Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002667 Chronic myeloid leukemia KEGG Homo sapiens 69 881
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
BAD ENSG00000002330 572 Cytoplasm 0.007633588 91.0 0.8827627 0.012942613
BRAF ENSG00000157764 673 Cytoplasm 0.008064516 103.0 5.669632 0.013896821
CBLC ENSG00000142273 23624 Cytoplasm 0.007692308 24.0 0.1617014 0.289855072
CDK4 ENSG00000135446 1019 Cytoplasm 0.008928571 78.0 7.111859 0.057609058
CHUK ENSG00000213341 1147 Cytoplasm 0.00877193 107.0 7.477827 0.024687004
GAB2 ENSG00000033327 9846 Cytoplasm 0.010204082 115.0 13.02278 0.061327231
MAP2K1 ENSG00000169032 5604 Cytoplasm 0.009009009 221.0 17.94798 0.00793912
PTPN11 ENSG00000179295 5781 Cytoplasm 0.009009009 89.0 3.866199 0.070224719
SHC3 ENSG00000148082 53358 Cytoplasm 0.008064516 29.0 0.1164935 0.25862069
SHC4 ENSG00000185634 399694 Cytoplasm 0.006578947 12.0 0.0 0.045454545
SOS1 ENSG00000115904 6654 Cytoplasm 0.009708738 123.0 7.396488 0.047181128
SOS2 ENSG00000100485 6655 Cytoplasm 0.009174312 71.0 2.932225 0.098591549
AKT2 ENSG00000105221 208 Cytoplasm/Nucleus 0.010869565 426.0 98.9397 0.004529136
ARAF ENSG00000078061 369 Cytoplasm/Nucleus 0.008 79.0 1.332594 0.023369036
BCL2L1 ENSG00000171552 598 Cytoplasm/Nucleus 0.008547009 41.0 3.283228 0.12804878
BCR ENSG00000186716 613 Cytoplasm/Nucleus 0.00990099 77.0 16.92835 0.121326042
CBL ENSG00000110395 867 Cytoplasm/Nucleus 0.00877193 76.0 6.282221 0.064912281
CBLB ENSG00000114423 868 Cytoplasm/Nucleus 0.008333333 48.0 0.3982382 0.136524823
CCND1 ENSG00000110092 595 Cytoplasm/Nucleus 0.009345794 86.0 17.28288 0.053077975
CDK6 ENSG00000105810 1021 Cytoplasm/Nucleus 0.00862069 74.0 8.644205 0.053683821
CDKN1A ENSG00000124762 1026 Cytoplasm/Nucleus 0.01 130.0 36.53723 0.037924866
CDKN1B ENSG00000111276 1027 Cytoplasm/Nucleus 0.00862069 55.0 2.614519 0.086195286
CDKN2A ENSG00000147889 1029 Cytoplasm/Nucleus 0.008130081 80.0 10.61262 0.03164557
CRK ENSG00000167193 1398 Cytoplasm/Nucleus 0.009009009 60.0 5.776461 0.119774011
CRKL ENSG00000099942 1399 Cytoplasm/Nucleus 0.00862069 55.0 3.238787 0.142087542
CTBP1 ENSG00000159692 1487 Cytoplasm/Nucleus 0.008 25.0 3.47028 0.21
CTBP2 ENSG00000175029 1488 Cytoplasm/Nucleus 0.007042254 15.0 0.9743397 0.247619048
E2F1 ENSG00000101412 1869 Cytoplasm/Nucleus 0.009433962 76.0 16.45142 0.073684211
HDAC2 ENSG00000196591 3066 Cytoplasm/Nucleus 0.008264463 32.0 8.870253 0.153225806
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 0.008264463 104.0 5.120017 0.016990291
IKBKG ENSG00000269335 8517 Cytoplasm/Nucleus 0.008196721 92.0 3.205768 0.020305781
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 0.008547009 217.0 5.422943 0.007509814
