Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002631 Maturity onset diabetes of the young KEGG Homo sapiens 25 76
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
PKLR ENSG00000143627 5313 Cytoplasm 0.0212766 6.0 0.2678571 0.33333333
GCK ENSG00000106633 2645 Cytoplasm/Nucleus 0.02564103 13.0 8.864683 0.23076923
HES1 ENSG00000114315 3280 Cytoplasm/Nucleus 0.01754386 5.0 0.0 0.1
HHEX ENSG00000152804 3087 Cytoplasm/Nucleus 0.02325581 5.0 0.3945993 0.5
NEUROD1 ENSG00000162992 4760 Cytoplasm/Nucleus 0.02380952 9.0 6.759623 0.22222222
NKX2-2 ENSG00000125820 4821 Cytoplasm/Nucleus 0.02631579 11.0 12.76272 0.2
PAX6 ENSG00000007372 5080 Cytoplasm/Nucleus 0.02631579 10.0 7.028286 0.26666667
SLC2A2 ENSG00000163581 6514 Membrane 0.02380952 7.0 0.4017857 0.42857143
FOXA2 ENSG00000125798 3170 Nucleus 0.02857143 13.0 11.20957 0.30769231
FOXA3 ENSG00000170608 3171 Nucleus 0.01923077 3.0 0.0 0.33333333
HNF1A ENSG00000135100 6927 Nucleus 0.03030303 21.0 46.16087 0.11428571
HNF1B ENSG00000275410 6928 Nucleus 0.02083333 9.0 2.011111 0.08333333
HNF4A ENSG00000101076 3172 Nucleus 0.03030303 20.0 25.81698 0.15789474
HNF4G ENSG00000164749 3174 Nucleus 0.01886792 3.0 0.1944444 0.0
MAFA ENSG00000182759 389692 Nucleus 0.02040816 7.0 0.0 0.14285714
MNX1 ENSG00000130675 3110 Nucleus 0.01851852 1.0 0.0 0.0
NEUROG3 ENSG00000122859 50674 Nucleus 0.025 12.0 17.74035 0.09090909
NKX6-1 ENSG00000163623 4825 Nucleus 0.02040816 3.0 0.2857143 0.0
NR5A2 ENSG00000116833 2494 Nucleus 0.02272727 6.0 0.0 0.2
ONECUT1 ENSG00000169856 3175 Nucleus 0.02380952 11.0 10.88714 0.01818182
PAX4 ENSG00000106331 5078 Nucleus 0.02564103 10.0 11.94437 0.35555556
PDX1 ENSG00000139515 3651 Nucleus 0.03125 25.0 76.98577 0.08666667
IAPP ENSG00000121351 3375 Secreted 0.0212766 5.0 0.5877345 0.2
INS ENSG00000254647 3630 Secreted 0.02272727 17.0 3.696399 0.05882353
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
PKLR ENSG00000143627 5313 Cytoplasm 861.0 198000.0 1.55E-6 0.008867461
GCK ENSG00000106633 2645 Cytoplasm/Nucleus 534.0 147000.0 1.55E-6 0.006956595
HES1 ENSG00000114315 3280 Cytoplasm/Nucleus 411.0 19500.0 1.55E-6 0.011761913
HHEX ENSG00000152804 3087 Cytoplasm/Nucleus 17.0 164.0 1.54E-6 0.183823529
NEUROD1 ENSG00000162992 4760 Cytoplasm/Nucleus 19.0 371.0 1.54E-6 0.046783626
NKX2-2 ENSG00000125820 4821 Cytoplasm/Nucleus 26.0 1630.0 1.54E-6 0.052307692
PAX6 ENSG00000007372 5080 Cytoplasm/Nucleus 126.0 19700.0 1.55E-6 0.51047619
SLC2A2 ENSG00000163581 6514 Membrane 177.0 61400.0 1.54E-6 0.007383154
FOXA2 ENSG00000125798 3170 Nucleus 113.0 94200.0 1.55E-6 0.020701643
FOXA3 ENSG00000170608 3171 Nucleus 19.0 387.0 1.54E-6 0.081871345
HNF1A ENSG00000135100 6927 Nucleus 107.0 21600.0 1.55E-6 0.050432023
HNF1B ENSG00000275410 6928 Nucleus 23.0 52.8 1.54E-6 0.011857708
HNF4A ENSG00000101076 3172 Nucleus 250.0 60000.0 1.56E-6 0.053654618
HNF4G ENSG00000164749 3174 Nucleus 7.0 7.48 1.53E-6 0.047619048
MAFA ENSG00000182759 389692 Nucleus 23.0 24.8 1.54E-6 0.019762846
MNX1 ENSG00000130675 3110 Nucleus 1.0 0.0 1.52E-6 0.0
NEUROG3 ENSG00000122859 50674 Nucleus 28.0 10400.0 1.54E-6 0.029100529
NKX6-1 ENSG00000163623 4825 Nucleus 8.0 0.263 1.52E-6 0.0
NR5A2 ENSG00000116833 2494 Nucleus 19.0 110.0 1.54E-6 0.140350877
ONECUT1 ENSG00000169856 3175 Nucleus 51.0 14800.0 1.55E-6 0.029803922
PAX4 ENSG00000106331 5078 Nucleus 13.0 25.3 1.54E-6 0.205128205
