Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002662 Prostate cancer KEGG Homo sapiens 85 1261
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
BAD ENSG00000002330 572 Cytoplasm 0.00617284 82.0 11.29863 0.012044565
CHUK ENSG00000213341 1147 Cytoplasm 0.007194245 116.0 11.5734 0.030884558
HSP90B1 ENSG00000166598 7184 Cytoplasm 0.006493506 15.0 1.188499 0.457142857
IGF1 ENSG00000017427 3479 Cytoplasm 0.007518797 70.0 14.9454 0.130848861
KRAS ENSG00000133703 3845 Cytoplasm 0.007518797 192.0 10.58318 0.025796248
MAP2K1 ENSG00000169032 5604 Cytoplasm 0.007142857 134.0 3.484685 0.026259679
SOS1 ENSG00000115904 6654 Cytoplasm 0.007874016 215.0 12.0273 0.025081504
SOS2 ENSG00000100485 6655 Cytoplasm 0.007092199 144.0 3.063554 0.034965035
AKT2 ENSG00000105221 208 Cytoplasm/Nucleus 0.008928571 485.0 132.5251 0.006040726
ATF4 ENSG00000128272 468 Cytoplasm/Nucleus 0.00621118 20.0 3.6554 0.2
BCL2 ENSG00000171791 596 Cytoplasm/Nucleus 0.006849315 39.0 2.370309 0.182186235
CASP9 ENSG00000132906 842 Cytoplasm/Nucleus 0.00617284 43.0 0.2394849 0.055370986
CCND1 ENSG00000110092 595 Cytoplasm/Nucleus 0.007633588 108.0 45.17678 0.047767394
CDK2 ENSG00000123374 1017 Cytoplasm/Nucleus 0.007692308 94.0 23.07572 0.074811256
CDKN1A ENSG00000124762 1026 Cytoplasm/Nucleus 0.0078125 130.0 33.22255 0.041621944
CDKN1B ENSG00000111276 1027 Cytoplasm/Nucleus 0.006944444 69.0 9.310125 0.065643649
CREB3 ENSG00000107175 10488 Cytoplasm/Nucleus 0.006329114 12.0 5.742995 0.378787879
CREB3L3 ENSG00000060566 84699 Cytoplasm/Nucleus 0.005555556 11.0 3.303937 0.290909091
CREB3L4 ENSG00000143578 148327 Cytoplasm/Nucleus 0.005319149 8.0 0.01428863 0.464285714
E2F1 ENSG00000101412 1869 Cytoplasm/Nucleus 0.007874016 85.0 29.1731 0.095798319
EP300 ENSG00000100393 2033 Cytoplasm/Nucleus 0.007936508 82.0 137.402 0.083709726
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 0.006802721 53.0 5.299089 0.07329463
HSP90AA1 ENSG00000080824 3320 Cytoplasm/Nucleus 0.0078125 63.0 15.34919 0.203789042
HSP90AB1 ENSG00000096384 3326 Cytoplasm/Nucleus 0.006849315 29.0 3.73963 0.332512315
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 0.006944444 110.0 9.81225 0.025020851
IKBKG ENSG00000269335 8517 Cytoplasm/Nucleus 0.006944444 97.0 8.37497 0.028565292
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 0.006622517 128.0 1.859121 0.024729331
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 0.008064516 206.0 70.84799 0.020648828
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 0.007692308 186.0 52.04458 0.018889858
MDM2 ENSG00000135679 4193 Cytoplasm/Nucleus 0.007246377 76.0 12.44339 0.069122807
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 0.007407407 121.0 11.66377 0.03815427
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 0.006535948 175.0 5.111552 0.006174056
PTEN ENSG00000171862 5728 Cytoplasm/Nucleus 0.007518797 95.0 22.93056 0.070996641
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 0.0078125 137.0 31.49543 0.041863461
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 0.008264463 124.0 39.1689 0.06490952