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 0.009803922 192.0 44.04739 0.015543194
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 0.00952381 177.0 33.92507 0.01540832
MDM2 ENSG00000135679 4193 Cytoplasm/Nucleus 0.00877193 80.0 19.94644 0.042721519
MYC ENSG00000136997 4609 Cytoplasm/Nucleus 0.010204082 88.0 60.79749 0.080198537
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 0.009009009 117.0 10.76598 0.027998821
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 0.008403361 179.0 11.88155 0.005021656
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 0.009345794 122.0 23.35071 0.031838504
SMAD4 ENSG00000141646 4089 Cytoplasm/Nucleus 0.009090909 42.0 24.49659 0.177700348
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 0.011235955 108.0 63.41296 0.081862236
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 0.010526316 97.0 36.26781 0.08419244
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 0.010204082 103.0 35.00342 0.05730059
PIK3CD ENSG00000171608 5293 Cytoskeleton 0.009259259 180.0 8.433605 0.01874612
AKT1 ENSG00000142208 207 Membrane 0.012048193 510.0 243.2155 0.004391541
AKT3 ENSG00000117020 10000 Membrane 0.010638298 424.0 89.7228 0.004047906
PIK3CA ENSG00000121879 5290 Membrane 0.00990099 207.0 26.02055 0.017494489
PIK3CG ENSG00000105851 5294 Membrane 0.009174312 181.0 5.834236 0.018845918
PIK3R1 ENSG00000145675 5295 Membrane 0.010204082 218.0 39.38361 0.016065615
PIK3R2 ENSG00000105647 5296 Membrane 0.009174312 190.0 9.66014 0.01487051
PIK3R5 ENSG00000141506 23533 Membrane 0.008849558 144.0 8.49166 0.018550894
RAF1 ENSG00000132155 5894 Membrane 0.008403361 131.0 8.047905 0.011509102
SHC1 ENSG00000160691 6464 Membrane 0.010526316 127.0 51.16728 0.054118235
TGFBR1 ENSG00000106799 7046 Membrane 0.00877193 60.0 24.03238 0.071186441
ABL1 ENSG00000097007 25 Unknown 0.009433962 72.0 49.8596 0.080203443
GRB2 ENSG00000177885 2885 Unknown 0.010204082 261.0 107.0666 0.010698497
PIK3CB ENSG00000051382 5291 Unknown 0.009259259 183.0 6.960839 0.017834624
PIK3R3 ENSG00000117461 8503 Unknown 0.009345794 170.0 28.80733 0.017264184
SHC2 ENSG00000129946 25759 Unknown 0.008064516 31.0 0.1255886 0.225806452
TGFBR2 ENSG00000163513 7048 Unknown 0.008695652 61.0 32.77984 0.055191257
E2F2 ENSG00000007968 1870 Nucleus 0.008695652 47.0 2.469789 0.123034228
E2F3 ENSG00000112242 1871 Nucleus 0.00877193 52.0 3.373719 0.107843137
HDAC1 ENSG00000116478 3065 Nucleus 0.009174312 55.0 25.07824 0.119191919
MECOM ENSG00000085276 2122 Nucleus 0.0078125 17.0 4.57358 0.139705882
RB1 ENSG00000139687 5925 Nucleus 0.009708738 164.0 55.74186 0.019078258
RUNX1 ENSG00000159216 861 Nucleus 0.008196721 27.0 9.759362 0.156695157
