2 PHKG2 2
CALM2 PRKACA 3
CALM2 PYGB 2
CALM2 PYGL 2
CALM2 PYGM 2
CALM3 HRAS 3
CALM3 KRAS 6
CALM3 NRAS 3
CALM3 PHKA1 2
CALM3 PHKA2 2
CALM3 PHKB 3
CALM3 PHKG1 3
CALM3 PHKG2 2
CALM3 PRKACA 3
CALM3 PYGB 2
CALM3 PYGL 2
CALM3 PYGM 2
CBLB AKT1 1
CBLB CRKL 6
CBLB GRB2 5
CBLB PIK3CA 2
CBLB PIK3CB 2
CBLB PIK3CD 2
CBLB PIK3CG 2
CBLB PIK3R1 6
CBLB PIK3R2 3
CBLB PIK3R3 1
CBLB PIK3R5 1
CBLB RAPGEF1 2
CBLB SHC1 4
CBL CALM1 2
CBL CALM2 2
CBL CALM3 2
CBL CBLB 4
CBLC PIK3CA 1
CBLC PIK3CB 1
CBLC PIK3CD 1
CBLC PIK3CG 1
CBLC PIK3R1 1
CBLC PIK3R2 1
CBLC PIK3R3 1
CBLC PIK3R5 1
CBLC RAPGEF1 2
CBL CRK 10
CBL CRKL 9
CBL GRB2 10
CBL HRAS 2
CBL PIK3CA 5
CBL PIK3CB 4
CBL PIK3CD 2
CBL PIK3CG 2
CBL PIK3R1 9
CBL PIK3R2 7
CBL PIK3R3 4
CBL PIK3R5 1
CBL RAPGEF1 6
CBL SH2B2 6
CBL SHC1 7
CBL SORBS1 4
CBL SOS1 5
CRK CRKL 3
CRK GRB2 5
CRK IRS1 2
CRK IRS2 3
CRKL GRB2 4
CRKL MAPK8 3
CRKL PIK3CA 1
CRKL PIK3CB 1
CRKL PIK3CD 1
CRKL PIK3CG 1
CRKL PIK3R1 5
CRKL PIK3R2 4
CRKL PIK3R3 1
CRKL PIK3R5 1
CRKL RAPGEF1 11
CRK MAPK8 6
CRK PIK3CA 2
CRK PIK3CB 2
CRK PIK3CD 2
CRK PIK3CG 1
CRK PIK3R1 6
CRK PIK3R2 4
CRK PIK3R3 3
CRK PIK3R5 1
CRK RAPGEF1 11
CRK RHOQ 2
CRK SOS1 5
EIF4EBP1 EIF4E1B 1
EIF4E EIF4EBP1 9
EIF4E RPS6 4
EXOC7 RHOQ 3
FBP1 GCK 2
FOXO1 G6PC 3
GCK PYGM 2
GRB2 AKT1 3
GRB2 AKT2 3
GRB2 AKT3 3
GRB2 CALM1 2
GRB2 CALM2 2
GRB2 CALM3 2
GRB2 HRAS 4
GRB2 INPP5D 5
GRB2 INSR 3
GRB2 IRS1 8
GRB2 IRS2 5
GRB2 IRS4 4
GRB2 KRAS 3
GRB2 MAP2K1 1
GRB2 MAPK1 2
GRB2 MTOR 1
GRB2 PDPK1 3
GRB2 PIK3CA 4
GRB2 PIK3CB 4
GRB2 PIK3CG 3
GRB2 PIK3R1 9
GRB2 PIK3R2 6
GRB2 PIK3R3 3
GRB2 PTPN1 4
GRB2 SH2B2 4
GRB2 SHC1 13
GRB2 SHC2 5
GRB2 SHC3 6
GRB2 SHC4 2
GRB2 SOCS1 5
GRB2 SOS1 12
GRB2 SOS2 7
GSK3B GYS1 8
GSK3B GYS2 3
GSK3B HRAS 1
GSK3B PRKAA1 1
GSK3B RPTOR 1
GSK3B SREBF1 3
GSK3B TSC1 3
GSK3B TSC2 4
GYS1 PPP1R3C 2
GYS2 PPP1R3C 2
HK1 PYGM 2
HK2 PYGM 2
HK3 PYGM 2
HRAS MAP2K1 4
HRAS MAP2K2 2
HRAS MAPK1 3
HRAS MAPK3 3
HRAS PIK3CA 8
HRAS PIK3CB 4
HRAS PIK3CD 7
HRAS PIK3CG 8
HRAS PIK3R1 7
HRAS PIK3R2 2
HRAS RAF1 14
HRAS SOS1 7
IKBKB IRS1 4
IKBKB IRS2 1
IKBKB IRS4 1
IKBKB TSC1 4
INPP5D RAF1 1
INPP5D SHC1 7
INS AKT1 2
INS AKT2 1
INS CBL 1
INS GSK3B 1
INS INPP5D 1
INS INSR 9
INS IRS1 3
INS IRS2 2
INS IRS4 1