PIK3CD ENSG00000171608 5293 Cytoskeleton 0.007633588 255.0 13.63122 0.014976069
AKT1 ENSG00000142208 207 Membrane 0.009615385 603.0 322.7942 0.004864933
AKT3 ENSG00000117020 10000 Membrane 0.00862069 476.0 119.857 0.005095091
ERBB2 ENSG00000141736 2064 Membrane 0.008196721 147.0 35.61291 0.050507874
FGFR1 ENSG00000077782 2260 Membrane 0.008130081 94.0 28.39658 0.123770304
FGFR2 ENSG00000066468 2263 Membrane 0.007462687 76.0 3.238212 0.165964912
HRAS ENSG00000174775 3265 Membrane 0.008849558 208.0 36.66536 0.036371237
IGF1R ENSG00000140443 3480 Membrane 0.0078125 119.0 25.49062 0.067084461
INSRR ENSG00000027644 3645 Membrane 0.006369427 24.0 1.281143 0.525362319
MTOR ENSG00000198793 2475 Membrane 0.007692308 104.0 5.265641 0.073188947
NRAS ENSG00000213281 4893 Membrane 0.007751938 172.0 25.99157 0.034135727
PDGFC ENSG00000145431 56034 Membrane 0.006896552 40.0 9.024508 0.170512821
PDGFRA ENSG00000134853 5156 Membrane 0.007407407 125.0 12.92557 0.051483871
PDGFRB ENSG00000113721 5159 Membrane 0.007194245 131.0 14.16164 0.050381679
PIK3CA ENSG00000121879 5290 Membrane 0.008 287.0 26.14225 0.015569796
PIK3CG ENSG00000105851 5294 Membrane 0.007575758 254.0 11.4172 0.01525007
PIK3R1 ENSG00000145675 5295 Membrane 0.008403361 294.0 48.50442 0.015114578
PIK3R2 ENSG00000105647 5296 Membrane 0.007462687 256.0 12.94456 0.015318627
PIK3R5 ENSG00000141506 23533 Membrane 0.00729927 207.0 11.89407 0.0155246
TGFA ENSG00000163235 7039 Membrane 0.006578947 34.0 1.849131 0.099821747
AR ENSG00000169083 367 Unknown 0.008064516 77.0 60.61361 0.138414217
CREB3L1 ENSG00000157613 90993 Unknown 0.005319149 8.0 0.01428863 0.464285714
CTNNB1 ENSG00000168036 1499 Unknown 0.008196721 165.0 122.2239 0.033111604
EGFR ENSG00000146648 1956 Unknown 0.008196721 221.0 81.18908 0.026203209
GRB2 ENSG00000177885 2885 Unknown 0.008695652 263.0 77.76825 0.020839985
GSK3B ENSG00000082701 2932 Unknown 0.007518797 143.0 142.7012 0.022160938
KLK3 ENSG00000142515 354 Unknown 0.006369427 16.0 0.2641496 0.308333333
PDPK1 ENSG00000140992 5170 Unknown 0.007352941 189.0 5.0089 0.026680176
PIK3CB ENSG00000051382 5291 Unknown 0.007246377 260.0 9.660412 0.014226314
PIK3R3 ENSG00000117461 8503 Unknown 0.0078125 234.0 25.06574 0.018781409
CCNE1 ENSG00000105173 898 Nucleus 0.006578947 50.0 2.375858 0.05877551
CCNE2 ENSG00000175305 9134 Nucleus 0.006289308 31.0 0.7530109 0.107526882
CREB1 ENSG00000118260 1385 Nucleus 0.007246377 44.0 18.42847 0.216701903
CREB3L2 ENSG00000182158 64764 Nucleus 0.005617978 8.0 0.1547042 0.357142857
CREB5 ENSG00000146592 9586 Nucleus 0.005882353 13.0 0.2043566 0.205128205
CREBBP ENSG00000005339 1387 Nucleus 0.007936508 90.0 156.2158 0.07690387
E2F2 ENSG00000007968 1870 Nucleus 0.006756757 50.0 4.206498 0.111836735
E2F3 ENSG00000112242 1871 Nucleus 0.007246377 59.0 6.895025 0.128579778
LEF1 ENSG00000138795 51176 Nucleus 0.007407407 61.0 61.06811 0.092349727
NKX3-1 ENSG00000167034 4824 Nucleus 0.005780347 9.0 0.23142 0.083333333
RB1 ENSG00000139687 5925 Nucleus 0.007407407 146.0 33.40611 0.023429381