TGFB1 ENSG00000105329 7040 Secreted 0.008264463 44.0 8.802207 0.068710359
TGFB2 ENSG00000092969 7042 Secreted 0.006993007 23.0 2.165513 0.071146245
TGFB3 ENSG00000119699 7043 Secreted 0.007518797 23.0 0.5587724 0.083003953
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BAD ENSG00000002330 572 Cytoplasm 4485.0 12100.0 1.55E-6 8.39E-5
BRAF ENSG00000157764 673 Cytoplasm 12094.0 42600.0 1.56E-6 4.04E-5
CBLC ENSG00000142273 23624 Cytoplasm 396.0 489.0 1.55E-6 0.0192
CDK4 ENSG00000135446 1019 Cytoplasm 2094.0 33700.0 1.56E-6 0.00259
CHUK ENSG00000213341 1147 Cytoplasm 9301.0 163000.0 1.56E-6 1.35E-4
GAB2 ENSG00000033327 9846 Cytoplasm 4097.0 11500.0 1.56E-6 0.00119
MAP2K1 ENSG00000169032 5604 Cytoplasm 23272.0 37700.0 1.56E-6 1.47E-5
PTPN11 ENSG00000179295 5781 Cytoplasm 9733.0 167000.0 1.56E-6 2.5E-4
SHC3 ENSG00000148082 53358 Cytoplasm 1052.0 3700.0 1.55E-6 0.0118
SHC4 ENSG00000185634 399694 Cytoplasm 146.0 151.0 1.55E-6 0.0152
SOS1 ENSG00000115904 6654 Cytoplasm 23511.0 177000.0 1.56E-6 6.54E-5
SOS2 ENSG00000100485 6655 Cytoplasm 6309.0 10000.0 1.56E-6 2.71E-4
AKT2 ENSG00000105221 208 Cytoplasm/Nucleus 23612.0 163000.0 1.56E-6 4.86E-5
ARAF ENSG00000078061 369 Cytoplasm/Nucleus 6326.0 11300.0 1.55E-6 1.03E-4
BCL2L1 ENSG00000171552 598 Cytoplasm/Nucleus 1045.0 12300.0 1.56E-6 0.0021
BCR ENSG00000186716 613 Cytoplasm/Nucleus 408.0 1660.0 1.56E-6 0.0434
CBL ENSG00000110395 867 Cytoplasm/Nucleus 5209.0 92900.0 1.56E-6 8.8E-4
CBLB ENSG00000114423 868 Cytoplasm/Nucleus 1299.0 34900.0 1.56E-6 0.00669
CCND1 ENSG00000110092 595 Cytoplasm/Nucleus 2739.0 100000.0 1.56E-6 0.00164
CDK6 ENSG00000105810 1021 Cytoplasm/Nucleus 1202.0 2340.0 1.55E-6 0.00147
CDKN1A ENSG00000124762 1026 Cytoplasm/Nucleus 3911.0 109000.0 1.56E-6 8.1E-4
CDKN1B ENSG00000111276 1027 Cytoplasm/Nucleus 1796.0 58900.0 1.56E-6 0.00264
CDKN2A ENSG00000147889 1029 Cytoplasm/Nucleus 1709.0 38000.0 1.56E-6 0.00396
CRK ENSG00000167193 1398 Cytoplasm/Nucleus 4161.0 46800.0 1.56E-6 8.51E-4
CRKL ENSG00000099942 1399 Cytoplasm/Nucleus 2208.0 9050.0 1.55E-6 0.00119
CTBP1 ENSG00000159692 1487 Cytoplasm/Nucleus 448.0 3790.0 1.55E-6 0.00878
CTBP2 ENSG00000175029 1488 Cytoplasm/Nucleus 113.0 16.7 1.55E-6 0.0209
E2F1 ENSG00000101412 1869 Cytoplasm/Nucleus 2673.0 379000.0 1.56E-6 0.00371
HDAC2 ENSG00000196591 3066 Cytoplasm/Nucleus 1401.0 42100.0 1.56E-6 0.011
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 10428.0 206000.0 1.56E-6 1.03E-4
IKBKG ENSG00000269335 8517 Cytoplasm/Nucleus 7020.0 201000.0 1.56E-6 2.07E-4
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 22859.0 10500.0 1.55E-6 9.5E-6
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 33563.0 1130000.0 1.56E-6 2.83E-5
