Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002643 Prion diseases KEGG Homo sapiens 34 110
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
FYN ENSG00000010810 2534 Cytoplasm 0.006535948 15.0 74.52033 0.133333333
IL1A ENSG00000115008 3552 Cytoplasm 0.005524862 4.0 0.0 0.166666667
MAP2K1 ENSG00000169032 5604 Cytoplasm 0.00617284 97.0 8.847337 0.003006873
PRKACB ENSG00000142875 5567 Cytoplasm 0.006097561 10.0 3.83956 0.311111111
PRKACG ENSG00000165059 5568 Cytoplasm 0.006060606 8.0 2.076665 0.392857143
PRKX ENSG00000183943 5613 Cytoplasm 0.005847953 3.0 1.195575 0.333333333
SOD1 ENSG00000142168 6647 Cytoplasm 0.006289308 12.0 32.53624 0.287878788
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 0.006134969 43.0 10.40002 0.015503876
HSPA5 ENSG00000044574 3309 Cytoplasm/Nucleus 0.005524862 5.0 29.0 0.1
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 0.006134969 100.0 8.466807 0.002424242
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 0.006622517 131.0 65.25742 0.004815032
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 0.006535948 124.0 53.70641 0.004720692
STIP1 ENSG00000168439 10963 Cytoplasm/Nucleus 0.005952381 8.0 19.24385 0.178571429
NCAM1 ENSG00000149294 4684 Membrane 0.00591716 9.0 10.21787 0.083333333
NCAM2 ENSG00000154654 4685 Membrane 0.005376344 5.0 0.0 0.1
PRNP ENSG00000171867 5621 Membrane 0.006289308 20.0 85.17365 0.047368421
BAX ENSG00000087088 581 Unknown 0.005555556 2.0 0.0 1.0
CASP12 ENSG00000204403 100506742 Unknown 0.004761905 1.0 0.0 0.0
PRKACA ENSG00000072062 5566 Unknown 0.00617284 11.0 7.260255 0.309090909
EGR1 ENSG00000120738 1958 Nucleus 0.006024096 12.0 1.163478 0.227272727
C1QA ENSG00000173372 712 Secreted 9.4697E-4 4.0 0.0 0.166666667
C1QB ENSG00000173369 713 Secreted 9.4697E-4 4.0 0.0 0.166666667
C1QC ENSG00000159189 714 Secreted 9.4697E-4 4.0 0.0 0.166666667
C5 ENSG00000106804 727 Secreted 0.006097561 27.0 88.68439 0.05982906
C6 ENSG00000039537 729 Secreted 0.005952381 18.0 42.10405 0.098039216
C7 ENSG00000112936 730 Secreted 0.005524862 19.0 0.0 0.087719298
C8A ENSG00000157131 731 Secreted 0.005524862 19.0 0.0 0.087719298
C8B ENSG00000021852 732 Secreted 0.005524862 20.0 0.0 0.078947368
C8G ENSG00000176919 733 Secreted 0.005524862 18.0 0.0 0.098039216
C9 ENSG00000113600 735 Secreted 0.005524862 24.0 0.0 0.054347826
CCL5 ENSG00000271503 6352 Secreted 0.00591716 9.0 0.5934066 0.25
IL6 ENSG00000136244 3569 Secreted 0.00625 17.0 11.94341 0.117647059
LAMC1 ENSG00000135862 3915 Secreted 0.005780347 4.0 0.0 0.166666667
IL1B ENSG00000125538 3553 Secreted/Nucleus 0.006369427 25.0 28.76927 0.07
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