TCF7 ENSG00000081059 6932 Nucleus 0.006134969 36.0 0.8720714 0.082539683
TCF7L1 ENSG00000152284 83439 Nucleus 0.005747126 27.0 0.0 0.028490028
TCF7L2 ENSG00000148737 6934 Nucleus 0.00625 37.0 0.3920379 0.057057057
EGF ENSG00000138798 1950 Secreted 0.0078125 104.0 25.52015 0.086631815
INS ENSG00000254647 3630 Secreted 0.0078125 66.0 12.21108 0.186013986
PDGFA ENSG00000197461 5154 Secreted 0.006802721 65.0 0.6510101 0.166346154
PDGFD ENSG00000170962 80310 Secreted 0.005952381 31.0 0.3466048 0.2
PDGFB ENSG00000100311 5155 Secreted/Nucleus 0.007042254 73.0 1.953567 0.148782344
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BAD ENSG00000002330 572 Cytoplasm 4485.0 12100.0 1.55E-6 8.39E-5
CHUK ENSG00000213341 1147 Cytoplasm 9301.0 163000.0 1.56E-6 1.35E-4
HSP90B1 ENSG00000166598 7184 Cytoplasm 126.0 23600.0 1.56E-6 0.0702
IGF1 ENSG00000017427 3479 Cytoplasm 1260.0 84400.0 1.56E-6 0.00215
KRAS ENSG00000133703 3845 Cytoplasm 15339.0 61700.0 1.56E-6 8.92E-5
MAP2K1 ENSG00000169032 5604 Cytoplasm 23272.0 37700.0 1.56E-6 1.47E-5
SOS1 ENSG00000115904 6654 Cytoplasm 23511.0 177000.0 1.56E-6 6.54E-5
SOS2 ENSG00000100485 6655 Cytoplasm 6309.0 10000.0 1.56E-6 2.71E-4
AKT2 ENSG00000105221 208 Cytoplasm/Nucleus 23612.0 163000.0 1.56E-6 4.86E-5
ATF4 ENSG00000128272 468 Cytoplasm/Nucleus 251.0 47000.0 1.56E-6 0.0171
BCL2 ENSG00000171791 596 Cytoplasm/Nucleus 1236.0 33900.0 1.56E-6 0.00248
CASP9 ENSG00000132906 842 Cytoplasm/Nucleus 2323.0 28000.0 1.55E-6 2.13E-4
CCND1 ENSG00000110092 595 Cytoplasm/Nucleus 2739.0 100000.0 1.56E-6 0.00164
CDK2 ENSG00000123374 1017 Cytoplasm/Nucleus 4222.0 396000.0 1.56E-6 0.00141
CDKN1A ENSG00000124762 1026 Cytoplasm/Nucleus 3911.0 109000.0 1.56E-6 8.1E-4
CDKN1B ENSG00000111276 1027 Cytoplasm/Nucleus 1796.0 58900.0 1.56E-6 0.00264
CREB3 ENSG00000107175 10488 Cytoplasm/Nucleus 85.0 370.0 1.55E-6 0.0244
CREB3L3 ENSG00000060566 84699 Cytoplasm/Nucleus 142.0 780.0 1.55E-6 0.0561
CREB3L4 ENSG00000143578 148327 Cytoplasm/Nucleus 132.0 716.0 1.55E-6 0.0622
E2F1 ENSG00000101412 1869 Cytoplasm/Nucleus 2673.0 379000.0 1.56E-6 0.00371
EP300 ENSG00000100393 2033 Cytoplasm/Nucleus 6386.0 1380000.0 1.56E-6 0.00143
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 1320.0 45800.0 1.56E-6 0.00162
HSP90AA1 ENSG00000080824 3320 Cytoplasm/Nucleus 2511.0 497000.0 1.56E-6 0.00586
HSP90AB1 ENSG00000096384 3326 Cytoplasm/Nucleus 510.0 22900.0 1.56E-6 0.03
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 10428.0 206000.0 1.56E-6 1.03E-4
IKBKG ENSG00000269335 8517 Cytoplasm/Nucleus 7020.0 201000.0 1.56E-6 2.07E-4
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 22859.0 10500.0 1.55E-6 9.5E-6
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 33563.0 1130000.0 1.56E-6 2.83E-5
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 29207.0 850000.0 1.56E-6 3.17E-5
MDM2 ENSG00000135679 4193 Cytoplasm/Nucleus 2666.0 363000.0 1.56E-6 0.00187
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 11386.0 280000.0 1.56E-6 2.06E-4
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 12604.0 63600.0 1.56E-6 3.76E-5