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 29207.0 850000.0 1.56E-6 3.17E-5
MDM2 ENSG00000135679 4193 Cytoplasm/Nucleus 2666.0 363000.0 1.56E-6 0.00187
MYC ENSG00000136997 4609 Cytoplasm/Nucleus 4967.0 1640000.0 1.57E-6 0.00195
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 11386.0 280000.0 1.56E-6 2.06E-4
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 12604.0 63600.0 1.56E-6 3.76E-5
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 11059.0 663000.0 1.57E-6 3.08E-4
SMAD4 ENSG00000141646 4089 Cytoplasm/Nucleus 2908.0 151000.0 1.56E-6 0.00134
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 7688.0 196000.0 1.56E-6 4.69E-4
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 6515.0 71100.0 1.56E-6 5.43E-4
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 8418.0 2450000.0 1.57E-6 7.36E-4
PIK3CD ENSG00000171608 5293 Cytoskeleton 14967.0 29900.0 1.56E-6 1.22E-4
AKT1 ENSG00000142208 207 Membrane 52751.0 2150000.0 1.57E-6 1.74E-5
AKT3 ENSG00000117020 10000 Membrane 22158.0 86500.0 1.56E-6 5.25E-5
PIK3CA ENSG00000121879 5290 Membrane 27859.0 414000.0 1.56E-6 5.51E-5
PIK3CG ENSG00000105851 5294 Membrane 13674.0 58900.0 1.56E-6 1.37E-4
PIK3R1 ENSG00000145675 5295 Membrane 31452.0 734000.0 1.56E-6 4.03E-5
PIK3R2 ENSG00000105647 5296 Membrane 17436.0 144000.0 1.56E-6 9.14E-5
PIK3R5 ENSG00000141506 23533 Membrane 7488.0 14200.0 1.56E-6 3.32E-4
RAF1 ENSG00000132155 5894 Membrane 23706.0 140000.0 1.56E-6 1.64E-5
SHC1 ENSG00000160691 6464 Membrane 13549.0 312000.0 1.56E-6 2.6E-4
TGFBR1 ENSG00000106799 7046 Membrane 2531.0 39000.0 1.56E-6 0.00147
ABL1 ENSG00000097007 25 Unknown 2172.0 94200.0 1.56E-6 0.0021
GRB2 ENSG00000177885 2885 Unknown 29079.0 822000.0 1.57E-6 5.64E-5
PIK3CB ENSG00000051382 5291 Unknown 17496.0 62500.0 1.56E-6 1.07E-4
PIK3R3 ENSG00000117461 8503 Unknown 10628.0 40100.0 1.56E-6 1.94E-4
SHC2 ENSG00000129946 25759 Unknown 1261.0 3710.0 1.55E-6 0.00739
TGFBR2 ENSG00000163513 7048 Unknown 2260.0 45400.0 1.56E-6 0.00186
E2F2 ENSG00000007968 1870 Nucleus 895.0 5110.0 1.56E-6 0.00857
E2F3 ENSG00000112242 1871 Nucleus 1112.0 29600.0 1.56E-6 0.00863
HDAC1 ENSG00000116478 3065 Nucleus 3183.0 336000.0 1.56E-6 0.00344
MECOM ENSG00000085276 2122 Nucleus 113.0 599.0 1.55E-6 0.136
RB1 ENSG00000139687 5925 Nucleus 4373.0 218000.0 1.56E-6 0.00126
RUNX1 ENSG00000159216 861 Nucleus 292.0 11700.0 1.56E-6 0.0256
TGFB1 ENSG00000105329 7040 Secreted 2432.0 180000.0 1.56E-6 0.00178
TGFB2 ENSG00000092969 7042 Secreted 1022.0 11300.0 1.55E-6 0.00412
TGFB3 ENSG00000119699 7043 Secreted 1259.0 22100.0 1.55E-6 0.00323
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BAD ENSG00000002330 572 Cytoplasm 1742.0 10705.01 4.2E-6 3.79E-4