FYN ENSG00000010810 2534 Cytoplasm 9828.0 511000.0 1.56E-6 4.85E-4
IL1A ENSG00000115008 3552 Cytoplasm 742.0 2960.0 1.55E-6 0.00662
MAP2K1 ENSG00000169032 5604 Cytoplasm 23272.0 37700.0 1.56E-6 1.47E-5
PRKACB ENSG00000142875 5567 Cytoplasm 6037.0 134000.0 1.56E-6 1.64E-4
PRKACG ENSG00000165059 5568 Cytoplasm 5482.0 69200.0 1.56E-6 1.33E-4
PRKX ENSG00000183943 5613 Cytoplasm 2758.0 10600.0 1.55E-6 2.09E-4
SOD1 ENSG00000142168 6647 Cytoplasm 195.0 103000.0 1.56E-6 0.0434
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 3468.0 49000.0 1.56E-6 3.9E-4
HSPA5 ENSG00000044574 3309 Cytoplasm/Nucleus 665.0 313000.0 1.56E-6 0.0143
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 22859.0 10500.0 1.55E-6 9.5E-6
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 33563.0 1130000.0 1.56E-6 2.83E-5
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 29207.0 850000.0 1.56E-6 3.17E-5
STIP1 ENSG00000168439 10963 Cytoplasm/Nucleus 23.0 123.0 1.55E-6 0.162
NCAM1 ENSG00000149294 4684 Membrane 142.0 36000.0 1.55E-6 0.0441
NCAM2 ENSG00000154654 4685 Membrane 9.0 0.721 1.53E-6 0.0556
PRNP ENSG00000171867 5621 Membrane 27.0 1400.0 1.55E-6 0.0513
BAX ENSG00000087088 581 Unknown 951.0 64300.0 1.56E-6 0.00233
CASP12 ENSG00000204403 100506742 Unknown 21.0 1.98 1.54E-6 0.0381
PRKACA ENSG00000072062 5566 Unknown 11354.0 1170000.0 1.56E-6 1.85E-4
EGR1 ENSG00000120738 1958 Nucleus 229.0 1580.0 1.56E-6 0.0265
C1QA ENSG00000173372 712 Secreted 142.0 2050.0 1.54E-6 0.0216
C1QB ENSG00000173369 713 Secreted 129.0 2470.0 1.54E-6 0.0257
C1QC ENSG00000159189 714 Secreted 129.0 491.0 1.54E-6 0.0258
C5 ENSG00000106804 727 Secreted 246.0 22300.0 1.55E-6 0.0106
C6 ENSG00000039537 729 Secreted 94.0 1050.0 1.54E-6 0.00755
C7 ENSG00000112936 730 Secreted 110.0 536.0 1.54E-6 0.0055
C8A ENSG00000157131 731 Secreted 120.0 264.0 1.54E-6 0.00462
C8B ENSG00000021852 732 Secreted 118.0 17.2 1.54E-6 0.00478
C8G ENSG00000176919 733 Secreted 106.0 13.5 1.54E-6 0.00593
C9 ENSG00000113600 735 Secreted 149.0 1570.0 1.54E-6 0.00317
CCL5 ENSG00000271503 6352 Secreted 554.0 19600.0 1.56E-6 0.00905
IL6 ENSG00000136244 3569 Secreted 1764.0 36100.0 1.56E-6 0.00384
LAMC1 ENSG00000135862 3915 Secreted 876.0 17300.0 1.55E-6 0.0105
IL1B ENSG00000125538 3553 Secreted/Nucleus 2345.0 54300.0 1.56E-6 0.00173
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
FYN ENSG00000010810 2534 Cytoplasm 960.0 74400.0 4.21E-6 0.0128
IL1A ENSG00000115008 3552 Cytoplasm 167.0 1150.0 4.18E-6 0.0866
MAP2K1 ENSG00000169032 5604 Cytoplasm 7272.0 15700.0 4.21E-6 8.17E-5
PRKACB ENSG00000142875 5567 Cytoplasm 2788.0 208000.0 4.22E-6 4.6E-4