PTEN ENSG00000171862 5728 Cytoplasm/Nucleus 3065.0 151000.0 1.56E-6 0.00178
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 11059.0 663000.0 1.57E-6 3.08E-4
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 8418.0 2450000.0 1.57E-6 7.36E-4
PIK3CD ENSG00000171608 5293 Cytoskeleton 14967.0 29900.0 1.56E-6 1.22E-4
AKT1 ENSG00000142208 207 Membrane 52751.0 2150000.0 1.57E-6 1.74E-5
AKT3 ENSG00000117020 10000 Membrane 22158.0 86500.0 1.56E-6 5.25E-5
ERBB2 ENSG00000141736 2064 Membrane 4475.0 103000.0 1.56E-6 0.00131
FGFR1 ENSG00000077782 2260 Membrane 4413.0 19900.0 1.56E-6 8.44E-4
FGFR2 ENSG00000066468 2263 Membrane 3779.0 10600.0 1.56E-6 0.00107
HRAS ENSG00000174775 3265 Membrane 21752.0 305000.0 1.56E-6 6.79E-5
IGF1R ENSG00000140443 3480 Membrane 2050.0 25200.0 1.56E-6 0.00201
INSRR ENSG00000027644 3645 Membrane 74.0 29.3 1.55E-6 0.0807
MTOR ENSG00000198793 2475 Membrane 6209.0 146000.0 1.56E-6 2.1E-4
NRAS ENSG00000213281 4893 Membrane 14710.0 64200.0 1.56E-6 1.13E-4
PDGFC ENSG00000145431 56034 Membrane 208.0 114.0 1.55E-6 0.0153
PDGFRA ENSG00000134853 5156 Membrane 2800.0 20200.0 1.56E-6 0.00142
PDGFRB ENSG00000113721 5159 Membrane 3968.0 9730.0 1.56E-6 0.00105
PIK3CA ENSG00000121879 5290 Membrane 27859.0 414000.0 1.56E-6 5.51E-5
PIK3CG ENSG00000105851 5294 Membrane 13674.0 58900.0 1.56E-6 1.37E-4
PIK3R1 ENSG00000145675 5295 Membrane 31452.0 734000.0 1.56E-6 4.03E-5
PIK3R2 ENSG00000105647 5296 Membrane 17436.0 144000.0 1.56E-6 9.14E-5
PIK3R5 ENSG00000141506 23533 Membrane 7488.0 14200.0 1.56E-6 3.32E-4
TGFA ENSG00000163235 7039 Membrane 649.0 57300.0 1.55E-6 0.00494
AR ENSG00000169083 367 Unknown 1492.0 269000.0 1.56E-6 0.011
CREB3L1 ENSG00000157613 90993 Unknown 135.0 1130.0 1.55E-6 0.0595
CTNNB1 ENSG00000168036 1499 Unknown 12389.0 1400000.0 1.57E-6 3.14E-4
EGFR ENSG00000146648 1956 Unknown 12590.0 758000.0 1.56E-6 2.83E-4
GRB2 ENSG00000177885 2885 Unknown 29079.0 822000.0 1.57E-6 5.64E-5
GSK3B ENSG00000082701 2932 Unknown 9387.0 367000.0 1.56E-6 1.84E-4
KLK3 ENSG00000142515 354 Unknown 361.0 29100.0 1.56E-6 0.0548
PDPK1 ENSG00000140992 5170 Unknown 7752.0 22600.0 1.56E-6 2.91E-4
PIK3CB ENSG00000051382 5291 Unknown 17496.0 62500.0 1.56E-6 1.07E-4
PIK3R3 ENSG00000117461 8503 Unknown 10628.0 40100.0 1.56E-6 1.94E-4
CCNE1 ENSG00000105173 898 Nucleus 1165.0 18600.0 1.56E-6 0.00595
CCNE2 ENSG00000175305 9134 Nucleus 468.0 1660.0 1.55E-6 0.0238
CREB1 ENSG00000118260 1385 Nucleus 1632.0 139000.0 1.56E-6 0.00288
CREB3L2 ENSG00000182158 64764 Nucleus 130.0 1140.0 1.55E-6 0.0565
CREB5 ENSG00000146592 9586 Nucleus 119.0 477.0 1.55E-6 0.0675
CREBBP ENSG00000005339 1387 Nucleus 4940.0 1650000.0 1.57E-6 0.00177
E2F2 ENSG00000007968 1870 Nucleus 895.0 5110.0 1.56E-6 0.00857
E2F3 ENSG00000112242 1871 Nucleus 1112.0 29600.0 1.56E-6 0.00863
LEF1 ENSG00000138795 51176 Nucleus 2852.0 276000.0 1.56E-6 0.0024
NKX3-1 ENSG00000167034 4824 Nucleus 32.0 8.98 1.55E-6 0.0343
RB1 ENSG00000139687 5925 Nucleus 4373.0 218000.0 1.56E-6 0.00126
TCF7 ENSG00000081059 6932 Nucleus 1197.0 2360.0 1.55E-6 0.00517