BRAF ENSG00000157764 673 Cytoplasm 3972.0 6132.577 4.2E-6 2.06E-4
CBLC ENSG00000142273 23624 Cytoplasm 274.0 1120.763 4.18E-6 0.035
CDK4 ENSG00000135446 1019 Cytoplasm 711.0 7090.933 4.2E-6 0.00407
CHUK ENSG00000213341 1147 Cytoplasm 2599.0 36153.6 4.21E-6 6.51E-4
GAB2 ENSG00000033327 9846 Cytoplasm 350.0 75.12536 4.18E-6 0.0202
MAP2K1 ENSG00000169032 5604 Cytoplasm 7272.0 15740.38 4.21E-6 8.17E-5
PTPN11 ENSG00000179295 5781 Cytoplasm 796.0 20049.31 4.2E-6 0.0115
SHC3 ENSG00000148082 53358 Cytoplasm 441.0 849.1556 4.19E-6 0.0232
SHC4 ENSG00000185634 399694 Cytoplasm 146.0 1547.293 4.17E-6 0.0105
SOS1 ENSG00000115904 6654 Cytoplasm 4893.0 29674.65 4.2E-6 7.29E-4
SOS2 ENSG00000100485 6655 Cytoplasm 3065.0 6034.529 4.19E-6 6.63E-4
AKT2 ENSG00000105221 208 Cytoplasm/Nucleus 12922.0 78105.47 4.22E-6 9.13E-5
ARAF ENSG00000078061 369 Cytoplasm/Nucleus 2172.0 2014.206 4.19E-6 3.38E-4
BCL2L1 ENSG00000171552 598 Cytoplasm/Nucleus 333.0 1700.349 4.2E-6 0.0103
BCR ENSG00000186716 613 Cytoplasm/Nucleus 210.0 88.4864 4.19E-6 0.101
CBL ENSG00000110395 867 Cytoplasm/Nucleus 912.0 35749.89 4.2E-6 0.0129
CBLB ENSG00000114423 868 Cytoplasm/Nucleus 489.0 4300.345 4.19E-6 0.0216
CCND1 ENSG00000110092 595 Cytoplasm/Nucleus 1212.0 11934.8 4.2E-6 0.00216
CDK6 ENSG00000105810 1021 Cytoplasm/Nucleus 544.0 1032.736 4.18E-6 0.00481
CDKN1A ENSG00000124762 1026 Cytoplasm/Nucleus 1218.0 21038.18 4.21E-6 0.00324
CDKN1B ENSG00000111276 1027 Cytoplasm/Nucleus 395.0 5163.975 4.2E-6 0.0186
CDKN2A ENSG00000147889 1029 Cytoplasm/Nucleus 665.0 1819.174 4.19E-6 0.00279
CRK ENSG00000167193 1398 Cytoplasm/Nucleus 1184.0 12216.01 4.21E-6 0.00506
CRKL ENSG00000099942 1399 Cytoplasm/Nucleus 831.0 3251.595 4.2E-6 0.006
CTBP1 ENSG00000159692 1487 Cytoplasm/Nucleus 135.0 738.0058 4.18E-6 0.0328
CTBP2 ENSG00000175029 1488 Cytoplasm/Nucleus 72.0 175.9326 4.17E-6 0.0387
E2F1 ENSG00000101412 1869 Cytoplasm/Nucleus 962.0 20410.09 4.21E-6 0.00696
HDAC2 ENSG00000196591 3066 Cytoplasm/Nucleus 217.0 5959.11 4.19E-6 0.0328
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 3098.0 92751.1 4.21E-6 5.25E-4
IKBKG ENSG00000269335 8517 Cytoplasm/Nucleus 2435.0 52492.89 4.21E-6 7.02E-4
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 7076.0 6362.52 4.2E-6 5.76E-5
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 9283.0 713798.1 4.23E-6 1.78E-4
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 8670.0 340044.6 4.23E-6 1.73E-4
MDM2 ENSG00000135679 4193 Cytoplasm/Nucleus 704.0 23910.3 4.21E-6 0.00538
MYC ENSG00000136997 4609 Cytoplasm/Nucleus 1499.0 110111.2 4.22E-6 0.00512
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 3288.0 55549.04 4.21E-6 4.97E-4
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 3700.0 14752.03 4.21E-6 1.6E-4