PRKACG ENSG00000165059 5568 Cytoplasm 2664.0 37400.0 4.2E-6 3.54E-4
PRKX ENSG00000183943 5613 Cytoplasm 2375.0 18600.0 4.2E-6 2.16E-4
SOD1 ENSG00000142168 6647 Cytoplasm 64.0 25800.0 4.19E-6 0.0655
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 610.0 8360.0 4.21E-6 0.00461
HSPA5 ENSG00000044574 3309 Cytoplasm/Nucleus 80.0 18200.0 4.15E-6 0.088
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 7076.0 6360.0 4.2E-6 5.76E-5
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 9283.0 714000.0 4.23E-6 1.78E-4
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 8670.0 340000.0 4.23E-6 1.73E-4
STIP1 ENSG00000168439 10963 Cytoplasm/Nucleus 8.0 346.0 4.16E-6 0.179
NCAM1 ENSG00000149294 4684 Membrane 16.0 1670.0 4.14E-6 0.0417
NCAM2 ENSG00000154654 4685 Membrane 9.0 5.21 4.09E-6 0.0556
PRNP ENSG00000171867 5621 Membrane 20.0 1710.0 4.15E-6 0.0474
BAX ENSG00000087088 581 Unknown 285.0 23700.0 4.2E-6 0.0102
CASP12 ENSG00000204403 100506742 Unknown 15.0 90.5 4.14E-6 0.0476
PRKACA ENSG00000072062 5566 Unknown 3252.0 490000.0 4.23E-6 5.84E-4
EGR1 ENSG00000120738 1958 Nucleus 12.0 3.66 4.17E-6 0.227
C1QA ENSG00000173372 712 Secreted 71.0 760.0 4.11E-6 0.0109
C1QB ENSG00000173369 713 Secreted 68.0 6080.0 4.15E-6 0.0105
C1QC ENSG00000159189 714 Secreted 65.0 1030.0 4.13E-6 0.0115
C5 ENSG00000106804 727 Secreted 114.0 40000.0 4.16E-6 0.00637
C6 ENSG00000039537 729 Secreted 54.0 1630.0 4.13E-6 0.0147
C7 ENSG00000112936 730 Secreted 59.0 61.2 4.09E-6 0.0123
C8A ENSG00000157131 731 Secreted 69.0 0.0 4.09E-6 0.00895
C8B ENSG00000021852 732 Secreted 71.0 0.0 4.09E-6 0.00845
C8G ENSG00000176919 733 Secreted 64.0 0.0 4.09E-6 0.0104
C9 ENSG00000113600 735 Secreted 90.0 1430.0 4.13E-6 0.00524
CCL5 ENSG00000271503 6352 Secreted 264.0 5060.0 4.19E-6 0.0229
IL6 ENSG00000136244 3569 Secreted 455.0 7980.0 4.2E-6 0.0214
LAMC1 ENSG00000135862 3915 Secreted 386.0 1220.0 4.17E-6 0.0257
IL1B ENSG00000125538 3553 Secreted/Nucleus 791.0 39400.0 4.21E-6 0.00772
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
C1QA C1QB 5
C1QA C1QC 3
C1QB C1QC 3
C5 C6 4
C5 C7 3
C5 C8B 4
C5 C9 2
C5 MAPK1 1
C5 MAPK3 1
C6 C7 2
C7 C8A 2
C7 C8B 2
C7 C8G 2
C8A C5 1
C8A C6 1
C8A C8B 2
C8A C8G 3
C8A C9 4
C8B C6 1
C8B C8G 2
C8B C9 3
C8G C5 1
C8G C6 1
C8G C9 2
C9 C6 1
C9 C7 1
CCL5 MAPK1 1
CCL5 MAPK3 1
EGR1 IL1B 2
ELK1 EGR1 3
FYN NCAM1 2
HSPA5 PRNP 4
IL1A IL1B 2
IL1B CCL5 1
IL1B ELK1 1
IL1B IL6 1
IL1B MAPK1 1
IL1B MAPK3 1
IL6 MAP2K1 2
IL6 MAP2K2 2
MAP2K1 MAP2K2 7
MAP2K1 MAPK1 13
MAP2K1 MAPK3 12
MAP2K2 MAPK1 10
MAP2K2 MAPK3 11
MAPK1 ELK1 9
MAPK1 MAPK3 4
MAPK3 ELK1 8
NCAM1 PRNP 3
NCAM2 PRNP 2
PRKACA FYN 2
PRKACA PRKACB 4
PRKACA PRKACG 3
PRKACB FYN 1
PRKACG FYN 1
PRNP SOD1 2