TCF7L1 ENSG00000152284 83439 Nucleus 1248.0 10700.0 1.55E-6 0.00508
TCF7L2 ENSG00000148737 6934 Nucleus 1660.0 14100.0 1.56E-6 0.00359
EGF ENSG00000138798 1950 Secreted 4432.0 61100.0 1.56E-6 9.73E-4
INS ENSG00000254647 3630 Secreted 1834.0 510000.0 1.56E-6 0.00309
PDGFA ENSG00000197461 5154 Secreted 1728.0 13900.0 1.55E-6 0.00357
PDGFD ENSG00000170962 80310 Secreted 200.0 65.7 1.55E-6 0.0135
PDGFB ENSG00000100311 5155 Secreted/Nucleus 2493.0 26100.0 1.56E-6 0.00256
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BAD ENSG00000002330 572 Cytoplasm 1742.0 10700.0 4.2E-6 3.79E-4
CHUK ENSG00000213341 1147 Cytoplasm 2599.0 36200.0 4.21E-6 6.51E-4
HSP90B1 ENSG00000166598 7184 Cytoplasm 79.0 40400.0 4.19E-6 0.0919
IGF1 ENSG00000017427 3479 Cytoplasm 502.0 2730.0 4.2E-6 0.00743
KRAS ENSG00000133703 3845 Cytoplasm 6144.0 82900.0 4.22E-6 3.01E-4
MAP2K1 ENSG00000169032 5604 Cytoplasm 7272.0 15700.0 4.21E-6 8.17E-5
SOS1 ENSG00000115904 6654 Cytoplasm 4893.0 29700.0 4.2E-6 7.29E-4
SOS2 ENSG00000100485 6655 Cytoplasm 3065.0 6030.0 4.19E-6 6.63E-4
AKT2 ENSG00000105221 208 Cytoplasm/Nucleus 12922.0 78100.0 4.22E-6 9.13E-5
ATF4 ENSG00000128272 468 Cytoplasm/Nucleus 177.0 29900.0 4.19E-6 0.0199
BCL2 ENSG00000171791 596 Cytoplasm/Nucleus 458.0 29500.0 4.21E-6 0.00984
CASP9 ENSG00000132906 842 Cytoplasm/Nucleus 975.0 20300.0 4.2E-6 8.09E-4
CCND1 ENSG00000110092 595 Cytoplasm/Nucleus 1212.0 11900.0 4.2E-6 0.00216
CDK2 ENSG00000123374 1017 Cytoplasm/Nucleus 809.0 69500.0 4.21E-6 0.00899
CDKN1A ENSG00000124762 1026 Cytoplasm/Nucleus 1218.0 21000.0 4.21E-6 0.00324
CDKN1B ENSG00000111276 1027 Cytoplasm/Nucleus 395.0 5160.0 4.2E-6 0.0186
CREB3 ENSG00000107175 10488 Cytoplasm/Nucleus 65.0 643.0 4.17E-6 0.0418
CREB3L3 ENSG00000060566 84699 Cytoplasm/Nucleus 73.0 341.0 4.17E-6 0.0548
CREB3L4 ENSG00000143578 148327 Cytoplasm/Nucleus 65.0 250.0 4.17E-6 0.0601
E2F1 ENSG00000101412 1869 Cytoplasm/Nucleus 962.0 20400.0 4.21E-6 0.00696
EP300 ENSG00000100393 2033 Cytoplasm/Nucleus 847.0 154000.0 4.22E-6 0.0101
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 193.0 24600.0 4.19E-6 0.0204
HSP90AA1 ENSG00000080824 3320 Cytoplasm/Nucleus 362.0 120000.0 4.21E-6 0.0466
HSP90AB1 ENSG00000096384 3326 Cytoplasm/Nucleus 181.0 31900.0 4.21E-6 0.0575
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 3098.0 92800.0 4.21E-6 5.25E-4
IKBKG ENSG00000269335 8517 Cytoplasm/Nucleus 2435.0 52500.0 4.21E-6 7.02E-4
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 7076.0 6360.0 4.2E-6 5.76E-5
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 9283.0 714000.0 4.23E-6 1.78E-4
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 8670.0 340000.0 4.23E-6 1.73E-4
MDM2 ENSG00000135679 4193 Cytoplasm/Nucleus 704.0 23900.0 4.21E-6 0.00538
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 3288.0 55500.0 4.21E-6 4.97E-4
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 3700.0 14800.0 4.21E-6 1.6E-4
PTEN ENSG00000171862 5728 Cytoplasm/Nucleus 1080.0 18300.0 4.2E-6 0.00586
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 3598.0 133000.0 4.22E-6 6.78E-4