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 3598.0 133251.2 4.22E-6 6.78E-4
SMAD4 ENSG00000141646 4089 Cytoplasm/Nucleus 651.0 15312.43 4.2E-6 0.00643
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 874.0 16378.18 4.2E-6 0.0136
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 907.0 17327.71 4.21E-6 0.0118
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 2254.0 393334.3 4.23E-6 0.00213
PIK3CD ENSG00000171608 5293 Cytoskeleton 7623.0 27461.99 4.21E-6 2.8E-4
AKT1 ENSG00000142208 207 Membrane 15717.0 482990.1 4.23E-6 9.3E-5
AKT3 ENSG00000117020 10000 Membrane 12844.0 58455.1 4.22E-6 8.89E-5
PIK3CA ENSG00000121879 5290 Membrane 8869.0 406593.6 4.23E-6 3.0E-4
PIK3CG ENSG00000105851 5294 Membrane 7696.0 36531.18 4.21E-6 2.71E-4
PIK3R1 ENSG00000145675 5295 Membrane 9027.0 145916.0 4.22E-6 2.65E-4
PIK3R2 ENSG00000105647 5296 Membrane 7733.0 62072.47 4.21E-6 2.71E-4
PIK3R5 ENSG00000141506 23533 Membrane 6010.0 17375.45 4.21E-6 3.4E-4
RAF1 ENSG00000132155 5894 Membrane 6431.0 23256.74 4.21E-6 1.06E-4
SHC1 ENSG00000160691 6464 Membrane 1385.0 23043.32 4.21E-6 0.00641
TGFBR1 ENSG00000106799 7046 Membrane 814.0 18996.69 4.19E-6 0.00408
ABL1 ENSG00000097007 25 Unknown 546.0 19278.7 4.2E-6 0.0114
GRB2 ENSG00000177885 2885 Unknown 5947.0 100270.7 4.22E-6 5.35E-4
PIK3CB ENSG00000051382 5291 Unknown 7887.0 42564.19 4.21E-6 3.07E-4
PIK3R3 ENSG00000117461 8503 Unknown 7005.0 28510.25 4.21E-6 3.03E-4
SHC2 ENSG00000129946 25759 Unknown 459.0 829.57 4.19E-6 0.0201
TGFBR2 ENSG00000163513 7048 Unknown 780.0 21637.46 4.2E-6 0.00455
E2F2 ENSG00000007968 1870 Nucleus 536.0 2264.757 4.19E-6 0.00852
E2F3 ENSG00000112242 1871 Nucleus 621.0 4500.686 4.2E-6 0.00958
HDAC1 ENSG00000116478 3065 Nucleus 340.0 15570.54 4.2E-6 0.0295
MECOM ENSG00000085276 2122 Nucleus 82.0 520.694 4.19E-6 0.0702
RB1 ENSG00000139687 5925 Nucleus 1685.0 9774.921 4.2E-6 0.00173
RUNX1 ENSG00000159216 861 Nucleus 122.0 559.9324 4.19E-6 0.0591
TGFB1 ENSG00000105329 7040 Secreted 838.0 46848.33 4.21E-6 0.00553
TGFB2 ENSG00000092969 7042 Secreted 374.0 2654.415 4.17E-6 0.00932
TGFB3 ENSG00000119699 7043 Secreted 440.0 9398.126 4.18E-6 0.00881
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
ABL1 BCR 5
ABL1 CBL 4
ABL1 CBLB 2
ABL1 CBLC 1
ABL1 CDKN1B 4
ABL1 CRK 7
ABL1 CRKL 6
ABL1 GRB2 4
ABL1 HDAC2 1
ABL1 MDM2 4
ABL1 MYC 2
ABL1 NFKBIA 2
ABL1 RB1 6
ABL1 SHC1 3
ABL1 SOS1 2
ABL1 STAT5A 1
ABL1 STAT5B 1
AKT1 AKT2 2
AKT1 BAD 10
AKT1 BCL2L1 5
AKT1 BRAF 4
AKT1 CDKN1A 9
AKT1 CDKN1B 9
AKT1 CHUK 10
AKT1 E2F2 2
AKT1 IKBKB 7
AKT1 IKBKG 5
AKT1 MDM2 11
AKT1 NFKB1 3
AKT1 RAF1 6
AKT1 RELA 4
AKT1 TP53 4
AKT2 BAD 4
AKT2 CDKN1A 5
AKT2 CDKN1B 3
AKT2 CHUK 8
AKT2 IKBKB 2
AKT2 MDM2 3