PRNP STIP1 3
C5 IL1B 1
C5 IL6 1
C6 FYN 1
CASP12 HSPA5 1
EGR1 CCL5 1
EGR1 PRKACA 1
EGR1 SOD1 1
ELK1 FYN 1
ELK1 MAP2K1 1
ELK1 NCAM1 1
ELK1 PRKACB 1
FYN IL1B 1
FYN MAPK1 1
HSPA5 STIP1 2
IL1A IL6 1
IL1B PRKACA 1
IL6 MAPK1 2
IL6 MAPK3 2
LAMC1 FYN 1
LAMC1 PRNP 1
MAPK1 EGR1 1
MAPK3 EGR1 1
NCAM2 NCAM1 1
PRKACA MAPK1 1
PRKACA MAPK3 1
PRKACB MAPK1 1
PRKACB MAPK3 1
PRKACB PRKACG 1
PRKACG MAPK1 1
PRKACG MAPK3 1
PRKX MAPK1 1
PRKX MAPK3 1
PRNP BAX 1
PRNP FYN 1
PRNP MAP2K1 1
PRNP MAP2K2 1
SOD1 BAX 1
SOD1 CCL5 1
SOD1 IL6 1
SOD1 MAP2K1 1
SOD1 MAP2K2 1
SOD1 MAPK1 1
SOD1 MAPK3 1
SOD1 STIP1 1
STIP1 PRKACA 1
STIP1 PRKACB 1
STIP1 PRKACG 1
STIP1 PRKX 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002643 pathway0002208 7 0.875 Terminal pathway of complement Reactome 8 29
pathway0002643 pathway0000700 5 0.8333333 ERK cascade ( EGF signaling pathway Diagram ) INOH 6 15
pathway0002643 pathway0000708 5 0.8333333 ERK cascade ( HGF signaling pathway ) INOH 6 15
pathway0002643 pathway0000714 5 0.8333333 ERK cascade ( VEGF signaling pathway ) INOH 6 15
pathway0002643 pathway0000704 4 0.8 ERK cascade ( GPCR Adenosine A2A receptor signaling pathway ) INOH 5 11
pathway0002643 pathway0000707 4 0.8 ERK cascade ( GPCR signaling (G alpha s, Epac and ERK) ) INOH 5 11
pathway0002643 pathway0002466 4 0.8 ERK cascade ( Integrin signaling pathway ) INOH 5 11
pathway0002643 pathway0002467 5 0.7142857 ERK cascade ( PDGF signaling pathway ) INOH 7 18
pathway0002643 pathway0001446 4 0.6666667 Negative feedback regulation of MAPK pathway Reactome 6 16
pathway0002643 pathway0000701 5 0.625 ERK cascade ( FGF signaling pathway ) INOH 8 26
pathway0002643 pathway0000709 5 0.625 ERK cascade ( IGF1 signaling pathway ) INOH 8 26
pathway0002643 pathway0000710 5 0.625 ERK cascade ( Insulin receptor signaling (D. melanogaster) ) INOH 8 26
pathway0002643 pathway0000711 5 0.625 ERK cascade ( Insulin receptor signaling (Mammal) ) INOH 8 26
pathway0002643 pathway0000713 5 0.625 ERK cascade ( NGF signaling pathway ) INOH 8 26
pathway0002643 pathway0001667 3 0.6 PKA-mediated phosphorylation of key metabolic factors Reactome 5 9
pathway0002643 pathway0000697 4 0.5714286 ERK cascade ( B cell receptor signaling ) INOH 7 22
pathway0002643 pathway0000699 4 0.5714286 ERK cascade ( CD4 T cell receptor signaling ) INOH 7 22
pathway0002643 pathway0000705 4 0.5714286 ERK cascade ( GPCR GroupI metabotropic glutamate receptor signaling pathway ) INOH 7 22
pathway0002643 pathway0000706 4 0.5714286 ERK cascade ( GPCR signaling (G alpha q) ) INOH 7 22
pathway0002643 pathway0000712 4 0.5714286 ERK cascade ( JAK-STAT pathway and regulation pathway Diagram ) INOH 7 22