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 2254.0 393000.0 4.23E-6 0.00213
PIK3CD ENSG00000171608 5293 Cytoskeleton 7623.0 27500.0 4.21E-6 2.8E-4
AKT1 ENSG00000142208 207 Membrane 15717.0 483000.0 4.23E-6 9.3E-5
AKT3 ENSG00000117020 10000 Membrane 12844.0 58500.0 4.22E-6 8.89E-5
ERBB2 ENSG00000141736 2064 Membrane 1298.0 15600.0 4.21E-6 0.00525
FGFR1 ENSG00000077782 2260 Membrane 1123.0 2720.0 4.2E-6 0.00607
FGFR2 ENSG00000066468 2263 Membrane 804.0 4320.0 4.2E-6 0.0115
HRAS ENSG00000174775 3265 Membrane 5956.0 121000.0 4.22E-6 4.77E-4
IGF1R ENSG00000140443 3480 Membrane 949.0 24700.0 4.21E-6 0.0063
INSRR ENSG00000027644 3645 Membrane 41.0 3.19 4.17E-6 0.177
MTOR ENSG00000198793 2475 Membrane 1046.0 26800.0 4.2E-6 0.00265
NRAS ENSG00000213281 4893 Membrane 4978.0 69500.0 4.21E-6 5.26E-4
PDGFC ENSG00000145431 56034 Membrane 149.0 29.7 4.19E-6 0.0184
PDGFRA ENSG00000134853 5156 Membrane 1243.0 7040.0 4.2E-6 0.00475
PDGFRB ENSG00000113721 5159 Membrane 1298.0 2650.0 4.2E-6 0.00489
PIK3CA ENSG00000121879 5290 Membrane 8869.0 407000.0 4.23E-6 3.0E-4
PIK3CG ENSG00000105851 5294 Membrane 7696.0 36500.0 4.21E-6 2.71E-4
PIK3R1 ENSG00000145675 5295 Membrane 9027.0 146000.0 4.22E-6 2.65E-4
PIK3R2 ENSG00000105647 5296 Membrane 7733.0 62100.0 4.21E-6 2.71E-4
PIK3R5 ENSG00000141506 23533 Membrane 6010.0 17400.0 4.21E-6 3.4E-4
TGFA ENSG00000163235 7039 Membrane 207.0 240.0 4.18E-6 0.00521
AR ENSG00000169083 367 Unknown 302.0 9580.0 4.21E-6 0.0471
CREB3L1 ENSG00000157613 90993 Unknown 66.0 279.0 4.17E-6 0.0583
CTNNB1 ENSG00000168036 1499 Unknown 2518.0 201000.0 4.22E-6 0.0017
EGFR ENSG00000146648 1956 Unknown 3897.0 239000.0 4.22E-6 0.00116
GRB2 ENSG00000177885 2885 Unknown 5947.0 100000.0 4.22E-6 5.35E-4
GSK3B ENSG00000082701 2932 Unknown 1991.0 174000.0 4.21E-6 0.00115
KLK3 ENSG00000142515 354 Unknown 50.0 35.5 4.18E-6 0.105
PDPK1 ENSG00000140992 5170 Unknown 1246.0 3680.0 4.2E-6 0.00166
PIK3CB ENSG00000051382 5291 Unknown 7887.0 42600.0 4.21E-6 3.07E-4
PIK3R3 ENSG00000117461 8503 Unknown 7005.0 28500.0 4.21E-6 3.03E-4
CCNE1 ENSG00000105173 898 Nucleus 299.0 1400.0 4.19E-6 0.0137
CCNE2 ENSG00000175305 9134 Nucleus 199.0 349.0 4.16E-6 0.025
CREB1 ENSG00000118260 1385 Nucleus 164.0 57500.0 4.21E-6 0.0403
CREB3L2 ENSG00000182158 64764 Nucleus 63.0 289.0 4.17E-6 0.0512
CREB5 ENSG00000146592 9586 Nucleus 47.0 127.0 4.17E-6 0.0944
CREBBP ENSG00000005339 1387 Nucleus 822.0 110000.0 4.22E-6 0.0095
E2F2 ENSG00000007968 1870 Nucleus 536.0 2260.0 4.19E-6 0.00852
E2F3 ENSG00000112242 1871 Nucleus 621.0 4500.0 4.2E-6 0.00958
LEF1 ENSG00000138795 51176 Nucleus 707.0 43000.0 4.21E-6 0.00819
NKX3-1 ENSG00000167034 4824 Nucleus 22.0 9.31 4.17E-6 0.0346
RB1 ENSG00000139687 5925 Nucleus 1685.0 9770.0 4.2E-6 0.00173
TCF7 ENSG00000081059 6932 Nucleus 347.0 497.0 4.18E-6 0.00488
TCF7L1 ENSG00000152284 83439 Nucleus 311.0 304.0 4.17E-6 0.00349
TCF7L2 ENSG00000148737 6934 Nucleus 413.0 1410.0 4.19E-6 0.00411
EGF ENSG00000138798 1950 Secreted 1534.0 18900.0 4.21E-6 0.00399
INS ENSG00000254647 3630 Secreted 449.0 32800.0 4.21E-6 0.0125