AKT2 TP53 2
AKT3 BAD 4
AKT3 CDKN1A 4
AKT3 CDKN1B 3
AKT3 CHUK 3
AKT3 IKBKB 2
AKT3 MDM2 4
AKT3 NFKB1 3
ARAF AKT1 1
ARAF AKT2 1
ARAF AKT3 1
ARAF BAD 2
ARAF BRAF 4
ARAF MAP2K1 10
ARAF MAP2K2 8
ARAF MAPK1 2
ARAF MAPK3 2
ARAF RAF1 2
ARAF STAT5A 1
ARAF STAT5B 1
BAD BCL2L1 9
BCL2L1 TP53 6
BCR CBL 2
BCR CBLB 1
BCR CBLC 1
BCR CRK 3
BCR CRKL 4
BCR GAB2 3
BCR GRB2 7
BCR MYC 3
BCR PIK3CA 2
BCR PIK3R1 2
BCR SHC1 5
BCR SOS1 3
BCR STAT5A 2
BCR STAT5B 2
BRAF AKT2 1
BRAF AKT3 1
BRAF BAD 1
BRAF CRK 2
BRAF MAP2K1 12
BRAF MAP2K2 11
BRAF MAPK1 6
BRAF MAPK3 6
BRAF RAF1 9
BRAF STAT5A 1
BRAF STAT5B 1
CBLB AKT1 1
CBLB CRKL 6
CBLB GRB2 5
CBLB PIK3CA 2
CBLB PIK3CB 2
CBLB PIK3CD 2
CBLB PIK3CG 2
CBLB PIK3R1 6
CBLB PIK3R2 3
CBLB PIK3R3 1
CBLB PIK3R5 1
CBLB PTPN11 3
CBLB SHC1 4
CBL CBLB 4
CBLC PIK3CA 1
CBLC PIK3CB 1
CBLC PIK3CD 1
CBLC PIK3CG 1
CBLC PIK3R1 1
CBLC PIK3R2 1
CBLC PIK3R3 1
CBLC PIK3R5 1
CBL CRK 10
CBL CRKL 9
CBL GRB2 10
CBL PIK3CA 5
CBL PIK3CB 4
CBL PIK3CD 2
CBL PIK3CG 2
CBL PIK3R1 9
CBL PIK3R2 7
CBL PIK3R3 4
CBL PIK3R5 1
CBL PTPN11 4
CBL SHC1 7
CBL SOS1 5
CBL TGFBR2 2
CCND1 CDK4 11
CCND1 CDK6 10
CCND1 CDKN1A 8
CCND1 CDKN1B 6
CCND1 E2F1 3
CCND1 E2F2 3
CCND1 E2F3 3
CCND1 HDAC1 3
CCND1 RB1 10
CDK4 AKT1 1
CDK4 AKT2 1
CDK4 AKT3 1
CDK4 CDK6 5
CDK4 CDKN1A 7
CDK4 CDKN1B 6
CDK4 CDKN2A 9
CDK4 E2F1 4
CDK4 RB1 11
CDK4 STAT5A 2
CDK4 STAT5B 1
CDK6 AKT1 1
CDK6 AKT2 1
CDK6 AKT3 1
CDK6 CDKN1A 8
CDK6 CDKN1B 4
CDK6 CDKN2A 8
CDK6 RB1 11
CDK6 RUNX1 4
CDKN1A E2F1 4
CDKN1A HDAC1 4
CDKN1A RB1 5
CDKN1B RB1 1
CDKN2A CCND1 3
CDKN2A CDKN1A 2
CDKN2A E2F1 6
CDKN2A E2F2 2
CDKN2A E2F3 2
CDKN2A HDAC1 2
CDKN2A MDM2 9
CDKN2A MYC 4
CDKN2A RB1 2
CDKN2A TP53 4
CHUK CCND1 2
CHUK IKBKB 11
CHUK IKBKG 10
CHUK MYC 4
CHUK NFKB1 10
CHUK NFKBIA 14
CHUK RELA 11
CHUK STAT5A 1
CHUK STAT5B 1
CRK CRKL 3
CRK GAB2 2
CRK GRB2 5
CRKL GAB2 4
CRKL GRB2 4
CRKL PIK3CA 1
CRKL PIK3CB 1
CRKL PIK3CD 1
CRKL PIK3CG 1
CRKL PIK3R1 5
CRKL PIK3R2 4
CRKL PIK3R3 1
CRKL PIK3R5 1
CRKL PTPN11 5
CRKL STAT5A 5
CRKL STAT5B 3
CRK PIK3CA 2
CRK PIK3CB 2
CRK PIK3CD 2
CRK PIK3CG 1
CRK PIK3R1 6
CRK PIK3R2 4
CRK PIK3R3 3
CRK PIK3R5 1
CRK PTPN11 3
CRK SOS1 5
CTBP1 CTBP2 4
CTBP1 HDAC1 5
CTBP1 HDAC2 4
CTBP1 MYC 2
CTBP1 RB1 4
CTBP2 HDAC2 2
E2F1 E2F2 4
E2F1 E2F3 2
E2F1 HDAC1 5
E2F1 MYC 3
E2F1 PIK3R3 2
E2F1 RB1 10
E2F2 MYC 2
E2F2 RB1 8
E2F3 HDAC1 3
E2F3 RB1 8
GAB2 AKT1 3
GAB2 AKT2 3
GAB2 AKT3 3
GAB2 GRB2 7
GAB2 MAPK1 4
GAB2 MAPK3 5
GAB2 PIK3CA 5
GAB2 PIK3CB 5
GAB2 PIK3CD 3
GAB2 PIK3CG 3
GAB2 PIK3R1 7
GAB2 PIK3R2 4
GAB2 PTPN11 7
GAB2 SHC1 7
GAB2 SOS1 3
GRB2 AKT1 3
GRB2 AKT2 3
GRB2 AKT3 3
GRB2 MAP2K1 1
GRB2 MAPK1 2
GRB2 PIK3CA 4
GRB2 PIK3CB 4
GRB2 PIK3CG 3
GRB2 PIK3R1 9
GRB2 PIK3R2 6
GRB2 PIK3R3 3
GRB2 PTPN11 9
GRB2 SHC1 13
GRB2 SHC2 5
GRB2 SHC3 6