INS MAPK1 2
INS MAPK3 2
INS MAPK8 2
INS MAPK9 2
INS PIK3CA 2
INS PIK3R1 2
INS PPP1R3A 1
INSR AKT1 2
INSR AKT2 2
INSR AKT3 1
INSR CBL 2
INSR INPP5D 1
INSR IRS1 14
INSR IRS2 8
INSR IRS4 3
INSR MAPK1 3
INSR MAPK3 3
INSR PIK3CA 3
INSR PIK3R1 9
INSR PIK3R3 3
INSR PPP1R3A 1
INSR PTPN1 5
INSR SH2B2 5
INSR SHC1 9
INSR SHC2 2
INSR SHC3 2
INSR SORBS1 4
INS SH2B2 1
INS SHC1 2
INS SLC2A4 1
IRS1 CBL 1
IRS1 CRKL 1
IRS1 INPP5D 2
IRS1 IRS2 4
IRS1 PDPK1 2
IRS1 PIK3CA 7
IRS1 PIK3CB 5
IRS1 PIK3CD 2
IRS1 PIK3CG 3
IRS1 PIK3R1 11
IRS1 PIK3R2 8
IRS1 PIK3R3 5
IRS1 PIK3R5 1
IRS1 PTPN1 4
IRS1 SH2B2 1
IRS1 SHC1 7
IRS1 SOS1 6
IRS1 SOS2 2
IRS2 PIK3CA 7
IRS2 PIK3CB 4
IRS2 PIK3CD 3
IRS2 PIK3CG 2
IRS2 PIK3R1 8
IRS2 PIK3R2 5
IRS2 PIK3R3 3
IRS2 PIK3R5 1
IRS2 SHC1 4
IRS2 SOS1 3
IRS2 SOS2 2
IRS4 PIK3CA 5
IRS4 PIK3CB 2
IRS4 PIK3CD 2
IRS4 PIK3CG 1
IRS4 PIK3R1 5
IRS4 PIK3R2 3
IRS4 PIK3R3 2
IRS4 PIK3R5 1
KRAS BRAF 5
KRAS MAPK1 3
KRAS MAPK3 2
KRAS PIK3CA 5
KRAS PIK3CB 4
KRAS PIK3CD 3
KRAS PIK3CG 5
KRAS PIK3R1 3
KRAS PIK3R2 3
KRAS RAF1 10
MAP2K1 AKT1 1
MAP2K1 AKT2 1
MAP2K1 AKT3 1
MAP2K1 GSK3B 1
MAP2K1 MAP2K2 7
MAP2K1 MAPK1 13
MAP2K1 MAPK10 2
MAP2K1 MAPK3 12
MAP2K1 MAPK8 4
MAP2K1 MAPK9 2
MAP2K1 NRAS 2
MAP2K1 PIK3CA 2
MAP2K1 RAF1 10
MAP2K2 AKT1 1
MAP2K2 AKT2 1
MAP2K2 AKT3 1
MAP2K2 MAPK1 10
MAP2K2 MAPK10 2
MAP2K2 MAPK3 11
MAP2K2 MAPK8 4
MAP2K2 MAPK9 2
MAP2K2 NRAS 2
MAP2K2 RAF1 7
MAPK10 AKT1 1
MAPK10 AKT2 1
MAPK10 AKT3 1
MAPK10 BAD 1
MAPK10 ELK1 3
MAPK10 IRS1 1
MAPK10 IRS2 1
MAPK10 IRS4 1
MAPK1 AKT1 2
MAPK1 AKT2 1
MAPK1 AKT3 1
MAPK1 BAD 3
MAPK1 ELK1 9
MAPK1 EXOC7 1
MAPK1 IRS1 4
MAPK1 IRS2 2
MAPK1 MAPK3 4
MAPK1 MKNK1 6
MAPK1 MKNK2 4
MAPK1 PPP1CA 4
MAPK1 RAF1 5
MAPK1 RPS6KB1 5
MAPK1 RPS6KB2 1
MAPK1 RPTOR 2
MAPK1 SHC1 5
MAPK1 SOS1 5
MAPK1 SREBF1 3
MAPK1 TSC2 6
MAPK3 AKT1 1
MAPK3 AKT2 1
MAPK3 AKT3 1
MAPK3 BAD 2
MAPK3 EIF4EBP1 1
MAPK3 ELK1 8
MAPK3 EXOC7 1
MAPK3 GSK3B 1
MAPK3 IRS1 3
MAPK3 IRS2 2
MAPK3 MKNK1 6
MAPK3 MKNK2 2
MAPK3 RAF1 5
MAPK3 RPS6KB1 2
MAPK3 RPS6KB2 1
MAPK3 RPTOR 2
MAPK3 SHC1 2
MAPK3 SOS1 2
MAPK3 SREBF1 3
MAPK3 TSC2 4
MAPK8 AKT2 1
MAPK8 AKT3 1
MAPK8 BAD 4
MAPK8 ELK1 3
MAPK8 IRS1 3
MAPK8 IRS2 1
MAPK8 MAPK9 4
MAPK8 MKNK1 1
MAPK8 MKNK2 3
MAPK8 RPS6KB1 4