PDGFA ENSG00000197461 5154 Secreted 640.0 2720.0 4.19E-6 0.0159
PDGFD ENSG00000170962 80310 Secreted 134.0 2.37 4.16E-6 0.0162
PDGFB ENSG00000100311 5155 Secreted/Nucleus 772.0 5250.0 4.2E-6 0.0141
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
AKT1 AKT2 2
AKT1 AR 6
AKT1 BAD 10
AKT1 CASP9 7
AKT1 CDKN1A 9
AKT1 CDKN1B 9
AKT1 CHUK 10
AKT1 CREB1 4
AKT1 CREBBP 4
AKT1 CTNNB1 3
AKT1 E2F2 2
AKT1 EGFR 4
AKT1 EP300 6
AKT1 FOXO1 13
AKT1 GSK3B 13
AKT1 HSP90AA1 7
AKT1 IKBKB 7
AKT1 IKBKG 5
AKT1 MDM2 11
AKT1 MTOR 11
AKT1 NFKB1 3
AKT1 RELA 4
AKT1 TP53 4
AKT2 BAD 4
AKT2 CASP9 3
AKT2 CDKN1A 5
AKT2 CDKN1B 3
AKT2 CHUK 8
AKT2 CREB1 1
AKT2 CTNNB1 2
AKT2 FOXO1 4
AKT2 GSK3B 8
AKT2 IKBKB 2
AKT2 MDM2 3
AKT2 TP53 2
AKT3 BAD 4
AKT3 CASP9 3
AKT3 CDKN1A 4
AKT3 CDKN1B 3
AKT3 CHUK 3
AKT3 CREB1 1
AKT3 FOXO1 5
AKT3 GSK3B 6
AKT3 IKBKB 2
AKT3 MDM2 4
AKT3 NFKB1 3
AR CCND1 5
AR CDKN1A 3
AR CTNNB1 6
AR EGFR 5
AR GSK3B 4
AR HSP90AA1 5
AR KLK3 7
AR NKX3-1 3
AR PIK3R1 4
ATF4 CREBBP 3
ATF4 EP300 2
BAD BCL2 7
BCL2 TP53 5
CCND1 CDK2 6
CCND1 CDKN1A 8
CCND1 CDKN1B 6
CCND1 CREBBP 3
CCND1 E2F1 3
CCND1 E2F2 3
CCND1 E2F3 3
CCND1 RB1 10
CCNE1 CDK2 12
CCNE1 CDKN1A 7
CCNE1 CDKN1B 9
CCNE1 NRAS 1
CCNE1 RB1 5
CCNE2 CDK2 7
CCNE2 CDKN1A 6
CCNE2 CDKN1B 6
CCNE2 RB1 2
CDK2 AKT1 1
CDK2 AKT2 1
CDK2 AKT3 1
CDK2 CDKN1A 11
CDK2 CDKN1B 12
CDK2 E2F1 7
CDK2 E2F2 2
CDK2 E2F3 4
CDK2 FOXO1 2
CDK2 MDM2 2
CDK2 RB1 12
CDK2 TP53 8
CDKN1A CREBBP 4
CDKN1A E2F1 4
CDKN1A HSP90AA1 3
CDKN1A RB1 5
CDKN1B RB1 1
CHUK CCND1 2
CHUK CREBBP 6
CHUK CTNNB1 4
CHUK HSP90AA1 6
CHUK HSP90AB1 5
CHUK IKBKB 11
CHUK IKBKG 10
CHUK MTOR 2
CHUK NFKB1 10
CHUK NFKBIA 14
CHUK RELA 11
CREB1 CREBBP 8
CREB1 EP300 4
CREB3 CREBBP 2
CREB3L1 CREBBP 2
CREB3L1 EP300 2
CREB3L2 CREBBP 2
CREB3L2 EP300 2
CREB3L3 CREBBP 2
CREB3L3 EP300 2
CREB3L4 CREBBP 2
CREB3L4 EP300 2
CREB5 CREBBP 2
CREB5 EP300 2
CREBBP CTNNB1 7
CREBBP EP300 5
CREBBP FOXO1 4
CREBBP IKBKB 3
CREBBP IKBKG 4
CREBBP LEF1 3
CREBBP MAPK3 2
CREBBP MDM2 4
CREBBP RELA 7
CREBBP TCF7 2
CREBBP TCF7L1 3
CREBBP TCF7L2 3
CREBBP TP53 8
CTNNB1 EP300 8
CTNNB1 FGFR1 4
CTNNB1 FOXO1 3
CTNNB1 GSK3B 10
CTNNB1 IGF1R 2
CTNNB1 KLK3 2
CTNNB1 LEF1 11
CTNNB1 PIK3CA 2
CTNNB1 PIK3R1 4
CTNNB1 TCF7 6
CTNNB1 TCF7L1 7
CTNNB1 TCF7L2 12
CTNNB1 TP53 2
E2F1 CCNE1 3
E2F1 CCNE2 2
E2F1 E2F2 4
E2F1 E2F3 2
E2F1 PIK3R3 2
E2F1 RB1 10
E2F2 CCNE1 2
E2F2 CCNE2 2
E2F2 RB1 8
E2F3 CCNE1 2
E2F3 CCNE2 2
E2F3 RB1 8
EGF AKT1 2
EGF BAD 2
EGF CREB1 1
EGF CTNNB1 1
EGF EGFR 13
EGF ERBB2 7
EGF FGFR1 2
EGF FGFR2 2
EGF GRB2 5
EGF HSP90AA1 1
EGF IGF1R 1
EGF MAP2K1 1
EGF MAP2K2 1
EGF MAPK1 1
EGF MAPK3 2
EGF MTOR 2
EGF PDGFRA 1
EGF PDGFRB 1
EGF PDPK1 2
EGF PIK3CA 2
EGF PIK3R1 3
EGF PIK3R2 2
EGFR AKT2 3
EGFR AKT3 3
EGFR CCNE1 1
EGFR CTNNB1 5
EGFR ERBB2 11
EGFR GRB2 12
EGFR HRAS 4
EGFR HSP90AA1 4
EGFR KRAS 3
EGFR MAPK1 4
EGFR MAPK3 3
EGFR MTOR 2
EGFR NRAS 4
EGFR PDPK1 3
EGFR PIK3CA 4
EGFR PIK3CB 4
EGFR PIK3CD 2
EGFR PIK3CG 2
EGFR PIK3R1 8
EGFR PIK3R2 7
EGFR PIK3R3 3
EGFR PIK3R5 3
EGFR SOS1 9
EGFR SOS2 7
EGFR TGFA 5
EGF SOS1 4
EP300 FOXO1 3
EP300 LEF1 5
EP300 MDM2 5
EP300 NFKB1 4