GRB2 SHC4 2
GRB2 SOS1 12
GRB2 SOS2 7
HDAC1 HDAC2 8
HDAC1 MDM2 4
HDAC1 NFKBIA 4
HDAC1 RB1 8
HDAC1 SMAD4 6
HDAC1 STAT5A 2
HDAC1 TP53 5
HDAC2 MDM2 2
HDAC2 NFKB1 2
HDAC2 RB1 5
HDAC2 RELA 5
HDAC2 SMAD4 3
HDAC2 TP53 4
IKBKB CDKN2A 1
IKBKB IKBKG 12
IKBKB NFKB1 9
IKBKB NFKBIA 14
IKBKB RELA 11
IKBKB STAT5A 1
IKBKB STAT5B 1
IKBKG AKT2 1
IKBKG AKT3 1
IKBKG NFKB1 8
IKBKG NFKBIA 11
IKBKG RELA 6
IKBKG STAT5A 1
IKBKG STAT5B 1
MAP2K1 AKT1 1
MAP2K1 AKT2 1
MAP2K1 AKT3 1
MAP2K1 MAP2K2 7
MAP2K1 MAPK1 13
MAP2K1 MAPK3 12
MAP2K1 PIK3CA 2
MAP2K1 RAF1 10
MAP2K1 STAT5A 1
MAP2K1 STAT5B 1
MAP2K2 AKT1 1
MAP2K2 AKT2 1
MAP2K2 AKT3 1
MAP2K2 MAPK1 10
MAP2K2 MAPK3 11
MAP2K2 RAF1 7
MAP2K2 STAT5A 1
MAP2K2 STAT5B 1
MAPK1 AKT1 2
MAPK1 AKT2 1
MAPK1 AKT3 1
MAPK1 BAD 3
MAPK1 CCND1 1
MAPK1 CDKN1A 1
MAPK1 CDKN1B 1
MAPK1 MAPK3 4
MAPK1 MYC 5
MAPK1 RAF1 5
MAPK1 RELA 1
MAPK1 RUNX1 1
MAPK1 SHC1 5
MAPK1 SMAD4 2
MAPK1 SOS1 5
MAPK1 STAT5A 6
MAPK1 STAT5B 3
MAPK1 TP53 4
MAPK3 AKT1 1
MAPK3 AKT2 1
MAPK3 AKT3 1
MAPK3 BAD 2
MAPK3 CCND1 1
MAPK3 CDKN1B 1
MAPK3 MYC 6
MAPK3 PTPN11 4
MAPK3 RAF1 5
MAPK3 RELA 1
MAPK3 RUNX1 1
MAPK3 SHC1 2
MAPK3 SOS1 2
MAPK3 STAT5A 5
MAPK3 STAT5B 2
MAPK3 TP53 3
MDM2 RB1 7
MDM2 TP53 12
MECOM CTBP2 1
MECOM HDAC2 1
MYC CCND1 1
MYC TP53 6
NFKB1 BCL2L1 2
NFKB1 NFKBIA 12
NFKB1 RELA 12
NFKBIA PIK3R1 4
NFKBIA RELA 14
PIK3CA AKT1 5
PIK3CA AKT2 4
PIK3CA AKT3 4
PIK3CA PIK3CD 2
PIK3CA PIK3R1 14
PIK3CA PIK3R2 7
PIK3CA PIK3R3 7
PIK3CA PTPN11 3
PIK3CA RELA 1
PIK3CA SHC1 3
PIK3CA SOS1 3
PIK3CA SOS2 1
PIK3CB AKT1 4
PIK3CB AKT2 4
PIK3CB AKT3 4
PIK3CB PIK3CA 2
PIK3CB PIK3CD 2
PIK3CB PIK3CG 2
PIK3CB PIK3R1 10
PIK3CB PIK3R2 6
PIK3CB PIK3R3 7
PIK3CB PTPN11 2
PIK3CB SHC1 3
PIK3CB SOS1 3
PIK3CB SOS2 1
PIK3CD AKT1 3
PIK3CD AKT2 3
PIK3CD AKT3 4
PIK3CD GRB2 2
PIK3CD PIK3CG 3
PIK3CD PIK3R1 10
PIK3CD PIK3R2 9
PIK3CD PIK3R3 4
PIK3CD SHC1 2
PIK3CD SOS1 2
PIK3CD SOS2 1
PIK3CG AKT1 5
PIK3CG AKT2 4
PIK3CG AKT3 4
PIK3CG MAP2K1 1
PIK3CG PIK3CA 2
PIK3CG PIK3R1 2
PIK3CG PIK3R2 2
PIK3CG PIK3R3 2
PIK3CG PIK3R5 6
PIK3CG PTPN11 2
PIK3CG SHC1 3
PIK3CG SOS1 3
PIK3CG SOS2 1
PIK3R1 AKT1 6
PIK3R1 AKT2 4
PIK3R1 AKT3 4
PIK3R1 PIK3R2 5
PIK3R1 PIK3R3 3
PIK3R1 PTPN11 7
PIK3R1 RELA 3
PIK3R1 SHC1 8
PIK3R1 SOS1 8
PIK3R1 SOS2 3
PIK3R1 TP53 3
PIK3R2 AKT1 4
PIK3R2 AKT2 3
PIK3R2 AKT3 3
PIK3R2 PIK3R3 4
PIK3R2 PTPN11 4
PIK3R2 SHC1 5
PIK3R2 SOS1 4
PIK3R2 SOS2 2
PIK3R3 AKT1 3
PIK3R3 AKT2 3
PIK3R3 AKT3 3
PIK3R3 GAB2 2
PIK3R3 PTPN11 2
PIK3R3 SHC1 1
PIK3R3 SOS1 2
PIK3R5 AKT1 4
PIK3R5 AKT2 3
PIK3R5 AKT3 3
PIK3R5 GAB2 2
PIK3R5 GRB2 2
PIK3R5 SHC1 2
PIK3R5 SOS1 2
PTPN11 AKT1 2
PTPN11 MAPK1 3
PTPN11 SHC1 4
PTPN11 SOS1 5
PTPN11 STAT5A 4
PTPN11 STAT5B 3
RAF1 AKT2 1
RAF1 AKT3 1
RAF1 BAD 3
RAF1 RB1 5
RAF1 STAT5A 1
RAF1 STAT5B 1
RELA BCL2L1 2
RELA TP53 3