PDX1 ENSG00000139515 3651 Nucleus 74.0 21800.0 1.55E-6 0.016660496
IAPP ENSG00000121351 3375 Secreted 42.0 4290.0 1.54E-6 0.268292683
INS ENSG00000254647 3630 Secreted 1834.0 510000.0 1.56E-6 0.003091273
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
PKLR ENSG00000143627 5313 Cytoplasm 404.0 577000.0 4.2E-6 0.0386458
GCK ENSG00000106633 2645 Cytoplasm/Nucleus 185.0 91100.0 4.18E-6 0.02109283
HES1 ENSG00000114315 3280 Cytoplasm/Nucleus 41.0 5200.0 4.14E-6 0.11341463
HHEX ENSG00000152804 3087 Cytoplasm/Nucleus 5.0 3.16 4.09E-6 0.5
NEUROD1 ENSG00000162992 4760 Cytoplasm/Nucleus 9.0 763.0 4.14E-6 0.22222222
NKX2-2 ENSG00000125820 4821 Cytoplasm/Nucleus 11.0 1780.0 4.14E-6 0.2
PAX6 ENSG00000007372 5080 Cytoplasm/Nucleus 10.0 1200.0 4.14E-6 0.26666667
SLC2A2 ENSG00000163581 6514 Membrane 50.0 5640.0 4.13E-6 0.0644898
FOXA2 ENSG00000125798 3170 Nucleus 13.0 1540.0 4.13E-6 0.30769231
FOXA3 ENSG00000170608 3171 Nucleus 3.0 0.0 4.05E-6 0.33333333
HNF1A ENSG00000135100 6927 Nucleus 21.0 9440.0 4.13E-6 0.11428571
HNF1B ENSG00000275410 6928 Nucleus 9.0 2.01 4.06E-6 0.08333333
HNF4A ENSG00000101076 3172 Nucleus 20.0 6700.0 4.13E-6 0.15789474
HNF4G ENSG00000164749 3174 Nucleus 3.0 0.194 4.05E-6 0.0
MAFA ENSG00000182759 389692 Nucleus 16.0 51.9 4.15E-6 0.04166667
MNX1 ENSG00000130675 3110 Nucleus 1.0 0.0 4.09E-6 0.0
NEUROG3 ENSG00000122859 50674 Nucleus 12.0 146.0 4.09E-6 0.09090909
NKX6-1 ENSG00000163623 4825 Nucleus 3.0 0.211 4.09E-6 0.0
NR5A2 ENSG00000116833 2494 Nucleus 6.0 0.0 4.09E-6 0.2
ONECUT1 ENSG00000169856 3175 Nucleus 11.0 1530.0 4.09E-6 0.01818182
PAX4 ENSG00000106331 5078 Nucleus 10.0 403.0 4.09E-6 0.35555556
PDX1 ENSG00000139515 3651 Nucleus 36.0 35800.0 4.17E-6 0.04761905
IAPP ENSG00000121351 3375 Secreted 5.0 0.513 4.09E-6 0.2
INS ENSG00000254647 3630 Secreted 449.0 32800.0 4.21E-6 0.01248807
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
FOXA2 PDX1 3
HES1 NEUROG3 3
HNF1A FOXA3 2
HNF1A HNF1B 3
HNF1A HNF4A 5
HNF1A HNF4G 2
HNF1A NR5A2 2
HNF4A NR5A2 2
HNF4A PKLR 2
MAFA INS 2
MAFA PDX1 4
NEUROD1 GCK 2
NEUROG3 NEUROD1 2
NEUROG3 NKX2-2 2
NEUROG3 PAX4 2
NKX2-2 INS 2
ONECUT1 HNF1B 3
ONECUT1 NEUROG3 2
ONECUT1 PDX1 2
PAX6 INS 2
PAX6 PDX1 2
PDX1 INS 2
PDX1 NKX6-1 2
PDX1 NR5A2 2
SLC2A2 GCK 2
FOXA2 GCK 1
FOXA2 HHEX 1
FOXA2 HNF4A 1
FOXA2 NEUROD1 1
FOXA2 NKX2-2 1
FOXA2 ONECUT1 2
FOXA2 PKLR 1
FOXA2 SLC2A2 1
GCK INS 1
HHEX HNF4A 1
HHEX PDX1 1
HNF1A FOXA2 1
HNF1A NEUROG3 1
HNF1A NKX2-2 1
HNF1A PAX6 1
HNF1A PKLR 2
HNF1A SLC2A2 2
HNF1B HNF4A 1
HNF4A FOXA3 1
HNF4A GCK 1
HNF4A NKX2-2 1
HNF4A PAX6 1
HNF4A SLC2A2 1
IAPP PDX1 1
MAFA NEUROD1 2
MNX1 PDX1 1
NEUROD1 IAPP 1
NEUROD1 INS 1
NEUROD1 PDX1 1
NEUROG3 PAX6 1
NKX2-2 GCK 1
NKX2-2 IAPP 1
NKX2-2 NKX6-1 1
ONECUT1 HNF4G 1
PAX4 FOXA2 1
PAX4 HES1 1
PAX4 HHEX 1
PAX4 HNF1A 1
PAX4 HNF1B 1
PAX4 HNF4A 1
PAX4 NKX2-2 1
PAX4 PAX6 1
PAX6 GCK 1
PAX6 IAPP 1
PDX1 GCK 1
PDX1 HNF1A 1
PDX1 HNF4A 1
PDX1 SLC2A2 1
PKLR GCK 2
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002631 pathway0001834 16 0.9411765 Regulation of gene expression in beta cells Reactome 17 54
pathway0002631 pathway0001836 4 0.8 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells Reactome 5 5
pathway0002631 pathway0001835 5 0.625 Regulation of gene expression in early pancreatic precursor cells Reactome 8 8
pathway0002631 pathway0001837 4 0.5714286 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Reactome 7 9