EP300 RB1 4
EP300 RELA 7
EP300 TCF7 2
EP300 TCF7L1 3
EP300 TCF7L2 6
EP300 TP53 11
ERBB2 AKT1 2
ERBB2 AKT2 2
ERBB2 AKT3 2
ERBB2 CTNNB1 3
ERBB2 FGFR1 2
ERBB2 GRB2 9
ERBB2 HRAS 5
ERBB2 HSP90AA1 6
ERBB2 MAPK1 2
ERBB2 MAPK3 2
ERBB2 PIK3CA 4
ERBB2 PIK3CB 3
ERBB2 PIK3CD 2
ERBB2 PIK3CG 3
ERBB2 PIK3R1 7
ERBB2 PIK3R2 4
ERBB2 PIK3R3 3
ERBB2 PIK3R5 2
ERBB2 SOS1 4
ERBB2 TGFA 4
FGFR1 AKT1 3
FGFR1 AKT2 3
FGFR1 AKT3 3
FGFR1 FGFR2 2
FGFR1 GRB2 3
FGFR1 HRAS 3
FGFR1 KRAS 2
FGFR1 NRAS 3
FGFR1 PIK3CA 3
FGFR1 PIK3CB 3
FGFR1 PIK3CD 2
FGFR1 PIK3CG 2
FGFR1 PIK3R1 5
FGFR1 PIK3R2 4
FGFR1 SOS1 6
FGFR1 SOS2 2
FGFR2 AKT1 3
FGFR2 AKT2 3
FGFR2 AKT3 3
FGFR2 CTNNB1 1
FGFR2 GRB2 6
FGFR2 PIK3CA 4
FGFR2 PIK3CB 3
FGFR2 PIK3CD 2
FGFR2 PIK3CG 2
FGFR2 PIK3R1 4
FGFR2 PIK3R2 2
FGFR2 SOS1 4
FGFR2 SOS2 2
FOXO1 CDKN1B 2
GRB2 AKT1 3
GRB2 AKT2 3
GRB2 AKT3 3
GRB2 HRAS 4
GRB2 HSP90AA1 3
GRB2 KRAS 3
GRB2 MAP2K1 1
GRB2 MAPK1 2
GRB2 MTOR 1
GRB2 PDGFRA 5
GRB2 PDGFRB 8
GRB2 PDPK1 3
GRB2 PIK3CA 4
GRB2 PIK3CB 4
GRB2 PIK3CG 3
GRB2 PIK3R1 9
GRB2 PIK3R2 6
GRB2 PIK3R3 3
GRB2 SOS1 12
GRB2 SOS2 7
GSK3B CCND1 3
GSK3B CREB1 2
GSK3B HRAS 1
GSK3B MDM2 2
GSK3B PTEN 2
GSK3B RELA 2
GSK3B TP53 8
HRAS MAP2K1 4
HRAS MAP2K2 2
HRAS MAPK1 3
HRAS MAPK3 3
HRAS PIK3CA 8
HRAS PIK3CB 4
HRAS PIK3CD 7
HRAS PIK3CG 8
HRAS PIK3R1 7
HRAS PIK3R2 2
HRAS SOS1 7
HSP90AA1 HSP90AB1 5
HSP90AA1 IKBKB 6
HSP90AA1 IKBKG 6
HSP90AA1 PDPK1 3
HSP90AA1 SOS1 1
HSP90AB1 IKBKB 5
HSP90AB1 IKBKG 5
HSP90B1 AR 1
IGF1 AKT1 1
IGF1 CDK2 1
IGF1 EGFR 1
IGF1 ERBB2 2
IGF1 FGFR1 1
IGF1 FOXO1 1
IGF1 GSK3B 1
IGF1 IGF1R 12
IGF1 INSRR 2
IGF1 MAPK1 3
IGF1 MAPK3 3
IGF1 MTOR 1
IGF1 PDGFRA 1
IGF1 PDGFRB 1
IGF1 PIK3CA 2
IGF1 PIK3R1 2
IGF1R AKT1 1
IGF1R AKT2 1
IGF1R AKT3 1
IGF1 RB1 1
IGF1R HRAS 2
IGF1R INS 3
IGF1R KRAS 1
IGF1R MAPK1 2
IGF1R MAPK3 2
IGF1R PDPK1 1
IGF1R PIK3CA 3
IGF1R PIK3CB 2
IGF1R PIK3CD 2
IGF1R PIK3CG 1
IGF1R PIK3R1 8
IGF1R PIK3R2 4
IGF1R PIK3R3 5
IGF1R PIK3R5 1
IKBKB IKBKG 12
IKBKB NFKB1 9
IKBKB NFKBIA 14
IKBKB RELA 11
IKBKG AKT2 1
IKBKG AKT3 1
IKBKG NFKB1 8
IKBKG NFKBIA 11
IKBKG RELA 6
INS AKT1 2
INS AKT2 1
INS EGFR 2
INS GSK3B 1
INS INSRR 2
INS MAPK1 2
INS MAPK3 2
INS PIK3CA 2
INS PIK3R1 2
INS RB1 3
KRAS MAPK1 3
KRAS MAPK3 2
KRAS PIK3CA 5
KRAS PIK3CB 4
KRAS PIK3CD 3
KRAS PIK3CG 5
KRAS PIK3R1 3
KRAS PIK3R2 3
LEF1 CCND1 3
LEF1 NRAS 2
LEF1 TCF7L2 2
MAP2K1 AKT1 1
MAP2K1 AKT2 1
MAP2K1 AKT3 1
MAP2K1 GSK3B 1
MAP2K1 MAP2K2 7
MAP2K1 MAPK1 13
MAP2K1 MAPK3 12
MAP2K1 NRAS 2
MAP2K1 PIK3CA 2
MAP2K2 AKT1 1
MAP2K2 AKT2 1
MAP2K2 AKT3 1
MAP2K2 MAPK1 10
MAP2K2 MAPK3 11
MAP2K2 NRAS 2
MAPK1 AKT1 2
MAPK1 AKT2 1
MAPK1 AKT3 1
MAPK1 BAD 3
MAPK1 BCL2 3
MAPK1 CCND1 1
MAPK1 CDK2 2
MAPK1 CDKN1A 1
MAPK1 CDKN1B 1
MAPK1 CREB1 1
MAPK1 CREBBP 1
MAPK1 FGFR1 2
MAPK1 MAPK3 4
MAPK1 RELA 1
MAPK1 SOS1 5
MAPK1 TP53 4
MAPK3 AKT1 1
MAPK3 AKT2 1
MAPK3 AKT3 1
MAPK3 AR 2
MAPK3 BAD 2
MAPK3 BCL2 3
MAPK3 CCND1 1
MAPK3 CDK2 2
MAPK3 CDKN1B 1
MAPK3 CREB1 1
MAPK3 FGFR1 2
MAPK3 GSK3B 1
MAPK3 RELA 1
MAPK3 SOS1 2
MAPK3 TP53 3
MDM2 RB1 7
MDM2 TP53 12
MTOR AKT2 3
MTOR AKT3 4
MTOR NFKB1 1
MTOR PDPK1 3
MTOR RELA 1
NFKB1 BCL2 1
NFKB1 NFKBIA 12
NFKB1 RELA 12